Dissecting inhibitory brain circuits with genetically-targeted technologies

Cortical interneuron loss and symptom heterogeneity in Huntington disease

(2014) Eric H. Kim et al.   ANNALS OF NEUROLOGY

Chemogenetic Tools to Interrogate Brain Functions

(2014) Scott M. Sternson et al.   Annual Review of Neuroscience

State-Dependent Architecture of Thalamic Reticular Subnetworks

(2014) Michael M. Halassa et al.   CELL

A Cortical Circuit for Gain Control by Behavioral State

(2014) Yu Fu et al.   CELL

In vivo optogenetic identification and manipulation of GABAergic interneuron subtypes

(2014) Lisa Roux et al.   CURRENT OPINION IN NEUROBIOLOGY

Optogenetic approaches for investigating neural pathways implicated in schizophrenia and related disorders

(2014) K. K. A. Cho et al.   HUMAN MOLECULAR GENETICS

Distribution and morphological characteristics of striatal interneurons expressing calretinin in mice: A comparison with human and nonhuman primates

(2014) Sarah Petryszyn et al.   JOURNAL OF CHEMICAL NEUROANATOMY

Activation of Prefrontal Cortical Parvalbumin Interneurons Facilitates Extinction of Reward-Seeking Behavior

(2014) D. R. Sparta et al.   JOURNAL OF NEUROSCIENCE

Global Optogenetic Activation of Inhibitory Interneurons during Epileptiform Activity

(2014) M. Ledri et al.   JOURNAL OF NEUROSCIENCE

Interneuron subtypes and orientation tuning

(2014) Seung-Hee Lee et al.   NATURE

Interneuron cell types are fit to function

(2014) Adam Kepecs et al.   NATURE

All-optical electrophysiology in mammalian neurons using engineered microbial rhodopsins

(2014) Daniel R Hochbaum et al.   NATURE METHODS

Optimized ratiometric calcium sensors for functional in vivo imaging of neurons and T lymphocytes

(2014) Thomas Thestrup et al.   NATURE METHODS

Dendritic Spikes Induce Ripples in Parvalbumin Interneurons during Hippocampal Sharp Waves

(2014) Balázs Chiovini et al.   NEURON

Striatal Cholinergic Interneurons Drive GABA Release from Dopamine Terminals

(2014) Alexandra B. Nelson et al.   NEURON

Optogenetic Countering of Glial Acidosis Suppresses Glial Glutamate Release and Ischemic Brain Damage

(2014) Kaoru Beppu et al.   NEURON

Structure-Guided Transformation of Channelrhodopsin into a Light-Activated Chloride Channel

(2014) A. Berndt et al.   SCIENCE

Local Impermeant Anions Establish the Neuronal Chloride Concentration

(2014) J. Glykys et al.   SCIENCE

Conversion of Channelrhodopsin into a Light-Gated Chloride Channel

(2014) J. Wietek et al.   SCIENCE

Genetic dissection of GABAergic neural circuits in mouse neocortex

(2014) Hiroki Taniguchi   Frontiers in Cellular Neuroscience

Recombineering strategies for developing next generation BAC transgenic tools for optogenetics and beyond

(2014) Jonathan T. Ting et al.   Frontiers in Behavioral Neuroscience

The inhibitory microcircuit of the substantia nigra provides feedback gain control of the basal ganglia output

(2014) Jennifer Brown et al.   eLife

Cell type-specific and time-dependent light exposure contribute to silencing in neurons expressing Channelrhodopsin-2

(2014) Alexander M Herman et al.   eLife

Enhancement of encoding and retrieval functions through theta phase-specific manipulation of hippocampus

(2014) Joshua H Siegle et al.   eLife

A PKA activity sensor for quantitative analysis of endogenous GPCR signaling via 2-photon FRET-FLIM imaging

(2014) Yao Chen et al.   Frontiers in Pharmacology

The long and short of GABAergic neurons

(2013) Antonio Caputi et al.   CURRENT OPINION IN NEUROBIOLOGY

Preprodynorphin-expressing neurons constitute a large subgroup of somatostatin-expressing GABAergic interneurons in the mouse neocortex

(2013) Jaerin Sohn et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Cell Type-Specific Inhibitory Inputs to Dendritic and Somatic Compartments of Parvalbumin-Expressing Neocortical Interneuron

(2013) H. Hioki et al.   JOURNAL OF NEUROSCIENCE

Transgene Expression in Target-Defined Neuron Populations Mediated by Retrograde Infection with Adeno-Associated Viral Vectors

(2013) M. Rothermel et al.   JOURNAL OF NEUROSCIENCE

A Reorganized GABAergic Circuit in a Model of Epilepsy: Evidence from Optogenetic Labeling and Stimulation of Somatostatin Interneurons

(2013) Z. Peng et al.   JOURNAL OF NEUROSCIENCE

Prefrontal parvalbumin interneurons shape neuronal activity to drive fear expression

(2013) Julien Courtin et al.   NATURE

Distinct behavioural and network correlates of two interneuron types in prefrontal cortex

(2013) D. Kvitsiani et al.   NATURE

A disinhibitory microcircuit initiates critical-period plasticity in the visual cortex

(2013) Sandra J. Kuhlman et al.   NATURE

Cortical interneurons that specialize in disinhibitory control

(2013) Hyun-Jae Pi et al.   NATURE

Dual origins of functionally distinct O-LM interneurons revealed by differential 5-HT3AR expression

(2013) Ramesh Chittajallu et al.   NATURE NEUROSCIENCE

Inhibition of inhibition in visual cortex: the logic of connections between molecularly distinct interneurons

(2013) Carsten K Pfeffer et al.   NATURE NEUROSCIENCE

A disinhibitory circuit mediates motor integration in the somatosensory cortex

(2013) Soohyun Lee et al.   NATURE NEUROSCIENCE

Neocortical interneurons: Functional diversity and clinical correlations

(2013) E. E. Benarroch   NEUROLOGY

Optogenetic Activation of an Inhibitory Network Enhances Feedforward Functional Connectivity in Auditory Cortex

(2013) Liberty S. Hamilton et al.   NEURON

A Unique Population of Ventral Tegmental Area Neurons Inhibits the Lateral Habenula to Promote Reward

(2013) Alice M. Stamatakis et al.   NEURON

Erbb4 Deletion from Fast-Spiking Interneurons Causes Schizophrenia-like Phenotypes

(2013) Isabel del Pino et al.   NEURON

Parvalbumin-Expressing Interneurons Linearly Control Olfactory Bulb Output

(2013) Hiroyuki K. Kato et al.   NEURON

Neocortical Somatostatin-Expressing GABAergic Interneurons Disinhibit the Thalamorecipient Layer 4

(2013) Han Xu et al.   NEURON

Selective suppression of excitatory synapses on GABAergic interneurons by norepinephrine in juvenile rat prefrontal cortical microcircuitry

(2013) H.-X. Wang et al.   NEUROSCIENCE

Electrophysiological Heterogeneity of Fast-Spiking Interneurons: Chandelier versus Basket Cells

(2013) Nadezhda V. Povysheva et al.   PLoS One

Compartmentalization of GABAergic Inhibition by Dendritic Spines

(2013) C. Q. Chiu et al.   SCIENCE

The Inhibitory Circuit Architecture of the Lateral Hypothalamus Orchestrates Feeding

(2013) J. H. Jennings et al.   SCIENCE

Challenges of understanding brain function by selective modulation of neuronal subpopulations

(2013) Arvind Kumar et al.   TRENDS IN NEUROSCIENCES

Novel designer receptors to probe GPCR signaling and physiology

(2013) Jürgen Wess et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Reciprocal connectivity between mitral cells and external plexiform layer interneurons in the mouse olfactory bulb

(2013) Longwen Huang et al.   Frontiers in Neural Circuits

On-demand optogenetic control of spontaneous seizures in temporal lobe epilepsy

(2013) Esther Krook-Magnuson et al.   Nature Communications

Arcuate AgRP neurons mediate orexigenic and glucoregulatory actions of ghrelin

(2013) Qian Wang et al.   Molecular Metabolism

Inhibitory Interneuron Deficit Links Altered Network Activity and Cognitive Dysfunction in Alzheimer Model

(2012) Laure Verret et al.   CELL

Activation of specific interneurons improves V1 feature selectivity and visual perception

(2012) Seung-Hee Lee et al.   NATURE

Behavior-dependent specialization of identified hippocampal interneurons

(2012) Damien Lapray et al.   NATURE NEUROSCIENCE

A toolbox of Cre-dependent optogenetic transgenic mice for light-induced activation and silencing

(2012) Linda Madisen et al.   NATURE NEUROSCIENCE

Distinct roles for direct and indirect pathway striatal neurons in reinforcement

(2012) Alexxai V Kravitz et al.   NATURE NEUROSCIENCE

Activation of VTA GABA Neurons Disrupts Reward Consumption

(2012) Ruud van Zessen et al.   NEURON

TRPV1 in GABAergic Interneurons Mediates Neuropathic Mechanical Allodynia and Disinhibition of the Nociceptive Circuitry in the Spinal Cord

(2012) Yong Ho Kim et al.   NEURON

The Spatial and Temporal Origin of Chandelier Cells in Mouse Neocortex

(2012) H. Taniguchi et al.   SCIENCE

Long-Range-Projecting GABAergic Neurons Modulate Inhibition in Hippocampus and Entorhinal Cortex

(2012) S. Melzer et al.   SCIENCE

Chemical genetics: receptor–ligand pairs for rapid manipulation of neuronal activity

(2011) Peer Wulff et al.   CURRENT OPINION IN NEUROBIOLOGY

Adeno-Associated Viral Vectors for Mapping, Monitoring, and Manipulating Neural Circuits

(2011) J. Nicholas Betley et al.   HUMAN GENE THERAPY

Rapid, reversible activation of AgRP neurons drives feeding behavior in mice

(2011) Michael J. Krashes et al.   JOURNAL OF CLINICAL INVESTIGATION

Selective Inhibition of Striatal Fast-Spiking Interneurons Causes Dyskinesias

(2011) A. H. Gittis et al.   JOURNAL OF NEUROSCIENCE

A disinhibitory microcircuit for associative fear learning in the auditory cortex

(2011) Johannes J. Letzkus et al.   NATURE

Amygdala circuitry mediating reversible and bidirectional control of anxiety

(2011) Kay M. Tye et al.   NATURE

Principles for applying optogenetic tools derived from direct comparative analysis of microbial opsins

(2011) Joanna Mattis et al.   NATURE METHODS

New Rabies Virus Variants for Monitoring and Manipulating Activity and Gene Expression in Defined Neural Circuits

(2011) Fumitaka Osakada et al.   NEURON

A Cre-Dependent, Anterograde Transsynaptic Viral Tracer for Mapping Output Pathways of Genetically Marked Neurons

(2011) Liching Lo et al.   NEURON

A Resource of Cre Driver Lines for Genetic Targeting of GABAergic Neurons in Cerebral Cortex

(2011) Hiroki Taniguchi et al.   NEURON

Anterograde or retrograde transsynaptic labeling of CNS neurons with vesicular stomatitis virus vectors

(2011) K. T. Beier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chemical and Genetic Engineering of Selective Ion Channel-Ligand Interactions

(2011) C. J. Magnus et al.   SCIENCE

Impaired Respiratory and Body Temperature Control Upon Acute Serotonergic Neuron Inhibition

(2011) R. S. Ray et al.   SCIENCE

Molecular and Cellular Approaches for Diversifying and Extending Optogenetics

(2010) Viviana Gradinaru et al.   CELL

Three groups of interneurons account for nearly 100% of neocortical GABAergic neurons

(2010) Bernardo Rudy et al.   Developmental Neurobiology

Fluorescent proteins at a glance

(2010) G.-J. Kremers et al.   JOURNAL OF CELL SCIENCE

Transgenic Targeting of Recombinant Rabies Virus Reveals Monosynaptic Connectivity of Specific Neurons

(2010) A. P. Weible et al.   JOURNAL OF NEUROSCIENCE

Genetic Fate Mapping Reveals That the Caudal Ganglionic Eminence Produces a Large and Diverse Population of Superficial Cortical Interneurons

(2010) G. Miyoshi et al.   JOURNAL OF NEUROSCIENCE

Regulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitry

(2010) Alexxai V. Kravitz et al.   NATURE

Transient neuronal inhibition reveals opposing roles of indirect and direct pathways in sensitization

(2010) Susan M Ferguson et al.   NATURE NEUROSCIENCE

Response Features of Parvalbumin-Expressing Interneurons Suggest Precise Roles for Subtypes of Inhibition in Visual Cortex

(2010) Caroline A. Runyan et al.   NEURON

Monosynaptic circuit tracing in vivo through Cre-dependent targeting and complementation of modified rabies virus

(2010) N. R. Wall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cholinergic Interneurons Control Local Circuit Activity and Cocaine Conditioning

(2010) I. B. Witten et al.   SCIENCE

Decreased number of parvalbumin and cholinergic interneurons in the striatum of individuals with Tourette syndrome

(2009) Yuko Kataoka et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Imaging neural activity in worms, flies and mice with improved GCaMP calcium indicators

(2009) Lin Tian et al.   NATURE METHODS

Optical Deconstruction of Parkinsonian Neural Circuitry

(2009) V. Gradinaru et al.   SCIENCE

Short promoters in viral vectors drive selective expression in mammalian inhibitory neurons, but do not restrict activity to specific inhibitory cell-types

(2009) Jason L. Nathanson   Frontiers in Neural Circuits

Petilla terminology: nomenclature of features of GABAergic interneurons of the cerebral cortex

(2008)   NATURE REVIEWS NEUROSCIENCE

Genetic Dissection of Neural Circuits

(2008) Liqun Luo et al.   NEURON

In Vivo Activation of Midbrain Dopamine Neurons via Sensitized, High-Affinity α6∗ Nicotinic Acetylcholine Receptors

(2008) Ryan M. Drenan et al.   NEURON