Journal
JOURNAL OF FUNCTIONAL FOODS
Volume 10, Issue -, Pages 499-510Publisher
ELSEVIER
DOI: 10.1016/j.jff.2014.08.002
Keywords
Anti-obesity; Fatty acid oxidation; PPARs; Yuzu peel; Yuzu pomace; Zebrafish
Categories
Funding
- KAKENHI [25860294, 25590073]
- Grants-in-Aid for Scientific Research [25860294, 25590073, 25670127] Funding Source: KAKEN
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Effects of yuzu peel (Citrus junos Siebold ex Tanaka), yuzu pomace after hexane extraction, and auraptene on metabolic disorders in zebrafish with diet-induced obesity (DIO) were evaluated. All materials tested exhibited anti-obesity effects. Yuzu peel significantly suppressed the rise in plasma triacylglycerol (TG) and liver lipid accumulation. The hepatic mRNA expression of pparab (peroxisome proliferator-activated receptor, alpha b) and its target genes were significantly upregulated by yuzu peel, which suggests enhanced fatty acid beta-oxidation in liver. In visceral adipose tissue, yuzu peel significantly increased the mRNA expression of pparg (peroxisome proliferator-activated receptor, gamma) and adipoqb (adiponectin, C1Q and collagen domain containing, b), which play roles in adipose differentiation and maintenance. Our findings suggest that yuzu peel exerts anti-obesity effects by activating hepatic PPAR alpha and adipocyte PPAR gamma pathways. Additionally, the anti-obesity effects of yuzu pomace suggest a novel application to achieve complete use of yuzu instead of disposal as industrial waste. (C) 2014 Elsevier Ltd. All rights reserved.
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