Review
Oncology
Raffaella Casolino, Vincenzo Corbo, Philip Beer, Chang-il Hwang, Salvatore Paiella, Valentina Silvestri, Laura Ottini, Andrew V. Biankin
Summary: Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis with lack of effective screening strategies and limited treatment options. However, germline variants in certain genes are emerging as potential targets for PDAC treatment and prevention, with important implications for broad cancer prevention.
Review
Biochemistry & Molecular Biology
Loredana Moro
Summary: Pancreatic cancer is an aggressive disease with poor prognosis, where only a small percentage of patients can undergo surgical resection. Chemotherapy and radiotherapy offer limited survival benefits. Research has focused on understanding the role of mitochondria in pancreatic cancer, as these organelles play crucial roles in cell survival and response to chemotherapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Jiajia Li, Liyao Peng, Qun Chen, Ziping Ye, Tiantian Zhao, Sicong Hou, Jianguo Gu, Qinglei Hang
Summary: Pancreatic cancer is a rapidly progressing disease with high mortality. Current treatment methods include surgery, radiotherapy, and chemotherapy, but the survival rate remains disappointing. Therefore, understanding the molecular mechanisms and developing targeted drugs are crucial for improving prognosis. Integrin beta 1, a common beta subunit of the integrin family, has been found to be closely related to vascular invasion, distant metastasis, and survival in pancreatic cancer patients, and targeted treatment with integrin beta 1 has shown initial success in animal models. This review summarizes the signaling pathways involving integrins in pancreatic cancer and focuses on the role of integrin beta 1 in the malignant behaviors of pancreatic cancer. The feasibility of integrin beta 1 as a diagnostic and prognostic biomarker in pancreatic cancer is also discussed, along with the progress of several clinical trials targeting integrin beta 1.
Review
Gastroenterology & Hepatology
Xing-Yu Liu, Chuan-Hao Guo, Zhi-Yuan Xi, Xin-Qi Xu, Qing-Yang Zhao, Li-Sha Li, Ying Wang
Summary: In pancreatic cancer research, histone methylation plays a crucial role, with writers and erasers potentially serving as therapeutic targets, while further research on reader domains is needed.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Medicine, General & Internal
Jin K. Kim, Xuan Qu, Chin-Tung Chen, J. Joshua Smith, Francisco Sanchez-Vega, Julio Garcia-Aguilar
Summary: Accurate clinical staging is crucial in rectal cancer for determining treatment and prognosis. This study aimed to investigate miRNA expression differences between stage I and II/III rectal cancers, identifying 19 overexpressed miRNAs with potential diagnostic value. Integration analysis revealed significant correlations between miRNA-mRNA pairs, suggesting these miRNAs could serve as diagnostic biomarkers for advanced rectal cancer.
Review
Medicine, Research & Experimental
Liaoran Niu, Wanli Yang, Lili Duan, Xiaoqian Wang, Yiding Li, Chengchao Xu, Chao Liu, Yujie Zhang, Wei Zhou, Jinqiang Liu, Qingchuan Zhao, Liu Hong, Daiming Fan
Summary: Colorectal cancer is the third most common cancer with high mortality rates, mainly attributed to metastasis. MicroRNAs play a significant role in manipulating malignant phenotypes in CRC, and certain miRNAs related to metastasis have potential as biomarkers or therapeutic targets. Further research is needed to translate these findings into clinical applications.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Review
Oncology
Moritz Reese, Sameer A. Dhayat
Summary: Pancreatic cancer has a poor prognosis due to its aggressive nature, late diagnosis, and resistance to treatment. Non-coding RNAs distributed through sEVs in the tumor microenvironment play a crucial role in intercellular communication and can serve as potential biomarkers and delivery vehicles for cancer therapy.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2021)
Article
Medicine, Research & Experimental
Anirban Goutam Mukherjee, Uddesh Ramesh Wanjari, Abilash Valsala Gopalakrishnan, Pragya Bradu, Aarthi Sukumar, Megha Patil, Kaviyarasi Renu, Abhijit Dey, Balachandar Vellingiri, Alex George, Raja Ganesan
Summary: This review provides a detailed study on pancreatic cancer and its association with different types of cancer related to diabetes. It discusses the combination of anti-diabetic drugs with other anti-cancer drugs and phytochemicals for the prevention and treatment of the disease. The migration and development of pancreatic cancer stem cells (CSCs) are also discussed. Additionally, it explores the mechanisms of diabetes development that enhance the proliferation of pancreatic CSCs, such as increased IGF factor levels, epigenetic modifications, DNA damage, and lifestyle factors like obesity and inflammation.
Review
Medicine, General & Internal
Xiangyu Chu, Dan Wei, Xinxin Liu, Di Long, Xiaodong Tian, Yinmo Yang
Summary: Pancreatic cancer is a highly aggressive malignancy with a poor prognosis. Aberrant expression of microRNAs (miRNAs) is often associated with the initiation, progression, and metastasis of pancreatic cancer. This review discusses the potential of integrating miRNAs into the treatment of pancreatic cancer and offers insights for the development of precision medicine.
CHINESE MEDICAL JOURNAL
(2022)
Review
Chemistry, Multidisciplinary
Hai-feng Hu, Zeng Ye, Yi Qin, Xiao-wu Xu, Xian-jun Yu, Qi-feng Zhuo, Shun-rong Ji
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a deadly cancer with high mortality rate due to lack of early diagnosis measures and strong resistance to chemotherapy. Research focus is on studying the functions of key driver genes and their clinical implications for further application.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Oncology
Jianbo Tian, Can Chen, Meilin Rao, Ming Zhang, Zequn Lu, Yimin Cai, Pingting Ying, Bin Li, Haoxue Wang, Lu Wang, Yao Li, Jinyu Huang, Linyun Fan, Xiaomin Cai, Caibo Ning, Yanmin Li, Fuwei Zhang, Wenzhuo Wang, Yuan Jiang, Yizhuo Liu, Min Wang, Heng Li, Chaoqun Huang, Zhiyong Yang, Jiang Chang, Ying Zhu, Xiaojun Yang, Xiaoping Miao
Summary: Understanding genetic variation in transcript splicing is crucial for studying the mechanisms of common diseases. This study conducted a genome-wide sQTL analysis on PDAC samples and discovered a large number of sQTLs associated with RNA-binding proteins and chromatin regulatory elements. Unlike eQTLs, sQTLs provided additional insights into disease mechanisms. Additionally, sQTLs had important implications for cancer signaling pathways, immune infiltration, and pharmaceutical targets.
Article
Chemistry, Medicinal
Jinlong Li, Dongdong Peng, Yun Xie, Zong Dai, Xiaoyong Zou, Zhanchao Li
Summary: The development of a new computational method for identifying potential small molecule-miRNA-cancer associations has shown high accuracy, precision, recall, and F1-measure, as well as excellent performance in predicting real data and through a case study. The model serves as a valuable tool for drug research and development, with potential small molecules and miRNAs related to cancer identified for further exploration.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2021)
Review
Oncology
Wei Zhang, Tingting Jiang, Keping Xie
Summary: Pancreatic cancer (PC) has a low 5-year survival rate and is the most lethal human cancer. Pancreatic premalignancy is linked to PC initiation and includes various lesions. Epigenetic dysregulation plays a role in pancreatic tumorigenesis, leading to alterations in gene expression. Understanding the mechanisms of epigenetic reprogramming in pancreatic premalignant lesions can aid in early detection and treatment of PC.
FRONTIERS IN ONCOLOGY
(2023)
Review
Oncology
Chiara Tommasi, Benedetta Pellegrino, Daniela Boggiani, Angelica Sikokis, Maria Michiara, Vera Uliana, Beatrice Bortesi, Francesco Bonatti, Paola Mozzoni, Silvana Pinelli, Anna Squadrilli, Maria Vittoria Viani, Diana Cassi, Giuseppe Maglietta, Marco Meleti, Antonino Musolino
Summary: Women with pathogenic germline mutations in BRCA1 and BRCA2 genes have an increased risk of developing breast and ovarian cancer, but there is high variability in the timing and manner of tumor onset, suggesting a potential role of other genetic, epigenetic, and environmental factors. MiRNAs can modulate gene expression in cancer and are dysregulated in breast cancer, but a standardized method for evaluation is needed for accurate data analysis. MiRNAs have the potential to serve as biological markers for BRCA mutation carriers, with discussions on the relationship between lifestyle, nutrition, miRNA expression, and BRCA mutations based on scientific evidence.
FRONTIERS IN ONCOLOGY
(2021)
Review
Cell Biology
Yi-Bo Yao, Chang-Fang Xiao, Jin-Gen Lu, Chen Wang
Summary: Caldesmon, an actin-binding protein, plays a crucial role in muscle contraction and cancer development. Studies have shown that caldesmon may be a potential therapeutic target for cancer treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
