Article
Health Care Sciences & Services
Seungyeong Yu, Mincheol Park, Jiseung Kang, Eunkyung Lee, Jieun Jung, Tae Kim
Summary: Vitamin D deficiency is closely related to the risk of schizophrenia and may lead to abnormal cortical gamma-band oscillations, which are associated with cognitive symptoms of the disease.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Renata Batista-Brito, Antara Majumdar, Alejandro Nuno, Claire Ward, Clayton Barnes, Kasra Nikouei, Martin Vinck, Jessica A. Cardin
Summary: GABAergic inhibition is crucial in cortical circuit development. Neuregulin 1 (Nrg1) and its receptor ErbB4 play a key role in the maturation and synaptic connectivity of interneurons. Conditional deletion of ErbB4 in parvalbumin-expressing (PV) interneurons in mice results in alterations in the activity of cortical neurons and disruption of cortical temporal organization. It also leads to dysregulation of excitatory pyramidal neuron dendritic architecture and a redistribution of spine density. These findings highlight the importance of early developmental Nrg1/ErbB4 signaling in the maturation of cortical circuits.
MOLECULAR PSYCHIATRY
(2023)
Article
Multidisciplinary Sciences
Noriaki Kanayama, Masayuki Hara, Kenta Kimura
Summary: Virtual reality allows for fast and controllable experimental body image settings, with EEG oscillatory activities providing insights into human multisensory integration processes. However, EEG data recorded in VR environments may be vulnerable to noise, posing challenges for measurement and analysis. The study highlights differences in brain activities between real and VR settings, emphasizing the need to consider these differences in investigating bodily self-perception using VR.
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
Yicong Zheng, Xiaonan L. Liu, Liang-Tien Hsieh, Mitzi Hurtado, Yan Wang, Tara A. Niendam, Cameron S. Carter, Charan Ranganath, J. Daniel Ragland
Summary: Individuals with schizophrenia show reduced sequence memory in a temporal sequence learning task compared to healthy controls, with differences in neural oscillations between fixed and random sequences in late blocks also being attenuated in the schizophrenia group. Disruption in modulation of alpha and beta 1 electroencephalography oscillations may be a candidate mechanism underlying temporal sequence memory deficits in schizophrenia.
BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING
(2021)
Article
Neurosciences
Anna-Lisa Schuler, Giulio Ferrazzi, Nigel Colenbier, Giorgio Arcara, Francesco Piccione, Florinda Ferreri, Daniele Marinazzo, Giovanni Pellegrino
Summary: This study investigates the relationship between cortical thickness and gamma synchrony in the brain. The results show a significant positive correlation between cortical thickness and gamma synchrony, indicating the involvement of underlying cell density in gamma circuitries. The findings contribute to the understanding of cortical functional and structural properties.
Article
Neurosciences
Adriano B. L. Tort, Maximilian Hammer, Jiaojiao Zhang, Jurij Brankack, Andreas Draguhn
Summary: The study found a strong correlation between instantaneous breathing frequency and the frequency and amplitude of theta and gamma oscillations in the brain. Changes in theta activity were found to precede and cause changes in breathing frequency, indicating control by the brain's functional state. On the other hand, changes in breathing frequency were found to cause changes in gamma frequency, suggesting influence by a peripheral reafference signal.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Pharmacology & Pharmacy
Meghan Musselman, Eric Huynh, Rachana Kelshikar, Eric Lee, Mohammed Malik, Justin Faden
Summary: Potassium channel modulators, particularly AUT00206, show promise in treating schizophrenia by targeting Kv3.1 and Kv3.2 potassium channels. These modulators have demonstrated effectiveness in improving symptoms and affecting dopamine levels. However, more research is needed to confirm these findings.
EXPERT OPINION ON INVESTIGATIONAL DRUGS
(2023)
Article
Clinical Neurology
Daisuke Koshiyama, Makoto Miyakoshi, Kumiko Tanaka-Koshiyama, Joyce Sprock, Gregory A. Light
Summary: Neural oscillations play a crucial role in information processing across brain regions. This study investigated the functional relationship between low-frequency phase and gamma oscillations in schizophrenia patients and healthy subjects. The results showed that there were significant alterations in low-frequency phase synchronization related to high-power gamma in schizophrenia patients, suggesting a core pathophysiologic abnormality. Understanding these functional relationships may contribute to the development of novel therapeutics.
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2022)
Article
Biology
Peijun Yuan, Ruichen Hu, Xue Zhang, Ying Wang, Yi Jiang
Summary: Temporal regularity plays a crucial role in guiding attention and coordinating behavior within a dynamic environment. Research suggests that higher-order regularity can serve as a temporal frame to recompose the dynamic profile of visual temporal attention. Neural entrainment is highlighted as a central mechanism for optimizing our conscious experience of the world in the time dimension.
Review
Biochemistry & Molecular Biology
Chitra Vinnakota, Matthew R. R. Hudson, Nigel C. C. Jones, Suresh Sundram, Rachel A. A. Hill
Summary: Glutamate N-methyl-D-aspartate receptor (NMDAR) hypofunction is believed to be responsible for schizophrenia symptoms. Among the NMDAR subunits, the GluN2D subunit is implicated in schizophrenia-related phenotypes, and further research into this subunit may lead to novel therapeutic targets for the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Bo Yao, Jason R. Taylor, Briony Banks, Sonja A. Kotz
Summary: Growing evidence suggests that theta-band activity in the auditory cortex phase-locks to rhythms of overt speech. This study investigated whether theta activity also encodes the rhythmic dynamics of inner speech by measuring EEG responses to speech quote reading onset. The findings show that direct quote reading is associated with increased theta phase synchrony, suggesting a functional role of theta phase modulation in reading-induced inner speech.
Article
Biochemistry & Molecular Biology
Yuki Yasumoto, Milan Stoiljkovic, Jung Dae Kim, Matija Sestan-Pesa, Xiao-Bing Gao, Sabrina Diano, Tamas L. Horvath
Summary: The study revealed a novel interaction between microglia and neurons in the ventral hippocampus, which plays a role in regulating synaptic number, reactive oxygen species production, and neuronal circuit functions, ultimately influencing anxiety-like behavior.
MOLECULAR PSYCHIATRY
(2021)
Review
Neurosciences
Linette Liqi Tan, Manfred Josef Oswald, Rohini Kuner
Summary: Pain is a complex perceptual phenomenon involving coordinated activity among local and distant brain networks. Brain oscillatory rhythms play a key role in pain networks by coordinating activity across local neuronal ensembles and anatomically distant brain areas. Therapeutic modulation of oscillatory rhythms has the potential to alleviate pain, with outstanding questions and challenges to be addressed in future research.
TRENDS IN NEUROSCIENCES
(2021)
Article
Multidisciplinary Sciences
ChangHui Pak, Tamas Danko, Vincent R. Mirabella, Jinzhao Wang, Yingfei Liu, Madhuri Vangipuram, Sarah Grieder, Xianglong Zhang, Thomas Ward, Yu-Wen Alvin Huang, Kang Jin, Philip Dexheimer, Eric Bardes, Alexis Mitelpunkt, Junyi Ma, Michael McLachlan, Jennifer C. Moore, Pingping Qu, Carolin Purmann, Jeffrey L. Dage, Bradley J. Swanson, Alexander E. Urban, Bruce J. Aronow, Zhiping P. Pang, Douglas F. Levinson, Marius Wernig, Thomas C. Sudhof
Summary: Heterozygous NRXN1 deletions are associated with schizophrenia and other neurodevelopmental disorders, causing impaired neurotransmitter release in human neurons. However, mouse neurons with NRXN1 deletions did not show the same impairment, suggesting a human-specific phenotype. The deletions also led to increased levels of CASK and characteristic gene-expression changes, highlighting the potential for future drug discovery targeting NRXN1 deletions.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Neurosciences
Angel Nunez, Washington Buno
Summary: The generation of theta rhythm involves interactions between the medial septum-diagonal band of Broca and intra-hippocampal circuits, as well as the intrinsic properties of neurons in these regions. Theta may serve as a timing mechanism to organize movement sequences, memory encoding, and spatial navigation trajectories, with interactions with gamma oscillations being critical for learning and memory processes. The disruption of this interaction is believed to underlie various neurophatological conditions.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Bo Cao, Raymond Y. Cho, Dachun Chen, Meihong Xiu, Li Wang, Jair C. Soares, Xiang Yang Zhang
MOLECULAR PSYCHIATRY
(2020)
Review
Clinical Neurology
Alexis G. McCathern, David S. Mathai, Raymond Y. Cho, Wayne K. Goodman, Eric A. Storch
EXPERT REVIEW OF NEUROTHERAPEUTICS
(2020)
Article
Psychiatry
Nicholas Murphy, Nithya Ramakrishnan, Christopher P. Walker, Nicola R. Polizzotto, Raymond Y. Cho
FRONTIERS IN PSYCHIATRY
(2020)
Article
Psychiatry
Brian A. Coffman, Gretchen Haas, Carl Olson, Raymond Cho, Avniel Singh Ghuman, Dean F. Salisbury
FRONTIERS IN PSYCHIATRY
(2020)
Article
Neurosciences
Mei Hong Xiu, XiaoE Lang, Da Chun Chen, Bo Cao, Thomas R. Kosten, Raymond Y. Cho, Hui Shi, Chang Wei Wei, An Shi Wu, Xiang Yang Zhang
Summary: The study found no detectable hippocampal subfield deficits in first-episode never-treated schizophrenia patients, but the hippocampal subfields may be involved in the symptoms and cognitive deficits of patients in the early phase of their illness.
Article
Psychiatry
Alfredo L. Sklar, Brian A. Coffman, Gretchen Haas, Avniel Ghuman, Raymond Cho, Dean F. Salisbury
SCHIZOPHRENIA RESEARCH
(2020)
Correction
Multidisciplinary Sciences
Bo Cao, Qinghua Luo, Yixiao Fu, Lian Du, Tian Qiu, Xiangying Yang, Xiaolu Chen, Qibin Chen, Jair C. Soares, Raymond Y. Cho, Xiang Yang Zhang, Haitang Qiu
SCIENTIFIC REPORTS
(2020)
Article
Clinical Neurology
Feng Fang, Beata Godlewska, Raymond Y. Cho, Sean I. Savitz, Sudhakar Selvaraj, Yingchun Zhang
Summary: This study investigated the effects of the antidepressant drug escitalopram on functional brain controllability in patients with major depressive disorder (MDD). The results showed that escitalopram treatment improved the brain controllability of MDD patients and predicted improvements in clinical scores.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Neurosciences
Feng Fang, Beata Godlewska, Raymond Y. Cho, Sean I. Savitz, Sudhakar Selvaraj, Yingchun Zhang
Summary: Personalized neuromodulation protocols can more effectively treat neurological diseases and psychiatric disorders. This study developed a personalized repetitive transcranial magnetic stimulation (rTMS) protocol and evaluated its feasibility in optimizing treatment efficiency for depression.
Article
Health Policy & Services
Jane E. Hamilton, Robert Suchting, David S. Buck, Arina Chesnokova, Sophiya Das, Melissa Allen, Raymond Y. Cho
Summary: Research indicates that high utilizers of the health care system are more likely to have mental illness, to be from socially disadvantaged groups, and to have limited access to community-based services. Through the study of different definitions of high utilization, three factors were identified as increasing the likelihood of high utilization: having a diagnosis of schizophrenia, having a co-occurring personality disorder diagnosis, and having less than a high school education.
JOURNAL OF HEALTH CARE FOR THE POOR AND UNDERSERVED
(2021)
Article
Emergency Medicine
Jessica Moe, Katherin Badke, Megan Pratt, Raymond Y. Cho, Pouya Azar, Heather Flemming, K. Anne Sutherland, Barbara Harvey, Lara Gurney, Julie Lockington, Penny Brasher, Sam Gill, Emma Garrod, Misty Bath, Andy Kestler
JOURNAL OF THE AMERICAN COLLEGE OF EMERGENCY PHYSICIANS OPEN
(2020)
Proceedings Paper
Acoustics
Boqiang Fan, Wayne Goodman, Raymond Y. Cho, Sameer A. Sheth, Richard R. Bouchard, Behnaam Aazhang
2020 IEEE INTERNATIONAL CONFERENCE ON ACOUSTICS, SPEECH, AND SIGNAL PROCESSING
(2020)
Article
Biology
Anthony J. E. Berndt, Katerina M. Othonos, Tianshun Lian, Stephane Flibotte, Mo Miao, Shamsuddin A. Bhuiyan, Raymond Y. Cho, Justin S. Fong, Seo Am Hur, Paul Pavlidis, Douglas W. Allan
Meeting Abstract
Neurosciences
Nicholas Murphy, Nithya Ramakrishnan, Christopher P. Walker, Nicola R. Polizzotto, Raymond Cho
BIOLOGICAL PSYCHIATRY
(2020)
Article
Psychology, Multidisciplinary
Nicola Riccardo Polizzotto, Nithya Ramakrishnan, Raymond Y. Cho
FRONTIERS IN PSYCHOLOGY
(2020)