Article
Oncology
Fabian Weykamp, Philipp Hoegen, Sebastian Regnery, Efthimios Katsigiannopulos, C. Katharina Renkamp, Kristin Lang, Laila Koenig, Elisabetta Sandrini, Eva Meixner, Carolin Rippke, Carolin Buchele, Jakob Liermann, Juergen Debus, Sebastian Klueter, Juliane Hoerner-Rieber
Summary: MR-guided SBRT is an effective and non-invasive treatment for liver metastases, with promising long-term local control. However, achieving distant tumor control still poses challenges.
Article
Medicine, General & Internal
Karl Bordeau, Morgan Michalet, Aicha Keskes, Simon Valdenaire, Pierre Debuire, Marie Cantaloube, Morgane Cabaille, William Jacot, Roxana Draghici, Sylvain Demontoy, Xavier Quantin, Marc Ychou, Eric Assenat, Thibault Mazard, Ludovic Gauthier, Marie Dupuy, Boris Guiu, Celine Bourgier, Norbert Ailleres, Pascal Fenoglietto, David Azria, Olivier Riou
Summary: Liver stereotactic body radiotherapy (SBRT) provides effective local control and minimal toxicity for liver metastases. This study presents the first clinical results of stereotactic MR-guided radiotherapy (MRgRT) for liver metastases from a prospective registry. The treatment was well-tolerated, with low rates of acute and late toxicities. The overall survival and local control rates were promising, but distant relapse remains a challenge.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Oncology
Hannah J. Roberts, Jennifer Y. Wo
Summary: Radiation therapy for primary liver cancers has historically been limited due to the risk of radiation-induced liver disease. However, stereotactic body radiation therapy (SBRT) has advanced to safely treat liver tumors while sparing functional liver tissue. Although studies have examined SBRT for liver cancers, there is a lack of well-powered randomized studies to definitively guide management strategies.
Article
Medicine, General & Internal
Morgan Michalet, Ons Bettaieb, Samia Khalfi, Asma Ghorbel, Simon Valdenaire, Pierre Debuire, Norbert Ailleres, Roxana Draghici, Mailys De Meric De Bellefon, Marie Charissoux, Pierre Boisselier, Sylvain Demontoy, Alexis Marguerit, Morgane Cabaille, Marie Cantaloube, Aicha Keskes, Touria Bouhafa, Marie-Pierre Farcy-Jacquet, Pascal Fenoglietto, David Azria, Olivier Riou
Summary: Stereotactic MR-guided Radiotherapy (MRgRT) is an interesting treatment option for adrenal gland metastases (AGM). This study reviewed data from 12 consecutive patients treated with MRgRT for AGM and assessed the treatment's impact on target volume coverage, organ protection, local control, and overall survival. The results showed improved dosimetric quality and good tolerance of the treatment, with high rates of local control and overall survival. Longer follow-up is needed to evaluate late toxicities and clinical outcomes.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Bichun Xu, Xianzhi Zhao, Di Chen, Wenjuan Zhao, Xiaoyan Wang, Changhua Ding, Zhiyong Yuan, Huojun Zhang
Summary: This study reports the feasibility and effectiveness of stereotactic body radiation therapy (SBRT) in the treatment of adrenal gland metastases (AGMs) from liver cancer. The results suggest that SBRT is a safe and effective technique for treating AGMs, especially in patients with smaller tumors.
Article
Oncology
Christos Moustakis, Oliver Blanck, Mark Ka Heng Chan, Judit Boda-Heggemann, Nicolaus Andratschke, Marciana-Nona Duma, Dirk Albers, Christian Baeumer, Roman Fehr, Stefan A. Koerber, Daniel Schmidhalter, Manfred Alraun, Wolfgang W. Baus, Eric Beckers, Mathias Dierl, Stephan Droege, Fatemeh Ebrahimi Tazehmahalleh, Jens Fleckenstein, Matthias Guckenberger, Christian Heinz, Christoph Henkenberens, Andreas Hennig, Janett Koehn, Christine Kornhuber, Thomas Krieger, Britta Loutfi-Krauss, Manfred Mayr, Markus Oechsner, Tina Pfeiler, Gerhard Pollul, Juergen Schoeffler, Heiko Tuemmler, Claudia Ullm, Mathias Walke, Rocco Weigel, Martin Wertman, Rolf Wiehle, Tilo Wiezorek, Lotte Wilke, Ulrich Wolf, Hans Theodor Eich, Daniela Schmitt
Summary: The study aimed to investigate the harmonization of liver stereotactic body radiation therapy treatment plans across different treatment planning systems, delivery techniques, and institutions by using a specific prescription method and providing best practice guidelines. The results showed that treatment plan harmonization was overall successful with minimal deviations from target planning objectives, and the GTV(D50%) prescription produced the smallest deviation. However, significant differences were observed between different systems based on the various dose prescription methods.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Article
Oncology
K. Bordeau, M. Michalet, A. Keskes, C. Debrigode, D. Azria, O. Riou
Summary: The incidence of primary hepatic tumours is increasing, and traditional treatments are insufficient. Liver stereotactic body radiotherapy has emerged as a potential local treatment option, but lacks international standardization. However, the latest guidelines and research contribute to the application and recognition of this technique, while new radiotherapy technologies offer hope for previously difficult-to-treat tumor locations.
CANCER RADIOTHERAPIE
(2022)
Article
Oncology
Joe Y. Chang, Reza J. Mehran, Lei Feng, Vivek Verma, Zhongxing Liao, James W. Welsh, Steven H. Lin, Michael S. O'Reilly, Melenda D. Jeter, Peter A. Balter, Stephen E. McRae, Donald Berry, John Heymach, Jack A. Roth
Summary: Long-term results from the revised STARS trial showed that survival after SABR is non-inferior to VATS L-MLND for operable stage IA NSCLC. SABR remains promising for such cases, with multidisciplinary management strongly recommended.
Article
Oncology
Fabian Weykamp, Efthimios Katsigiannopulos, Lars Piskorski, Sebastian Regnery, Philipp Hoegen, Jonas Ristau, C. Katharina Renkamp, Jakob Liermann, Tobias Forster, Kristin Lang, Laila Koenig, Carolin Rippke, Carolin Buchele, Juergen Debus, Sebastian Klueter, Juliane Hoerner-Rieber
Summary: This study assessed the dosimetry benefits of stereotactic magnetic resonance (MR)-guided online adaptive radiotherapy (SMART) for liver metastases. The adapted plan showed significantly superior tumor coverage and improved sparing of organs-at-risk (OAR) compared to the predicted plan.
Article
Oncology
F. Cuccia, E. Pastorello, C. Franzese, L. Belgioia, M. Bignardi, M. Federico, V. Figlia, N. Giaj Levra, S. Badellino, P. Borghetti, G. Marvaso, G. Montesi, A. Pontoriero, I. Fazio, G. Ferrera, F. Alongi, M. Scorsetti
Summary: Excellent safety and efficacy results were achieved through stereotactic body radiotherapy (SBRT) for spine oligometastases. Prostate histology and oligorecurrent disease were predictive factors for improved clinical outcomes.
Article
Oncology
Robert Olson, Will Jiang, Mitchell Liu, Alanah Bergman, Devin Schellenberg, Benjamin Mou, Abraham Alexander, Hannah Carolan, Fred Hsu, Stacy Miller, Siavash Atrchian, Elisa Chan, Clement Ho, Islam Mohamed, Angela Lin, Tanya Berrang, Andrew Bang, Nick Chng, Quinn Matthews, Sarah Baker, Vicky Huang, Ante Mestrovic, Derek Hyde, Chad Lund, Howard Pai, Boris Valev, Shilo Lefresene, Scott Tyldesley
Summary: This study confirms that the incidence of high-grade toxic effects in the large cohort of patients receiving SABR for oligometastases is less than 5%. The lower rates of toxic effects compared to previous studies may support further enrollment in randomized phase 3 clinical trials.
Article
Multidisciplinary Sciences
Caroline John, Riccardo Dal Bello, Nicolaus Andratschke, Matthias Guckenberger, Judit Boda-Heggemann, Eleni Gkika, Frederick Mantel, Hanno M. Specht, Carmen Stromberger, Franz Zehentmayr, Oliver Blanck, Panagiotis Balermpas
Summary: The study investigated the feasibility and safety of a second course of thoracic SBRT with PTV overlap, and found it to be safe and achieve reasonable local control. Factors correlating with tumor control were identified as peripheral location and dose.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Zhongde Mu, Qi Wang, Chang Guo, Yong Feng, Hongcheng Gu, Zhenyu Zhai, Jianfeng Wu, Xia He
Summary: This study reports the first case of liver SBRT in China based on internal electromagnetic motion monitoring, which had high tracking accuracy and did not delay treatment time. The patient did not show any severe side effects except for grade I myelotoxicity. The internal electromagnetic motion monitoring system provides a real-time and direct way to track liver tumor targets.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
Article
Oncology
Nagore Garcia-Exposito, Ricard Ramos, Valentin Navarro-Perez, Kevin Molina, Maria Dolores Arnaiz, Susana Padrones, Jose Carlos Ruffinelli, Cristina Santos, Ferran Guedea, Arturo Navarro-Martin
Summary: Colorectal cancer is a common malignancy and lung and liver are the most common sites of metastasis. Surgery has been the traditional treatment for lung metastases, but stereotactic body radiotherapy (SBRT) is becoming increasingly favored. This study aimed to compare the local control rates of SBRT and surgery in patients with colorectal cancer lung metastases.
Article
Oncology
Edward Taylor, Jelena Lukovic, Michael Velec, Andrea Shessel, Teodor Stanescu, Laura Dawson, Daniel Letourneau, Patricia Lindsay
Summary: Liver cancer patients may benefit from MR-guided daily adaptive re-planning to ensure OAR dose constraints are met, as CBCT-based IGRT may result in over-dosing of OARs in patients whose doses were limited by OAR dose at the time of reference planning.
Article
Chemistry, Multidisciplinary
Xiaolei Cai, Min Chen, Aleksander Prominski, Yiliang Lin, Nicholas Ankenbruck, Jillian Rosenberg, Mindy Nguyen, Jiuyun Shi, Anastasia Tomatsidou, Glenn Randall, Dominique Missiakas, John Fung, Eugene B. Chang, Pablo Penaloza-MacMaster, Bozhi Tian, Jun Huang
Summary: The study introduces a multifunctional nanoparticle that can capture and inactivate SARS-CoV-2 virus, efficiently blocking viral infection to host cells through surface neutralizing antibodies in vitro. Additionally, the nanoparticle has photothermal function to generate heat for virus inactivation. It significantly outperforms neutralizing antibodies in treating authentic SARS-CoV-2 infection in vivo and provides a flexible platform for potential broad protection against SARS-CoV-2 and its variants.
Article
Endocrinology & Metabolism
Piotr Witkowski, Louis H. Philipson, John B. Buse, R. Paul Robertson, Rodolfo Alejandro, Melena D. Bellin, Fouad Kandeel, David Baidal, Jason L. Gaglia, Andrew M. Posselt, Roi Anteby, Piotr J. Bachul, Yaser Al-Salmay, Kumar Jayant, Angelica Perez-Gutierrez, Rolf N. Barth, John J. Fung, Camillo Ricordi
Summary: In many countries, clinical islet allotransplantation has been successfully regulated as tissue/organ for transplantation and is considered safe and effective for selected patients with type 1 diabetes mellitus. However, in the United States, the FDA views pancreatic islets as a biologic drug, which has prevented islet transplantation from moving into the clinical arena. We propose including islets into the existing regulatory framework for organ transplantation, while maintaining FDA oversight, to ensure quality and efficacy.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Surgery
Andy Chao Hsuan Lee, Arianna Edobor, Thirushan Wigakumar, Maria Lysandrou, Laura K. Johnston, Phillip McMullen, Vikranth Mirle, Ashley Diaz, Ryan Piech, Rebecca Rose, Martin Jendrisak, Diego di Sabato, Kumaran Shanmugarajah, John Fung, Jessica Donington, Maria Lucia Madariaga
Summary: Ex vivo lung perfusion (EVLP) plays an important role in assessing and preserving lungs prior to transplantation. This study found that immune cell composition changed in both the perfusate and tissue compartments during EVLP, with neutrophils and NK cells returning to baseline and monocytes remaining depleted. These findings suggest that EVLP may have immunomodulatory effects and can reduce the immunogenicity of lungs prior to transplantation.
CLINICAL TRANSPLANTATION
(2022)
Article
Gastroenterology & Hepatology
Thomas G. Cotter, Matthew A. Odenwald, Angelica Perez-Gutierrez, Kumar Jayant, Diego DiSabato, Michael Charlton, John Fung
Summary: Static cold preservation is crucial for storing donor livers, and there is an ongoing debate about whether to use University of Wisconsin solution (UW) or histidine-tryptophan-ketoglutarate solution (HTK) in this process. Recent data from the US suggest that HTK is at least equal to UW in preserving livers from donation after circulatory death (DCD).
LIVER TRANSPLANTATION
(2022)
Article
Immunology
Andy Chao Hsuan Lee, Arianna Edobor, Maria Lysandrou, Vikranth Mirle, Amir Sadek, Laura Johnston, Ryan Piech, Rebecca Rose, John Hart, Beth Amundsen, Martin Jendrisak, James Michael Millis, Jessica Donington, Maria Lucia Madariaga, Rolf N. Barth, Diego di Sabato, Kumaran Shanmugarajah, John Fung
Summary: NMP can alter the immune profile of donor livers, providing a potential strategy for immune modulation prior to transplantation.
FRONTIERS IN IMMUNOLOGY
(2022)
Editorial Material
Gastroenterology & Hepatology
John Fung, Diego DiSabato, Chih-Yi Liao, Osmanuddin Ahmed, Anjana Pillai
HEPATOBILIARY & PANCREATIC DISEASES INTERNATIONAL
(2023)
Article
Oncology
Aditya Juloori, Rohan R. Katipally, Jeffrey M. Lemons, Anurag K. Singh, Renuka Iyer, Jared R. Robbins, Ben George, William A. Hall, Sean P. Pitroda, Fauzia Arif, John Fung, Anjana Pillai, Chih-Yi Liao, Manish Sharma, Stanley L. Liauw
Summary: This study investigated the safety and efficacy of stereotactic body radiation therapy (SBRT) with immunotherapy in patients with hepatocellular carcinoma (HCC). The results showed that the combination of SBRT with nivolumab plus ipilimumab had better survival and efficacy compared to immunotherapy alone in HCC patients, suggesting the need for further investigation.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Osman Ahmed, Qian Yu, Mikin Patel, Gloria Hwang, Anjana Pillai, Chih-yi Liao, John Fung, Talia Baker
Summary: A combination therapy of yttrium-90 transarterial radioembolization (TARE) and systemic gemcitabine, cisplatin, and capecitabine is safe and effective for the first-line treatment of locally advanced intrahepatic cholangiocarcinoma (iCCA), resulting in high rates of downstaging and favorable overall survival.
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
(2023)
Review
Medicine, General & Internal
Kumar Jayant, Thomas G. Cotter, Isabella Reccia, Francesco Virdis, Mauro Podda, Nikolaos Machairas, Ramesh P. Arasaradnam, Diego Di Sabato, John C. LaMattina, Rolf N. Barth, Piotr Witkowski, John J. Fung
Summary: This study compared the outcomes of high-MELD and low-MELD living-donor liver transplant recipients and found no significant differences in patient survival, graft survival, and most complications between the two groups. However, the high-MELD group had a higher risk of pulmonary infection, abdominal fluid collection, and prolonged ICU stay.
JOURNAL OF CLINICAL MEDICINE
(2023)
Meeting Abstract
Immunology
Angelica Perez-Gutierrez, Braden Juengel, Sambhavi Krishnamoorthy, Piotr J. Bachul, Piotr Witkowski, Rolf N. Barth, John Fung
Meeting Abstract
Immunology
Govind Rangrass, Angelica Perez-Gutierrez, Dinesh J. Kurian, Aalok K. Kacha, Kymberly Harrington, John Fung
Meeting Abstract
Immunology
Piotr J. Bachul, Mateusz Ogledzinski, Braden Juengel, Yaser Al-Salmay, Jayant Kumar, Angelica Perez-Gutierrez, Lindsay Basto, Laurencia Perea, Ling-Jia Wang, Martin Tibudan, Rolf Barth, John Fung, Piotr Witkowski
Meeting Abstract
Immunology
Piotr J. Bachul, Mateusz Ogledzinski, Braden Juengel, Yaser Al-Salmay, Jayant Kumar, Lindsay Basto, Laurencia Perea, Ling-Jia Wang, Martin Tibudan, Angelica Perez-Gutierrez, Celeste Thomas, Louis Philipson, Rolf Barth, John Fung, Piotr Witkowski
Meeting Abstract
Immunology
Thomas G. Cotter, Matthew A. Odenwald, Angelica Perez-Gutierrez, Kumar Jayant, Diego DiSabato, Michael Charlton, John Fung
Meeting Abstract
Immunology
Diego Di Sabato, Thomas G. Cotter, Matthew A. Odenwald, Angelica Perez-Gutierrez, Jayant Kumar, Michael Charlton, John Fung
