Article
Food Science & Technology
Feyisola Fisayo Ajayi, Priti Mudgil, Amie Jobe, Priya Antony, Ranjit Vijayan, Chee-Yuen Gan, Sajid Maqsood
Summary: Hypercholesterolemia is a serious global public health concern. Natural products have emerged as an alternative therapy for ameliorating this condition. This study aimed to produce novel bioactive peptides from quinoa protein hydrolysates using enzymatic hydrolysis methods and found that chymotrypsin-generated hydrolysates showed higher inhibitory potential against cholesterol esterase and pancreatic lipase. Several bioactive peptides were identified as potential inhibitors for these enzymes. The results suggest that quinoa protein hydrolysates can be considered as an alternative therapy for hypercholesterolemia.
Review
Nutrition & Dietetics
Arthur T. Kopylov, Kristina A. Malsagova, Alexander A. Stepanov, Anna L. Kaysheva
Summary: The transformation of plant sterols and their effects on humans are still under investigation, with reports suggesting their potential impact on endocrine balance and overall physiological health.
Review
Nutrition & Dietetics
Nestor Ibarz-Blanch, Diego Morales, Enrique Calvo, Laura Ros-Medina, Begona Muguerza, Francisca Isabel Bravo, Manuel Suarez
Summary: This study reviews the mechanisms of blood pressure regulation by natural antihypertensive compounds and their efficacy depending on consumption time. While many studies have investigated the impact of food-derived compounds such as phenolic compounds or peptides on blood pressure, only a few have addressed the relevance of time consumption. Therefore, further research is needed to fully understand the interactions along the time-nutrition-hypertension axis.
Article
Agriculture, Multidisciplinary
Virginia Blanco-Morales, Ramona de los Angeles Silvestre, Elena Hernandez-Alvarez, Encarnacion Donoso-Navarro, Amparo Alegria, Guadalupe Garcia-Llatas
Summary: This study demonstrates the feasibility of simultaneous enrichment with PS and GOS in milk-based fruit beverages, which has a hypocholesterolemic effect.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Chemistry, Applied
Simonetta Caira, Gabriella Pinto, Gianluca Picariello, Paola Vitaglione, Sabrina De Pascale, Andrea Scaloni, Francesco Addeo
Summary: A purification procedure followed by mass spectrometry analysis was used to identify milk-derived peptides in the plasma of healthy volunteers after consuming pasteurized milk. The study revealed individual variability in the presence of peptides from various bovine milk proteins, including caseins and beta-lactoglobulin. The potential bioactivity and immunogenicity of these peptides and their effects on human health require further investigation.
Article
Biochemistry & Molecular Biology
Carla Balcells-Esponera, Cristina Borras-Novell, Miriam Lopez-Abad, Inmaculada Cubells Serra, Anna Basseda Puig, Montserrat Izquierdo Renau, Ana Herranz Barbero, Isabel Iglesias-Platas
Summary: The concentration of bioactive peptides in preterm human milk is influenced by maternal factors and can affect neonatal growth. Maternal gestational age, pre-pregnancy BMI, and galactagogue treatment are associated with milk insulin levels; mothers with gestational diabetes have higher adiponectin levels in their milk; pre-pregnancy BMI is correlated with leptin levels; and the presence of labor and multiple pregnancy are related to milk MFG-E8 levels.
Review
Nutrition & Dietetics
Paola Nieri, Sara Carpi, Roberta Esposito, Maria Costantini, Valerio Zupo
Summary: The search for novel sources of nutrients is an important goal for sustainable progress. Microalgae, particularly diatoms, are considered as sustainable sources of nutrients for humans. This review focuses on the bio-pharmacological activities of diatoms and their extracts for human disease prevention and treatment, as well as their nutraceutical applications.
Article
Engineering, Biomedical
Min Suk Lee, Jin Jeon, Sihyeon Park, Juhan Lim, Hee Seok Yang
Summary: Studies have shown that multifunctional bioactive peptides in casein can improve bone regeneration. By designing a tissue engineering platform and modifying the material surface, the MDP-DOPA group demonstrated faster mineral deposition and higher bone density compared to other groups.
BIOACTIVE MATERIALS
(2023)
Article
Food Science & Technology
Viola Galli, Manuel Venturi, Eleonora Mari, Simona Guerrini, Lisa Granchi
Summary: This study found that certain strains of lactic acid bacteria can release bioactive compounds, such as GABA, in fermented milk, which have positive effects on human health. By selecting and combining different strains, fermented milk products with high GABA concentrations can be produced.
INTERNATIONAL DAIRY JOURNAL
(2022)
Review
Nutrition & Dietetics
Humberto Pena-Jorquera, Valeska Cid-Jofre, Leslie Landaeta-Diaz, Fanny Petermann-Rocha, Miquel Martorell, Hermann Zbinden-Foncea, Gerson Ferrari, Carlos Jorquera-Aguilera, Carlos Cristi-Montero
Summary: Atherosclerosis, chronic non-communicable diseases, and metabolic syndrome are interconnected and contribute to global health concerns. Adopting a plant-based diet has gained popularity as an alternative to mitigate the risk factors associated with these conditions.
Review
Nutrition & Dietetics
Mrinal Samtiya, Sweta Samtiya, Prarabdh C. Badgujar, Anil Kumar Puniya, Tejpal Dhewa, Rotimi E. Aluko
Summary: Milk-derived bioactive peptides have various potential attributes and are gaining global interest due to their health-promoting properties. However, further research on their mechanisms of action and human trials are needed.
Review
Infectious Diseases
Norma Rivera-Fernandez, Jhony Anacleto-Santos, Brenda Casarrubias-Tabarez, Teresa De Jesus Lopez-Perez, Marcela Rojas-Lemus, Nelly Lopez-Valdez, Teresa Fortoul
Summary: Apicomplexan parasites, including Toxoplasma gondii, Cryptosporidium, and Plasmodium falciparum, cause medically important diseases such as toxoplasmosis, cryptosporidiosis, and malaria. Current drugs for these diseases have limitations, and peptide-based drugs have emerged as potential alternatives due to their ability to kill infectious agents and modulate the immune response. However, the development of effective peptide drugs still faces challenges.
Article
Biochemistry & Molecular Biology
Ton Baars, Betty van Esch, Luuk van Ooijen, Zuomin Zhang, Pieter Dekker, Sjef Boeren, Mara Diks, Johan Garssen, Kasper Hettinga, Remco Kort
Summary: This study aimed to characterize the microbiota and peptidomic composition of raw milk kefir and investigate its potential anti-allergic effects using validated research models for food allergy. The raw milk kefir was produced with a defined freeze-dried starter culture, and samples were taken during fermentation at seven time intervals. Peptide compositions were analyzed in the raw and heat-treated milk, as well as the kefir products made from these milks. The results showed that only raw milk kefir suppressed the acute allergic skin response in sensitized mice, indicating its potential health benefits.
Review
Food Science & Technology
Mohammed Sharif Swallah, Xiaoqing Yang, Jiaxin Li, Joseph Kudadam Korese, Sainan Wang, Hongliang Fan, Hansong Yu, Qing Huang
Summary: Glycine max, an economically important grain crop, has varied potential health benefits. Recent studies have focused on the bioavailability and bioaccessibility of soybean bioactive compounds. This review presents evidence-based information on the therapeutic and nutritional importance of soybean phytochemicals and their implications on general health. The bioavailability, metabolism, and safety of soybean phytochemicals are also discussed, as well as the need for clinical trials to confirm these functional properties in humans.
FOOD REVIEWS INTERNATIONAL
(2023)
Review
Food Science & Technology
Samir Mahgoub, Mahmoud Alagawany, Maha Nader, Safaa M. Omar, Mohamed E. Abd El-Hack, Ayman Swelum, Shaaban S. Elnesr, Asmaa F. Khafaga, Ayman E. Taha, Mayada R. Farag, Ruchi Tiwari, Gopi Marappan, Ashraf S. El-Sayed, Shailesh K. Patel, Mamta Pathak, Izabela Michalak, Etab S. Al-Ghamdi, Kuldeep Dhama
Summary: Bioactive peptides are protein fragments formed by amino acids that have beneficial effects on human bodies and can be obtained from various sources. They can act as food preservatives with antioxidant and antimicrobial effects, and improve the treatment of diseases.
FOOD REVIEWS INTERNATIONAL
(2023)
Article
Nutrition & Dietetics
Reetta Holma, Reijo Laatikainen, Helena Orell, Heikki Joensuu, Katri Peuhkuri, Tuija Poussa, Riitta Korpela, Pia Osterlund
Article
Multidisciplinary Sciences
Stefania Noerman, Anton Klavus, Elina Jarvela-Reijonen, Leila Karhunen, Seppo Auriola, Riitta Korpela, Raimo Lappalainen, Urho M. Kujala, Sampsa Puttonen, Marjukka Kolehmainen, Kati Hanhineva
SCIENTIFIC REPORTS
(2020)
Review
Pharmacology & Pharmacy
Hanne Salmenkari, Riitta Korpela, Heikki Vapaatalo
Summary: Inflammatory bowel diseases require new treatment options to control inflammation and fibrosis, and RAS inhibitors may be a cost-effective and effective alternative. While animal studies have shown the efficacy of RAS inhibitors in colitis, human data are still limited. Retrospective studies indicate that IBD patients using RAS inhibitors have a milder disease course and fewer hospitalizations.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Elina Jarvela-Reijonen, Suvi Jarvinen, Leila Karhunen, Tiina Fohr, Tero Myllymaki, Essi Sairanen, Sanni Lindroos, Katri Peuhkuri, Maarit Hallikainen, Jussi Pihlajamaki, Sampsa Puttonen, Riitta Korpela, Miikka Ermes, Raimo Lappalainen, Urho M. Kujala, Marjukka Kolehmainen, Jaana Laitinen
Summary: The study found that better nocturnal recovery was associated with better diet quality, lower alcohol consumption, and possibly less intuitive eating.
JOURNAL OF OCCUPATIONAL MEDICINE AND TOXICOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Tuulia Onali, Anne Kivimaki, Matti Mauramo, Tuula Salo, Riitta Korpela
Summary: Wild berries such as lingonberry and bilberry are rich in phytochemicals and demonstrate anticancer effects on digestive tract cancers. Studies indicate that these berries inhibit tumor formation and cancer cell growth in colorectal cancer, supporting their potential as antiproliferative and antitumor agents.
Article
Medicine, Research & Experimental
Zan Pang, Hanna Launonen, Riitta Korpela, Heikki Vapaatalo
Summary: This study found that low sodium diet, dibutyryl-cAMP and Ang II can stimulate the local synthesis of aldosterone in the large intestine, similar to the adrenal glands.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Hanna Launonen, Lotta Luiskari, Jere Linden, Aino Siltari, Hanne Salmenkari, Riitta Korpela, Heikki Vapaatalo
Summary: In this study, we examined the effect of the aldosterone synthase inhibitor FAD286 on intestinal inflammation. Contrary to expectations, FAD286 did not inhibit intestinal aldosterone synthesis and even exacerbated the signs of inflammation, indicating its harmful effects.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2023)
Article
Physiology
Z. Pang, R. Korpela, H. Vapaatalo
Summary: In this study, the presence of the complete aldosterone production process from precursor corticosterone to final product aldosterone was detected in the murine large intestine. The enzyme activity of CYP11B2, involved in aldosterone synthesis, was higher in the large intestine compared to the small intestine, and increased during the dark period in the ileum and colon. The highest concentration of aldosterone was detected in the large intestine during the dark period. Overall, this study highlights the widespread presence of CYP11B2 enzyme activity throughout the intestine, with higher aldosterone production occurring in the large intestine during the dark period, and no differences observed between early and late light hours.
JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2022)
Article
Physiology
H. Launonen, Z. Pang, J. Linden, A. Siltari, R. Korpela, H. Vapaatalo
Summary: Aldosterone, the main mineralocorticoid, is synthesized from cholesterol in the adrenal cortex and regulates sodium and potassium balance. Recent studies show that aldosterone can be locally produced in tissues other than the adrenal cortex, such as the brain, heart, blood vessels, kidneys, and adipocytes. The research suggests that aldosterone may also be synthesized in the intestine.
JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2021)
Article
Physiology
L. Varmavuori, H. Launonen, R. Korpela, H. Vapaatalo
JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2020)
Article
Medicine, Research & Experimental
L-U Suojanen, A. J. Ahola, S. Kupila, R. Korpela, K. H. Pietilainen
CONTEMPORARY CLINICAL TRIALS COMMUNICATIONS
(2020)
Article
Dentistry, Oral Surgery & Medicine
Qingru Jiang, Veera Kainulainen, Iva Stamatova, Sok-Ja Janket, Jukka H. Meurman, Riitta Korpela
Article
Psychology, Clinical
Elina Jarvela-Reijonen, Sampsa Puttonen, Leila Karhunen, Essi Sairanen, Jaana Laitinen, Mikko Kolehmainen, Jussi Pihlajamaki, Urho M. Kujala, Riitta Korpela, Miikka Ermes, Raimo Lappalainen, Marjukka Kolehmainen
INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE
(2020)
Article
Physiology
L. Pasanen, H. Launonen, A. Siltari, R. Korpela, H. Vapaatalo, H. Salmenkari, R. A. Forsgard
JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2019)
Article
Nutrition & Dietetics
Reijo Laatikainen, Jonna Jalanka, Jussi Loponen, Sanna-Maria Hongisto, Markku Hillila, Jari Koskenpato, Riitta Korpela, Anne Salonen