Article
Surgery
Felix Nickel, Franziska Lang, Karl-Friedrich Kowalewski, Caelan Max Haney, Marc Menrath, Christoph Berchtold, Katrin Hoffmann, Martin Loos, Arianeb Mehrabi, Pascal Probst, Thomas Schmidt, Martin Schneider, Markus K. Diener, Oliver Strobel, Beat P. Muller-Stich, Thilo Hackert
Summary: The results of recent RCTs were confirmed in this real-world study showing that drains are not necessary for standard pancreatoduodenectomy and distal pancreatectomy. Omission of drains led to a reduction in complications and shorter hospital stay.
BRITISH JOURNAL OF SURGERY
(2022)
Review
Gastroenterology & Hepatology
Amandeep Singh, Manik Aggarwal, Rajat Garg, Matthew Walsh, Tyler Stevens, Prabhleen Chahal
Summary: Spontaneous internal pancreatic fistula is a rare and complex complication of acute pancreatitis, more common in males, alcoholics, severe AP, and infected necrosis. Diagnosis requires a high index of suspicion, with treatment strategies including medical and nonsurgical interventions, and some cases may require surgical intervention.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Gastroenterology & Hepatology
Kirill Basiliya, Govert Veldhuijzen, Christian Gerges, Johannes Maubach, Uwe Will, B. Joseph Elmunzer, Martijn W. J. Stommel, Reinier Akkermans, Peter D. Siersema, Erwin-Jan M. van Geenen
Summary: Based on a systematic review of 13 studies, it was found that EUS-guided pancreatic duct intervention showed superior outcomes compared to ERP-guided intervention in terms of pancreatic duct opacification, cannulation success, stent placement, and possibly clinical outcomes such as pain resolution. However, due to limited data, the adverse event rates between the two treatment modalities could not be accurately compared.
Article
Medicine, General & Internal
Maria Joao Amaral, Joao Freitas, Mariana Amaral, Marco Serodio, Rui Caetano Oliveira, Paulo Donato, Jose Guilherme Tralhao
Summary: The aim of this study was to investigate the association between preoperative biliary drainage (PBD) and morbidity following cephalic pancreaticoduodenectomy (CPD) for pancreatic ductal adenocarcinoma (PDAC) as well as its prognostic impact. A retrospective study was conducted involving 128 patients, who were divided into two groups: those who underwent PBD (group 1) and those who did not (group 2). The results showed that PBD was associated with increased bacterial colonization of the bile, but did not significantly increase postoperative complications or influence overall survival and disease-free survival.
Article
Gastroenterology & Hepatology
Ahmed A. Messallam, Douglas G. Adler, Raj J. Shah, Jose M. Nieto, Robert Moran, B. Joseph Elmunzer, Natalie Cosgrove, Dan Mullady, Harkirat Singh, Gregory Cote, Georgios Papachristou, Mohamed O. Othman, Chao Zhang, Huma Javaid, Michael Mercado, Steven Tsistrakis, Nikhil A. Kumta, Satish Nagula, Christopher J. Dimaio, Madeleine S. Birch, Linda Jo Taylor, Nicolas Labarre, Samuel Han, Thomas Hollander, Steven A. Keilin, Qiang Cai, Field F. Willingham
Summary: This study found that H2O2-assisted endoscopic necrosectomy had a higher clinical success rate and a shorter time to resolution with equivalent complication rates relative to standard necrosectomy.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Oncology
Xinxin Liu, Kai Chen, Xiangyu Chu, Guangnian Liu, Yinmo Yang, Xiaodong Tian
Summary: Prophylactic intra-peritoneal drainage after pancreatic surgery may benefit high-risk PD patients but may not provide clear benefits for DP patients. Drain placement in PD patients showed lower mortality but higher rates of CR-POPF, while in DP patients, it increased CR-POPF, wound infection, and readmission rates.
FRONTIERS IN ONCOLOGY
(2021)
Review
Gastroenterology & Hepatology
Juanita N. Chui, Sumit Sahni, Jaswinder S. Samra, Anubhav Mittal
Summary: Postoperative pancreatic fistula (POPF) is a severe complication following pancreatic surgery, and its pathophysiology is poorly understood. Recent studies have shown that postoperative or post-pancreatectomy acute pancreatitis (PPAP) plays a critical role in the development of POPF.
Article
Gastroenterology & Hepatology
Saad Saffo, Chengwei Peng, Ronald Salem, Tamar Taddei, Anil Nagar
Summary: The study findings suggest that NAC may improve survival rates, and PBD should be reserved for patients with jaundice requiring NAC. It is important to note that the use of PBD is not always necessary and may lead to postoperative complications and reinterventions.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Surgery
Ilaria Pergolini, Stephan Schorn, Ruediger Goess, Alexander R. Novotny, Guralp O. Ceyhan, Helmut Friess, Ihsan Ekin Demir
Summary: The use of drains in pancreatic surgery is controversial, and this survey reveals diverse habits, experiences, and opinions among surgeons. Some surgeons believe that drains can reduce the risk of complications such as pancreatic fistula and facilitate early detection and management, while others are concerned about the increased risk of infection and other complications associated with drains. The management of drains also varies widely.
Article
Gastroenterology & Hepatology
Kevin M. Turner, Aaron M. Delman, Michael E. Johnston Johnston II, Dennis Hanseman, Gregory C. Wilson, Syed A. Ahmad, Sameer H. Patel
Summary: This study aimed to compare the rates of treatment for post-operative exocrine pancreatic insufficiency (EPI) and diabetes mellitus (DM) in patients with chronic pancreatitis who underwent Duodenal Preserving Pancreatic Head Resections (DPPHR) and Pancreaticoduodenectomy (PD). The results showed that the DPPHR group had a lower rate of new persistent treatment for EPI post-operatively compared to the PD group. There was no difference in the rate of new onset DM between the two groups. Additionally, both groups had similar efficacy in terms of pain control.
Article
Surgery
Jie Ma, Peiqiang Jiang, Bai Ji, Yanqing Song, Yahui Liu
Summary: This study found that the incidence of CRPF after LPD was 9.7%, mainly grade B fistulas. Elevated levels of CRP and PCT can be used as biomarkers to predict CRPF, with PCT having a higher predictive value.
Article
Oncology
Francesco Tonelli, Francesca Marini, Francesca Giusti, Teresa Iantomasi, Francesco Giudici, Maria Luisa Brandi
Summary: In this study, we described the post-operative complications, pancreatic sequelae, and post-surgical progression/relapse of PNENs in MEN1 patients. Our results showed that a more conservative intervention was associated with the absence of post-surgical complications, but required further pancreas surgeries for tumor relapse in 40.0% of the operated cases.
Review
Gastroenterology & Hepatology
Li Lian Kuan, Ashley R. Dennison, Giuseppe Garcea
Summary: Peri-operative glucocorticosteroid may decrease post-operative complications and improve median overall survival in major pancreatic resections. Further randomized clinical trials are needed to confirm these effects.
Article
Surgery
Yusheng Shi, Weishen Wang, Weihua Qiu, Shulin Zhao, Jian Wang, Yuanchi Weng, Zhen Huo, Jiabin Jin, Yue Wang, Xiaxing Deng, Baiyong Shen, Chenghong Peng
Summary: This study retrospectively analyzed 450 cases of robot-assisted pancreaticoduodenectomy to describe the experience and learning curve, with improvements in operative time and estimated blood loss observed over time. The inflexion points in the RPD learning curve were identified around cases 100 and 250, and a significantly lower incidence of pancreatic leak was found in the last 350 cases compared to the first 100 cases.
Article
Oncology
Yuwen Bao, Mengdie Zhang, Pengfei Wu, Yingpeng Wang, Bin Wan, Xin Li, Haixia Ding
Summary: This study evaluated the cost-effectiveness of open pancreaticoduodenectomy (OPD) versus OPD combined with TRIANGLE operation (OPD-TRIANGLE) for patients with pancreatic cancer. The results showed that OPD-TRIANGLE yielded additional 0.0402 QALYs at an incremental cost of US$1501.83 compared with OPD, and the corresponding ICER was US$37,358.96 per QALY.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Surgery
Thomas F. Seykora, Brett L. Ecker, Matthew T. McMillan, Laura Maggino, Joal D. Beane, Zhi Ven Fong, Robert H. Hollis, Nigel B. Jamieson, Ammar A. Javed, Stacy J. Kowalsky, John W. Kunstman, Giuseppe Malleo, Katherine E. Poruk, Kevin Soares, Vicente Valero, Lavanniya K. P. Velu, Ammara A. Watkins, Charles M. Vollmer, William E. Fisher, Mark P. Callery, Tara S. Kent, Michael G. House, Adam C. Berger, Christopher L. Wolfgang, Carlos Fernandez-del Castillo, Horacio J. Asbun, John A. Stauffer, Mark Bloomston, Ericka Haverick, Carl R. Schmidt, John D. Christein, Chad G. Ball, Elijah Dixon, Steven J. Hughes, Jeffrey A. Drebin, Michael Sprys, Amer H. Zureikat, Stephen W. Behrman, Claudio Bassi, Euan J. Dickson, Ronald R. Salem
Article
Gastroenterology & Hepatology
Timothy D. Murtha, John W. Kunstman, James M. Healy, Peter S. Yoo, Ronald R. Salem
JOURNAL OF GASTROINTESTINAL SURGERY
(2020)
Editorial Material
Oncology
John W. Kunstman
ANNALS OF SURGICAL ONCOLOGY
(2020)
Article
Surgery
John W. Kunstman, Whitney S. Brandt, Sara Abou Azar, Raymond A. Jean, Ronald R. Salem
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2020)
Article
Surgery
Danielle R. Heller, Norman G. Nicolson, Nita Ahuja, Sajid Khan, John W. Kunstman
Article
Oncology
Annabelle L. Fonseca, Deepa Cherla, Anai N. Kothari, Ching-Wei D. Tzeng, Martin J. Heslin, Krista R. Mehari, Fabian M. Johnston, Hop S. Tran-Cao
Summary: Medicaid expansion is associated with increased access to care processes and improved outcomes in PDAC patients. ME has helped to reduce disparities in PDAC treatment and outcomes in ME states.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Editorial Material
Oncology
Annabelle L. Fonseca, Fabian M. Johnston, Hop S. Tran-Cao
ANNALS OF SURGICAL ONCOLOGY
(2021)
Editorial Material
Oncology
Annabelle L. Fonseca, Hamza Khan, Krista R. Mehari, Deepa Cherla, Martin J. Heslin, Fabian M. Johnston
ANNALS OF SURGICAL ONCOLOGY
(2022)
Editorial Material
Oncology
Annabelle L. Fonseca, Martin J. Heslin, Fabian M. Johnston, Hop S. Tran-Cao
ANNALS OF SURGICAL ONCOLOGY
(2021)
Review
Oncology
Annabelle L. Fonseca, Hamza Khan, Krista R. Mehari, Deepa Cherla, Martin J. Heslin, Fabian M. Johnston
Summary: This article critically assesses and summarizes disparities in access to oncologic therapies for pancreatic cancer through a systematic review. The results show significant sociodemographic disparities in pancreatic cancer care, and multiple factors contribute to these disparities.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Gastroenterology & Hepatology
Annabelle L. Fonseca, Isaac C. Payne, Sandra L. Wong, Marcus C. B. Tan
Summary: This study surveyed medical oncologists in the Deep South to understand attitudes and practice patterns regarding resectability and referral patterns for colorectal liver metastases. The results showed wide variations in perceptions of resectability and referral patterns among medical oncologists, indicating a need for wider dissemination of resectability criteria and more involvement of liver surgeons in the management of patients with colorectal liver metastases.
JOURNAL OF GASTROINTESTINAL SURGERY
(2022)
Article
Multidisciplinary Sciences
Yasheen Gao, Melinda Wang, Xiaojia Guo, Joanna Hu, Tian-min Chen, Sade M. B. Finn, Jill Lacy, John W. Kunstman, Charles H. Cha, Melena D. Bellin, Marie E. Robert, Gary Desir, Fred S. Gorelick
Summary: Dysregulated renalase expression in PDAC tissues and its corresponding plasma levels are associated with advanced tumor characteristics, decreased overall survival, and reduced resectability in patients with locally advanced/borderline resectable PDAC.
Article
Surgery
Victoria A. Marks, Walter R. Hsiang, Waez Umer, Afash Haleem, Dana Kim, John W. Kunstman, Michael S. Leapman, Kevin M. Schuster
Summary: This study examines the availability of telehealth for colorectal cancer patients in a national sample of accredited hospitals during the COVID-19 pandemic. It identifies predictive factors for telehealth availability and highlights the need to consider these factors when formulating telehealth policies.
AMERICAN JOURNAL OF SURGERY
(2022)
Editorial Material
Surgery
Annabelle L. Fonseca, Martin J. Heslin
AMERICAN JOURNAL OF SURGERY
(2023)
Article
Surgery
Annabelle L. Fonseca, Christina L. Roland, Janice N. Cormier, Keila E. Torres, Kelly H. Hunt, Andrew J. Bishop, Ashleigh Guadagnolo, Barry W. Feig
