Review
Medical Laboratory Technology
Nick Verougstraete, Veronique Stove, Christophe P. P. Stove
Summary: The collection of capillary blood microsamples via finger-prick is convenient and patient-centric, enabling remote monitoring of diabetes patients. However, there is heterogeneity in the study designs and data evaluation on HbA(1c) determination using microsampling. This review provides a critical overview of the literature and discusses the challenges and possibilities of implementing microsampling for reliable HbA(1c) determination, including the use of liquid blood microsamples.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Alessia Cafaro, Matteo Conti, Federica Pigliasco, Sebastiano Barco, Roberto Bandettini, Giuliana Cangemi
Summary: Therapeutic drug monitoring (TDM) is a specialized field in laboratory medicine that involves measuring drug concentrations in biological fluids to optimize efficacy and reduce side effects. Microsampling offers a convenient alternative for pharmacokinetics studies and TDM, providing less invasive options for patients.
Article
Chemistry, Analytical
Katleen Van Uytfanghe, Maria del Mar Ramirez Fernandez, Aurelie De Vos, Sarah M. R. Wille, Christophe Pol Stove
Summary: This study developed a new method for PEth measurements and achieved good comparison results through the collaboration of two laboratories. The research demonstrates that the method has good comparability and reproducibility, allowing for accurate cross-validation between laboratory networks.
Article
Multidisciplinary Sciences
Satoshi Kubo, Rhea Kataria, Yikun Yao, Justin Q. Gabrielski, Lixin Zheng, Tovah E. Markowitz, Waipan Chan, Jian Song, Arun K. Boddapati, Keita Saeki, Bjoern Haupl, Ann Y. Park, Yan H. Cheng, Jing Cui, Thomas Oellerich, Michael J. Lenardo
Summary: Apoptosis is a genetically regulated program of cell death that plays a key role in immune disease processes. The transcription factor EBF4 was identified as a regulator of T cell death and cytotoxic immune function in humans, suggesting its importance in immune responses.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Nuclear Science & Technology
Ch S. S. S. Avinash, Kulbir Singh, E. Hemanth Rao, B. Malarvizhi, Sanjay Kumar Das, R. Suresh Kumar, G. Lydia, D. Ponraju, B. K. Nashine, S. Athmalingam, B. Venkatraman
Summary: An innovative sodium loop has been designed for irradiating material specimens at high temperature. The design was validated through experiments and achieved satisfactory results.
ANNALS OF NUCLEAR ENERGY
(2022)
Article
Biochemical Research Methods
Sigrid Deprez, Christophe P. Stove
Summary: In the field of solid organ transplantation, chemotherapy and autoimmune disorders, therapeutic drug monitoring (TDM) is necessary for immunosuppressant drugs due to their narrow therapeutic window and high variability. This review discusses the use of dried blood samples as an alternative for TDM, including pre-analytical considerations and implementation in clinical practice. The cost-effectiveness, availability of multiplexed methods, harmonization, and patient perception are also addressed. Future developments and obstacles for implementing dried blood-based TDM are discussed. & COPY; 2022 Elsevier B.V. All rights reserved.
JOURNAL OF CHROMATOGRAPHY A
(2023)
Article
Biochemical Research Methods
Cahaya Azzahra Rahmadhani, Yahdiana Harahap, Tesia Aisyah Rahmania
Summary: This study developed and validated an analytical method for quantifying favipiravir extracted from VAMS using HPLC-Photodiode Array with remdesivir as an internal standard. The method met the validation requirements by FDA 2018 and demonstrated sensitivity, linearity, selectivity, accuracy, precision, recovery, and stability. The VAMS technique with the developed method could be a safe and comfortable biosampling approach for COVID-19 therapy.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2023)
Article
Chemistry, Analytical
Long Yuan, Di Jiang, Andrew Pinkham, Melissa Kirkland
Summary: Capillary microsampling is a preferred technique for blood collection in rats and mice. A validated CMS LC-MS/MS assay for the quantification of BIIB131 in rat plasma has been developed and successfully applied to a safety study in rats.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Article
Pharmacology & Pharmacy
Yahdiana Harahap, Steven Steven, Herman Suryadi
Summary: This study developed and validated a UPLC-MS/MS method using VAMS and 4-OHCP-d4 as an internal standard to analyze CP and 4-OHCP. The method has the advantages of small sample volume and not being affected by hematocrit values, and it meets the validation requirements set by the FDA.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Psychiatry
Brett A. Clementz, David A. Parker, Rebekah L. Trotti, Jennifer E. McDowell, Sarah K. Keedy, Matcheri S. Keshavan, Godfrey D. Pearlson, Elliot S. Gershon, Elena I. Ivleva, Ling-Yu Huang, S. Kristian Hill, John A. Sweeney, Olivia Thomas, Matthew Hudgens-Haney, Robert D. Gibbons, Carol A. Tamminga
Summary: The current clinical phenomenological diagnosis in psychiatry lacks the ability to capture biologically homologous disease entities. A biomarker approach, termed Psychosis Biotypes, has successfully identified neurobiological homology in cases with schizophrenia, schizoaffective, and bipolar I disorder with psychosis. Different Psychosis Biotypes show distinct neurobiological characteristics, which may offer meaningful targets for treatments and etiological investigations.
SCHIZOPHRENIA BULLETIN
(2022)
Article
Medical Laboratory Technology
Milene Menestrina Dewes, Laura Ce da Silva, Yasmin Fazenda Meireles, Mariana Viana de Freitas, Marcos Frank Bastiani, Lilian Feltraco Lizot, Roberta Zilles Hahn, Marina Venzon Antunes, Rafael Linden
Summary: A sensitive LC-MS/MS assay for the determination of uracil (U) in small serum samples was developed and compared U concentrations in venous plasma obtained after phlebotomy and serum obtained with the Tasso-SST (R) device.
CLINICAL BIOCHEMISTRY
(2022)
Article
Materials Science, Multidisciplinary
Armin Salmasi, Imran Hanif, Torbjorn Jonsson, Henrik Larsson
Summary: Liquid phase migration (LPM) and its potential impact on cobalt capping in cemented carbides were investigated through experiments and simulations. A model for LPM was developed and integrated with Thermo-Calc software to predict the final microstructure. The model's predictions somewhat matched experimental observations, especially in cases with grain size and binder phase volume fraction gradients. It was also observed that LPM can cause a phenomenon resembling cobalt capping due to gradients in carbon activity.
INTERNATIONAL JOURNAL OF REFRACTORY METALS & HARD MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Guoming Wang, Lei Guo, Zhihua Guo, Sophia Lee Guan, Nan Zhu, Kaijie Qi, Chao Gu, Shaoling Zhang
Summary: In this study, the expression patterns of PbrEBF1, PbrEBF2, and PbrEBF3 in response to ethylene and 1-MCP treatment were investigated. PbrEBF3 showed potential association with fruit ripening and interaction with PbrEILs. PbrEBF3 plays a central role in pear fruit ripening through mediation of the ethylene signaling pathway.
Article
Biochemical Research Methods
Suzanne L. Parker, Steven C. Wallis, Cheryl Fourie, Melissa Lassig-Smith, Therese Starr, Avinash Chikatamarla, Tavey Dorofaeff, Mark D. Chatfield, Jeffrey Lipman, Jason A. Roberts
Summary: Reducing the volume of blood sampled from neonatal or paediatric patients is crucial for research purposes, with skin prick and capillary microsamples producing comparable results to conventional arterial blood sampling in terms of meropenem concentrations. CMS samples have been found to be stable when stored in the capillary tube for certain durations.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Thermodynamics
David A. Yaegers, Jason W. Hartwig, Chase Camarotti, J. N. Chung
Summary: This paper presents new experimental data on the wicking rate of 12 screens with liquid nitrogen and validates a room temperature based model for cryogenic nitrogen. The results suggest that the room temperature model can be used to compute wicking velocities for most screen types.
INTERNATIONAL COMMUNICATIONS IN HEAT AND MASS TRANSFER
(2023)
Article
Biochemical Research Methods
Scott Summerfield, Matthew Barfield, Neil Spooner, Steve White
Article
Biochemical Research Methods
Clive Felgate, Neil Spooner, Robert Calloway
Article
Biochemical Research Methods
Tina Panchal, Neil Spooner, Matthew Barfield
Editorial Material
Biochemical Research Methods
Neil Spooner, Melanie Anderson, Lieve Dillen, Luca Ferrari, Martijn Hilhorst, Zamas Lam, Marco Michi, James Munday, John Smeraglia, Scott Summerfield, Dieter Zimmer
Editorial Material
Biochemical Research Methods
Neil Spooner, Stephanie Cape, Scott Summerfield
Editorial Material
Biochemical Research Methods
Neil Spooner, Ismael Zamora, Carla Marshall-Waggett, Mike Lee
Editorial Material
Biochemical Research Methods
Neil Spooner, Chris Beaver, John Kolman, Scott Sunnmerfield, Liz Thomas, Tom Verhaeghe, Amanda Wilson
Editorial Material
Biochemical Research Methods
Neil Spooner
Article
Biochemical Research Methods
Shefali R. Patel, Peter Bryan, Neil Spooner, Philip Timmerman, Enaksha Wickremsinhe
Editorial Material
Biochemical Research Methods
Howard M. Hill, Neil Spooner
Article
Biochemical Research Methods
Neil Spooner, Kenneth D. Anderson, Joe Siple, Enaksha R. Wickremsinhe, Yang Xu, Mike Lee
Article
Biochemical Research Methods
Paul Abu-Rabie, Bikalpa Neupane, Neil Spooner, James Rudge, Philip Denniff, Hussain Mulla, Hitesh Pandya
Editorial Material
Biochemical Research Methods
Neil Spooner, Melanie Anderson, Enaksha R. Wickremsinhe
Article
Biochemical Research Methods
Arundhuti Sen, Molly Gilllett, Lucy Weaver, Matthew Barfield, Pawanbir Singh, Florian Lapierre, Neil Spooner
Article
Biochemical Research Methods
Sheelan Ahmad, Daniel Baker, Darragh Murnane, Neil Spooner, Ute Gerhard
Summary: This study provides evidence for the potential of solid-phase microextraction (SPME) as an alternative platform for the determination of plasma protein binding (PPB).
