Article
Food Science & Technology
Efaishe Tweuhanga Angaleni Kavela, Lilla Szaloki-Dorko, Monika Mate
Summary: This study assessed the efficiency of green solvents for extracting anthocyanins and total phenolic content from lyophilised chokeberry pomace. The results showed that 50% ethanol + 1% citric acid yielded the highest anthocyanin content, while 50% glycerol + 1% formic acid yielded the highest total phenolic content.
Review
Biochemistry & Molecular Biology
Reza Zare, Rachel Kimble, Ali Ali Redha, Giuseppe Cerullo, Tom Clifford
Summary: Athletes are increasingly using chokeberry supplements, which are rich in polyphenols, to enhance exercise performance by modifying oxidative stress and inflammation. This systematic review aims to explore the effects of chokeberry supplementation on athletic performance, oxidative stress markers, inflammation, and haematology. Ten studies were included, involving athletes from various sports, and the comprehensive summary showed that chokeberry supplementation may improve the redox balance of athletes, but further evidence is required to determine its effects on inflammation, platelet function, iron metabolism, and exercise performance.
Article
Chemistry, Multidisciplinary
Maciej Oziemblowski, Magdalena Trenka, Marta Czaplicka, Damian Maksimowski, Agnieszka Nawirska-Olszanska
Summary: This study compared the physical and chemical properties of fresh and PEF-preserved black chokeberry fruit juices, finding that the PEF method increased dry weight, sugars, and polyphenols in the juices while decreasing antioxidant activity. Ultra-weak luminescence also slightly increased during the process.
APPLIED SCIENCES-BASEL
(2022)
Article
Food Science & Technology
Andrzej Sidor, Agnieszka Drozdzynska, Anna Brzozowska, Anna Gramza-Michalowska
Summary: The study on chokeberry fruit processing techniques found that freeze-drying is the most desirable method for preserving polyphenols, while soaking the fruit in a suspension of cinnamon or cloves accelerates the loss of anthocyanins. The results could be valuable for manufacturers looking to develop new products with enhanced pro-health potential.
Article
Food Science & Technology
Vera Schmid, Jan Steck, Esther Mayer-Miebach, Diana Behsnilian, Mirko Bunzel, Heike P. Karbstein, M. Azad Emin
Summary: The study focused on the impact of extrusion processing on chokeberry pomace powder rich in dietary fiber and polyphenols, showing that high molecular weight soluble DF contents slightly increase while total DF contents remain unchanged. The contents of thermolabile anthocyanins decrease with increased mechanical stress and temperature, but phenolic acids and flavonoids are largely unaffected. Techno-functional and physical properties of the extrudates support the potential use of granulated chokeberry pomace powder as a rich food ingredient.
Article
Cell Biology
Nebojsa Tasic, Vladimir L. J. Jakovljevic, Miroslav Mitrovic, Boris Djindjic, Danijela Tasic, Dalibor Dragisic, Zoran Citakovic, Zorana Kovacevic, Kristina Radoman, Vladimir Zivkovic, Sergey Bolevich, Tamara Nikolic Turnic
Summary: The study showed that supplementation of Alixir 400 PROTECT (R) has positive effects on clinical and biochemical parameters in patients with metabolic syndrome, especially in terms of blood pressure, lipid levels and blood sugar. Increasing polyphenols or SAE consumption may be a beneficial strategy for reducing cardiovascular risk.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Kristina Habschied, Jelena Nisevic, Vinko Krstanovic, Ante Loncaric, Kristina Valek Lendic, Kresimir Mastanjevic
Summary: By adding chokeberry juice, a functional beverage with high antioxidant potential and no added sugars was developed, which can be consumed by people of all age groups. Further improvements were made by adding mint essential oil and carbonation. The polyphenol content, antioxidative activity, and nutritional value of the beverage were also analyzed.
APPLIED SCIENCES-BASEL
(2023)
Article
Food Science & Technology
Elena Y. Platonova, Mikhail Shaposhnikov, Hye-Yeon Lee, Ji-Hyeon Lee, Kyung-Jin Min, Alexey Moskalev
Summary: Black chokeberry extract is rich in biologically active compounds with various anti-aging effects, such as lifespan extension, metabolic improvement, neuroprotection, and antiviral activity, which may be associated with hormesis, antioxidant defense activation, insulin signaling modulation, and anti-inflammatory activity.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2021)
Article
Nutrition & Dietetics
Yue Zhu, Yu-long Wei, Ioanna Karras, Peng-ju Cai, Yu-hang Xiao, Cheng-li Jia, Xiao-lin Qian, Shi-yu Zhu, Lu-jie Zheng, Xin Hu, Ai-dong Sun
Summary: This study demonstrated that black chokeberry polyphenols can alleviate HFD-induced obesity by modulating the composition and function of gut microbiota and improving lipid metabolism disorder via the glycerophospholipid metabolism signaling pathway.
FRONTIERS IN NUTRITION
(2022)
Article
Nutrition & Dietetics
Raul Lopez-Fernandez-Sobrino, Jorge R. Soliz-Rueda, Maria Margalef, Anna Arola-Arnal, Manuel Suarez, Francisca Bravo, Begona Muguerza
Summary: This study investigated the ACEi activity and BP lowering effects of wine lees from different grape varieties, with Cabernet wine lees showing significant antihypertensive effects related to high levels of anthocyanins and flavanols. The potential of Cabernet wine lees for controlling arterial BP was confirmed, suggesting a promising commercial use in the wine industry.
Editorial Material
Cardiac & Cardiovascular Systems
Franz H. Messerli, Chirag Bavishi, Adrian W. Messerli, George C. M. Siontis
Summary: This editorial discusses the association between midlife blood pressure and the severity of white matter hyperintensities in the UK Biobank cohort study.
EUROPEAN HEART JOURNAL
(2021)
Article
Food Science & Technology
Elena Daskalova, Slavi Delchev, Lyudmila Vladimirova-Kitova, Spas Kitov, Petko Denev
Summary: The study found that supplementation with phenolic-rich aronia melanocarpa (AM) functional beverages significantly increased high-density lipoprotein cholesterol levels in aging rats, while improving the total cholesterol/high-density lipoprotein cholesterol and low-density lipoprotein cholesterol/high-density lipoprotein cholesterol indices.
Article
Agronomy
Lubomir Gurcik, Zuzana Bajusova, Jana Ladvenicova, Jozef Palkovic, Katarina Novotna
Summary: This scientific paper focuses on the research of growing and processing medicinal plants, particularly black chokeberry. The paper develops an economic efficiency model for the establishment and operation of a black chokeberry plantation in Slovakia. The model considers intensive cultivation methods and presents three alternatives for processing the total production, including selling the harvest, producing apple-aronia juice in different ratios.
Article
Biochemistry & Molecular Biology
Makar A. Gerasimov, Irina B. Perova, Konstantin I. Eller, Michail Y. Akimov, Anna M. Sukhanova, Galina M. Rodionova, Galina V. Ramenskaya
Summary: The purpose of this study was to investigate the qualitative and quantitative composition of biologically active substances in the fresh fruits of five different varieties of black chokeberry. Samples were obtained from the Michurin Federal Scientific Center in the Tambov region of Russia. Using modern chemical-analytical methods, the content and profiles of various compounds were determined, including anthocyanin pigments, proanthocyanidins, flavonoids, hydroxycinnamic acids, organic acids, monosaccharides, disaccharides, and sorbitol. The most promising varieties in terms of bioactive substance content were identified based on the results.
Article
Food Science & Technology
Dragica Gajic, Ivana Stojanovic, Ivan Koprivica, Nada Pejnovic, Katarina Savikin, Nada Cujic-Nikolic, Tamara Saksida
Summary: Chokeberry extract (CE) delayed melanoma appearance and increased immune cell infiltration in the tumor microenvironment. CE did not directly affect the melanoma cells, but splenocytes isolated from CE-treated animals showed strong cytotoxic effect on melanoma cells.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Review
Chemistry, Medicinal
Alexander G. Panossian, Thomas Efferth, Alexander N. Shikov, Olga N. Pozharitskaya, Kenny Kuchta, Pulok K. Mukherjee, Subhadip Banerjee, Michael Heinrich, Wanying Wu, De-an Guo, Hildebert Wagner
Summary: Adaptogens are herbal medicinal and nutritional products promoting adaptability and survival in living organisms. They have pharmacologically pleiotropic effects on the neuroendocrine-immune system and exhibit a biphasic dose-effect response. Further research focusing on discovering new combinations of adaptogens and potential synergistic effects is needed to explore their full potential in treating stress and aging-related diseases.
MEDICINAL RESEARCH REVIEWS
(2021)
Review
Neurosciences
Thomas Brendler, Josef A. Brinckmann, Ulrich Feiter, Nigel Gericke, Lucy Lang, Olga N. Pozharitskaya, Alexander N. Shikov, Michael Smith, Ben-Erik van Wyk
Summary: Modern regulatory systems create barriers for traditional herbal medicines to enter international markets, aiming to ensure consumer safety and product quality. This unintentional regulatory favoritism may hinder innovation and create economic hurdles for botanicals from developing countries to enter global health product markets.
CURRENT NEUROPHARMACOLOGY
(2021)
Review
Plant Sciences
Alexander N. Shikov, Igor A. Narkevich, Elena Flisyuk, Vladimir G. Luzhanin, Olga N. Pozharitskaya
Summary: Herbal medicine in Russia has a long history, with the evolution of medicinal plant handling from handwritten herbalist manuscripts to Pharmacopoeias carefully traced, including discussions on the pharmacological effects, safety, and clinical data of traditional and officinal herbal plants. The 14th edition of the Russian Pharmacopoeia contains descriptions of 107 medicinal plants, with 25 new monographs added in comparison to the previous edition.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Soolmaz Soleimani, Morteza Yousefzadi, Sepideh Babaei Mahani Nezhad, Olga N. Pozharitskaya, Alexander N. Shikov
Summary: This study characterized the biological activities of phlorotannins-rich fractions from brown algae and tested the protective effect and stability of a cream formulation containing phlorotannins against UV radiation. The results showed that the brown algae extract has potential application as a sunscreen protective substance.
JOURNAL OF APPLIED PHYCOLOGY
(2022)
Article
Chemistry, Medicinal
Alexander N. Shikov, Ekaterina D. Obluchinskaya, Elena Flisyuk, Inna I. Terninko, Yulia E. Generalova, Olga N. Pozharitskaya
Summary: Natural deep eutectic solvents (NADES) have been extensively studied for the extraction of food, medicinal plants, and seaweeds, but their ability for co-extraction of trace elements from natural sources remains unclear. This study aimed to investigate the capability of common NADES for co-extraction of trace elements from Fucus vesiculosus. The results showed that all tested NADES did not recover arsenic and cobalt.
Article
Chemistry, Medicinal
Ekaterina D. Obluchinskaya, Olga N. Pozharitskaya, Denis Zakharov, Elena Flisyuk, Inna I. Terninko, Yulia E. Generalova, Irina E. Smekhova, Alexander N. Shikov
Summary: This study investigated the biochemical composition and antioxidant properties of Fucus vesiculosus from the Arctic region. The results showed variations in monosaccharide, phlorotannin, and flavonoid accumulation in relation to water salinity. Antioxidant activity was negatively correlated with the amount of fucoidan monosaccharides. The Metal Pollution Index showed medium correlation with reproductive phases, but strong correlation with salinity and sampling site. Based on the data, Fucus vesiculosus from the Arctic can be safely used for food and drug development.
Article
Chemistry, Medicinal
Ekaterina D. Obluchinskaya, Olga N. Pozharitskaya, Alexander N. Shikov
Summary: This study compared the anti-inflammatory effects of fucoidans from different brown seaweeds and determined their relationship with composition. The results showed that fucoidans exhibited radical scavenging, antioxidant, inhibition of protein denaturation, and cell membrane stabilization effects. Fucoidans could be a promising agent for the treatment of inflammatory-related diseases.
Article
Biochemistry & Molecular Biology
Alexander N. Shikov, Veronika A. Shikova, Anastasiia O. Whaley, Marina A. Burakova, Elena Flisyuk, Andrei K. Whaley, Inna I. Terninko, Yulia E. Generalova, Irina Gravel, Olga N. Pozharitskaya
Summary: This study examined the ability of acid-based natural deep eutectic solvents (NADES) to co-extract glycyrrhizic acid (GA) and trace elements from licorice roots. The results showed that lactic acid-based NADES had higher extraction efficiency for GA compared to other tested NADES. The recovery of trace elements by all tested NADES was low. Calculations indicate that the NADES extracts of licorice roots are nontoxic and pose no health risks.
Article
Plant Sciences
Xuanbin Wang, Yan Ma, Qihe Xu, Alexander N. Shikov, Olga N. Pozharitskaya, Elena Flisyuk, Meifeng Liu, Hongliang Li, Liliana Vargas-Murga, Pierre Duez
Summary: This review summarizes the pharmacology, toxicology, and clinical efficacy of flavonoids and saponins, which have received increasing research attention. Flavonoids and saponins have been studied extensively in relation to oxidative stress, inflammation, and cancer. Flavonoids have shown effects on various health conditions such as chronic venous insufficiency and diabetes, while saponins have shown potential in treating conditions like venous edema and erectile dysfunction. However, more research is needed to understand their pharmacokinetics, purity, and long-term toxicities.
Article
Food Science & Technology
Melanie Poivre, Marie-Helene Antoine, Kirill Kryshen, Anastasia Atsapkina, Alexander N. Shikov, Laure Twyffels, Amandine Nachtergael, Pierre Duez, Joelle Nortier
Summary: Herbs used in traditional medicine can have both beneficial and harmful effects on human health. A study conducted in Belgium investigated the cytotoxicity and genotoxicity of Aristolochia and Magnolia extracts on human kidney cells. The study also evaluated the mutagenicity of these extracts using the Ames test. The results showed that the Aristolochia-Magnolia combination was more genotoxic and cytotoxic to human kidney cells, and it exhibited mutagenic effects in the presence of a microsomial liver fraction.
Article
Biology
Soolmaz Soleimani, Morteza Yousefzadi, Sepideh Babaei Mahani Nezhad, Olga N. Pozharitskaya, Alexander N. Shikov
Summary: In this study, the ethyl acetate fraction (EF) isolated from Padina boergesenii brown seaweed was evaluated for its antioxidant activity and cytotoxicity against UVB-induced cytotoxicity in HaCaT human keratinocytes. It was then used as a bio-filter in the formulation of sunscreen, and its physical properties and stability were investigated. The results showed that the EF exhibited significant DPPH radical scavenging and protected HaCaT keratinocytes from UVB irradiation. The sunscreen formulated with EF showed high stability and promising properties for the development of cosmetics and skin care products.
Article
Chemistry, Medicinal
Ekaterina D. Obluchinskaya, Olga N. Pozharitskaya, Vadim A. Shevyrin, Elena G. Kovaleva, Elena V. Flisyuk, Alexander N. Shikov
Summary: Phlorotannins are secondary metabolites produced mainly by brown seaweeds and have diverse bioactivities. Ultrasonic-assisted extraction (UAE) using solvents such as methanol, acetone, ethanol, and ethyl acetate is a suitable method for extracting polyphenols. Natural deep eutectic solvents (NADES) have been proposed as green solvents for the extraction of polyphenols, and optimization of extraction conditions can lead to high yield of phlorotannins with antioxidant potential. Chemical profiling of phlorotannins in NADES extract showed the presence of 32 different compounds, indicating that NADES could be an effective alternative for the extraction of phlorotannins with high antioxidant potential.
Article
Plant Sciences
Ekaterina D. Obluchinskaya, Olga N. Pozharitskaya, Elena V. Gorshenina, Denis V. Zakharov, Elena V. Flisyuk, Inna I. Terninko, Yuliya E. Generalova, Alexander N. Shikov
Summary: The impact of the geographic location of Fucus distichus L. on its biochemical composition, antiradical properties, and health risk was evaluated in this study. The main carbohydrates varied among different regions, with the highest level found in samples from the Barents Sea. Most Arctic F. distichus samples showed low or undetectable levels of heavy metals and were deemed safe for daily consumption. The results support the potential use of Arctic F. distichus as a rich source of polysaccharides, polyphenols, and flavonoids with important antiradical activity.
Article
Plant Sciences
Anastasiia O. O. Whaley, Andrei K. K. Whaley, Elena L. L. Kovaleva, Larisa N. N. Frolova, Anastasia A. A. Orlova, Vladimir G. G. Luzhanin, Elena V. V. Flisyuk, Larisa V. V. Shigarova, Olga N. N. Pozharitskaya, Alexander N. N. Shikov
Summary: Pharmacopoeias are essential for quality control of medicinal plants and their products, especially considering the significant reliance on medicinal plants for healthcare worldwide. However, standardizing medicinal plant material can be challenging due to unknown active components, lack of analysis procedures, and variability in chemical composition. In this review, we analyzed literature data on medicinal plants in different pharmacopoeias and proposed more rational methods for quality assessment and standardization.
PHYTOCHEMISTRY REVIEWS
(2023)
