Article
Infectious Diseases
Johannes Leiner, Vincent Pellissier, Anne Nitsche, Sebastian Koenig, Sven Hohenstein, Irit Nachtigall, Gerhard Hindricks, Christoph Kutschker, Boris Rolinski, Julian Gebauer, Anja Prantz, Joerg Schubert, Joerg Patzschke, Andreas Bollmann, Martin Wolz
Summary: The study aimed to develop a prediction model for accurately identifying false negative SARS-CoV-2 rapid antigen test results. Results showed that false negative results can be effectively predicted using ten routinely available variables. This helps guide clinical decision-making and prevent nosocomial infections.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Substance Abuse
Sarah Meyers, Elisha M. Wachman
Summary: This case report describes a case where imatinib led to a false-positive amphetamine result on urine drug testing. A 21-year-old female with chronic myelocytic leukemia and history of opioid use disorder reinitiated imatinib therapy during her third trimester of pregnancy, resulting in positive amphetamine test results which were later found to be false through further testing.
JOURNAL OF ADDICTION MEDICINE
(2021)
Article
Public, Environmental & Occupational Health
Yannick Galipeau, Abishek Xavier, Aaron Dyks, Curtis Cooper, Marc-Andre Langlois
Summary: Efficient and rapid identification of active SARS-CoV-2 infections is crucial for monitoring and controlling the spread of the virus. Nucleic acid testing and rapid antigen tests are widely used methods. This case report highlights the occurrence of sustained false positive results, which were ruled out by alternative testing methods. It emphasizes the importance of using alternative tests to confirm results in case of false positives and the need for broader awareness in healthcare and public health communities.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Toxicology
Stephanie T. Weiss, Laura J. Veach, William McGill, Jeffrey Brent
Summary: This study aimed to estimate the types and rates of false negatives in urine drug screening (UDS) compared to comprehensive testing by liquid chromatography-mass spectrometry (LC-MS) in trauma patients. The results showed that false negatives for potentially important psychoactive and nonpsychoactive substances are common when toxicologic testing is limited to routine UDS in trauma patients. Therefore, expanding screening in this patient population is recommended.
CLINICAL TOXICOLOGY
(2022)
Article
Immunology
Yi-Qiang Lin, Ya-Ling Gao, Mao Wang, Shui-Di Yan, Li-Rong Lin
Summary: This study investigates the clinical characteristics of patients with false-positive HIV screening test results and identifies potential diseases unrelated to HIV. Characterization of these patients can help in interpreting HIV screening test results.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Obstetrics & Gynecology
Elizabeth G. Raymond, Holly A. Anger, Erica Chong, Sue Haskell, Melissa Grant, Christy Boraas, Kristina Tocce, Joey Banks, Bliss Kaneshiro, Maureen K. Baldwin, Leah Coplon, Paula Bednarek, Tara Shochet, Ingrida Platais
Summary: The study examined the proportion of positive high-sensitivity urine pregnancy test results after successful medication abortion over time. Results showed that the proportion of participants with positive tests decreased with time, but nearly one-fifth of participants still had positive tests 4 weeks after treatment.
Article
Medicine, Legal
Eiji Kakizaki, Norihiro Shinkawa, Ai Sonoda, Nobuhiro Yukawa
Summary: This study identified the potential for false-positive results in diatom testing due to the reuse of flasks, which may impact the detection of diatoms in closed organs of drowning victims.
FORENSIC SCIENCE INTERNATIONAL
(2022)
Article
Oncology
Joseph A. Arthur, Michael Tang, Zhanni Lu, David Hui, Kristy Nguyen, Eden Mae Rodriguez, Tonya Edwards, Sriram Yennurajalingam, Shalini Dalal, Rony Dev, Akhila Reddy, Kimberson Tanco, Ali Haider, Diane D. Liu, Eduardo Bruera
Summary: This study found that approximately 1 in 4 patients receiving opioid therapy for cancer pain had abnormal results in random UDT testing. Random UDT was able to detect abnormalities earlier than targeted UDT. These findings suggest that random UDT may be justified in patients with cancer pain.
Article
Immunology
Mengjia Qian, Bijun Zhu, Yanxia Zhan, Lingyan Wang, Qi Shen, Miaomiao Zhang, Lei Yue, Duojiao Wu, Hao Chen, Xiangdong Wang, Yunfeng Cheng
Summary: The negative prediction accuracy rate of the original specimen is significant when the mNGS test is negative. However, other laboratory assays results and clinical presentations should always be carefully considered prior to drawing a diagnosis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Virology
Michael J. Wilson, Dominic Sparkes, Chloe Myers, Anna A. Smielewska, Mir Mubariz Husain, Christopher Smith, Kathryn J. Rolfe, Hongyi Zhang, Hamid Jalal
Summary: Confirmatory testing is necessary to reduce false positives, but can lead to delays in results. Establishing a threshold for confirmatory testing can streamline the process and improve accuracy when needed.
JOURNAL OF CLINICAL VIROLOGY
(2021)
Article
Pediatrics
Katarzyna Zybert, Urszula Borawska-Kowalczyk, Lukasz Wozniacki, Malwina Dawidziuk, Mariusz Oltarzewski, Dorota Sands
Summary: This study identified 11 cystic fibrosis patients with false-negative newborn screening results, diagnosed based on clinical symptoms or siblings with positive screening results. The diagnosis was significantly delayed compared to patients with positive screening results. Additional diagnostics should be performed in the presence of clinical symptoms, even if the screening results are negative.
JORNAL DE PEDIATRIA
(2022)
Article
Medicine, General & Internal
Shista Priyadarshini, F. N. U. Manas, Sheela Prabhu
Summary: Urine pregnancy kit tests are commonly used but may fail to detect pregnancy due to the rare hook-effect, resulting in false negative results and potential risks of inadvertent lab and radiation exposure.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yan Liu, Lulu Yang, Hui Xu, Yiyuan Yang, Yiqian Liang, Aimin Yang, Xiaojiang Tang, Shengkai Lei, Ioannis Christakis, Pornpeera Jitpratoom, Jianjun Xue
Summary: Tc-99m-MIBI SPECT/CT parathyroid imaging has good sensitivity and high specificity in accurately locating hyperparathyroidism. The accuracy of localization is positively correlated with lesion weight and parathyroid hormone levels. Lightweight lesions are the main source of false-negative results in Tc-99m-MIBI SPECT/CT parathyroid imaging.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
Review
Medicine, General & Internal
Anna Macios, Andrzej Nowakowski
Summary: False negative results in cervical cancer screening pose serious risks to women, and they can be caused by various factors, including misinterpretation, clearance of HPV genetic material, and errors in histological interpretation, sampling, and laboratory procedures.
Article
Gastroenterology & Hepatology
M. J. Domper Arnal, S. Garcia Mateo, S. Hermoso-Duran, D. Abad, P. Carrera-Lasfuentes, A. Velazquez-Campoy, O. Abian Franco, A. Lanas
Summary: Female sex, NNP, and the use of PPIs combined with other drugs were identified as independent risk factors for FP FIT results, especially in males.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2021)
Article
Medical Laboratory Technology
Roger L. Bertholf, Gary M. Reisfield
LABORATORY MEDICINE
(2017)
Editorial Material
Pathology
Steven H. Kroft, Roger L. Bertholf
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
(2019)
Editorial Material
Medical Laboratory Technology
Steven H. Kroft, Roger L. Bertholf
LABORATORY MEDICINE
(2019)
Article
Medical Laboratory Technology
Sandra C. Bishop-Freeman, Roger L. Bertholf, Robert H. Powers, Lisa C. Mayhew, Ruth E. Winecker
LABORATORY MEDICINE
(2020)
Editorial Material
Medical Laboratory Technology
Roger L. Bertholf
LABORATORY MEDICINE
(2020)
Editorial Material
Medical Laboratory Technology
Roger L. Bertholf
LABORATORY MEDICINE
(2020)
Editorial Material
Medical Laboratory Technology
Roger L. Bertholf
LABORATORY MEDICINE
(2020)
Editorial Material
Medical Laboratory Technology
Roger L. Bertholf
LABORATORY MEDICINE
(2020)
Letter
Substance Abuse
Gary M. Reisfield, Scott A. Teitelbaum, Roger L. Bertholf, Bruce A. Goldberger
JOURNAL OF ADDICTION MEDICINE
(2022)
Editorial Material
Medical Laboratory Technology
Zhicheng Jin, Roger L. Bertholf, Xin Yi
CLINICAL CHEMISTRY
(2022)
Article
Medical Laboratory Technology
Zhicheng Jin, Roger L. Bertholf, Xin Yi
Summary: This article presents an LC-MS/MS method developed without an immunoextraction procedure, which is able to separate and quantify 1 alpha,25-dihydroxyvitamin D accurately. The method discovered the presence of two epimers of PTAD derivatization product, which may impact the quantitation results.
JOURNAL OF APPLIED LABORATORY MEDICINE
(2022)
Editorial Material
Medical Laboratory Technology
Joesph R. Wiencek, Allison B. Chambliss, Roger L. Bertholf, Steven W. Cotten, Christina Ellervik, Justin D. Kreuter, Kamran M. Mirza, Zahra Shajani-Yi
CLINICAL CHEMISTRY
(2022)
Editorial Material
Medical Laboratory Technology
Roger L. Bertholf
CLINICAL CHEMISTRY
(2023)
Review
Medical Laboratory Technology
Zhicheng Jin, Roger L. Bertholf, Xin Yi
Summary: Vitamin D has gained attention in recent years. Its bioactive form, 1,25(OH)(2)D, plays a critical role in regulating calcium and phosphorus levels and is involved in the immune system. However, measuring 1,25(OH)(2)D accurately is challenging due to its low concentration and lipophilicity.
CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES
(2023)
Article
Medicine, General & Internal
Zhicheng Jin, Rongrong Huang, Paul Christensen, Roger L. Bertholf, Xin Yi
Summary: This study aimed to establish a convenient laboratory test to evaluate the plasma clearance of iohexol in living kidney donors. Iohexol was measured using liquid chromatography-tandem mass spectrometry (LC-MS/MS), and automated data integration and result calculation were achieved using a custom Python script and a laboratory informatics system (LIS) vendor's direct media interface for automated result reporting.
JOURNAL OF CLINICAL MEDICINE
(2023)