Article
Chemistry, Organic
Bin Wang, Hua-Yi Jiang, Jin Yang, Jun Li, Bing-Chao Yan, Xi Chen, Kun Hu, Xing-Ren Li, Han-Dong Sun, Jun Deng, Pema-Tenzin Puno
Summary: A compound called rugosiformisin A was isolated from Isodon rugosiformis and its structure was determined using different techniques. Furthermore, a successful synthesis of rugosiformisin A was achieved, highlighting important steps in the process.
Article
Food Science & Technology
Gabriele Vilkickyte, Lina Raudone
Summary: This study found that early stages of lingonberries vegetation are best for high levels of most phenolics and triterpenoids, while the end of berry vegetation is optimal for anthocyanins. Additionally, increased biosynthesis of triterpenoids and phenolic acids precursors was observed in winter samples. Geographical, climatic, and edaphic factors affect the chemodiversity of lingonberries, indicating different conditions for the accumulation of specific compounds.
Review
Nutrition & Dietetics
Linda Nezbedova, Tony McGhie, Mark Christensen, Julian Heyes, Noha Ahmed Nasef, Sunali Mehta
Summary: This study summarizes the association between apple consumption and cancer incidence, as well as the main phytochemical patterns observed in apples and their bioavailability after consumption.
Article
Food Science & Technology
Qinzhang Jiang, Shengwei Wang, Yuzhe Yang, Jinxin Luo, Ruili Yang, Wu Li
Summary: In this study, rice bean was extracted using different methods to determine its polyphenol content. Base hydrolysis was found to be the most effective method for extracting bound polyphenols from rice bean, which contributed to 71.15% of the total phenolic content. A total of 35 individual phenolics were identified in rice bean, with different phenolic compositions in the free and bound fractions. The bound phenolics from base hydrolysis exhibited superior antioxidant activity compared to other extraction methods. These findings suggest that the bound fraction of rice bean should be considered when assessing its potential health benefits.
Article
Integrative & Complementary Medicine
Gao Wei, Wang Yi, Wang Ru, Wang Yi-Hai, Xu Jing-Wen, He Xiang-Jiu
Summary: This study discovered that the rhizomes of giant taro contain piperidine alkaloids with significant antitumor activity. Compounds 3-5 were found to reduce colony formation rate and induce apoptosis in AGS cells, while compound 4 induced cell death through the proapoptotic pathway.
CHINESE JOURNAL OF NATURAL MEDICINES
(2022)
Article
Biochemistry & Molecular Biology
Juan Su, Xiong Fu, Qiang Huang, Guang Liu, Chao Li
Summary: The aim of this study was to investigate the liberation and phytochemical profile of bound polyphenols present in dietary fiber isolated from Rosa roxburghii fruit pomace, and to explore their biological activity and prebiotic potential. The results showed that the bound polyphenols were released during colonic fermentation at a higher ratio compared to gastrointestinal digestion, and they exhibited antioxidant and alpha-glucosidase inhibitory activity. Furthermore, the study demonstrated that the dietary fiber had a stronger prebiotic effect, promoting the growth of beneficial bacteria and the production of short chain fatty acids. The bound polyphenols may serve as important functional food ingredients in Rosa roxburghii fruit pomace.
Article
Plant Sciences
Shu-Rong Chen, Yih-Fung Chen, Jue-Jun Lin, Tzu-Yi Ke, Yun-Sheng Lin, Yuan-Bin Cheng
Summary: Three new alkaloids were discovered from the whole plant of Hippobroma longiflora, along with five known compounds. The structures of the alkaloids were determined using various spectroscopic techniques. The neuroprotective effects of three major secondary metabolites were also evaluated.
Review
Biochemistry & Molecular Biology
Yuan-Yuan Huang, Lu Chen, Guo-Xu Ma, Xu-Dong Xu, Xue-Gong Jia, Fu-Sheng Deng, Xue-Jian Li, Jing-Quan Yuan
Summary: The genus Maytenus, a member of the Celastraceae family, has been used in traditional medicine and is known for its unique bioactivities, attracting research interests. Over the past 45 years, numerous new compounds, including rare maytansine and its homologues, have been discovered through research efforts.
Article
Multidisciplinary Sciences
Uriel Nava-Solis, Mario Rodriguez-Canales, Ana Bertha Hernandez-Hernandez, David Arturo Velasco-Melgoza, Brenda Paola Moreno-Guzman, Marco Aurelio Rodriguez-Monroy, Maria Margarita Canales-Martinez
Summary: This study investigated the antimicrobial activity of methanolic extract from Prosopis laevigata leaves against various bacteria and fungi, and analyzed its chemical composition. The results showed that the extract had strong antimicrobial activity, especially against certain pathogenic bacteria and fungi.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Applied
Gabriela Boscariol Rasera, Francielle Miranda de Matos, Anna Paula de Souza Silva, Severino Matias de Alencar, Raquel Bridi, Adriano Costa de Camargo, Ruann Janser Soares de Castro
Summary: Germination has been found to improve the antioxidant properties of mustard by increasing the bio-accessibility of phenolic compounds. In this study, the in vitro digestion process was simulated to evaluate the impact of germination on mustard phenolic bio-accessibility. Liquid chromatography-mass spectrometry analysis identified resveratrol, formononetin, and cryptochlorogenic acid as key phenolic compounds. Results showed that digestion positively affected the antioxidant potential of soluble phenolics, although it appeared to negate the improvement caused by germination. However, germinated digested mustard had significantly higher concentrations of sinapic acid compared to non-germinated.
Article
Food Science & Technology
Marianela Desiree Rodriguez, Joaquin Garcia-Cordero, Diana Suarez-Coca, Maria Luisa Ruiz del Castillo, Gracia Patricia Blanch, Sonia de Pascual-Teresa
Summary: Grapes are a rich source of polyphenols in the Mediterranean diet and can provide antioxidants to the human diet. The market for seedless grape varieties has been rapidly growing, but these varieties are not well characterized yet. This study investigated the impact of grape variety on composition and absorbable fraction after in vitro digestion. Results showed that black and red varieties have the potential to increase antioxidant content in the diet. Furthermore, all polyphenols, except flavanols, see a reduction in their bioavailable fraction under in vitro conditions.
Article
Biochemistry & Molecular Biology
Supachoke Mangmool, Issaree Kunpukpong, Worawan Kitphati, Natthinee Anantachoke
Summary: Bioassay-guided separation of young leaves extracts of Syzygium antisepticum led to the isolation of various natural compounds from ethyl acetate and methanol extracts. These compounds showed strong antioxidant and anticholinesterase activities, indicating their potential as sources of antioxidants and anticholinesterase agents.
Review
Biochemistry & Molecular Biology
Ashraf M. A. Qasem, Michael G. Rowan, Ian S. Blagbrough
Summary: This article reviews the taxonomy, conformation of the skeleton, and potential therapeutic applications of plants containing piperidine alkaloids. It also provides an overview of recently reported isolated alkaloids and discusses their potential as lead compounds in drug development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Lingmin Dai, Ke Zhong, Yan Ma, Xiaoqian Cui, Yuhang Sun, Ang Zhang, Guomin Han
Summary: Acetaldehyde plays a critical role in modifying the phenolic profile of red wine during aging and the acetaldehyde-mediated condensation may be responsible for the variation of antioxidant activity. The study found that the disappearance of monomeric phenolics and the formation of polymeric phenolics induced by acetaldehyde can be divided into two phases, with the second phase significantly reducing the antioxidant activity of wine. Controlling the level of acetaldehyde allows for prolonged biological activity during wine aging.
Article
Chemistry, Applied
Shutian Wu, Danyu Shen, Ruohui Wang, Qingyang Li, Runhong Mo, Yuewen Zheng, Ye Zhou, Yihua Liu
Summary: The majority of phenolic compounds in walnut kernels exist in the free form, showing high radical scavenging activity. There is a strong correlation between the antioxidant activities of phenolics and their contents. Acetone is effective for extracting soluble phenolics, while methanol is better for extracting insoluble bound phenolics.
Article
Chemistry, Applied
Chuan-Rui Zhang, Wajid Khan, Jehan Bakht, Muraleedharan G. Nair
Article
Multidisciplinary Sciences
Amila A. Dissanayake, C. Michael Wagner, Muraleedharan G. Nair
Article
Plant Sciences
Amila A. Dissanayake, Baram A. H. Ameen, Muraleedharan G. Nair
JOURNAL OF NATURAL PRODUCTS
(2017)
Article
Multidisciplinary Sciences
Juma A. Mmongoyo, Felicia Wu, John E. Linz, Muraleedharan G. Nair, Jovin K. Mugula, Robert J. Tempelman, Gale M. Strasburg
Article
Food Science & Technology
J. A. Mmongoyo, M. G. Nair, J. E. Linz, F. Wu, J. K. Mugula, A. A. Dissanayake, C. Zhang, D. M. Day, J. M. Wee, G. M. Strasburg
WORLD MYCOTOXIN JOURNAL
(2017)
Article
Food Science & Technology
Amila A. Dissanayake, Chuan-Rui Zhang, Gary L. Mills, Muraleedharan G. Nair
JOURNAL OF FUNCTIONAL FOODS
(2018)
Article
Multidisciplinary Sciences
Amila A. Dissanayake, C. Michael Wagner, Muraleedharan G. Nair
Article
Chemistry, Applied
Amila A. Dissanayake, Juma A. Mmongoyo, Muraleedharan G. Nair
Summary: Several new bioactive compounds were isolated from Dioscorea sansibarensis Pax yam collected from Tanzania for the first time, with phenanthrenes 3-5 exhibiting the highest anti-inflammatory activity. Phenolics (6-8) and steroidal sapogenins (9-11) showed moderate inhibition compared to traditional NSAIDs, and compounds 6-11 exhibited moderate antioxidant activity.
NATURAL PRODUCT RESEARCH
(2022)
Article
Plant Sciences
Amila Abishake Dissanayake, Kambou Georges, Muraleedharan Gopalan Nair
Summary: Bioassay guided study of Cleome viscosa Linn. leaves led to the isolation of a new cembrenoid diterpene and three known compounds, showing anti-inflammatory and antioxidant activities comparable to conventional drugs.
Article
Multidisciplinary Sciences
Xingyu Lu, Amila A. Dissanayake, Chuqiao Xiao, Jie Gao, Mouming Zhao, Muraleedharan G. Nair
Summary: In this study, five sterols were isolated and identified from Laminaria japonica, showing significant anti-inflammatory and antioxidant activities.
Article
Multidisciplinary Sciences
Amila A. Dissanayake, C. Michael Wagner, Muraleedharan G. Nair
Summary: The study found that compounds in sea lamprey exhibit anti-inflammatory and antioxidant activities, indicating that consumption of sea lamprey may offer health benefits in addition to nutritional benefits.
Article
Pharmacology & Pharmacy
Wajid Khan, Jehan Bakht, Muraleedharan G. Nair, Muhammad Nazir Uddin, Mohammad Shafi
PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2018)
Article
Chemistry, Medicinal
Alessandra C. Dametto, Nivaldo Boralle, Chuan-Rui Zhang, Dulce H. S. Silva, Muraleedharan G. Nair
NATURAL PRODUCT COMMUNICATIONS
(2018)
Article
Chemistry, Medicinal
Amila A. Dissanayake, Chuan-Rui Zhang, Mohamed K. A. Gaber, Muraleedharan G. Nair
NATURAL PRODUCT COMMUNICATIONS
(2017)
Meeting Abstract
Chemistry, Multidisciplinary
Muraleedharan Nair
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2016)