Dynamically regulated sumoylation of HDAC2 controls p53 deacetylation and restricts apoptosis following genotoxic stress

Mule determines the apoptotic response to HDAC inhibitors by targeted ubiquitination and destruction of HDAC2

(2011) J. Zhang et al.   GENES & DEVELOPMENT

Methyltransferase Set7/9 regulates p53 activity by interacting with Sirtuin 1 (SIRT1)

(2011) Xiangyu Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hdac1 and Hdac2 Act Redundantly to Control p63 and p53 Functions in Epidermal Progenitor Cells

(2010) Matthew LeBoeuf et al.   DEVELOPMENTAL CELL

Overlapping functions of Hdac1 and Hdac2 in cell cycle regulation and haematopoiesis

(2010) Roel H Wilting et al.   EMBO JOURNAL

SUMO engages multiple corepressors to regulate chromatin structure and transcription

(2010) Jian Ouyang et al.   Epigenetics

Immunohistochemical detection of histone deacetylases in endometrial carcinoma: involvement of histone deacetylase 2 in the proliferation of endometrial carcinoma cells

(2010) Hussein Fakhry et al.   HUMAN PATHOLOGY

Histone deacetylase inhibitors enhance the anticancer activity of nutlin-3 and induce p53 hyperacetylation and downregulation of MDM2 and MDM4 gene expression

(2010) Chithra D. Palani et al.   INVESTIGATIONAL NEW DRUGS

The SUMO pathway: emerging mechanisms that shape specificity, conjugation and recognition

(2010) Jaclyn R. Gareau et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Coordination of PAD4 and HDAC2 in the regulation of p53-target gene expression

(2010) P Li et al.   ONCOGENE

p21 does not protect cancer cells from apoptosis induced by nongenotoxic p53 activation

(2010) M Xia et al.   ONCOGENE

Emerging roles of desumoylating enzymes

(2009) Jung Hwa Kim et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Histone deacetylases: salesmen and customers in the post-translational modification market

(2009) André Brandl et al.   BIOLOGY OF THE CELL

Blinded by the Light: The Growing Complexity of p53

(2009) Karen H. Vousden et al.   CELL

HDAC2 mediates therapeutic resistance of pancreatic cancer cells via the BH3-only protein NOXA

(2009) P Fritsche et al.   GUT

STAT6 and STAT1 are essential antagonistic regulators of cell survival in classical Hodgkin lymphoma cell line

(2009) D Baus et al.   LEUKEMIA

Complementary Quantitative Proteomics Reveals that Transcription Factor AP-4 Mediates E-box-dependent Complex Formation for Transcriptional Repression ofHDM2

(2009) Wei-Chi Ku et al.   MOLECULAR & CELLULAR PROTEOMICS

HDAC expression and clinical prognosis in human malignancies

(2008) Wilko Weichert   CANCER LETTERS

Statins Increase p21 through Inhibition of Histone Deacetylase Activity and Release of Promoter-Associated HDAC1/2

(2008) Y.-C. Lin et al.   CANCER RESEARCH

Acetylation Is Indispensable for p53 Activation

(2008) Yi Tang et al.   CELL

Class I Histone Deacetylase Expression Has Independent Prognostic Impact in Human Colorectal Cancer: Specific Role of Class I Histone Deacetylases In vitro and In vivo

(2008) W. Weichert et al.   CLINICAL CANCER RESEARCH

The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men

(2008) Xiang-Jiao Yang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Transforming pathways unleashed by a HDAC2 mutation in human cancer

(2008) S Ropero et al.   ONCOGENE

PCAF is an HIF-1α cofactor that regulates p53 transcriptional activity in hypoxia

(2008) G Xenaki et al.   ONCOGENE

Histone deacetylase 2 expression predicts poorer prognosis in oral cancer patients

(2008) Hao-Hueng Chang et al.   ORAL ONCOLOGY