Review
Oncology
Kevin M. Sullivan, Yuman Fong
Summary: This article reviews and describes the use of robotic surgery in liver surgery and provides a detailed introduction to multivisceral resections. The existing reports indicate that robotic multivisceral resection in liver surgery is feasible and has good outcomes in experienced hands. As robotic technology advances and experience grows, further investigation should be conducted in this field.
Article
Medicine, General & Internal
Shinichiro Nakada, Yuichiro Otsuka, Jun Ishii, Tetsuya Maeda, Kazutaka Kimura, Yu Matsumoto, Yuko Ito, Hideaki Shimada, Kimihiko Funahashi, Masayuki Ohtsuka, Hironori Kaneko
Summary: In this retrospective study, researchers found that the predictor of conversion to hand-assisted laparoscopic surgery (HALS) in laparoscopic liver resection (LLR) was a tumor located in segments 7 or 8. Conversion to HALS did not result in significantly different blood loss compared to direct selection of HALS, and there were similar operation time, hospital stay, and severe complication rates.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Linh M. Duong, Hui Cai, Martha J. Shrubsole, Christina E. Bailey, Kamran Idrees, Xiao-Ou Shu
Summary: Robotic surgery is not inferior to laparoscopic surgery in treating early-stage HCC and may be associated with improved long-term survival.
Article
Surgery
Linda Feldbruegge, Santiago Andres Ortiz Galindo, Oliver Frisch, Christian Benzing, Felix Krenzien, Anna Riddermann, Anika Kaestner, Nora Franziska Nevermann, Thomas Malinka, Wenzel Schoening, Johann Pratschke, Moritz Schmelzle
Summary: The study found that robotic liver surgery is safe and feasible for patients with prior abdominal surgeries, despite limited experience in the field. Baseline characteristics and perioperative outcomes in robotic liver resection showed no significant differences between patients with and without prior surgeries.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Medicine, General & Internal
Yaron Rudnicki, Ron Pery, Sherief Shawki, Susanne Warner, Sean Patrick Cleary, Kevin T. Behm
Summary: This case series describes the initial institutional experience of synchronous robotic colorectal and liver resections for metastatic colorectal cancer. Eight patients underwent the surgeries without any intra-operative complications or conversions. There were two post-operative complications, but overall short-term outcomes and oncologic resection quality were acceptable.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Surgery
E. Lorenz, J. Arend, M. Franz, M. Rahimli, A. Perrakis, V. Negrini, A. A. Gumbs, R. S. Croner
Summary: Minimally invasive liver surgery, including robotic and laparoscopic approaches, is safe and feasible for treating liver tumors. Both approaches show similar and adequate oncological results, with robotic surgery potentially being more advantageous for advanced and technically challenging procedures.
LANGENBECKS ARCHIVES OF SURGERY
(2021)
Article
Oncology
Cheng Xi, Maoqun Zhu, Tianhao Ji, Yulin Tan, Lin Zhuang, Zhiping Yuan, Zheng Zhang, Litian Xu, Zhilin Liu, Xuezhong Xu, Wenbo Xue, Wei Ding
Summary: A novel difficulty scoring system (NDSS) was developed to predict the surgical difficulty of laparoscopic hepatectomy. Patient characteristics, laboratory tests, intraoperative variables, and pathological characteristics were assessed. The NDSS was found to have a higher area under the receiver operating characteristic than the traditional scoring system, and a nomogram was established based on the NDSS for predicting the difficulty of liver resection surgery.
FRONTIERS IN ONCOLOGY
(2022)
Article
Surgery
Maria Conticchio, Antonella Delvecchio, Valentina Ferraro, Matteo Stasi, Annachiara Casella, Nicola Chetta, Emma De Marinis, Andrea Madaro, Margherita Raele, Rosalinda Filippo, Michele Ammendola, Michele Tedeschi, Nicola deAngelis, Riccardo Memeo
Summary: Spontaneous rupture of hepatocellular carcinoma (HCC) is a rare complication, and its management requires considering the clinical conditions of the patient and the best curative treatment. We reported a case of an emergency robotic liver resection for a ruptured HCC in an elderly patient. Minimally invasive liver resection is currently recognized as a safe and feasible approach for the treatment of HCC in elderly patients.
INTERNATIONAL JOURNAL OF MEDICAL ROBOTICS AND COMPUTER ASSISTED SURGERY
(2023)
Article
Surgery
Emanuele Balzano, Lorenzo Bernardi, Giovanni Tincani, Davide Ghinolfi, Fabio Melandro, Jessica Bronzoni, Sonia Meli, Giuseppe Arenga, Giandomenico Biancofiore, Laura Crocetti, Paolo De Simone
Summary: The study compared outcomes of robotic liver resection (RLR) and laparoscopic liver resection (LLR) for hepatocellular carcinoma and found that concurrent implementation of both programs was feasible and safe with similar long-term oncologic outcomes.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Multidisciplinary Sciences
Koki Takase, Takuya Sakamoto, Yutaka Takeda, Yoshiaki Ohmura, Yoshiteru Katsura, Go Shinke, Kenji Kawai, Kohei Murakami, Yoshinori Kagawa, Toru Masuzawa, Atsushi Takeno, Taishi Hata, Kohei Murata
Summary: The study compared the surgical outcomes of laparoscopic repeat liver resection (LRLR) and laparoscopic primary liver resection (LPLR), showing no significant differences in conversion rate to laparotomy, intraoperative bleeding, and postoperative bile leakage rate between the two procedures.
SCIENTIFIC REPORTS
(2021)
Article
Surgery
Motokazu Sugimoto, Naoto Gotohda, Masashi Kudo, Shin Kobayashi, Shinichiro Takahashi, Masaru Konishi
Summary: This study aimed to evaluate the necessity of intraoperative drain placement (IDP) in laparoscopic liver resection (LLR). After comparing clinicopathological data and postoperative outcomes between patients with and without IDP, the study found that the incidence and severity of postoperative complications were similar in both groups, indicating that LLR can be safely performed without IDP.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Surgery
Chetana Lim, Claire Goumard, Chady Salloum, Antonella Tudisco, Niccolo Napoli, Ugo Boggi, Daniel Azoulay, Olivier Scatton
Summary: The 3D-LLR and RLR systems provide comparable surgical margins and similar short- and long-term oncological outcomes for hepatocellular carcinoma patients, with no significant differences observed in operative time, morbidity, margins, and survival rates.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Surgery
Lin Zhu, Yanzhe Liu, Minggen Hu, Zhiming Zhao, Chenggang Li, Xuan Zhang, Xianglong Tan, Fei Wang, Rong Liu
Summary: Background laparoscopy is considered the standard method for left lateral sectionectomy, but the impact of robotic-assisted surgery on ordinary cases is still unknown. A retrospective study comparing robotic and laparoscopic left lateral sectionectomy showed that robotic surgery had potential advantages in selected complex cases, but no clinical benefit was found compared to laparoscopy in ordinary cases.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Surgery
Wei Chen, Xiaoyu Zhang, Jincai Jiang, Yufu Ye, Zhenglong Zhai, Wendi Hu, Xiang Li, Yiwen Chen, Yan Chen, Yifan Hong, Lan Jia, Xueli Bai, Tingbo Liang
Summary: By comparing with LLR, we found that robotic-assisted liver resection in the posterosuperior region has shorter operative time and lower blood loss, and is as safe and feasible as LLR.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Surgery
Fabrizio Di Benedetto, Paolo Magistri, Stefano Di Sandro, Carlo Sposito, Christian Oberkofler, Ellie Brandon, Benjamin Samstein, Cristiano Guidetti, Alexandros Papageorgiou, Samuele Frassoni, Vincenzo Bagnardi, Pierre-Alain Clavien, Davide Citterio, Tomoaki Kato, Henrik Petrowsky, Karim J. Halazun, Vincenzo Mazzaferro, Robotic HPB Study Grp
Summary: This study examined the short-term and long-term outcomes of robotic liver resection (RLR) for hepatocellular carcinoma (HCC) in Western high-volume centers. The study found that RLR had shorter hospital stays and lower incidence of postoperative liver failure compared to open liver resection (OLR). Furthermore, there were no significant differences in tumor recurrence and overall survival rates between the two groups.
Article
Immunology
Amit Nair, Laia Coromina Hernandez, Shimul Shah, Xaralambos Zervos, Michael Zimmerman, Kazunari Sasaki, Teresa Diago, Koji Hashimoto, Masato Fujiki, Federico Aucejo, Jessica Bollinger, Tiffany L. Kaiser, Charles M. Miller, Cristiano Quintini, John J. Fung, Bijan Eghtesad
Summary: In liver transplantation, delaying the initiation of calcineurin inhibitors (CNI) and using induction rabbit antithymocyte globulin (rATG) may help preserve early kidney function, especially when CNI initiation is delayed beyond 10 days or target tacrolimus levels are lower.
Article
Surgery
Angelica Perez-Gutierrez, Umar Siddiqi, Gene Kim, Govind Rangrass, Aalok Kacha, Valluvan Jeevanandam, Yolanda Becker, Lisa Potter, John Fung, Talia B. Baker
Summary: This paper presents the best practices for successful execution of combined heart-liver-kidney transplantation, including patient selection, perioperative planning, and coordination among transplant teams. By careful selection and collaboration, this highly challenging operation can be successfully performed.
CLINICAL TRANSPLANTATION
(2022)
Editorial Material
Gastroenterology & Hepatology
John J. Fung
LIVER TRANSPLANTATION
(2022)
Article
Immunology
Mohamed Rela, Jesus Quintero, Mureo Kasahara, Paolo Muiesan, Francisco Hernandez-Oliveros, Rajesh Rajalingam, Sadhana Shankar, Blayne Amir Sayed, Diego di Sabato, Ashwin Rammohan, John Fung, Itxarone Bilbao
Summary: The incidence and distribution of cancers in children are different from adults. Nonhepatic cancers should be considered in pediatric liver transplantation. With longer post-transplant survival and increased risk of new cancers, guidelines and best practices are needed for nonhepatic cancers in pediatric liver transplantation.
Article
Chemistry, Multidisciplinary
Xiaolei Cai, Min Chen, Aleksander Prominski, Yiliang Lin, Nicholas Ankenbruck, Jillian Rosenberg, Mindy Nguyen, Jiuyun Shi, Anastasia Tomatsidou, Glenn Randall, Dominique Missiakas, John Fung, Eugene B. Chang, Pablo Penaloza-MacMaster, Bozhi Tian, Jun Huang
Summary: The study introduces a multifunctional nanoparticle that can capture and inactivate SARS-CoV-2 virus, efficiently blocking viral infection to host cells through surface neutralizing antibodies in vitro. Additionally, the nanoparticle has photothermal function to generate heat for virus inactivation. It significantly outperforms neutralizing antibodies in treating authentic SARS-CoV-2 infection in vivo and provides a flexible platform for potential broad protection against SARS-CoV-2 and its variants.
Article
Endocrinology & Metabolism
Piotr Witkowski, Louis H. Philipson, John B. Buse, R. Paul Robertson, Rodolfo Alejandro, Melena D. Bellin, Fouad Kandeel, David Baidal, Jason L. Gaglia, Andrew M. Posselt, Roi Anteby, Piotr J. Bachul, Yaser Al-Salmay, Kumar Jayant, Angelica Perez-Gutierrez, Rolf N. Barth, John J. Fung, Camillo Ricordi
Summary: In many countries, clinical islet allotransplantation has been successfully regulated as tissue/organ for transplantation and is considered safe and effective for selected patients with type 1 diabetes mellitus. However, in the United States, the FDA views pancreatic islets as a biologic drug, which has prevented islet transplantation from moving into the clinical arena. We propose including islets into the existing regulatory framework for organ transplantation, while maintaining FDA oversight, to ensure quality and efficacy.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Editorial Material
Gastroenterology & Hepatology
John Fung, Diego DiSabato, Chih-Yi Liao, Osmanuddin Ahmed, Anjana Pillai
HEPATOBILIARY & PANCREATIC DISEASES INTERNATIONAL
(2023)
Article
Oncology
Aditya Juloori, Rohan R. Katipally, Jeffrey M. Lemons, Anurag K. Singh, Renuka Iyer, Jared R. Robbins, Ben George, William A. Hall, Sean P. Pitroda, Fauzia Arif, John Fung, Anjana Pillai, Chih-Yi Liao, Manish Sharma, Stanley L. Liauw
Summary: This study investigated the safety and efficacy of stereotactic body radiation therapy (SBRT) with immunotherapy in patients with hepatocellular carcinoma (HCC). The results showed that the combination of SBRT with nivolumab plus ipilimumab had better survival and efficacy compared to immunotherapy alone in HCC patients, suggesting the need for further investigation.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Osman Ahmed, Qian Yu, Mikin Patel, Gloria Hwang, Anjana Pillai, Chih-yi Liao, John Fung, Talia Baker
Summary: A combination therapy of yttrium-90 transarterial radioembolization (TARE) and systemic gemcitabine, cisplatin, and capecitabine is safe and effective for the first-line treatment of locally advanced intrahepatic cholangiocarcinoma (iCCA), resulting in high rates of downstaging and favorable overall survival.
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
(2023)
Review
Medicine, General & Internal
Kumar Jayant, Thomas G. Cotter, Isabella Reccia, Francesco Virdis, Mauro Podda, Nikolaos Machairas, Ramesh P. Arasaradnam, Diego Di Sabato, John C. LaMattina, Rolf N. Barth, Piotr Witkowski, John J. Fung
Summary: This study compared the outcomes of high-MELD and low-MELD living-donor liver transplant recipients and found no significant differences in patient survival, graft survival, and most complications between the two groups. However, the high-MELD group had a higher risk of pulmonary infection, abdominal fluid collection, and prolonged ICU stay.
JOURNAL OF CLINICAL MEDICINE
(2023)
Meeting Abstract
Immunology
Mateusz Ogledzinski, Piotr J. Bachul, Braden Juengel, Yaser Al-Salmay, Jayant Kumar, Angelica Perez-Gutierrez, Lindsay Basto, Laurencia Perea, Ling-Jia Wang, Martin Tibudan, Rolf Barth, John Fung, Piotr Witkowski
Meeting Abstract
Immunology
Angelica Perez-Gutierrez, Braden Juengel, Piotr J. Bachul, Yaser AlSalmay, Piotr Witkowski, John Fung, Yolanda T. Becker, Rolf N. Barth
Meeting Abstract
Immunology
Angelica Perez-Gutierrez, Braden Juengel, Sambhavi Krishnamoorthy, Piotr J. Bachul, Piotr Witkowski, Rolf N. Barth, John Fung
Meeting Abstract
Immunology
Govind Rangrass, Angelica Perez-Gutierrez, Dinesh J. Kurian, Aalok K. Kacha, Kymberly Harrington, John Fung
Meeting Abstract
Immunology
Piotr J. Bachul, Mateusz Ogledzinski, Braden Juengel, Yaser Al-Salmay, Jayant Kumar, Angelica Perez-Gutierrez, Lindsay Basto, Laurencia Perea, Ling-Jia Wang, Martin Tibudan, Rolf Barth, John Fung, Piotr Witkowski