Ribosomal Elongation Factor 4 Promotes Cell Death Associated with Lethal Stress

Unraveling the Physiological Complexities of Antibiotic Lethality

(2015) Daniel J. Dwyer et al.   Annual Review of Pharmacology and Toxicology

Mitochondrial EF4 links respiratory dysfunction and cytoplasmic translation in Caenorhabditis elegans

(2014) Fang Yang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Reactive oxygen species and the bacterial response to lethal stress

(2014) Xilin Zhao et al.   CURRENT OPINION IN MICROBIOLOGY

Antibiotics induce redox-related physiological alterations as part of their lethality

(2014) D. J. Dwyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structure of elongation factor 4 bound to a clockwise ratcheted ribosome

(2014) M. G. Gagnon et al.   SCIENCE

EF4 knockout E. coli cells exhibit lower levels of cellular biosynthesis under acidic stress

(2014) Fang Yang et al.   Protein & Cell

Superoxide-Mediated Protection of Escherichia coli from Antimicrobials

(2013) Michael Mosel et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The paradox of elongation factor 4: highly conserved, yet of no physiological significance?

(2013) Dejiu Zhang et al.   BIOCHEMICAL JOURNAL

EF-G and EF4: translocation and back-translocation on the bacterial ribosome

(2013) Hiroshi Yamamoto et al.   NATURE REVIEWS MICROBIOLOGY

Fe-S Cluster Biosynthesis Controls Uptake of Aminoglycosides in a ROS-Less Death Pathway

(2013) B. Ezraty et al.   SCIENCE

Cell Death from Antibiotics Without the Involvement of Reactive Oxygen Species

(2013) Y. Liu et al.   SCIENCE

Killing by Bactericidal Antibiotics Does Not Depend on Reactive Oxygen Species

(2013) I. Keren et al.   SCIENCE

YihE Kinase Is a Central Regulator of Programmed Cell Death in Bacteria

(2013) Angella Dorsey-Oresto et al.   Cell Reports

Rapid Killing of Acinetobacter baumannii by Polymyxins Is Mediated by a Hydroxyl Radical Death Pathway

(2012) Timothy R. Sampson et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Role of Oxidative Stress in Persister Tolerance

(2012) Yanxia Wu et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Inhibitors of Reactive Oxygen Species Accumulation Delay and/or Reduce the Lethality of Several Antistaphylococcal Agents

(2012) Yuanli Liu et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A Ferritin Mutant of Mycobacterium tuberculosis Is Highly Susceptible to Killing by Antibiotics and Is Unable To Establish a Chronic Infection in Mice

(2012) Ruchi Pandey et al.   INFECTION AND IMMUNITY

Curcumin reduces the antimicrobial activity of ciprofloxacin against Salmonella Typhimurium and Salmonella Typhi

(2012) S. A. Marathe et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Protein Aggregation Caused by Aminoglycoside Action Is Prevented by a Hydrogen Peroxide Scavenger

(2012) Jiqiang Ling et al.   MOLECULAR CELL

The complex of tmRNA–SmpB and EF-G on translocating ribosomes

(2012) David J. F. Ramrath et al.   NATURE

Eradication of bacterial persisters with antibiotic-generated hydroxyl radicals

(2012) Sarah Schmidt Grant et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Toxin-Antitoxin Systems in Bacteria and Archaea

(2011) Yoshihiro Yamaguchi et al.   Annual Review of Genetics

tmRNA regulates synthesis of the ArfA ribosome rescue factor

(2011) Fernando Garza-Sánchez et al.   MOLECULAR MICROBIOLOGY

A Toxin-Antitoxin Module in Bacillus subtilis Can Both Mitigate and Amplify Effects of Lethal Stress

(2011) Xiangli Wu et al.   PLoS One

The conserved protein EF4 (LepA) modulates the elongation cycle of protein synthesis

(2011) H. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Elongation factor 4 (EF4/LepA) accelerates protein synthesis at increased Mg2+ concentrations

(2011) M. Pech et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

H2S: A Universal Defense Against Antibiotics in Bacteria

(2011) K. Shatalin et al.   SCIENCE

Contribution of reactive oxygen species to pathways of quinolone-mediated bacterial cell death

(2010) X. Wang et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Interrupted Catalysis: The EF4 (LepA) Effect on Back-Translocation

(2010) Hanqing Liu et al.   JOURNAL OF MOLECULAR BIOLOGY

How antibiotics kill bacteria: from targets to networks

(2010) Michael A. Kohanski et al.   NATURE REVIEWS MICROBIOLOGY

Contribution of Oxidative Damage to Antimicrobial Lethality

(2009) X. Wang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Translation factor LepA contributes to tellurite resistance in Escherichia coli but plays no apparent role in the fidelity of protein synthesis

(2009) Shinichiro Shoji et al.   BIOCHIMIE

The Stationary-Phase Sigma Factor  S Is Responsible for the Resistance of Escherichia coli Stationary-Phase Cells to mazEF-Mediated Cell Death

(2009) I. Kolodkin-Gal et al.   JOURNAL OF BACTERIOLOGY

Superoxide protects Escherichia coli from bleomycin mediated lethality

(2009) Richard M. Burger et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Hydroxyurea Induces Hydroxyl Radical-Mediated Cell Death in Escherichia coli

(2009) Bryan W. Davies et al.   MOLECULAR CELL

Endogenous Nitric Oxide Protects Bacteria Against a Wide Spectrum of Antibiotics

(2009) I. Gusarov et al.   SCIENCE

Bacterial Toxin–Antitoxin Systems: More Than Selfish Entities?

(2009) Laurence Van Melderen et al.   PLoS Genetics

Mistranslation of Membrane Proteins and Two-Component System Activation Trigger Antibiotic-Mediated Cell Death

(2008) Michael A. Kohanski et al.   CELL

The Membrane-bound GTPase Guf1 Promotes Mitochondrial Protein Synthesis under Suboptimal Conditions

(2008) Heike Bauerschmitt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Communication Factor EDF and the Toxin–Antitoxin Module mazEF Determine the Mode of Action of Antibiotics

(2008) Ilana Kolodkin-Gal et al.   PLOS BIOLOGY