Article
Radiology, Nuclear Medicine & Medical Imaging
Adrian Kobe, Yanick Kindler, Ernst Klotz, Gilbert Puippe, Florian Messmer, Hatem Alkadhi, Thomas Pfammatter
Summary: This study aimed to evaluate the fusion of pre-RFA MR imaging with post-treatment P-CT for predicting local tumor recurrence after RFA of HCCs. The results showed that this method is highly accurate in determining treatment success by predicting local tumor recurrence.
INVESTIGATIVE RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Damiano Caruso, Elisa Rosati, Nicola Panvini, Marco Rengo, Davide Bellini, Giulia Moltoni, Benedetta Bracci, Elena Lucertini, Marta Zerunian, Michela Polici, Domenico De Santis, Elsa Iannicelli, Paolo Anibaldi, Iacopo Carbone, Andrea Laghi
Summary: LBW-adapted CM administration for abdominal CT reduces the volume of injected CM and improves both image quality and parenchymal enhancement.
INSIGHTS INTO IMAGING
(2021)
Article
Biochemistry & Molecular Biology
Alexey A. Lipengolts, Yulia A. Finogenova, Vsevolod A. Skribitsky, Kristina E. Shpakova, Adi Anaki, Menachem Motiei, Alevtina S. Semkina, Maxim A. Abakumov, Anna V. Smirnova, Elena Y. Grigorieva, Rachela Popovtzer
Summary: In this study, core/shell Fe3O4@Au theranostic nanoparticles were developed with the aim of providing bimodal CT and MRI enhancement. These nanoparticles showed significant enhancement of tumors and tumor blood vessels and accumulated in the liver and spleen. They were found to be non-toxic and effective contrast agents for CT and MRI diagnostics, with potential applications in cancer diagnostics and beyond.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Ying Zhang, Kazushi Numata, Yuewu Du, Shin Maeda
Summary: Hepatocellular carcinoma, ranking third in cancer incidence, poses a significant threat to cancer patients. Early diagnosis through research on cirrhosis and HCC offers hope for a favorable prognosis. Non-invasive medical imaging, particularly contrast media enhancement scan, has become the mainstream method for early diagnosis. Different contrast media with distinct advantages play important roles in various imaging modalities, necessitating knowledge of appropriate imaging approaches and characteristic contrast media for HCC diagnosis and treatment.
FRONTIERS IN ONCOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Donghe Chen, Shuye Yang, Jingjing Chen, Tiancheng Li, Yinuo Liu, Xin Zhao, Tingting Zhang, Mimi Xu, Huatao Wang, Kui Zhao, Xinhui Su
Summary: This retrospective study evaluated the diagnostic accuracy of [F-18]-OC PET/CT in neuroendocrine neoplasms (NENs), and compared it with contrast-enhanced CT/MRI. The results showed that [F-18]-OC PET/CT had high sensitivity, specificity, and accuracy, making it a promising imaging modality for initial diagnosis and detecting metastasis or postoperative recurrence in NENs.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yuan Xue, Bin Xiao, Zhiyang Xia, Lixiong Dai, Qian Xia, Lei Zhong, Chunrong Zhu, Jiang Zhu
Summary: This study evaluated the ability of Mn-BnO-TyEDTA MRI contrast agent to detect hepatocellular carcinoma in a mouse model. Results showed that it provides comparable hepatobiliary tumor contrast enhancement to Gd-EOB-DTPA.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ali Pourvaziri, Amirkasra Mojtahed, Peter F. Hahn, Michael S. Gee, Avinash Kambadakone, Dushyant Sahani
Summary: This study aims to assess the impact of dual-energy CT (DECT) in renal lesion assessment and compare it with single-energy CT (SECT) and contrast-enhanced MRI. The results show that DECT has similar diagnostic accuracy to MRI in assessing renal lesions and reduces the need for additional and follow-up imaging.
EUROPEAN RADIOLOGY
(2023)
Article
Otorhinolaryngology
Matthew E. Lin, Carlos X. Castellanos, Joseph R. Acevedo, Jeffrey C. Yu, Niels C. Kokot
Summary: PET/CT surveillance imaging is cost-effective for patients with human papillomavirus-positive oropharyngeal squamous cell carcinoma, especially when the cost does not exceed $1678.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2023)
Article
Oncology
Fei Wang, Rui Guo, Yan Zhang, Boqi Yu, Xiangxi Meng, Hanjing Kong, Yang Yang, Zhi Yang, Nan Li
Summary: This study investigated the value of F-18-FDG PET/MRI in the preoperative assessment of ESCC and compared it with other imaging methods. The results showed that F-18-FDG PET/MRI had higher accuracy and area under the curve in diagnosing primary tumors and regional lymph node metastases. Therefore, F-18-FDG PET/MRI may be a potential supplement or alternative imaging method for preoperative staging of ESCC.
FRONTIERS IN ONCOLOGY
(2022)
Article
Chemistry, Applied
Hamed Nosrati, Marziyeh Salehiabar, Faezeh Mozafari, Jalil Charmi, Nuri Erdogan, Mohammadreza Ghaffarlou, Fatemeh Abhari, Hossein Danafar, Ali Ramazani, Yavuz Nuri Ertas
Summary: Early diagnosis and treatment of cancer is crucial, and theranostic systems play a significant role in this aspect. In this study, bi-functional nanoparticles were developed as dual MRI/CT contrast agent and carrier of natural anticancer drug. These nanoparticles showed good performance in both MRI and CT imaging contrast, while also demonstrating high biocompatibility and anticancer activity.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Otorhinolaryngology
Shoaib Ahmad, Manish Mair, Puteri Abdul Haris, Abbas Haider, Andrew Baker, Peter Conboy, Harriet Walter, Lakshmiah Raj, Simon Wright, Ram Vaidhyanath, Sridhar Thiagarajan
Summary: This retrospective study evaluated the utility of FDG PET in initial staging and management of head and neck cancers, finding that PET-CT changed management in 36.4% of cases. It concluded that PET-CT plays an important role in appropriate initial staging and subsequent treatment planning.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2021)
Article
Oncology
Alexandre Lugat, Eric Frampas, Yann Touchefeu, Eric Mirallie, Maelle Le Bras, Helene Senellart, Aurore Rauscher, Vincent Fleury, Loic Campion, Vincent Rohmer, Olivier-Francois Couturier, Rachida Lebtahi, Francois Rouzet, Philippe Ruszniewski, Francoise Kraeber-Bodere, Mickael Bourgeois, Catherine Ansquer
Summary: In this multicentric study, Ga-68-DOTANOC PET/CT showed higher sensitivity compared to conventional imaging techniques in evaluating the spread of neuroendocrine tumors. It had a significant impact on therapeutic management for almost half of the patients with grade 1-2 gastroenteropancreatic neuroendocrine tumors.
Review
Radiology, Nuclear Medicine & Medical Imaging
Alecio F. Lombardi, Ya-Jun Ma, Hyungseok Jang, Saeed Jerban, Jiang Du, Eric Y. Chang, Christine B. Chung
Summary: This systematic review provides an overview of alternative methods to computed tomography (CT), such as ultrashort echo time, zero echo time, gradient-echo, susceptibility-weighted image MR sequences, and artificial intelligence. It summarizes the technical background, research and clinical applications, advantages, limitations, and future opportunities for these techniques.
INVESTIGATIVE RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Keitaro Sofue, Eisuke Ueshima, Atsuhiro Masuda, Sachiyo Shirakawa, Yoh Zen, Yoshiko Ueno, Yushi Tsujita, Takeru Yamaguchi, Shinji Yabe, Takeshi Tanaka, Noriko Inomata, Hirochika Toyama, Takumi Fukumoto, Yuzo Kodama, Takamichi Murakami
Summary: The ECV fraction can be used to assess pancreatic fibrosis and predict postoperative pancreatic fistula. Evaluation of pancreatic tissue can be conducted through multiphasic CE-CT to obtain relevant results.
EUROPEAN RADIOLOGY
(2022)
Article
Gastroenterology & Hepatology
N. Moreno-Lopez, S. Mvouama, A. Bourredjem, I Fournel, T. Perrin, A. Flaris, P. Rat, O. Facy
Summary: This study assessed the benefit of rectal contrast enema CT scan (RCE-CT) for early diagnosis of anastomotic leaks (AL) following colorectal surgery. The results showed that RCE-CT had increased negative predictive value, sensitivity, and lower false-negative rate compared to regular CT scan.
TECHNIQUES IN COLOPROCTOLOGY
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Federico Bruno, Domenico Albano, Andrea Agostini, Massimo Benenati, Roberto Cannella, Damiano Caruso, Michaela Cellina, Diletta Cozzi, Ginevra Danti, Federica De Muzio, Francesco Gentili, Giuliana Giacobbe, Salvatore Gitto, Giulia Grazzini, Irene Grazzini, Carmelo Messina, Anna Palmisano, Pierpaolo Palumbo, Alessandra Bruno, Francesca Grassi, Roberta Grassi, Roberta Fusco, Vincenza Granata, Andrea Giovagnoni, Vittorio Miele, Antonio Barile
Summary: Metabolic and overload disorders are rare but important diseases that affect different organs and tissues. Imaging plays a crucial role in early detection and accurate diagnosis, especially in specific organs involved in metabolic pathways. MRI is particularly useful due to its multiparametric properties, but advanced imaging techniques may also be required for accurate characterization and quantification. This review aims to describe the various alterations resulting from these disorders and their imaging findings.
JAPANESE JOURNAL OF RADIOLOGY
(2023)
Review
Oncology
Vincenza Granata, Roberta Fusco, Sergio Venanzio Setola, Roberta Galdiero, Nicola Maggialetti, Lucrezia Silvestro, Mario De Bellis, Elena Di Girolamo, Giulia Grazzini, Giuditta Chiti, Maria Chiara Brunese, Andrea Belli, Renato Patrone, Raffaele Palaia, Antonio Avallone, Antonella Petrillo, Francesco Izzo
Summary: Pancreatic cancer is one of the deadliest cancers, and late diagnosis is the main reason for its high mortality rate. Surgical resection is the only curative treatment, so early diagnosis is crucial for improving survival. Therefore, it is appropriate to stratify patients based on familial and genetic risk and develop screening protocols using minimally invasive diagnostic tools.
Review
Medicine, General & Internal
Vincenza Granata, Roberta Fusco, Sergio Venanzio Setola, Igino Simonetti, Carmine Picone, Ester Simeone, Lucia Festino, Vito Vanella, Maria Grazia Vitale, Agnese Montanino, Alessandro Morabito, Francesco Izzo, Paolo Antonio Ascierto, Antonella Petrillo
Summary: Immunotherapy is a significant change in oncological treatment, but only a minority of patients benefit from it. The efficacy of immunotherapy is affected by factors such as genetic features and intra-tumor heterogeneity. Classic imaging assessment methods like CT or MRI have limited role in immunotherapy due to different response patterns and the need to assess immunotherapy-related toxic effects promptly.
Review
Medicine, General & Internal
Vincenza Granata, Roberta Fusco, Valeria D'Alessio, Igino Simonetti, Francesca Grassi, Lucrezia Silvestro, Raffaele Palaia, Andrea Belli, Renato Patrone, Mauro Piccirillo, Francesco Izzo
Summary: The aim of this study was to analyze the use of Electrochemotherapy (ECT) in treating primary and secondary liver tumors in different locations and with different histologies. Other Local Ablative Therapies (LAT) were also discussed. The analysis of these papers shows that ECT is safe and effective for treating large lesions, regardless of their histology. Compared to other thermal ablation techniques, ECT performs better in lesions larger than 6 cm and can be safely used for lesions located near vital structures. ECT spares vessels and bile ducts, can be repeated, and can be performed between chemotherapeutic cycles.
Review
Health Care Sciences & Services
Giuliana Giacobbe, Vincenza Granata, Piero Trovato, Roberta Fusco, Igino Simonetti, Federica De Muzio, Carmen Cutolo, Pierpaolo Palumbo, Alessandra Borgheresi, Federica Flammia, Diletta Cozzi, Michela Gabelloni, Francesca Grassi, Vittorio Miele, Antonio Barile, Andrea Giovagnoni, Nicoletta Gandolfo
Summary: Gender Medicine is a branch of medicine that studies the differences in diseases between men and women. It is important to value these differences in healthcare in order to provide personalized therapies and gender-specific prevention initiatives. This article assesses potential gender differences in clinical-radiological practice and their impact on health and healthcare.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Health Care Sciences & Services
Michela Gabelloni, Lorenzo Faggioni, Roberta Fusco, Igino Simonetti, Federica De Muzio, Giuliana Giacobbe, Alessandra Borgheresi, Federico Bruno, Diletta Cozzi, Francesca Grassi, Mariano Scaglione, Andrea Giovagnoni, Antonio Barile, Vittorio Miele, Nicoletta Gandolfo, Vincenza Granata
Summary: Due to the rich vascularization and lymphatic drainage of the pulmonary tissue, lung metastases (LM) are not uncommon in patients with cancer. Radiomics, an active research field aimed at extracting quantitative data from diagnostic images, has potential applications in lesion characterization, treatment planning, and prognostic assessment of patients with LM. This article provides a systematic review of the literature to illustrate the current applications, strengths, and weaknesses of radiomics in this field.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Health Care Sciences & Services
Carmen Cutolo, Roberta Fusco, Igino Simonetti, Federica De Muzio, Francesca Grassi, Piero Trovato, Pierpaolo Palumbo, Federico Bruno, Nicola Maggialetti, Alessandra Borgheresi, Alessandra Bruno, Giuditta Chiti, Eleonora Bicci, Maria Chiara Brunese, Andrea Giovagnoni, Vittorio Miele, Antonio Barile, Francesco Izzo, Vincenza Granata
Summary: Liver resection is the most effective treatment for primary liver malignancies and metastatic disease. The type of resection depends on various factors, including the type of malignancy, tumor size, and relation with blood and biliary vessels. Imaging, such as ultrasonography, computed tomography, and magnetic resonance imaging, plays a critical role in postoperative assessment and diagnosing complications.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Biology
Vincenza Granata, Roberta Fusco, Federica De Muzio, Carmen Cutolo, Francesca Grassi, Maria Chiara Brunese, Igino Simonetti, Orlando Catalano, Michela Gabelloni, Silvia Pradella, Ginevra Danti, Federica Flammia, Alessandra Borgheresi, Andrea Agostini, Federico Bruno, Pierpaolo Palumbo, Alessandro Ottaiano, Francesco Izzo, Andrea Giovagnoni, Antonio Barile, Nicoletta Gandolfo, Vittorio Miele
Summary: The only cure for intrahepatic cholangiocarcinoma (iCCA) is surgical resection, and early diagnosis is crucial for improving survival. Artificial Intelligence models can help assess high-risk patients, leading to better diagnosis. Therefore, identifying high-risk patients and utilizing non-invasive screening methods are important.
Review
Oncology
Vincenza Granata, Roberta Fusco, Sergio Venanzio Setola, Roberta Galdiero, Nicola Maggialetti, Renato Patrone, Alessandro Ottaiano, Guglielmo Nasti, Lucrezia Silvestro, Antonio Cassata, Francesca Grassi, Antonio Avallone, Francesco Izzo, Antonella Petrillo
Summary: In this narrative review, the role of radiomics in assessing prognostic features for liver metastases patients is discussed. Radiomics analysis allows the assessment of textural characteristics in radiological images, which can provide biological data without invasive procedures. However, issues such as poor standardization, reproducibility, and clinical study results hamper the translation of radiomics analysis into clinical practice.
INFECTIOUS AGENTS AND CANCER
(2023)
Review
Medicine, General & Internal
Francesca Grassi, Vincenza Granata, Roberta Fusco, Federica De Muzio, Carmen Cutolo, Michela Gabelloni, Alessandra Borgheresi, Ginevra Danti, Carmine Picone, Andrea Giovagnoni, Vittorio Miele, Nicoletta Gandolfo, Antonio Barile, Valerio Nardone, Roberta Grassi
Summary: The role of radiotherapy in the treatment of lung neoplasms, along with surgery and systemic therapies, has become essential. The focus has shifted towards improving survival outcomes, quality of life, treatment compliance, and management of side effects. Imaging plays a crucial role in evaluating treatment efficacy and identifying rare effects, especially when multiple treatments are involved. Radiation recall pneumonitis, a rare complication, needs to be recognized and characterized accurately, requiring prompt identification and the best therapeutic strategy for minimal disruption of ongoing cancer treatment. Artificial intelligence could play a critical role in this regard, provided a larger patient dataset is available.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Federica De Muzio, Roberta Fusco, Carmen Cutolo, Giuliana Giacobbe, Federico Bruno, Pierpaolo Palumbo, Ginevra Danti, Giulia Grazzini, Federica Flammia, Alessandra Borgheresi, Andrea Agostini, Francesca Grassi, Andrea Giovagnoni, Vittorio Miele, Antonio Barile, Vincenza Granata
Summary: Rectal cancer is a highly lethal malignancy and surgery is the most common treatment option. The choice of surgical approach aims to maximize function while minimizing the risk of recurrence, and is determined by a multidisciplinary team assessing patient and tumor characteristics. Total mesorectal excision, including both low anterior resection and abdominoperineal resection, remains the standard of care for rectal cancer. Rating: 8 out of 10.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Carmine Picone, Roberta Fusco, Michele Tonerini, Salvatore Claudio Fanni, Emanuele Neri, Maria Chiara Brunese, Roberta Grassi, Ginevra Danti, Antonella Petrillo, Mariano Scaglione, Nicoletta Gandolfo, Andrea Giovagnoni, Antonio Barile, Vittorio Miele, Claudio Granata, Vincenza Granata
Summary: In modern clinical practice, imaging techniques are increasingly used in emergencies, leading to a higher frequency of examinations and increased radiation exposure. The management of pregnant women is particularly critical as they are at higher risk. While ultrasound and magnetic resonance imaging are preferred, computed tomography remains necessary in certain cases. Protocol optimization is crucial in reducing risks. This review aims to evaluate different diagnostic tools and protocols to control radiation dose in emergency conditions involving abdominal pain and trauma.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Oncology
Luigi Cioffi, Giulio Belli, Francesco Izzo, Corrado Fantini, Alberto D'Agostino, Gianluca Russo, Renato Patrone, Vincenza Granata, Andrea Belli
Summary: Recent advancements in laparoscopic surgery and technical modifications have shown potential for improving clinical outcomes, feasibility, and patient safety in extensive liver tumor surgeries, leading to reduced complications and mortality rates.
Review
Medicine, General & Internal
Orlando Catalano, Roberta Fusco, Federica De Muzio, Igino Simonetti, Pierpaolo Palumbo, Federico Bruno, Alessandra Borgheresi, Andrea Agostini, Michela Gabelloni, Carlo Varelli, Antonio Barile, Andrea Giovagnoni, Nicoletta Gandolfo, Vittorio Miele, Vincenza Granata
Summary: Breast ultrasound has made significant technological advancements, transitioning from a low-resolution grayscale technique to a high-performing, multiparametric modality. This review covers the range of commercially available technical tools, including microvasculature imaging, high-frequency transducers, extended field-of-view scanning, elastography, contrast-enhanced ultrasound, and more. It also discusses the expanded applications of breast ultrasound in clinical scenarios, such as primary ultrasound, complementary ultrasound, and second-look ultrasound. The review concludes by acknowledging the ongoing limitations and challenges in breast ultrasound.
