Review
Chemistry, Analytical
Hai-Peng Wang, Pu Chen, Jia-Wei Dai, Dan Liu, Jing-Yan Li, Yu-Peng Xu, Xiao-Li Chu
Summary: This article reviews various chemometric methods applied in modern spectral analysis in recent years, emphasizing practicality, including spectral pre-processing, wavelength selection, data dimension reduction, quantitative calibration, pattern recognition, calibration transfer, calibration maintenance, and multispectral data fusion. Future trends in chemometric methods in the field of spectral analysis are also discussed.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2022)
Article
Biochemical Research Methods
Bart Corsaro, Tong-yuan Yang, Rocio Murphy, Ivo Sonderegger, Andrew Exley, Sylvie Bertholet, Naveen Dakappagari, Francis Dessy, Fabio Garofolo, Lisa Kierstead, Holger Koch, Ghanashyam Sarikonda, Natasha Savoie, Richard Siggers, Therese Solstad, Yanmei Lu, Mark Milton, Jean-Claude Marshall, Jason DelCarpini, Boris Gorovits, Swati Gupta, Lynne Jesaitis, John Kamerud, Arno Kromminga, Anna Ma, Jim McNally, Haoheng Yan, Bonnie Wu, Daniela Verthelyi, Susan Kirshner, Joao Pedras-Vasconcelos, Manoj Rajadhyaksha, Roland F. Staack, Elana Cherry, Isabelle Cludts, Madeleine Dahlback, George R. Gunn, Akiko Ishii-Watabe, Vibha Jawa, Robert Kubiak, Michael Partridge, Marco Petrillo, Samuel O. Pine, Johann Poetzl, Sam Song, Chris Stebbins, Yuling Wu, Lucia Zhang, Sumit Kar, Meina Liang, Mohsen Rajabi Abhari, Becky Schweighardt, Kay Stubenrauch, Yuanxin Xu
Summary: The 14th edition of the Workshop on Recent Issues in Bioanalysis had over 1000 attendees from various pharmaceutical and biotechnology companies, discussing key issues and proposing practical solutions to improve scientific excellence and regulatory compliance in bioanalysis.
Article
Chemistry, Physical
I Vukanac, M. Durasevic, J. Krneta Nikolic, G. Pantelic, M. Rajacic, M. Jankovic, N. Sarap, D. Todorovic
Summary: This paper presents the procedure of preparing radioactive standards by spiking selected matrices with a certified mixture of radionuclides and validating it. The uncertainty budget of standard total activity is elaborated in detail. The experimentally obtained efficiency curves are compared with the curves obtained by the efficiency transfer, and the homogeneity of prepared standard bulk materials is confirmed by checking the efficiency versus density dependence for individual gamma ray energies. Additionally, the results of participation in recent IAEA PT scheme are discussed.
RADIATION PHYSICS AND CHEMISTRY
(2021)
Article
Biochemical Research Methods
Sarah Hersey, Steve Keller, Joel Mathews, Lindsay King, Abbas Bandukwala, Flora Berisha, Mary Birchler, Joe Bower, Valerie Clausen, Jose Duarte, Fabio Garofolo, Shirley Hopper, Sumit Kar, Omar Mabrouk, Jean-Claude Marshall, Kristina McGuire, Michael Naughton, Yoshiro Saito, Imelda Schuhmann, Gizette Sperinde, Priscila Teixeira, Alessandra Vitaliti, Yow-Ming Wang, Richard Wnek, Yan Zhang, Sue Spitz, Vilma Decman, Steven Eck, Jose Estevam, Polina Goihberg, Enrique Gomez Alcaide, Christele Gonneau, Michael Nathan Hedrick, Gregory Hopkins, Fabian Junker, Sandra Nuti, Ulrike Sommer, Nathan Standifer, Chad Stevens, Erin Stevens, Carrie Hendricks, Meenu Wadhwa, Albert Torri, Mark Ma, Shannon Harris, Seema Kumar, Michael A. Partridge, Teresa Caiazzo, Shannon Chilewski, Isabelle Cludts, Kelly Coble, Boris Gorovits, Christine Grimaldi, Gregor Jordan, John Kamerud, Beth Leary, Meina Liang, Hanjo Lim, Andrew Mayer, Ellen O'Connor, Nisha Palackal, Johann Poetzl, Sandra Prior, Mohsen Rajabi Abhari, Natasha Savoie, Catherine Soo, Mark Ware, Bonnie Wu, Yang Xu, Tong-Yuan Yang, Jad Zoghbi
Summary: The 15th edition of the Workshop on Recent Issues in Bioanalysis (15th WRIB) was a significant event that attracted nearly 900 professionals from pharma and biotech companies, CROs, and regulatory agencies. The workshop provided a platform for active discussions on current topics in bioanalysis, including biomarkers, immunogenicity, gene therapy, cell therapy, and vaccines.
Article
Engineering, Environmental
Paul L. Edmiston, Noah Hill, Riley Hershberger, Heather Hartmann, Erika Carter, Craig Divine
Summary: A passive sampler using a porous organosilica adsorbent was developed and its performance characteristics were evaluated. The sampler demonstrated integrated response and accurately measured time-averaged PFAS concentrations even in situations with significant concentration changes. The adsorption mechanism of PFAS and sampling rates of specific compounds were also studied.
ENVIRONMENTAL SCIENCE-WATER RESEARCH & TECHNOLOGY
(2023)
Editorial Material
Biochemical Research Methods
Giane Sumner, Steve Keller, James Huleatt, Roland F. Staack, Leslie Wagner, Mitra Azadeh, Abbas Bandukwala, Liching Cao, Xiulian Du, Gabriela Franco Salinas, Fabio Garofolo, Shannon Harris, Shirley Hopper, Chad Irwin, Qin Ji, Julie Joseph, Lindsay King, Arvind Kinhikar, Yang Lu, Rosa Luo, Omar Mabrouk, Ludovic Malvaux, Jean-Claude Marshall, Kristina McGuire, Vincent Mikol, Robert Neely, Xiazi Qiu, Yoshiro Saito, Bruno Salaun, Ingrid Scully, John Smeraglia, Therese Solstad, Jeroen Stoop, Huaping Tang, Priscila Teixeira, Yixin Wang, Mike Wright, Luis Mendez, Chris Beaver, Jacqueline Eacret, Amelia Au-Yeung, Vilma Decman, Francis Dessy, Steven Eck, Polina Goihberg, Enrique Gomez Alcaide, Christele Gonneau, Katharine Grugan, Michael Nathan Hedrick, Sumit Kar, Sarita Sehra, Erin Stevens, Chad Stevens, Yongliang Sun, Fred McCush, LaKenya Williams, Sally Fischer, Bonnie Wu, Gregor Jordan, Chris Burns, Isabelle Cludts, Kelly Coble, Christine Grimaldi, Neil Henderson, Alison Joyce, Gregor Lotz, Yanmei Lu, Linlin Luo, Florian Neff, Gizette Sperinde, Kay-Gunnar Stubenrauch, Yuting Wang, Mark Ware, Weifeng Xu
Summary: The 16th Workshop on Recent Issues in Bioanalysis (16th WRIB) was held in Atlanta, GA, USA from September 26-30, 2022. With over 1000 professionals from pharma/biotech companies, CROs, and regulatory agencies in attendance, the conference focused on the latest topics in bioanalysis. The event included a comprehensive program of workshops covering various aspects of bioanalysis, biomarkers, immunogenicity, gene therapy, cell therapy, and vaccines, with special workshops on ICH M10 BMV guidelines, mass spectrometry innovation, and flow cytometry bioanalysis.
Article
Meteorology & Atmospheric Sciences
Julia Perim de Faria, Ulrich Bundke, Andrew Freedman, Timothy B. Onasch, Andreas Petzold
Summary: The performance of the CAPS PMSSA was evaluated against proven technologies in an optical-closure study, showing good agreement in measuring scattering, extinction, and absorption coefficients. The CAPS PMSSA absorption measurements compared well with the PSAP measurements for small particle sizes and modest SSA values. The study concludes that the CAPS PMSSA is a robust and reliable instrument for direct measurement of scattering and extinction coefficients, with relative accuracy decreasing for larger SSAs and particle sizes.
ATMOSPHERIC MEASUREMENT TECHNIQUES
(2021)
Article
Biochemical Research Methods
Susan Spitz, Yan Zhang, Sally Fischer, Kristina McGuire, Ulrike Sommer, Lakshmi Amaravadi, Abbas Bandukwala, Steven Eck, Fabio Garofolo, Rafiqul Islam, Gregor Jordan, Lindsay King, Yoshiro Saito, Giane Sumner, Linda Terry, Alessandra Vitaliti, Yow-Ming Wang, Christine Grimaldi, Alison Joyce, Rachel Palmer, Matthew Andisik, Marcela Araya, Mitra Azadeh, Daniel Baltrukonis, Rebecca Elliott, Sam Haidar, Seema Kumar, Andrew Mayer, Florian Neff, Nisha Palackal, Kun Peng, Mohsen Rajabi Abhari, Christina Satterwhite, Natasha Savoie, Catherine Soo, Stephen Vinter, Jan Welink, Weili Yan, Kevin Maher, David Lanham, Sylvie Bertholet, Naveen Dakappagari, Christele Gonneau, Cherie Green, Fabian Junker, Sumit Kar, Lisa Patti-Diaz, Shyam Sarikonda, Megan McCausland, Priscila Camillo Teixeira, Vilma Decman, Jose Estevam, Michael Hedrick, Alberto Hidalgo Robert, Gregory Hopkins, Sandra Nuti, Shabnam Tangri, Richard Wnek, Suman Dandamudi, Arindam Dasgupta, Anna Edmison, Patrick Faustino, Michael McGuinness, Gustavo Mendes Lima Santos, Tahseen Mirza, Diaa Shakleya, Susan Stojdl, Nilufer Tampal, Jinhui Zhang, Elana Cherry, Isabelle Cludts, Andrew Exley, Akiko Ishii-Watabe, Susan Kirshner, Joao Pedras-Vasconcelos, Meiyu Shen, Richard Siggers, Therese Solstad, Daniela Verthelyi, Haoheng Yan, Lucia Zhang
Summary: The 14th edition of the Workshop on Recent Issues in Bioanalysis gathered over 1000 representatives from various pharmaceutical and biotechnology companies, as well as regulatory agencies, for a comprehensive coverage of major issues in the field. The resulting White Paper provides recommendations and practical solutions to enable scientific excellence, improved quality, and better regulatory compliance within the global Bioanalytical Community.
Article
Chemistry, Analytical
Jost Stergar, Rok Hren, Matija Milanic
Summary: The study developed a custom-made laboratory HSI system for biomedical applications, with a focus on design, calibration, characterization, and verification protocols. The study also illustrated the advantages of the system in biomedical applications.
Article
Chemistry, Analytical
Javier de Lucas
Summary: An experimental procedure for characterizing the size-of-source effect is proposed in this paper, which is an important factor causing uncertainty in the measurement of direct reading radiation thermometers. The procedure and uncertainty calculation described in the paper are aligned with the requirements of metrological traceability in industry and science. The results of applying and validating this procedure in the calibration laboratories of radiation thermometry in the industrial field are presented.
Article
Chemistry, Analytical
K. M. T. S. Bandara, Kazuhito Sakai, Tamotsu Nakandakari, Kozue Yuge
Summary: This research introduces a low-cost, easy-to-assemble NDIR device for monitoring N2O gas concentration in agricultural soils, with tests conducted on humidity tolerance and saturation rate to validate the calibration model. The newly developed instrument achieved continuous measuring of soil N2O gas through a submerged diffusion cell, with high repeatability and accuracy in laboratory experiments.
Article
Biochemical Research Methods
Anna Lauren, Manuela Braun, Chiara Cazzin, Kelly Colleti, Chris Cox, Lisa Dietz, Thomas Emrich, Kristin Geddes, Kate Herr, Tracy Iles, Alexandra Rogue, Yvan Verlinden, Philip Timmerman
Summary: This manuscript summarizes the discussions of the European Bioanalysis Forum on practical and scientific considerations related to bioanalytical applications of quantitative polymerase chain reaction. It emphasizes the recommendation to consider principles of context of use when defining assay acceptance criteria for method validation criteria and sample analysis.
Article
Chemistry, Multidisciplinary
Sina Shafiezadeh, Gian Marco Duma, Giovanni Mento, Alberto Danieli, Lisa Antoniazzi, Fiorella Del Popolo Cristaldi, Paolo Bonanni, Alberto Testolin
Summary: There is a growing interest in using artificial intelligence techniques for predicting epileptic seizures. Machine learning algorithms can extract statistical regularities from electroencephalographic (EEG) time series to anticipate abnormal brain activity. However, evaluating the performance of predictive models is challenging, as the use of questionable cross-validation schemes can introduce correlated signals into the training and test sets. This study demonstrates the importance of rigorous evaluation protocols in ensuring the generalizability of predictive models.
APPLIED SCIENCES-BASEL
(2023)
Review
Biochemical Research Methods
Asako Uchiyama, Yoichi Naritomi, Yoshitaka Hashimoto, Takeshi Hanada, Kyoko Watanabe, Kumiko Kitta, Genki Suzuki, Takao Komatsuno, Takahiro Nakamura
Summary: This report discusses the importance of using quantitative polymerase chain reaction (qPCR) in bioanalysis and the need to improve its reliability. qPCR can detect target DNA/RNA and provides quantitative and long-term analysis. The authors also provide considerations and validation criteria for bioanalysis using qPCR. The discussion in this report is expected to contribute to the development of validation and sample analysis for pharmaceuticals analyzed using qPCR.
Article
Environmental Sciences
Malgorzata Kasprzak, Federico A. Geser, Malgorzata Sliz, Eduardo Yukihara, Sabine Mayer
Summary: The Calibration Laboratory at the Paul Scherrer Institute is responsible for calibrating and verifying radiation protection instruments and dosemeters. The laboratory is involved in research and development projects to meet the increasing calibration needs and comply with new regulations.
RADIATION PROTECTION DOSIMETRY
(2023)
