Article
Medicine, General & Internal
Paul J. Brindley, Melinda Bachini, Sumera I. Ilyas, Shahid A. Khan, Alex Loukas, Alphonse E. Sirica, Bin Tean Teh, Sopit Wongkham, Gregory J. Gores
Summary: Cholangiocarcinoma is a highly lethal adenocarcinoma of the hepatobiliary system that can be associated with liver fluke infection but often has no identifiable cause. This Primer reviews the epidemiology, pathophysiological mechanisms, diagnosis and management of cholangiocarcinoma, and highlights the patient experience and future directions.
NATURE REVIEWS DISEASE PRIMERS
(2021)
Review
Oncology
Matteo Renzulli, Daryl Ramai, Jameel Singh, Samridhi Sinha, Nicolo Brandi, Anna Maria Ierardi, Elisa Albertini, Rodolfo Sacco, Antonio Facciorusso, Rita Golfieri
Summary: Cholangiocarcinoma and combined hepatocellular cholangiocarcinoma are aggressive primary malignancies with liver resection as the main treatment modality. Locoregional therapies can provide local tumor control and increase chances of survival.
Article
Gastroenterology & Hepatology
Jennifer L. Tomlinson, Juan W. Valle, Sumera I. Ilyas
Summary: Recent literature has advanced our understanding of the tumour immune microenvironment and identified new patient subtypes. Inhibitory immune cells and immune escape mechanisms employed by tumour cells contribute to poor tumour immunogenicity. Strategies to block inhibitory immune cell recruitment can re-equip the immune system to target the tumour.
JOURNAL OF HEPATOLOGY
(2023)
Review
Gastroenterology & Hepatology
Colm J. O'Rourke, Patricia Munoz-Garrido, Jesper B. Andersen
Summary: Cholangiocarcinoma (CCA) is a rare disease without diagnostic biomarkers, making population screening infeasible. Most CCA patients require systemic clinical management, and this review discusses the therapeutic potential of molecular targets at different stages of development, as well as the successes and failures of CCA-targeted therapies and the lessons learned.
Article
Gastroenterology & Hepatology
Mengjie Deng, Peng Ran, Lingli Chen, Yunzhi Wang, Zixiang Yu, Ke Cai, Jinwen Feng, Zhaoyu Qin, Yanan Yin, Subei Tan, Yang Liu, Chen Xu, Guoming Shi, Yuan Ji, Jian-Yuan Zhao, Jian Zhou, Jia Fan, Yingyong Hou, Chen Ding
Summary: This study provides a comprehensive characterization of cholangiocarcinoma (CCA) using integrative genomic analysis and proteomic clustering. The research identifies subtypes, molecular features, and potential therapeutic targets of CCA. Additionally, the study reveals immune landscape differences related to HBV infection and suggests new therapeutic approaches for CCA.
Review
Gastroenterology & Hepatology
Chiara Raggi, Maria Letizia Taddei, Colin Rae, Chiara Braconi, Fabio Marra
Summary: Metabolic reprogramming is a characteristic of cancer, allowing tumor cells to survive and proliferate in resource-limited conditions. Cholangiocarcinoma, the second most common form of primary liver cancer, is associated with metabolic alterations such as increased aerobic glycolysis and glutamine anaplerosis. Therapeutic interventions targeting these metabolic changes may have potential benefits for treating cholangiocarcinoma.
JOURNAL OF HEPATOLOGY
(2022)
Article
Oncology
Wenwei Liao, Qingbo Feng, Huixian Liu, Jinpeng Du, Xiangzheng Chen, Yong Zeng
Summary: Cholangiocarcinoma (CCA) is a primary biliary malignancy with a poor prognosis and limited treatment options. Recently, circular RNAs (circRNAs) have gained attention as potential therapeutic targets and prognostic biomarkers for CCA. Dysregulated circRNAs play vital roles in the development of CCA through various mechanisms, including disruption of miRNA regulation, interaction with RNA-binding proteins, activation of signaling pathways, and modulation of proteins and peptides. Inflammatory microenvironment and chemotherapy resistance are also influenced by circRNAs in CCA. Therefore, circRNAs are crucial for early diagnosis and prediction of CCA, and further research is needed to understand their roles and mechanisms in CCA.
Review
Gastroenterology & Hepatology
Meng-Ju Wu, Lei Shi, Joshua Merritt, Andrew X. Zhu, Nabeel Bardeesy
Summary: Isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) are frequently mutated metabolic genes in human cancers, leading to the production of an oncometabolite, R-2-hydroxyglutarate, which inhibits various enzymes. IDH mutations are common in intrahepatic cholangiocarcinoma (iCCA). Inhibiting mutant IDH delays tumor progression, but not all patients benefit from this treatment.
Review
Oncology
Timo Alexander Auer, Federico Collettini, Laura Segger, Uwe Pelzer, Raphael Mohr, Felix Krenzien, Bernhard Gebauer, Dominik Geisel, Clarissa Hosse, Wenzel Schoening, Uli Fehrenbach
Summary: cHCC-CCA is a rare form of liver cancer that combines features of both hepatocellular and biliary tract cancer. There is currently no established interventional therapy for cHCC-CCA due to its rarity. This review aims to provide an overview of current radiologic interventions for CCA, review the existing literature, and explore the potential role of these interventions in the treatment of cHCC-CCA in the future.
Article
Gastroenterology & Hepatology
Maria Reig, Giuseppe Cabibbo
Summary: The potential impact of DAAs in BCLC-B/C stage patients with HCC is understudied, as HCC patients have been excluded from DAA trials. The decision on using DAAs should be made based on individual patient profiles.
JOURNAL OF HEPATOLOGY
(2021)
Review
Gastroenterology & Hepatology
Aurelie Beaufrere, Julien Calderaro, Valerie Paradis
Summary: Combined hepatocellular-cholangiocarcinoma (cHCC-CCA) is a tumor with both hepatocytic and biliary differentiation, whose diagnosis is primarily based on morphology and immunostaining, with a prognosis worse than hepatocellular carcinoma and treatment limited to surgery.
JOURNAL OF HEPATOLOGY
(2021)
Review
Medicine, General & Internal
Dong Woo Shin, Sung-Hoon Moon, Jong Hyeok Kim
Summary: Cholangiocarcinoma (CCA), a tumor of the bile duct epithelium, is increasing in incidence and is difficult to diagnose early. Imaging modalities such as ultrasound, computed tomography, and magnetic resonance imaging are important in detecting and staging CCA. Endoscopic ultrasound and endoscopic retrograde cholangiopancreatography are recommended for further evaluation and obtaining tissue samples. Serum tumor markers can also be useful in diagnosing CCA in some patients.
Article
Medicine, General & Internal
Lipika Goyal, Funda Meric-Bernstam, Antoine Hollebecque, Juan W. Valle, Chigusa Morizane, Thomas B. Karasic, Thomas A. Abrams, Junji Furuse, Robin K. Kelley, Philippe A. Cassier, Heinz-Josef Kluempen, Heung-Moon Chang, Li-Tzong Chen, Josep Tabernero, Do-Youn Oh, Amit Mahipal, Markus Moehler, Edith P. Mitchell, Yoshito Komatsu, Kunihiro Masuda, Daniel Ahn, Robert S. Epstein, Abdel-Baset Halim, Yao Fu, Tehseen Salimi, Volker Wacheck, Yaohua He, Mei Liu, Karim A. Benhadji, John A. Bridgewater
Summary: In this study, 103 patients with FGFR2-altered intrahepatic cholangiocarcinoma were treated with futibatinib for a median duration of 17.1 months. The results showed that futibatinib treatment could effectively inhibit tumor growth, improve survival, and maintain quality of life for patients.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Review
Medicine, General & Internal
Sudha Kodali, Akshay Shetty, Soumya Shekhar, David W. Victor, Rafik M. Ghobrial
Summary: Cholangiocarcinoma, a tumor arising from differentiation of cholangiocytes, can develop anywhere in the biliary tree. Early diagnosis allows for surgical resection, while late-stage intrahepatic cholangiocarcinoma cases may require chemotherapy, locoregional therapies, and radiation as treatment options.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Oncology
Hang Li, Li Chen, Guang-Yu Zhu, Xijuan Yao, Rui Dong, Jin-He Guo
Summary: Cholangiocarcinoma is the second most common type of primary liver malignancy, with surgical resection being the preferred treatment for eligible patients. Interventional treatment has become an acceptable palliative option for unresectable CCA, providing locoregional control, symptom relief, and improved quality of life.
FRONTIERS IN ONCOLOGY
(2021)
Article
Surgery
Farid Froghi, Fiammetta Soggiu, Federico Ricciardi, Cecilia Vindrola-Padros, Lefteris Floros, Daniel Martin, Helder Filipe, Massimo Varcada, Kurinchi Gurusamy, Satya Bhattacharya, Angela Fanshawe, Bogdan Delcea, Pawan Mathur, Brian Davidson, G. A. P. GAP Collaborators
Summary: This study examined the feasibility and efficacy of using cardiac output evaluation to optimize fluid administration in patients with acute pancreatitis (AP) in a general surgery ward. The results showed that ward-based GDFT is feasible and may have potential efficacy, but further large multi-site randomized controlled trials (RCTs) are needed to confirm its clinical and cost effectiveness.
INTERNATIONAL JOURNAL OF SURGERY
(2022)
Review
Psychology, Developmental
Audrey Linden, Lawrence Best, Freya Elise, Danielle Roberts, Aoife Branagan, Yong Boon Ernest Tay, Laura Crane, James Cusack, Brian Davidson, Ian Davidson, Caroline Hearst, William Mandy, Dheeraj Rai, Edward Smith, Kurinchi Gurusamy
Summary: Mental health difficulties are prevalent in autistic individuals, and finding interventions to improve their mental health is a top priority. However, there is currently a lack of high-quality network meta-analysis on the benefits and harms of different interventions. Available evidence suggests that cognitive behavioural therapy may decrease anxiety and depression in autistic individuals, mindfulness therapy may decrease anxiety and depression in autistic adults with previous mental health conditions, and behavioural interventions may provide some benefit for depression in autistic children. Further research is needed to obtain more high-quality evidence. Autistic individuals should have access to mental health interventions available to non-autistic individuals, following person-centred care principles.
Review
Emergency Medicine
Mauro Podda, Belinda De Simone, Marco Ceresoli, Francesco Virdis, Francesco Favi, Johannes Wiik Larsen, Federico Coccolini, Massimo Sartelli, Nikolaos Pararas, Solomon Gurmu Beka, Luigi Bonavina, Raffaele Bova, Adolfo Pisanu, Fikri Abu-Zidan, Zsolt Balogh, Osvaldo Chiara, Imtiaz Wani, Philip Stahel, Salomone Di Saverio, Thomas Scalea, Kjetil Soreide, Boris Sakakushev, Francesco Amico, Costanza Martino, Andreas Hecker, Nicola De'Angelis, Mircea Chirica, Joseph Galante, Andrew Kirkpatrick, Emmanouil Pikoulis, Yoram Kluger, Denis Bensard, Luca Ansaloni, Gustavo Fraga, Ian Civil, Giovanni Domenico Tebala, Isidoro Di Carlo, Yunfeng Cui, Raul Coimbra, Vanni Agnoletti, Ibrahima Sall, Edward Tan, Edoardo Picetti, Andrey Litvin, Dimitrios Damaskos, Kenji Inaba, Jeffrey Leung, Ronald Maier, Walt Biffl, Ari Leppaniemi, Ernest Moore, Kurinchi Gurusamy, Fausto Catena
Summary: This study used the Delphi method to reach a consensus among an international expert group on the optimal follow-up strategies for patients with splenic injuries treated with NOM. The study identified eleven clinical research questions and provided 28 recommendations with an agreement rate of >= 80%.
WORLD JOURNAL OF EMERGENCY SURGERY
(2022)
Correction
Emergency Medicine
Marco Ceresoli, Michele Pisano, Fikri Abu-Zidan, Niccolo Allievi, Kurinchi Gurusamy, Walt L. Biffl, Giovanni D. Tebala, Fausto Catena, Luca Ansaloni, Massimo Sartelli, Yoram Kluger, Gianluca Baiocchi, Federico Coccolini
WORLD JOURNAL OF EMERGENCY SURGERY
(2022)
Article
Pediatrics
Aoife Branagan, Ivan Yu, Kurinchi Gurusamy, Jan Miletin
Summary: This study conducted a network meta-analysis of different surfactant treatment strategies for respiratory distress syndrome (RDS) and found no clear benefit of surfactant treatment at any threshold of fraction of inspired oxygen (FiO(2)). The use of surfactant at a threshold of 60% FiO(2) may increase the risk of complications. More randomized trials are urgently needed to provide robust evidence for surfactant delivery at different thresholds.
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
(2023)
Review
Multidisciplinary Sciences
Smriti Panda, Pirabu Sakthivel, Kurinchi S. Gurusamy, Atul Sharma, Alok Thakar
Summary: There is considerable uncertainty in the treatment options for resectable hypopharyngeal cancer, and no definitive optimal treatment strategy has been identified.
Article
Medicine, General & Internal
Hannah Warren, Thomas Wagner, Michael A. Gorin, Steven Rowe, Beverley Fiona Holman, Deborah Pencharz, Soha El-Sheikh, Ravi Barod, Prasad Patki, Faiz Mumtaz, Axel Bex, Veeru Kasivisvanathan, Caroline M. Moore, Nicholas Campain, Jon Cartledge, Andrew Scarsbrook, Fahim Hassan, Tim S. O'Brien, Grant D. Stewart, Iosif Mendichovszky, Sabina Dizdarevic, Ammar Alanbuki, William H. Wildgoose, Tze Wah, Cecilia Vindrola-Padros, Elena Pizzo, Hakim-Moulay Dehbi, Paula Lorgelly, Kurinchi Gurusamy, Mark Emberton, Maxine G. B. Tran
Summary: The incidence of renal tumours is increasing and anatomic imaging cannot reliably distinguish benign tumours from renal cell carcinoma. Tc-99m-sestamibi SPECT/CT has shown high diagnostic accuracy for benign renal oncocytomas and other oncocytic renal neoplasms of low malignant potential in single-centre studies. The primary aim of MULTI-MIBI is to assess feasibility of a multicentre study of Tc-99m-sestamibi SPECT/CT against a reference standard of histopathology from surgical resection or biopsy.
Article
Radiology, Nuclear Medicine & Medical Imaging
Thomas Dowrick, Guofang Xiao, Daniil Nikitichev, Eren Dursun, Neils van Berkel, Moustafa Allam, Bongjin Koo, Joao Ramalhinho, Stephen Thompson, Kurinchi Gurusamy, Ann Blandford, Danail Stoyanov, Brian R. Davidson, Matthew J. Clarkson
Summary: This research aims to find a suitable method for tracked stereo laparoscope calibration within the operating theater. A custom calibration rig was designed and compared with freehand calibration, resulting in significantly reduced errors.
Article
Gastroenterology & Hepatology
Floris M. Thunnissen, Daan J. Comes, Carmen S. S. Latenstein, Martijn W. J. Stommel, Cornelis J. H. M. van Laarhoven, Joost P. H. Drenth, Marten A. Lantinga, Femke Atsma, Philip R. de Reuver
Summary: This study defined the ideal outcome for the treatment of uncomplicated gallstone disease through expert meetings and surveys, and found that 64.2% of patients achieved this outcome based on analysis of Dutch patient data.
Review
Health Care Sciences & Services
Danielle Amanda Roberts, Eila Watson, Christopher Macdonald, Yarunnessa Khan, Sarah Prideaux, Alwin Puthiyakunnel Saji, Emilia Postaleniec, Jashan Selvakumar, Mahta Haghighat Ghahfarokhi, Brian Davidson, Kurinchi Gurusamy
Summary: The study aims to compare different interventions for pain and cachexia in people with pancreatic cancer and develop an evidence-based care pathway. Systematic reviews and network meta-analysis will be conducted, and surveys and focus groups involving patients, carers, and healthcare professionals will be performed. The project's completion is expected by April 2024, and the results will be published within 12 months.
JMIR RESEARCH PROTOCOLS
(2023)
Article
Acoustics
Hisham Assi, Rui Cao, Madhura Castelino, Ben Cox, Fiona J. Gilbert, Janek Gro, Kurinchi Gurusamy, Lina Hacker, Aoife M. Ivory, James Joseph, Ferdinand Knieling, Martin J. Leahy, Ledia Lilaj, Srirang Manohar, Igor Meglinski, Carmel Moran, Andrea Murray, Alexander A. Oraevsky, Mark D. Pagel, Manojit Pramanik, Jason Raymond, Mithun Kuniyil Ajith Singh, William C. Vogt, Lihong Wang, Shufan Yang, Sarah E. Bohndiek
Summary: Photoacoustic imaging has a promising potential in clinical trials, but its adoption in healthcare systems for clinical decision making faces barriers such as education, training, and data interpretation. The International Photoacoustic Standardisation Consortium identified these barriers and developed plans to address them.
Article
Computer Science, Artificial Intelligence
Joao Ramalhinho, Soojeong Yoo, Thomas Dowrick, Bongjin Koo, Murali Somasundaram, Kurinchi Gurusamy, David J. Hawkes, Brian Davidson, Ann Blandford, Matthew J. Clarkson
Summary: This paper evaluates the value of augmented reality overlay in laparoscopic surgery. The study finds that compared to a baseline condition, augmented reality can decrease the localization error of surgeons and introduce improvements in usability and user confidence in the surgical task.
MEDICAL IMAGE ANALYSIS
(2023)
Proceedings Paper
Acoustics
Nina Montana-Brown, Joao Ramalhinho, Bongjin Koo, Moustafa Allam, Brian Davidson, Kurinchi Gurusamy, Yipeng Hu, Matthew J. Clarkson
Summary: This paper proposes a multi-modal, self-supervised registration paradigm for simultaneous alignment of laparoscopic ultrasound, video, and CT scan of the liver. Preliminary experiments show that registration of multiple features can facilitate the alignment of both data sources.
SIMPLIFYING MEDICAL ULTRASOUND, ASMUS 2022
(2022)
Article
Engineering, Biomedical
Joao Ramalhinho, Bongjin Koo, Nina Montana-Brown, Shaheer U. Saeed, Ester Bonmati, Kurinchi Gurusamy, Stephen P. Pereira, Brian Davidson, Yipeng Hu, Matthew J. Clarkson
Summary: In this study, a deep hashing network-based method for the registration of laparoscopic ultrasound (LUS) with computed tomography (CT) is proposed. By learning hash codes of vessel images, the registration success rate can be significantly improved. This approach is easily generalizable to other registration problems and does not require annotated data for training.
INTERNATIONAL JOURNAL OF COMPUTER ASSISTED RADIOLOGY AND SURGERY
(2022)
Article
Engineering, Biomedical
Thomas Dowrick, Brian Davidson, Kurinchi Gurusamy, Matthew J. Clarkson
Summary: This study demonstrates the use of synthetic data generated with Unity game engine for training a liver segmentation model in image guided surgery. The results show that synthetic data outperforms real data in some cases, although the overall performance is slightly lower compared to models trained on real data only.
INTERNATIONAL JOURNAL OF COMPUTER ASSISTED RADIOLOGY AND SURGERY
(2022)