Journal
JOURNAL OF FUNCTIONAL FOODS
Volume 5, Issue 4, Pages 2002-2006Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jff.2013.07.016
Keywords
Heptamethoxyflavone; MK-801; Schizophrenia-like behavior; Locomotion; Y-maze test; Open field test
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Funding
- Japan Society for the Promotion of Science [23700941]
- Science Research Promotion Fund of The Promotion and Mutual Aid Corporation for Private Schools of Japan
- Research Promotion Fund of Ehime Industrial Promotion Foundation
- Grants-in-Aid for Scientific Research [23700941] Funding Source: KAKEN
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Enhanced dopaminergic activity in rodents has been shown to lead to locomotor hyperactivity. MK-801, an NMDA (N-methyl-D-aspartate) receptor antagonist, indirectly activates dopaminergic activity in humans and rodents, and has the ability to induce locomotor hyperactivity. Abnormalities in locomotor activity are a prominent feature in the positive symptoms of schizophrenia. We showed here that the citrus flavonoid 3,5,6,7,8,3',4'-heptamethoxyflavone (HMF) has a protective effect on hyperactivity induced by MK-801 in the Y-maze test and open field test. These results suggest that HMF has the ability to relieve MK-801-induced schizophrenia positive symptom-like behavior. (C) 2013 Elsevier Ltd. All rights reserved.
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