Chitosan functionalisation of gold nanoparticles encourages particle uptake and induces cytotoxicity and pro-inflammatory conditions in phagocytic cells, as well as enhancing particle interactions with serum components

Development of Noncytotoxic Chitosan–Gold Nanocomposites as Efficient Antibacterial Materials

(2015) Anna Regiel-Futyra et al.   ACS Applied Materials & Interfaces

The oxidative potential of differently charged silver and gold nanoparticles on three human lung epithelial cell types

(2015) Paul Schlinkert et al.   JOURNAL OF NANOBIOTECHNOLOGY

Ultrasmall Gold Nanoparticles as Carriers for Nucleus-Based Gene Therapy Due to Size-Dependent Nuclear Entry

(2014) Shuaidong Huo et al.   ACS Nano

Protein Corona Fingerprinting Predicts the Cellular Interaction of Gold and Silver Nanoparticles

(2014) Carl D. Walkey et al.   ACS Nano

Surface Chemistry of Gold Nanoparticles Mediates Their Exocytosis in Macrophages

(2014) Nuri Oh et al.   ACS Nano

Quantification of Al2O3 nanoparticles in human cell lines applying inductively coupled plasma mass spectrometry (neb-ICP-MS, LA-ICP-MS) and flow cytometry-based methods

(2014) Steffi Böhme et al.   JOURNAL OF NANOPARTICLE RESEARCH

Turning the chitosan surface from hydrophilic to hydrophobic by layer-by-layer electro-assembly

(2014) Jia-Ru Ye et al.   RSC Advances

Polymer-Coated Nanoparticles Interacting with Proteins and Cells: Focusing on the Sign of the Net Charge

(2013) Dominik Hühn et al.   ACS Nano

Biomedicine: The new gold standard

(2013) Karen Weintraub   NATURE

Rapid formation of plasma protein corona critically affects nanoparticle pathophysiology

(2013) Stefan Tenzer et al.   Nature Nanotechnology

Facile Preparation of Cationic Gold Nanoparticle-Bioconjugates for Cell Penetration and Nuclear Targeting

(2012) Isaac Ojea-Jiménez et al.   ACS Nano

T Cell-Specific siRNA Delivery Using Antibody-Conjugated Chitosan Nanoparticles

(2012) Jangwook Lee et al.   BIOCONJUGATE CHEMISTRY

The role of surface charge in cellular uptake and cytotoxicity of medical nanoparticles

(2012) Eleonore Fröhlich   International Journal of Nanomedicine

Nanoparticle Surface Charge Mediates the Cellular Receptors Used by Protein–Nanoparticle Complexes

(2012) Candace C. Fleischer et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Effects of nanoparticle surface-coupled peptides, functional endgroups, and charge on intracellular distribution and functionality of human primary reticuloendothelial cells

(2012) Matthias Bartneck et al.   Nanomedicine-Nanotechnology Biology and Medicine

Exocytosis of peptide functionalized gold nanoparticles in endothelial cells

(2012) Dorota Bartczak et al.   Nanoscale

Plasma protein binding of positively and negatively charged polymer-coated gold nanoparticles elicits different biological responses

(2012) Zhou J. Deng et al.   Nanotoxicology

Biomolecular coronas provide the biological identity of nanosized materials

(2012) Marco P. Monopoli et al.   Nature Nanotechnology

Fabrication of Bacillus cereus electrochemical immunosensor based on double-layer gold nanoparticles and chitosan

(2012) Xiaobin Kang et al.   SENSORS AND ACTUATORS B-CHEMICAL

Amino-Functionalized Polystyrene Nanoparticles Activate the NLRP3 Inflammasome in Human Macrophages

(2011) Oleg Lunov et al.   ACS Nano

Differential Uptake of Functionalized Polystyrene Nanoparticles by Human Macrophages and a Monocytic Cell Line

(2011) Oleg Lunov et al.   ACS Nano

Effect of Gold Nanoparticle Aggregation on Cell Uptake and Toxicity

(2011) Alexandre Albanese et al.   ACS Nano

Nanoparticle Size Is a Critical Physicochemical Determinant of the Human Blood Plasma Corona: A Comprehensive Quantitative Proteomic Analysis

(2011) Stefan Tenzer et al.   ACS Nano

Effects of hydrophobic and hydrophilic modifications on gene delivery of amphiphilic chitosan based nanocarriers

(2011) Bingqing Wang et al.   BIOMATERIALS

PEGylated dendrimer-entrapped gold nanoparticles for in vivo blood pool and tumor imaging by computed tomography

(2011) Chen Peng et al.   BIOMATERIALS

Chitosan oligosaccharides inhibit LPS-induced over-expression of IL-6 and TNF-α in RAW264.7 macrophage cells through blockade of mitogen-activated protein kinase (MAPK) and PI3K/Akt signaling pathways

(2011) Pan Ma et al.   CARBOHYDRATE POLYMERS

Double-walled carbon nanotubes trigger IL-1β release in human monocytes through Nlrp3 inflammasome activation

(2011) Etienne Meunier et al.   Nanomedicine-Nanotechnology Biology and Medicine

Surface charge of gold nanoparticles mediates mechanism of toxicity

(2011) Nicole M. Schaeublin et al.   Nanoscale

Effects of Transport Inhibitors on the Cellular Uptake of Carboxylated Polystyrene Nanoparticles in Different Cell Lines

(2011) Tiago dos Santos et al.   PLoS One

Addressing Brain Tumors with Targeted Gold Nanoparticles: A New Gold Standard for Hydrophobic Drug Delivery?

(2011) Yu Cheng et al.   Small

Hardening of the Nanoparticle-Protein Corona in Metal (Au, Ag) and Oxide (Fe3O4, CoO, and CeO2) Nanoparticles

(2011) Eudald Casals et al.   Small

Activation of stress-related signalling pathway in human cells upon SiO2 nanoparticles exposure as an early indicator of cytotoxicity

(2011) Bashir Mohamed et al.   JOURNAL OF NANOBIOTECHNOLOGY

Rapid Uptake of Gold Nanorods by Primary Human Blood Phagocytes and Immunomodulatory Effects of Surface Chemistry

(2010) Matthias Bartneck et al.   ACS Nano

Time Evolution of the Nanoparticle Protein Corona

(2010) Eudald Casals et al.   ACS Nano

The effect of surface modification of amorphous silica particles on NLRP3 inflammasome mediated IL-1β production, ROS production and endosomal rupture

(2010) Tomohiro Morishige et al.   BIOMATERIALS

The Influence of Surface Composition of Nanoparticles on their Interactions with Serum Albumin

(2010) Lennart Treuel et al.   CHEMPHYSCHEM

Doxorubicin-incorporated nanoparticles composed of poly(ethylene glycol)-grafted carboxymethyl chitosan and antitumor activity against glioma cells in vitro

(2010) Young-Il Jeong et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Dispersion and Stability Optimization of TiO2Nanoparticles in Cell Culture Media

(2010) Zhaoxia Ji et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Effective protection and controlled release of insulin by cationic β-cyclodextrin polymers from alginate/chitosan nanoparticles

(2010) Nan Zhang et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Chitosan−Cholesterol-Based Cellular Delivery of Anionic Nanoparticles

(2010) Amit Ranjan Maity et al.   Journal of Physical Chemistry C

Gold Nanoparticles for the Improved Anticancer Drug Delivery of the Active Component of Oxaliplatin

(2010) Sarah D. Brown et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

What the Cell “Sees” in Bionanoscience

(2010) Dorota Walczyk et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Effect of Nanoparticle Surface Charge at the Plasma Membrane and Beyond

(2010) Rochelle R. Arvizo et al.   NANO LETTERS

Nanoparticle-induced unfolding of fibrinogen promotes Mac-1 receptor activation and inflammation

(2010) Zhou J. Deng et al.   Nature Nanotechnology

Role of surface charge and oxidative stress in cytotoxicity of organic monolayer-coated silicon nanoparticles towards macrophage NR8383 cells

(2010) Sourav Bhattacharjee et al.   Particle and Fibre Toxicology

Nanoparticles activate the NLR pyrin domain containing 3 (Nlrp3) inflammasome and cause pulmonary inflammation through release of IL-1  and IL-1 

(2010) A. S. Yazdi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chitosan-based formulations of drugs, imaging agents and biotherapeutics

(2009) Maryam Amidi et al.   ADVANCED DRUG DELIVERY REVIEWS

Biodegradation, biodistribution and toxicity of chitosan

(2009) T. Kean et al.   ADVANCED DRUG DELIVERY REVIEWS

Cellular uptake mechanism and intracellular fate of hydrophobically modified glycol chitosan nanoparticles

(2009) Hae Yun Nam et al.   JOURNAL OF CONTROLLED RELEASE

Activation of Inflammasomes Requires Intracellular Redistribution of the Apoptotic Speck-Like Protein Containing a Caspase Recruitment Domain

(2009) N. B. Bryan et al.   JOURNAL OF IMMUNOLOGY

Instability of Cationic Gold Nanoparticle Bioconjugates: The Role of Citrate Ions

(2009) Isaac Ojea-Jiménez et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Anti-tumor activity of paclitaxel-loaded chitosan nanoparticles: An in vitro study

(2009) Fang Li et al.   Materials Science & Engineering C-Materials for Biological Applications

An investigation into the potential for different surface-coated quantum dots to cause oxidative stress and affect macrophage cell signallingin vitro

(2009) Martin J. D. Clift et al.   Nanotoxicology

Understanding biophysicochemical interactions at the nano–bio interface

(2009) Andre E. Nel et al.   NATURE MATERIALS

Diagnosing lung cancer in exhaled breath using gold nanoparticles

(2009) Gang Peng et al.   Nature Nanotechnology

Sniffing the Unique “Odor Print” of Non-Small-Cell Lung Cancer with Gold Nanoparticles

(2009) Orna Barash et al.   Small

Nuclear penetration of surface functionalized gold nanoparticles

(2009) Yan-Juan Gu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Effects and uptake of gold nanoparticles deposited at the air–liquid interface of a human epithelial airway model

(2009) C. Brandenberger et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Highly Efficient System To Deliver Taxanes into Tumor Cells: Docetaxel-Loaded Chitosan Oligomer Colloidal Carriers

(2008) Maria V. Lozano et al.   BIOMACROMOLECULES

Self-assembled glycol chitosan nanoparticles for the sustained and prolonged delivery of antiangiogenic small peptide drugs in cancer therapy

(2008) Jong-Ho Kim et al.   BIOMATERIALS

Differential requirement for the activation of the inflammasome for processing and release of IL-1  in monocytes and macrophages

(2008) M. G. Netea et al.   BLOOD

Hydrophobically modified glycol chitosan nanoparticles-encapsulated camptothecin enhance the drug stability and tumor targeting in cancer therapy

(2008) Kyung Hyun Min et al.   JOURNAL OF CONTROLLED RELEASE

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

(2008) Veit Hornung et al.   NATURE IMMUNOLOGY

Disorders Involving Calcium, Phosphorus, and Magnesium

(2008) Sharon M. Moe   PRIMARY CARE

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

(2008) C. Dostert et al.   SCIENCE