Integration of metabolomics in heart disease and diabetes research: current achievements and future outlook

Metabolomic analyses reveal profound differences in glycolytic and tricarboxylic acid cycle metabolism in glucose-responsive and -unresponsive clonal β-cell lines

(2011) Peter Spégel et al.   BIOCHEMICAL JOURNAL

Lipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans

(2011) Eugene P. Rhee et al.   JOURNAL OF CLINICAL INVESTIGATION

Beyond glucose: metabolic shifts in responses to the effects of the oral glucose tolerance test and the high-fructose diet in rats

(2011) Shuhai Lin et al.   Molecular BioSystems

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease

(2011) Zeneng Wang et al.   NATURE

Metabolite profiles and the risk of developing diabetes

(2011) Thomas J Wang et al.   NATURE MEDICINE

Procedures for large-scale metabolic profiling of serum and plasma using gas chromatography and liquid chromatography coupled to mass spectrometry

(2011) Warwick B Dunn et al.   Nature Protocols

Cardiotoxicity of kinase inhibitors: the prediction and translation of preclinical models to clinical outcomes

(2011) Thomas Force et al.   NATURE REVIEWS DRUG DISCOVERY

Infant feeding and the risk of type 1 diabetes

(2010) Mikael Knip et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

The role of metabolites and metabolomics in clinically applicable biomarkers of disease

(2010) Mamas Mamas et al.   ARCHIVES OF TOXICOLOGY

Systems level studies of mammalian metabolomes: the roles of mass spectrometry and nuclear magnetic resonance spectroscopy

(2010) Warwick B. Dunn et al.   CHEMICAL SOCIETY REVIEWS

DNA Damage Links Mitochondrial Dysfunction to Atherosclerosis and the Metabolic Syndrome

(2010) John R. Mercer et al.   CIRCULATION RESEARCH

Metabolomics and Atherosclerosis

(2010) Sascha N. Goonewardena et al.   Current Atherosclerosis Reports

Alterations in Skeletal Muscle Fatty Acid Handling Predisposes Middle-Aged Mice to Diet-Induced Insulin Resistance

(2010) D. P. Y. Koonen et al.   DIABETES

Copper(II)-selective chelation improves function and antioxidant defences in cardiovascular tissues of rats as a model of diabetes: comparisons between triethylenetetramine and three less copper-selective transition-metal-targeted treatments

(2010) J. Lu et al.   DIABETOLOGIA

Insulin resistance is associated with a metabolic profile of altered protein metabolism in Chinese and Asian-Indian men

(2010) E. S. Tai et al.   DIABETOLOGIA

Glucose and Insulin Abnormalities in Patients with Heart Failure

(2010) Christi Deaton et al.   European Journal of Cardiovascular Nursing

Metabolomic distinction and insights into the pathogenesis of human primary dilated cardiomyopathy

(2010) Danny Alexander et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Metabolomics in Angiotensin II-Induced Cardiac Hypertrophy

(2010) Eero Mervaala et al.   HYPERTENSION

Proteomic and metabolomic analysis of atrial profibrillatory remodelling in congestive heart failure

(2010) Ayesha I. De Souza et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Practical Analytical Approach for the Identification of Biomarker Candidates in Prediabetic State Based upon Metabonomic Study by Ultraperformance Liquid Chromatography Coupled to Electrospray Ionization Time-of-Flight Mass Spectrometry

(2010) Haruhito Tsutsui et al.   JOURNAL OF PROTEOME RESEARCH

Metabolomic Approach with LC-QTOF to Study the Effect of a Nutraceutical Treatment on Urine of Diabetic Rats

(2010) Joanna Godzien et al.   JOURNAL OF PROTEOME RESEARCH

Metabolites Secreted by Human Atherothrombotic Aneurysms Revealed through a Metabolomic Approach

(2010) Michal Ciborowski et al.   JOURNAL OF PROTEOME RESEARCH

Plasma metabolomics reveals biomarkers of the atherosclerosis

(2010) Xi Chen et al.   JOURNAL OF SEPARATION SCIENCE

Metabonomic fingerprints of fasting plasma and spot urine reveal human pre-diabetic metabolic traits

(2010) Xinjie Zhao et al.   Metabolomics

Lipidomic analysis of variation in response to simvastatin in the Cholesterol and Pharmacogenetics Study

(2010) Rima Kaddurah-Daouk et al.   Metabolomics

Evaluation of extraction processes for intracellular metabolite profiling of mammalian cells: matching extraction approaches to cell type and metabolite targets

(2010) Christopher A. Sellick et al.   Metabolomics

Integration of metabolomics and transcriptomics data to aid biomarker discovery in type 2 diabetes

(2010) Susan C. Connor et al.   Molecular BioSystems

Getting biological about the genetics of diabetes

(2010) Christopher B Newgard et al.   NATURE MEDICINE

High-resolution magic-angle-spinning NMR spectroscopy for metabolic profiling of intact tissues

(2010) Olaf Beckonert et al.   Nature Protocols

Global metabolic profiling procedures for urine using UPLC–MS

(2010) Elizabeth J Want et al.   Nature Protocols

Metabolomic study of the LDL receptor null mouse fed a high-fat diet reveals profound perturbations in choline metabolism that are shared with ApoE null mice

(2010) Kian-Kai Cheng et al.   PHYSIOLOGICAL GENOMICS

Quantitative Metabolomics by 1H-NMR and LC-MS/MS Confirms Altered Metabolic Pathways in Diabetes

(2010) Ian R. Lanza et al.   PLoS One

Insulin Sensitivity Is Reflected by Characteristic Metabolic Fingerprints - A Fourier Transform Mass Spectrometric Non-Targeted Metabolomics Approach

(2010) Marianna Lucio et al.   PLoS One

Metabolic Footprint of Diabetes: A Multiplatform Metabolomics Study in an Epidemiological Setting

(2010) Karsten Suhre et al.   PLoS One

Leptin therapy in insulin-deficient type I diabetes

(2010) M.-y. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effect of traditional Chinese medicine berberine on type 2 diabetes based on comprehensive metabonomics

(2010) Yan Gu et al.   TALANTA

Chemometrics in metabolomics—A review in human disease diagnosis

(2009) Rasmus Madsen et al.   ANALYTICA CHIMICA ACTA

Development and Performance of a Gas Chromatography−Time-of-Flight Mass Spectrometry Analysis for Large-Scale Nontargeted Metabolomic Studies of Human Serum

(2009) Paul Begley et al.   ANALYTICAL CHEMISTRY

Development of a Robust and Repeatable UPLC−MS Method for the Long-Term Metabolomic Study of Human Serum

(2009) Eva Zelena et al.   ANALYTICAL CHEMISTRY

Targeted Metabolomic Evaluation of Arginine Methylation and Cardiovascular Risks

(2009) Zeneng Wang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Metabolomic strategies to study lipotoxicity in cardiovascular disease

(2009) Claire L. Waterman et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Metabonomic characterization of early atherosclerosis in hamsters with induced cholesterol

(2009) Weibin Zha et al.   BIOMARKERS

Metabolomic Profiling Reveals Distinct Patterns of Myocardial Substrate Use in Humans With Coronary Artery Disease or Left Ventricular Dysfunction During Surgical Ischemia/Reperfusion

(2009) Aslan T. Turer et al.   CIRCULATION

Tetracycline Treatment Retards the Onset and Slows the Progression of Diabetes in Human Amylin/Islet Amyloid Polypeptide Transgenic Mice

(2009) J. F. Aitken et al.   DIABETES

Metabolomics Applied to Diabetes Research: Moving From Information to Knowledge

(2009) J. R. Bain et al.   DIABETES

Silent myocardial ischemia is associated with altered plasma phospholipids

(2009) Hailong Lin et al.   JOURNAL OF CLINICAL LABORATORY ANALYSIS

Beneficial effects of soluble epoxide hydrolase inhibitors in myocardial infarction model: Insight gained using metabolomic approaches

(2009) Ning Li et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Metabonomic study of biochemical changes in the serum of type 2 diabetes mellitus patients after the treatment of metformin hydrochloride

(2009) Taoguang Huo et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Metabolomic study of myocardial ischemia and intervention effects of Compound Danshen Tablets in rats using ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry

(2009) Yonghai Lv et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Improving Metabolite Knowledge in Stable Atherosclerosis Patients by Association and Correlation of GC-MS and1H NMR Fingerprints

(2009) Joanna Teul et al.   JOURNAL OF PROTEOME RESEARCH

Metabonomic Variations in the Drug-Treated Type 2 Diabetes Mellitus Patients and Healthy Volunteers

(2009) Yuqian Bao et al.   JOURNAL OF PROTEOME RESEARCH

Analytical Error Reduction Using Single Point Calibration for Accurate and Precise Metabolomic Phenotyping

(2009) Frans M. van der Kloet et al.   JOURNAL OF PROTEOME RESEARCH

NMR-based metabolomics of urine for the atherosclerotic mouse model using apolipoprotein-E deficient mice

(2009) Gregory C. Leo et al.   MAGNETIC RESONANCE IN CHEMISTRY

Systems biology approaches and pathway tools for investigating cardiovascular disease

(2009) Craig E. Wheelock et al.   Molecular BioSystems

High heritability of metabolomic profiles in families burdened with premature cardiovascular disease

(2009) Svati H Shah et al.   Molecular Systems Biology

Metabonomic identification of novel biomarkers in doxorubicin cardiotoxicity and protective effect of the natural antioxidant oleuropein

(2009) Ioanna Andreadou et al.   NMR IN BIOMEDICINE

Metabonomics study of atherosclerosis rats by ultra fast liquid chromatography coupled with ion trap-time of flight mass spectrometry

(2009) Fengxia Zhang et al.   TALANTA

Novel molecular insights into RhoA GTPase-induced resistance to aqueous humor outflow through the trabecular meshwork

(2008) Min Zhang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Correlative and quantitative 1H NMR-based metabolomics reveals specific metabolic pathway disturbances in diabetic rats

(2008) Shucha Zhang et al.   ANALYTICAL BIOCHEMISTRY

Heart spotting

(2008) Hamid el Azzouzi et al.   BASIC RESEARCH IN CARDIOLOGY

Genomics in cardiac metabolism

(2008) J.-L. Samuel et al.   CARDIOVASCULAR RESEARCH

Mitochondrial Overload and Incomplete Fatty Acid Oxidation Contribute to Skeletal Muscle Insulin Resistance

(2008) Timothy R. Koves et al.   Cell Metabolism

Metabolomic strategies to identify tissue-specific effects of cardiovascular drugs

(2008) Minna T Jänis et al.   Expert Opinion on Drug Metabolism & Toxicology

Evaluation of the repeatability of ultra-performance liquid chromatography–TOF-MS for global metabolic profiling of human urine samples

(2008) Helen G. Gika et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Metabolite profiling of blood from individuals undergoing planned myocardial infarction reveals early markers of myocardial injury

(2008) Gregory D. Lewis et al.   JOURNAL OF CLINICAL INVESTIGATION

Causes of early-onset type 1 diabetes: toward data-driven environmental approaches

(2008) Pierre Bougnères et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Dysregulation of lipid and amino acid metabolism precedes islet autoimmunity in children who later progress to type 1 diabetes

(2008) Matej Orešič et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Proteomic and metabolomic analysis of cardioprotection: Interplay between protein kinase C epsilon and delta in regulating glucose metabolism of murine hearts

(2008) Manuel Mayr et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Application of Metabolomics to Cardiovascular Biomarker and Pathway Discovery

(2008) Gregory D. Lewis et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Nuclear magnetic resonance-based metabolomics predicts exercise-induced ischemia in patients with suspected coronary artery disease

(2008) Ignasi Barba et al.   MAGNETIC RESONANCE IN MEDICINE

Metabolomics as a tool to evaluate exercise-induced improvements in insulin sensitivity

(2008) Jeanette Kuhl et al.   Metabolomics

Metabolic profiling of the human response to a glucose challenge reveals distinct axes of insulin sensitivity

(2008) Oded Shaham et al.   Molecular Systems Biology

HMDB: a knowledgebase for the human metabolome

(2008) D. S. Wishart et al.   NUCLEIC ACIDS RESEARCH

Current challenges in metabolomics for diabetes research: a vital functional genomic tool or just a ploy for gaining funding?

(2008) Julian L. Griffin et al.   PHYSIOLOGICAL GENOMICS