Review
Cell Biology
Zhenli Li, Mingda Zhao, Xingshun Qi, Yufu Tang, Shuqun Cheng
Summary: Hepatocellular carcinoma (HCC) is a common and aggressive malignancy, and portal vein tumour thrombus (PVTT) is a serious complication associated with poor prognosis. Recent studies have implicated tumor microenvironment, stem cells, abnormal gene expression, and non-coding RNA deregulation in PVTT formation and development. However, the precise molecular mechanisms of PVTT in HCC patients remain largely unknown. In this review, we provide a brief summary of the molecular mechanisms underlying PVTT in HCC.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Article
Medicine, Research & Experimental
Wei-Hang Zhu, Jie Chen, Run-Kai Huang, Yuan Zhang, Ze-Xuan Huang, Xiu-Qing Pang, Bo Hu, Yang Yang, Xing Li
Summary: CD45(+)EPCs play a role in promoting portal vein tumor thrombus (PVTT) formation in HCC by differentiating into erythroid-transdifferentiated myeloid cells (EDMCs) induced by HCC macrophages, which migrate from the circulation to the tumor microenvironment.
Article
Surgery
Ahmed Shehta, Ahmed Farouk, Ahmed Nabieh Elghawalby, Mohamed Elshobary, Ahmed Aboelenin, Amgad Fouad, Mahmoud Abdelwahab Ali
Summary: The study evaluated the experience of liver resection for hepatocellular carcinoma patients with macroscopic portal vein invasion and found that patients with macroscopic PVI had lower overall survival rates and higher incidence of post-operative morbidities. However, there were no significant differences in terms of recurrence rate and disease-free survival rates between the two groups.
JOURNAL OF SURGICAL RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Zili Hu, Zhenyun Yang, Jiongliang Wang, Yizhen Fu, Zhiwen Hu, Zhongguo Zhou, Minshan Chen, Yaojun Zhang
Summary: This study suggests that neoadjuvant hepatic arterial infusion chemotherapy followed by hepatectomy is associated with longer survival outcome compared to hepatectomy alone for hepatocellular carcinoma patients with portal vein tumor thrombus. The survival benefit is limited to patients who respond to neoadjuvant FOLFOX-HAIC.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Pathology
Wei-Xing Guo, Shi-Ye Yang, Lei Guo, Jin-Kai Feng, Jie Xue, Jie Shi, Wan Yee Lau, Dong Yu, Shu-Qun Cheng
Summary: PVTT-HCC is a rare type of HCC with poor survival outcomes. RNA-Seq analysis revealed differential gene expression between PVTT-HCC and HCC-PVTT, suggesting distinct biological characteristics.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Multidisciplinary Sciences
Xiao-fei Zhang, Lin Lai, Hui Zhou, Yuan-jun Mo, Xu-quan Lu, Min Liu, Yun-xin Lu, En-cun Hou
Summary: This meta-analysis suggests that SBRT plus TACE is superior to monotherapy in treating HCC with PVTT, as it improves survival rates and treatment response without significant increase in adverse events.
Article
Medicine, Research & Experimental
Jianrong Wang, Junxue Wang, Jianzhu Wang, Ziliang Qian, Wensheng Xu, Xiaofeng Hang
Summary: This case study demonstrated the effectiveness of combining TACE, apatinib, and anti-PD-1 antibodies in treating advanced HCC with portal vein tumor thrombus. By analyzing ctDNA fragmentation, the treatment strategy was able to significantly reduce intrahepatic tumors and decrease AFP and ctDNA levels, leading to a sustained positive response at the 23-month follow-up.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2021)
Review
Oncology
Fangzhou Luo, Mengxia Li, Jun Ding, Shusen Zheng
Summary: HCC with PVTT remains a challenging healthcare issue worldwide with no global consensus or standard guidelines for its management. In western countries, Sorafenib and Lenvatinib are recommended as first-line treatment options, but more aggressive approaches such as transarterial chemoembolization and radiotherapy have shown promise in improving prognosis and extending survival time for patients.
FRONTIERS IN ONCOLOGY
(2021)
Review
Biology
Guoteng Qiu, Kunlin Xie, Zhaoxing Jin, Chuang Jiang, Hu Liu, Haifeng Wan, Jiwei Huang
Summary: Portal vein tumor thrombus (PVTT) is a common complication of hepatocellular carcinoma (HCC) indicating a poor prognosis. Monotherapy is ineffective for HCC-PVTT patients with high recurrence rates. Multidisciplinary management offers hope for improved survival benefits through accurate diagnosis, staging, and implementation of various treatment protocols in the absence of universal guidelines.
Article
Oncology
Chengjian He, Naijian Ge, Xiangdong Wang, Hai Li, Shiguang Chen, Yefa Yang
Summary: This study evaluated the safety and efficacy of conversion therapy with portal vein embolization (PVE) and transcatheter arterial chemoembolization (TACE) in patients with large unresectable hepatocellular carcinoma (HCC) and ipsilateral portal vein tumor thrombus (PVTT). The results showed that PVE + TACE treatment prolonged overall survival and conferred more favorable outcomes compared to treatment with tyrosine kinase inhibitors (TKIs) + TACE.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Zhongbao Tan, Jian Lu, Guangyu Zhu, Li Chen, Yong Wang, Qi Zhang, Tao Pan, Junying Wang, Jinhe Guo, Gaojun Teng
Summary: In patients with hepatocellular carcinoma (HCC) complicated by portal vein tumour thrombus (PVTT), portal vein irradiation stent implantation (PVIS) plus transcatheter arterial chemoembolization (TACE) provides a significantly better survival outcome compared to radiotherapy (RT) plus TACE.
CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY
(2021)
Review
Gastroenterology & Hepatology
Arvinder Soin, Mickael Lesurtel, Prashant Bhangui, Lorenzo Cocchi, Mohamed Bouattour, Pierre-Alain Clavien
Summary: In this debate, the authors discuss the suitability of liver transplantation for patients with hepatocellular carcinoma and portal vein tumor thrombosis. The argument for liver transplantation is based on the belief that it provides greater clinical benefits in terms of survival outcomes compared to palliative systemic therapy after successful downstaging treatment. The counterargument is that the evidence for liver transplantation in this setting is limited, and expected survival in these patients may still be lower than the accepted thresholds for liver transplantation.
JOURNAL OF HEPATOLOGY
(2023)
Article
Health Care Sciences & Services
Ming-Feng Li, Huei-Lung Liang, Chia-Ling Chiang, Wei-Lun Tsai, Wen-Chi Chen, Cheng-Chung Tsai, I-Shu Chen
Summary: The new HAIC regimen is effective in treating Vp4 HCC patients, but additional sorafenib use does not provide any survival benefit.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Oncology
Wei Zhang, Deliang Ouyang, Zhangkan Huang, Xu Che
Summary: This study compared the efficacy of hepatic artery infusion chemotherapy (HAIC) versus sorafenib in patients with hepatocellular carcinoma (HCC) accompanied by portal vein tumor thrombus (PVTT). The results showed that HAIC group had significantly higher rates of complete response, partial response, objective response rate, and disease control rate compared to the sorafenib group. Moreover, the overall survival and progression-free survival rates were significantly higher in the HAIC group.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Xiao-Hui Zhao, Hai-Liang Li, Chen-Yang Guo, Quan-Jun Yao, Wei-Li Xia, Hong-Tao Hu
Summary: This study aimed to investigate the efficacy and safety of TACE in combination with 125I seed implantation and RFA for the treatment of HCC complicated by PVTT. The results showed that the combination of TACE and 125I seed implantation can effectively inactivate PVTT and achieve downstaging, and the addition of RFA can significantly improve patient survival.
JOURNAL OF HEPATOCELLULAR CARCINOMA
(2023)
Article
Gastroenterology & Hepatology
Kei Hagiwara, Norifumi Harimoto, Takahiro Yamanaka, Norihiro Ishii, Takehiko Yokobori, Mariko Tsukagoshi, Akira Watanabe, Kenichiro Araki, Tomoharu Yoshizumi, Ken Shirabe
Summary: This study investigates the role of HSC-derived M2BPGi in activating KCs and how it impacts liver regeneration. The findings suggest that the M2BPGi-activated KCs secrete GRP78, which promotes hepatocyte proliferation and facilitates liver regeneration. The administration of GRP78 improves the survival rate in a lethal mouse model of liver failure.
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Yuriko Tsutsui, Sachiyo Yoshio, Takahiro Tomiyama, Tomonari Shimagaki, Shinji Itoh, Noboru Harada, Yuichi Yoshida, Shiori Yoshikawa, Eiji Kakazu, Tatsuya Kanto, Tomoharu Yoshizumi
Summary: This study aimed to determine whether serum BDNF could be a feasible biomarker for sepsis in patients undergoing living-donor liver transplantation (LDLT). The results showed that LDLT patients with lower preoperative serum BDNF were more prone to sepsis, and serum BDNF was associated with hepatic function, nutritional status, and immune status.
HEPATOLOGY RESEARCH
(2023)
Article
Oncology
Yumiko Kinoshita, Rieko Izukura, Junji Kishimoto, Maki Kanaoka, Hayato Fujita, Koji Ando, Shuntaro Nagai, Sayuri Akiyoshi, Tetsuzo Tagawa, Makoto Kubo, Junichi Inokuchi, Kenoki Ohuchida, Eiji Oki, Kentaro Tanaka, Masatoshi Eto, Tomoharu Yoshizumi, Masafumi Nakamura, Akiko Chishaki
Summary: This study assessed the reliability, validity, and responsiveness of the Japanese version of the EORTC QLQ-ELD14 questionnaire for evaluating the health-related quality of life in elderly Japanese patients with cancer. The results showed that the questionnaire has acceptable reliability and validity in this population.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Immunology
Rigel Suzuki, Yuki Ono, Koji Noshita, Kwang Su Kim, Hayato Ito, Yuhei Morioka, Tomokazu Tamura, Daisuke Okuzaki, Tetsuzo Tagawa, Tomoyoshi Takenaka, Tomoharu Yoshizumi, Teppei Shimamura, Shingo Iwami, Takasuke Fukuhara
Summary: Smoking is closely related to the severity of COVID-19, but the connection between smoking history and SARS-CoV-2 infectivity is unknown. This study found that recent ex-smokers had higher levels of ACE2 expression in the lungs compared to non-smokers and long-term ex-smokers. The efficiency of SARS-CoV-2 infection was found to be enhanced depending on the ACE2 expression level. Gene analysis showed a correlation between smoking and the expression of inflammatory signaling genes, which decreased with longer duration of smoking cessation.
MICROBIOLOGY AND IMMUNOLOGY
(2023)
Article
Oncology
Nami Yamashita, Yoshihiro Morimoto, Atsushi Fushimi, Rehan Ahmad, Atrayee Bhattacharya, Tatsuaki Daimon, Naoki Haratake, Yuka Inoue, Satoshi Ishikawa, Masaaki Yamamoto, Tsuyoshi Hata, Sayuri Akiyoshi, Qiang Hu, Tao Liu, Henry Withers, Song Liu, Geoffrey I. Shapiro, Tomoharu Yoshizumi, Mark D. Long, Donald Kufe
Summary: In certain cancer cells, the chromatin remodeling complex SWI/SNF PBAF's subunit polybromo-1 (PBRM1) drives DNA damage resistance and immune evasion through unclear mechanisms. This study found that MUC1-C is necessary for PBRM1 expression in triple-negative breast cancer (TNBC) cells, and the two proteins form a nuclear complex. Transcriptional and chromatin accessibility analysis showed that MUC1-C and PBRM1 increase the expression of STAT1 and IRF1 by enhancing chromatin accessibility on their respective genes, as well as other genes involved in DNA damage resistance and immune evasion.
MOLECULAR CANCER RESEARCH
(2023)
Article
Surgery
Hirofumi Hasuda, Tetsuo Ikeda, Yutaka Makizaki, Haruka Yokota, Yoshiki Tanaka, Hiroshi Ohno, Mototsugu Shimokawa, Hiroya Matsuoka, Yasue Kimura, Eiji Oki, Tomoharu Yoshizumi
Summary: The gut microbiome of patients with esophageal squamous cell carcinoma is altered, with differences in microbial diversity and composition compared to healthy individuals. These alterations are more pronounced after surgical intervention.
Article
Immunology
Takeshi Kurihara, Noboru Harada, Akinari Morinaga, Takahiro Tomiyama, Katsuya Toshida, Yukiko Kosai, Takahiro Tomino, Takeo Toshima, Yoshihiro Nagao, Kazutoyo Morita, Shinji Itoh, Tomoharu Yoshizumi
Summary: Recurrence of hepatocellular carcinoma (HCC) after living donor liver transplant (LDLT) is an essential factor defining prognosis, and surgical resection is the only curative treatment. However, the factors that define whether surgical resection is possible remain unclear.
TRANSPLANTATION PROCEEDINGS
(2023)
Article
Peripheral Vascular Disease
Yutaka Matsubara, Shogo Kawanami, Go Kinoshita, Shun Kurose, Yoshino Shinichiro, Koichi Morisaki, Tadashi Furuyama, Tomoharu Yoshizumi
Summary: Objective Postoperative limb infection is associated with poor prognosis and low amputation-free survival rate after surgical revascularization in patients with critical limb-threatening ischemia. This study provides new evidence supporting the use of perioperative therapeutic antibiotics in these patients.
Article
Surgery
Koichi Morisaki, Atsushi Guntani, Daisuke Matsuda, Yutaka Matsubara, Go Kinoshita, Shogo Kawanami, Sho Yamashita, Kenichi Honma, Terutoshi Yamaoka, Shinsuke Mii, Kimihiro Komori, Tadashi Furuyama, Tomoharu Yoshizumi
Summary: This study retrospectively analyzed data of patients with chronic limb-threatening ischemia (CLTI) who received infrainguinal revascularization between 2015 and 2020. The results showed that low serum albumin levels, congestive heart failure, high wound grade, infra-malleolar involvement (P1-2), and endovascular therapy (EVT) were independent risk factors for major amputation in CLTI patients.
ANNALS OF VASCULAR SURGERY
(2023)
Review
Oncology
Sachie Omori, Tomoko Shigechi, Kana Kawaguchi, Hideki Ijichi, Eiji Oki, Tomoharu Yoshizumi
Summary: TLS in solid tumors is a life-threatening condition that can be complicated by DIC. Early recognition and treatment of patients at risk of TLS is crucial to prevent fatal situations. This case report and literature review focuses on identifying the distinctive features and hazards of TLS in breast cancer.
ANTICANCER RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Woo-Hyoung Kang, Shin Hwang, Masaki Kaibori, Jong Man Kim, Kyung Sik Kim, Tsuyoshi Kobayashi, Hiroto Kayashima, Yang Seok Koh, Keiichi Kubota, Akira Mori, Yutaka Takeda, Sung Su Yun, Kousuke Matsui, Kan Toriguchi, Hiroaki Nagano, Myung Hee Yoon, Yuji Soejima, Shunichi Ariizumi, Bum-Soo Kim, Yohan Park, Hee Chul Yu, Bong Wan Kim, Jung Bok Lee, Sang-Jae Park, Jin-Young Jang, Hiroki Yamaue, Masafumi Nakamura, Masakazu Yamamoto, Itaru Endo
Summary: The ADV score, calculated from the concentrations of AFP, DCP, and TV, has been shown to be prognostic of HCC recurrence following HR or liver transplantation. This international validation study demonstrated that ADV score is an integrated surrogate biomarker for post-resection prognosis of HCC.
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2023)
Article
Oncology
Fumihiko Kinoshita, Mototsugu Shimokawa, Tomoyoshi Takenaka, Tatsuro Okamoto, Kenichi Taguchi, Yoshinao Oda, Tomoharu Yoshizumi
Summary: The presence of noninvasive areas in lung adenocarcinoma has a prognostic impact due to differences in clinicopathological factors. Ground-glass opacity on computed tomography imaging serves as a favorable prognostic factor in non-small-cell lung cancer.
Review
Andrology
Takashi Nagai, Taku Naiki, Yosuke Sugiyama, Toshiki Etani, Maria Aoki, Masakazu Gonda, Toshiharu Morikawa, Keitaro Iida, Nami Tomiyama, Ryosuke Ando, Noriyasu Kawai, Takahiro Yasui
Summary: The prognosis of advanced urothelial carcinoma (aUC) is poor, and traditional treatment includes cisplatin-based chemotherapy. Immune checkpoint inhibitors (ICIs) have been widely used in aUC patients, improving their prognosis. This review summarizes the parameters reflecting the status of aUC patients treated with ICIs based on current evidence, which can be helpful in predicting treatment effectiveness and prognosis.
TRANSLATIONAL ANDROLOGY AND UROLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Taichi Nagano, Shinkichi Takamori, Asato Hashinokuchi, Kyoto Matsydo, Mikihiro Kohno, Naoko Miura, Tomoyoshi Takenaka, Takeshi Kamitani, Mototsugu Shimokawa, Kousei Ishigami, Yoshinao Oda, Tomoharu Yoshizumi
Summary: This study aimed to determine the validity of preoperative evaluation of clinical T (cT) factor in non-small cell lung cancer (NSCLC) by comparing radiological and pathological tumor sizes. Data from 1,799 patients were analyzed and the concordance between cT and pathological T (pT) factors was assessed. The study found that the radiological invasive area of tumors with cT1, CTR <1, or adenocarcinoma on preoperative CT may be underestimated compared with pathological invasive diameter.
GENERAL THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Endocrinology & Metabolism
Kazuhiro Kai, Toshifumi Fujiwara, Yoshihiro Nagao, Eiji Oki, Tomoharu Yoshizumi, Masatoshi Eto, Yasuharu Nakashima
Summary: This study investigated the effects of sleeve gastrectomy on bone and psoas muscle density and cross-sectional area using retrospective clinical CT scans. The results showed that sleeve gastrectomy significantly improved anthropometric measures without causing changes in serum calcium and phosphorus levels. However, there was a significant decrease in the psoas muscle mass after surgery.