Article
Medicine, General & Internal
Hao Zhou, Lin Li, Hao Sun, Hua Li, Yuxuan Wu, Xiaomin Zhang, Jinsong Zhang
Summary: The study demonstrates that remote ischemic preconditioning can alleviate secondary liver injury following hemorrhagic shock by activating autophagy, improving blood pressure adaptability, reducing lactate and aminotransferase levels, delaying the decrease in liver density, attenuating inflammatory response and apoptosis.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Physiology
Yanlong Ren, Shujin Lin, Wenxian Liu, Huiguo Ding
Summary: This study investigated the cardioprotective effects of hepatic remote preconditioning against injury induced by ischemia/reperfusion, showing that hepatic RIPC can reduce infarct size, improve left ventricular pressure and mechanical activity, as well as decrease the release of phosphocreatine kinase-myocardial band and lactate dehydrogenase.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Ludmila Filaretova, Olga Komkova, Maria Sudalina, Natalia Yarushkina
Summary: Remote ischemic preconditioning (RIPC) has been shown to protect various organs from ischemia-reperfusion injury, with glucocorticoids potentially playing a role in this protective effect. Studies demonstrated that RIPC reduced gastric erosion area in rats, and the involvement of glucocorticoids was confirmed through experiments with glucocorticoid inhibitors and receptor antagonists.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Xinyao Tian, Yan Hu, Yuanxing Liu, Zhe Yang, Haiyang Xie, Lin Zhou, Shusen Zheng
Summary: The study utilized microarray to detect changes in circRNA and mRNA expression in response to hepatic ischemia-reperfusion injury and ischemic preconditioning intervention, identifying a potential target circRNA closely related to protective signaling. By constructing circRNA-miRNA-mRNA axes, the study revealed factors that may play a vital role in the protective mechanism of ischemic preconditioning.
FRONTIERS IN MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Marco Moscarelli, Gianni D. Angelini, Costanza Emanueli, Saadeh Suleiman, Martino Pepe, Gaetano Contegiacomo, Prakash P. Punjabi
Summary: The study, based on multiple studies, confirmed the cardioprotective effect of RIPC on patients undergoing valve intervention, but did not observe improvement in post-operative clinical outcomes.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Cell Biology
Eliana P. Bin, Tamara Zaobornyj, Mariana Garces, Veronica D'Annunzio, Bruno Buchholz, Timoteo Marchini, Pablo Evelson, Ricardo J. Gelpi, Martin Donato
Summary: The rupture of the plasma membrane is the key point in cell death, which can be prevented by remote ischemic preconditioning through inhibiting MMP-2 activity. Besides, remote ischemic preconditioning also improves mitochondrial function, increasing membrane potential, ATP production and respiratory control.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Katharina Feige, Sebastian Roth, Rene M'Pembele, Anna Galow, Sarah Koenig, Martin Stroethoff, Annika Raupach, Giovanna Lurati Buse, Alexander M. Mathes, Markus W. Hollmann, Ragnar Huhn, Carolin Torregroza
Summary: The adverse impact of common diseases like diabetes mellitus and acute hyperglycemia on morbidity and mortality from myocardial infarction (MI) has been well documented. The relationship between blood glucose and mortality appears linear, and this seems to be independent of a diagnosis of diabetes. This study investigates the influence of acute and prolonged hyperglycemia on the protective effect of transferred human RIPC-plasma and suggests that hyperglycemia might obstruct translation into the clinical setting.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Erliang Kong, Yongchang Li, Xuqiang Geng, Jianxin Wang, Yan He, Xudong Feng
Summary: This study demonstrated that ischemic preconditioning (IPC) could protect against hepatic ischemia-reperfusion injury (HIRI) by activating autophagy and regulating endoplasmic reticulum stress (ERS)-dependent apoptosis in hepatocytes.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Loic Benoit, Audrey Dieu, Maxime Foguenne, Eliano Bonaccorsi-Riani
Summary: Ischemia-reperfusion injury (IRI) is an inflammatory process in organ transplantation. Sevoflurane has shown potential benefits in reducing hepatic IRI (HIRI). Experimental studies support its protective effects, but clinical studies have conflicting results. Further clinical trials are needed to determine the clinical relevance of sevoflurane as a protective factor against HIRI.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Yi-Na Zhang, Qiong Wu, Nan-Nan Zhang, Hui-Sheng Chen
Summary: Ischemic preconditioning (IPC) can protect the blood-brain barrier (BBB) by interfering with glycocalyx, improving neurological pathology in rat models of cerebral ischemia-reperfusion injury (IRI).
TRANSLATIONAL STROKE RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Changjiang Gu, Fanqi Kong, Junkai Zeng, Xiangwu Geng, Yanqing Sun, Xiongsheng Chen
Summary: Delayed remote ischemic preconditioning (RIPC) has protective effects against spinal cord ischemia-reperfusion injury (SCIRI) in mice, and SIRT3 is involved in this protection through the NMDAR-AMPK-PGC-1 alpha signaling pathway.
CELL AND BIOSCIENCE
(2023)
Article
Medicine, Research & Experimental
Asmaa A. Khalifa, Mennatallah A. Ali, Nahed H. Elsokkary, Samar S. Elblehi, Mahmoud M. El-Mas
Summary: This study investigated the protective effects of simultaneous exposure to a minimal dose of erythropoietin (EPO) and remote ischemic preconditioning (RIPC) against skeletal muscle ischemia and reperfusion (S-I/R) injury. The results showed that the combined application of RIPC and EPO significantly ameliorated the structural and functional abnormalities as well as mitochondrial oxidative and apoptotic damage caused by S-I/R injury.
Article
Physiology
Badr Khbouz, Francois Lallemand, Arianna Cirillo, Pascal Rowart, David Legouis, Nor Eddine Sounni, Agnes Noel, Pascal De Tullio, Sophie de Seigneux, Francois Jouret
Summary: This study investigates the protective effects and mechanisms of kidney-centered irradiation against renal ischemia-reperfusion injury (I/R). Kidney irradiation increased vascular surface in the renal parenchyma and conferred resistance against renal I/R damage. These findings suggest potential strategies for the treatment of ischemic acute kidney injury.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Bo Qi, Xiao-Qiang Wang, Shu-Ting Pan, Pei-Ying Li, Ling-Ke Chen, Qiang Xia, Li-Qun Yang, Wei-Feng Yu
Summary: The study found that remote ischemic preconditioning (RIPC) did not have significant protective effects on living liver donors and recipients following pediatric liver transplantation. Limited protective effects were observed in some aspects, but overall, RIPC did not significantly improve the prognosis for transplant recipients.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Lucia Kindernay, Veronika Farkasova, Jan Neckar, Jaroslav Hrdlicka, Kirsti Ytrehus, Tanya Ravingerova
Summary: Aging reduces cardiac tolerance to ischemia/reperfusion injury, with remote ischemic preconditioning showing similar protective effects in younger and mature rats.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Editorial Material
Biochemistry & Molecular Biology
Shima Tavakol, Alexander M. Seifalian
BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY
(2022)
Review
Cell & Tissue Engineering
Shima Tavakol, Hani Tavakol, Mo S. Alavijeh, Alexander Seifalian
Summary: Nanomachines, including viruses, have been around for thousands of years. In 2019, the world had to come together to fight against SARS-CoV-2, a life-threatening nanomachine causing COVID-19. This research focuses on finding biomaterials that can inhibit the signaling pathways and ligand sites of the virus.
CURRENT STEM CELL RESEARCH & THERAPY
(2022)
Review
Materials Science, Biomaterials
Latifa W. Allahou, Seyed Yazdan Madani, Alexander Seifalian
Summary: Chemotherapy is the main treatment for cancer, but with limited efficacy and off-target toxicity. Nanotechnology has been utilized to enhance drug delivery of chemotherapeutic agents, with nanoparticles and liposomes being successful developments. Liposomes, in particular, are biocompatible, low in toxicity, and effective in encapsulating and delivering chemotherapeutic agents to cancer cells.
INTERNATIONAL JOURNAL OF BIOMATERIALS
(2021)
Review
Biochemistry & Molecular Biology
Raziyeh Najafloo, Jila Majidi, Alimohamad Asghari, Mina Aleemardani, Seyed Kamran Kamrava, Sara Simorgh, Amelia Seifalian, Zohreh Bagher, Alexander M. Seifalian
Summary: The mechanism of anosmia in COVID-19 patients is multifaceted, involving factors such as inflammation, cell apoptosis, and odor transmission. Novel treatment strategies for long-term anosmia involve smart drug delivery, tissue engineering, and cell therapy to support efficient recovery of the olfactory system.
ACS CHEMICAL NEUROSCIENCE
(2021)
Review
Pharmacology & Pharmacy
Mehrnoush Mehrarya, Behnaz Gharehchelou, Samin Haghighi Poodeh, Elham Jamshidifar, Sara Karimifard, Bahareh Farasati Far, Iman Akbarzadeh, Alexander Seifalian
Summary: Infection is a disease caused by bacteria, and antibiotics are used for treatment. Delivering antibiotics to the infection site can prevent damage to the patient's body. Niosome nanoparticles, made from non-ionic surfactants, are ideal carriers for drug/antibiotic delivery and have shown effectiveness in treating local infections and delivering drugs.
JOURNAL OF DRUG TARGETING
(2022)
Article
Polymer Science
Dalal A. Alromi, Seyed Yazdan Madani, Alexander Seifalian
Summary: Nanoparticles, particularly magnetic nanoparticles, are considered promising tools for cancer treatment due to their unique properties such as magnetic control in an external magnetic field.
Article
Biochemistry & Molecular Biology
Mina Aleemardani, Pariya Zare, Amelia Seifalian, Zohreh Bagher, Alexander M. Seifalian
Summary: Peripheral nerve injury is a common medical condition impacting patient quality of life. Graphene-based materials show promise in neural tissue engineering to enhance nerve regeneration, with some products already in preclinical stages.
Review
Pharmacology & Pharmacy
Shima Tavakol, Hani Tavakol, Mo S. Alavijeh, Alexander Seifalian
Summary: This passage discusses the global efforts to combat the SARS-CoV-2 virus and the resulting COVID-19 illness in 2019. The variants of the virus, such as Alpha, Beta, Gamma, Delta, and Epsilon, show differences in cellular and molecular mechanisms, and they exhibit higher transmissibility rates and viral loads while evading neutralizing antibodies. New variants can be diagnosed using specific primers in the clinical laboratory, and there are controversial findings regarding the efficacy of vaccines against these variants.
CURRENT PHARMACEUTICAL DESIGN
(2022)
Article
Endocrinology & Metabolism
Shiva Hashemizadeh, Soheila Pourkhodadad, Saereh Hosseindoost, Sina Pejman, Maryam Kamarehei, Abolfazl Badripour, Ameneh Omidi, Seyed Khalil Pestehei, Alexander M. Seifalian, Mahmoudreza Hadjighassem
Summary: Damage to the spinal cord leads to inflammation and motor impairments. Inhibiting pro-inflammatory cells and activating anti-inflammatory cells may provide a potential treatment strategy. Ac-SDKP has protective effects, improving motor recovery, rescuing motor neurons, reducing inflammatory cytokine levels, and increasing anti-inflammatory gene expression.
Review
Dermatology
Marjan Mirhaj, Sheyda Labbaf, Mohamadreza Tavakoli, Alexander Marcus Seifalian
Summary: Wound healing is a complex process, and the current treatment strategies face challenges. Dressings and skin substitutes are the most effective, convenient, and cost-effective method for treating chronic wounds, and advances in materials science offer hope for treatment. There is a need to improve current treatment strategies to meet the increasing demands of the aging population and diabetes-related wounds.
INTERNATIONAL WOUND JOURNAL
(2022)
Review
Chemistry, Multidisciplinary
Yasamin Davatgaran Taghipour, Amir Zarebkohan, Roya Salehi, Fariborz Rahimi, Vladimir P. Torchilin, Michael R. Hamblin, Alexander Seifalian
Summary: The lack of efficient strategies for targeted delivery and accumulation of therapeutic cargoes in the tumor microenvironment (TME) is a key issue in the treatment of solid tumors. This review focuses on dual targeting approaches, which combine biological strategies and physicochemical responsive smart delivery strategies, to increase the accumulation of nanoparticles within the TME and improve targeting efficiency towards cancer cells. The efficiency and rationale behind the choice of ligands for dual targeting strategies are critically reviewed. New approaches for smart drug delivery, including TME-specific responsive linkers and camouflaged nanoparticles, are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Biochemistry & Molecular Biology
Mercedeh Babaluei, Fatemeh Mottaghitalab, Alexander Seifalian, Mehdi Farokhi
Summary: This study developed an injectable hydrogel for wound dressings, containing sodium carboxymethylcellulose/polyacrylamide/polydopamine with vitamin C (CMC/PAAm/PDA VitC) and silk fibroin/alginate nanoparticles loaded with curcumin (SF/SANPs CUR). The hydrogels demonstrated stable properties, biocompatibility, and antibacterial activity against MRSA. In preclinical rat models, the hydrogels showed significant support for full-thickness burn regeneration, wound closure, and anti-inflammatory effects.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Biotechnology & Applied Microbiology
Mahsa Tashakori-Miyanroudi, Atousa Janzadeh, Alexander Seifalian, Nahid Aboutaleb, Yaser Azizi, Fatemeh Ramezani
Summary: Despite scientific advances, the number of cardiovascular patients is increasing worldwide. To protect damaged cardiomyocytes from further harm, novel and safer approaches are needed to help regeneration and prevent fibrosis. In this study, a systematic review of in vitro and preclinical studies of carbon nanotubes (CNTs) and carbon nanofibers (CNFs) for help to treat heart damage was conducted. The results showed that CNTs/CNFs in hydrogels increase conductivity, promote cardiac cell proliferation, and enhance expression of genes associated with stem cell differentiation into cardiac cells.
Article
Pharmacology & Pharmacy
Neda Keyhanvar, Nosratollah Zarghami, Alexander Seifalian, Peyman Keyhanvar, Rana Sarvari, Roya Salehi, Reza Rahbarghazi, Mohammadreza Ranjkesh, Molood Akbarzadeh, Mahdi Mahdipour, Mohamamd Nouri
Summary: This study aimed to direct mesenchymal stem cells (MSCs) towards keratinocyte-like cells (KLCs) using cell imprinting and sheet technology. Culturing AT-MSCs on a PDMS substrate with keratinocyte cell-imprinted topography induced differentiation towards keratinocyte-like cells. The data suggests that the keratinocyte cell-imprinted substrate can provide a specific niche and topographical cues to orient AT-MSCs towards KLCs.
ADVANCED PHARMACEUTICAL BULLETIN
(2022)
Article
Dentistry, Oral Surgery & Medicine
Farshid Bastami, Mohammad-Hadi Noori-Kooshki, Hassan Semyari, Reza Tabrizi, Alireza Abrishamchian, Fatemeh Mashhadi-Abbas, Shahriar Shahab, Alexander Seifalian
Summary: The study evaluated the effects of MWCNT/HA granules with or without L-PRF on bone regeneration in a sheep model. Results showed that there was no significant inflammation around the granules, and new lamellar bone was regenerated. The addition of L-PRF to MWCNT/HA significantly improved new bone formation, while the use of MWCNT/HA granules alone also significantly increased new bone formation compared to control.
ORAL AND MAXILLOFACIAL SURGERY-HEIDELBERG
(2022)