Article
Cell Biology
Dan Dong, Lei Na, Kailing Zhou, Zhuo Wang, Yu Sun, Qianqian Zheng, Jian Gao, Chenghai Zhao, Wei Wang
Summary: The research revealed that FZD5 prevents EMT in gastric cancer and is associated with longer survival. ELF3 acts as a downstream effector of FZD5, repressing ZEB1 expression and guarding against EMT.
CELL COMMUNICATION AND SIGNALING
(2021)
Review
Biochemistry & Molecular Biology
Joanna Kozak, Alicja Forma, Marcin Czeczelewski, Pawel Kozyra, Elzbieta Sitarz, Elzbieta Radzikowska-Buchner, Monika Sitarz, Jacek Baj
Summary: Epithelial-mesenchymal transition (EMT) is a key process in the development of gastric cancer, affecting patient outcomes. There is an urgent need for research on pharmacological agents targeting EMT to prevent progression and potential metastasis of gastric cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Dong Ik Cha, Jeeyun Lee, Woo Kyoung Jeong, Seung Tae Kim, Jae-Hun Kim, Jung Yong Hong, Won Ki Kang, Kyoung-Mee Kim, Seon Woo Kim, DongilW Choi
Summary: The study developed a predictive model for the epithelial-to-mesenchymal transition (EMT) subtype of gastric cancer using computed tomography (CT) images and known clinicopathologic variables. A nomogram was constructed for individualized estimation of EMT subtype, providing a useful screening tool for personalized medicine.
EUROPEAN RADIOLOGY
(2022)
Article
Pathology
Yalan Liu, Lingli Chen, Dongxian Jiang, Lijuan Luan, Jie Huang, Yingyong Hou, Chen Xu
Summary: The study aims to explore the relationship between OPN and HER2 in gastric cancer, particularly in the context of EMT. Nanostring analysis revealed differential gene expression between HER2 3+ and non-3+ areas, with OPN showing a positive correlation with HER2. Knocking down OPN and HER2 resulted in decreased invasion/migration abilities in GC cell lines, indicating a potential role of HER2 in promoting EMT through the regulation of OPN.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Article
Oncology
Sadaaki Nishimura, Yurie Yamamoto, Atsushi Sugimoto, Shuhei Kushiyama, Shingo Togano, Kenji Kuroda, Tomohisa Okuno, Hiroaki Kasashima, Masaichi Ohira, Kiyoshi Maeda, Masakazu Yashiro
Summary: This study reveals the critical role of LCN2 in gastric cancer progression, involving its regulation of MMP2 activity and contribution to EMT signaling. Low LCN2 expression is associated with poor prognosis in gastric cancer patients.
Article
Immunology
Junquan Song, Rongyuan Wei, Shiying Huo, Jianpeng Gao, Xiaowen Liu
Summary: Through the analysis of differentially expressed genes between metastatic gastric cancer and primary gastric cancer, a metastasis-related epithelial-mesenchymal transition signature (MEMTS) was constructed. High MEMTS indicates a poor prognosis in patients with gastric cancer, and patients with low MEMTS may benefit more from adjuvant chemoradiotherapy. MEMTS reliably predicts the response to immunotherapy in gastric cancer and is significantly associated with cancer-associated fibroblasts and stromal score in the tumor microenvironment.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Liangliang An, Yongqiang Liu
Summary: This study revealed the significant up-regulation of ZNF460 in gastric cancer, and its expression correlated with tumor grade, lymph node metastasis, and H. pylori infection. Functionally, diminished ZNF460 expression inhibited gastric cancer cell proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) in vitro, and suppressed tumor growth in vivo. Mechanistically, ZNF460 combined with apolipoprotein C1 (APOC1) promoter to facilitate APOC1 transcription and accelerated EMT, thereby promoting gastric cancer progression.
EXPERIMENTAL CELL RESEARCH
(2023)
Article
Medicine, Research & Experimental
Tong Zhu, Xiaoming Zou, Chunfa Yang, Liangliang Li, Bing Wang, Rong Li, Hongxuan Li, Zhangxuan Xu, Di Huang, Qingyun Wu
Summary: Neutrophil extracellular traps (NETs) in gastric cancer (GC) are associated with tumor progression, metastasis risk, and tumor microenvironment. The study found that NETs formation is affected by the tumor microenvironment and may exacerbate GC progression through promoting epithelial-mesenchymal transition (EMT). Hence, targeting NETs may be therapeutically beneficial in GC treatment.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Oncology
Wanting Song, Yi Bai, Jialin Zhu, Fanxin Zeng, Chunmeng Yang, Beibei Hu, Mingjun Sun, Chenyan Li, Shiqiao Peng, Moye Chen, Xuren Sun
Summary: By analyzing gene expression data and clinical information of gastric cancer patients, a risk model was constructed to predict patient prognosis. The model exhibited good performance in prognosis prediction and was validated successfully.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Cell Biology
Yuan-jie Liu, Shu-hong Zeng, Yi-dou Hu, Yong-hua Zhang, Jie-pin Li
Summary: This study demonstrates that overexpression of NREP in gastric cancer is associated with poor prognosis, potentially influencing the activation of cancer-associated fibroblasts and epithelial-mesenchymal transition. Additionally, the expression of NREP correlates with the abundance of M2 macrophages, suggesting it could serve as a prognostic biomarker and therapeutic target for gastric cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Yi Sun, Rui Du, Yulong Shang, Changhao Liu, Linhua Zheng, Ruiqing Sun, Yuanyong Wang, Guofang Lu
Summary: This study reveals the significant role of ARHGAP35 in gastric cancer, specifically in regulating cell morphology and motility through cytoskeletal reorganization and EMT, respectively. Targeting the ARHGAP35/RhoA/E-cadherin pathway could be a potential therapeutic approach for treating gastric cancer.
Article
Pharmacology & Pharmacy
Xiuyuan Zhang, Yiming Li, Pengbo Hu, Liang Xu, Hong Qiu
Summary: In this study, the joint role of epithelial-mesenchymal transition (EMT) and the immune microenvironment in gastric cancer (GC) progression was investigated. A model called EIRG_score was developed to predict prognosis and immunotherapeutic response. The results showed that the EIRG_score was significantly associated with prognosis, immune infiltration, gene mutation, chemotherapeutic drug sensitivity, and immunotherapy response.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Aitao Sun, JinBo Li, Weijing Kong, Xiaodong Jiang
Summary: This study investigates the expression and underlying mechanisms of the immunoglobulin superfamily containing leucine-rich repeat (ISLR) in gastric cancer (GC). The findings suggest that ISLR is overexpressed in GC tumor tissues and cells and is associated with lymph node metastasis, tumor size, and clinical stage. Additionally, ISLR regulates the epithelial-mesenchymal transition (EMT) signaling pathway and affects cell viability, proliferation, migration, and invasion in GC cells. These results provide new evidence for the role of ISLR in GC progression.
Review
Oncology
Xiaobo Zheng, Fuzhen Dai, Lei Feng, Hong Zou, Li Feng, Mingqing Xu
Summary: The interplay between epithelial-mesenchymal plasticity and cancer stem cells plays a crucial role in cancer progression, affecting the aggressiveness of tumor cells and their response to treatment. Understanding the dynamic nature of EMT as a hybrid state rather than a binary model is important for unraveling the complexities of cancer biology and developing targeted therapeutic interventions.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Cheng Zhang, Yu Liang, Chun-Dong Zhang, Jun-Peng Pei, Kun-Zhe Wu, Yong-Zhi Li, Dong-Qiu Dai
Summary: LINC01235 is significantly over-expressed in gastric cancer cells and tissues, and its high expression is positively correlated with poor prognosis. It can promote cancer cell metastasis through the EMT pathway.