Bioanalytical LC–MS of therapeutic oligonucleotides

Bioanalysis of an oligonucleotide and its metabolites by liquid chromatography–tandem mass spectrometry

(2010) Pan Deng et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Chemistry at the 2′ Position of Constituent Nucleotides Controls Degradation Pathways of Highly Modified Oligonucleotide Molecules

(2010) C. Jeffrey Calvitt et al.   OLIGONUCLEOTIDES

Critical topics in ensuring data quality in bioanalytical LC–MS method development

(2010) Daniel E Mulvana   Bioanalysis

Reversed-phase ion-pair liquid chromatography analysis and purification of small interfering RNA

(2009) Sean M. McCarthy et al.   ANALYTICAL BIOCHEMISTRY

Origins and Mechanisms of miRNAs and siRNAs

(2009) Richard W. Carthew et al.   CELL

The promises and pitfalls of RNA-interference-based therapeutics

(2009) Daniela Castanotto et al.   NATURE

Bioanalysis of siRNA and oligonucleotide therapeutics in biological fluids and tissues

(2009) Guy A Tremblay et al.   Bioanalysis

Examination of real-time polymerase chain reaction methods for the detection and quantification of modified siRNA

(2008) Suzanne Stratford et al.   ANALYTICAL BIOCHEMISTRY

Resolution of liver cirrhosis using vitamin A–coupled liposomes to deliver siRNA against a collagen-specific chaperone

(2008) Yasushi Sato et al.   NATURE BIOTECHNOLOGY

Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates

(2008) M. Frank-Kamenetsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolite identification of small interfering RNA duplex by high-resolution accurate mass spectrometry

(2008) Yan Zou et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY