Challenges in developing bioanalytical assays for characterization of antibody–drug conjugates

Cell-based assays: fuelling drug discovery

(2010) Elisa Michelini et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Safety, Pharmacokinetics, and Preliminary Clinical Activity of Inotuzumab Ozogamicin, a Novel Immunoconjugate for the Treatment of B-Cell Non-Hodgkin's Lymphoma: Results of a Phase I Study

(2010) Anjali Advani et al.   JOURNAL OF CLINICAL ONCOLOGY

A novel homogeneous Biotin–digoxigenin based assay for the detection of human anti-therapeutic antibodies in autoimmune serum

(2010) Zhihua Julia Qiu et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Evaluation of a generic immunoassay with drug tolerance to detect immune complexes in serum samples from cynomolgus monkeys after administration of human antibodies

(2010) Kay Stubenrauch et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Clinical immunogenicity specificity assessments: A platform evaluation

(2010) Kun Peng et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Anti-CD22-MCC-DM1: an antibody-drug conjugate with a stable linker for the treatment of non-Hodgkin's lymphoma

(2010) A G Polson et al.   LEUKEMIA

Multiple personal genomes await

(2010) J. Craig Venter   NATURE

Has the revolution arrived?

(2010) Francis Collins   NATURE

Three-dimensional tissue culture based on magnetic cell levitation

(2010) Glauco R. Souza et al.   Nature Nanotechnology

Brentuximab Vedotin (SGN-35) for Relapsed CD30-Positive Lymphomas

(2010) Anas Younes et al.   NEW ENGLAND JOURNAL OF MEDICINE

Unwanted immunogenicity: lessons learned and future challenges

(2010) Meenu Wadhwa et al.   Bioanalysis

Comparison of assay formats for drug-tolerant immunogenicity testing

(2010) Anthony M Butterfield et al.   Bioanalysis

Antibody-Drug Conjugates for the Treatment of Non-Hodgkin's Lymphoma: Target and Linker-Drug Selection

(2009) A. G. Polson et al.   CANCER RESEARCH

Antibody-Drug Conjugate Targets

(2009) B. Teicher   CURRENT CANCER DRUG TARGETS

Gastrosplenic Fistula From Hodgkin's Lymphoma

(2009) Carolyn D. Seib et al.   JOURNAL OF CLINICAL ONCOLOGY

Technology comparisons for anti-therapeutic antibody and neutralizing antibody assays in the context of an anti-TNF pharmacokinetic study

(2009) Kelly M. Loyet et al.   JOURNAL OF IMMUNOLOGICAL METHODS

The Pharmacologic Basis for Antibody-Auristatin Conjugate Activity

(2009) S. C. Alley et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Assessing specificity for immunogenicity assays

(2009) Steven J Swanson et al.   Bioanalysis

Challenges in developing antidrug antibody screening assays

(2009) Robert Dodge et al.   Bioanalysis

Anti-CD22-MCC-DM1 and MC-MMAF Conjugates: Impact of Assay Format on Pharmacokinetic Parameters Determination

(2008) Jean-Philippe Stephan et al.   BIOCONJUGATE CHEMISTRY

3-D Tissue Culture Systems for the Evaluation and Optimization of Nanoparticle-Based Drug Carriers

(2008) Thomas Tyrel Goodman et al.   BIOCONJUGATE CHEMISTRY

Contribution of Linker Stability to the Activities of Anticancer Immunoconjugates

(2008) Stephen C. Alley et al.   BIOCONJUGATE CHEMISTRY

Combination of the anti-CD30-auristatin-E antibody-drug conjugate (SGN-35) with chemotherapy improves antitumour activity in Hodgkin lymphoma

(2008) Ezogelin Oflazoglu et al.   BRITISH JOURNAL OF HAEMATOLOGY

Antibody-Drug Conjugates for Cancer Therapy

(2008) Paul J. Carter et al.   CANCER JOURNAL

Targeting HER2-Positive Breast Cancer with Trastuzumab-DM1, an Antibody-Cytotoxic Drug Conjugate

(2008) G. D. Lewis Phillips et al.   CANCER RESEARCH

Considerations for the development of therapeutic monoclonal antibodies

(2008) Patrick G Swann et al.   CURRENT OPINION IN IMMUNOLOGY

Rapid identification of reactive cysteine residues for site-specific labeling of antibody-Fabs

(2008) Jagath R. Junutula et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Recommendations for the validation of immunoassays used for detection of host antibodies against biotechnology products

(2008) Gopi Shankar et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Systemic chemotherapy for cancer: from weapon to treatment

(2008) Heikki Joensuu   LANCET ONCOLOGY

Anti-CD30 diabody-drug conjugates with potent antitumor activity

(2008) K. M. Kim et al.   MOLECULAR CANCER THERAPEUTICS

Engineered anti-CD70 antibody-drug conjugate with increased therapeutic index

(2008) C. F. McDonagh et al.   MOLECULAR CANCER THERAPEUTICS

Maleimide conjugation markedly enhances the immunogenicity of both human and murine idiotype-KLH vaccines

(2008) Kamran Kafi et al.   MOLECULAR IMMUNOLOGY

Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index

(2008) Jagath R Junutula et al.   NATURE BIOTECHNOLOGY

Targeted Cancer Therapy: Conferring Specificity to Cytotoxic Drugs

(2007) Ravi V. J. Chari   ACCOUNTS OF CHEMICAL RESEARCH