Article
Neurosciences
Marcin Wyroslak, Katarzyna Lebida, Jerzy W. Mozrzymas
Summary: The study examined the plasticity of tonic inhibition in hippocampal pyramidal neurons under NMDAR-dependent GABAergic inhibitory long-term potentiation (iLTP) induction protocol. It was found that alpha 5-containing GABA(A)Rs played a key role in mediating the plastic change in tonic current during this process.
Article
Neurosciences
Marcin Wyroslak, Grzegorz Dobrzanski, Jerzy W. Mozrzymas
Summary: In this study, we investigated the effect of NMDA-induced plasticity on tonic inhibition in somatostatin- and parvalbumin-containing interneurons. Our results showed that NMDA application enhanced tonic conductance in somatostatin-containing interneurons, while reducing tonic inhibition in both fast-spiking and non-fast-spiking parvalbumin-positive cells. These changes were associated with alterations in the content of α5 and δ-subunit-containing GABA(A) receptors.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Neurosciences
Yun Fei Feng, Yin Yong Zhou, Kai Ming Duan
Summary: Postpartum depression is a serious disease that has a high incidence and severe impact on pregnant women and infants. However, the mechanism of this condition is still unclear. Recent studies have shown that GABA receptors, especially extrasynaptic receptors, are closely associated with postpartum depression. This review focuses on the function of GABA receptors, particularly extrasynaptic receptors, and their association with postpartum depression.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Cell Biology
Kunwei Wu, David Castellano, Qingjun Tian, Wei Lu
Summary: The study reveals distinct roles of GluN2A and GluN2B-NMDA receptors in regulating tonic inhibition in hippocampal neurons, with NMDAR subunit-specific mechanisms at play. Tonic inhibition is modulated by various factors in both physiological and pathological conditions.
Article
Neurosciences
Chiranjivi Neupane, Ramesh Sharma, Yoon Hyung Pai, So Yeong Lee, Byeong Hwa Jeon, Hyun-Woo Kim, Javier E. Stern, Jin Bong Park
Summary: Chronic salt loading recruits NR2D subunit-containing NMDARs to generate an Mg2+-resistant tonic I-NMDA in nondepolarized VP neurons, affecting the E/I balance, with NR2D activation being a key factor in this mechanism.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Yangning Lu, Tosif Ahamed, Ben Mulcahy, Jun Meng, Daniel Witvliet, Sihui Asuka Guan, Douglas Holmyard, Wesley Hung, Quan Wen, Andrew D. Chisholm, Aravinthan D. T. Samuel, Mei Zhen
Summary: In C. elegans, the motor circuit of juvenile stage generates adult-like bending waves with dorsal-ventral symmetry, despite having asymmetric wiring between motor neurons and muscles. This is achieved through the coordination between excitatory and inhibitory motor neurons for dorsal muscle contraction and ventral muscle relaxation, respectively.
Article
Plant Sciences
Nasiara Karim, Imran Khan, Abeer Abdelhalim, Sobia Ahsan Halim, Ajmal Khan, Ahmed Al-Harrasi
Summary: The study showed that stigmasterol is a potential candidate for the treatment of neurological disorders by modulating GABA receptors, which can alleviate anxiety and seizure symptoms.
Article
Clinical Neurology
Lynne M. Bird, Cesar Ochoa-Lubinoff, Wen-Hann Tan, Gali Heimer, Raun D. Melmed, Amit Rakhit, Jeannie Visootsak, Matthew J. During, Christina Holcroft, Rebecca D. Burdine, Alexander Kolevzon, Ronald L. Thibert
Summary: This study evaluated the safety, tolerability, and exploratory efficacy of Gaboxadol in individuals with Angelman syndrome. Gaboxadol was found to be generally well-tolerated and showed some efficacy in improving symptoms, warranting further studies.
Review
Neurosciences
Ayla Arslan
Summary: GABA(A) receptors play a key role in inhibiting the adult brain, with specific subtypes like the delta-subunit-GABA(A) receptors expressed in areas like the hippocampus. These receptors, containing the delta subunit, have integrative roles in network oscillations, adding complexity to the understanding of their functions.
JOURNAL OF INTEGRATIVE NEUROSCIENCE
(2021)
Review
Pharmacology & Pharmacy
Ritchy Hodebourg, Peter W. Kalivas, Anna Kruyer
Summary: Recent research suggests that perisynaptic astroglia and signaling in the extracellular matrix play a key role in regulating synaptic pathology in substance use and stress disorders. Drugs and stress can initiate long-lasting changes in brain synapses through enduring neuroadaptations in astroglia and the ECM, indicating that modulating extrasynaptic regulators may be therapeutically useful.
TRENDS IN PHARMACOLOGICAL SCIENCES
(2022)
Article
Neurosciences
Martin Field, Istvan P. Lukacs, Emily Hunter, Richard Stacey, Puneet Plaha, Laurent Livermore, Olaf Ansorge, Peter Somogyi
Summary: The study found that specific types of interneurons in the human neocortex, such as rosehip cells and layer 2-3 innervating cells, exhibit larger tonic GABA(A) receptor currents compared to other interneuron types, potentially allowing for selective modulation of cortical circuitry. Patient parameters like age, seizures, cancer type, and anticonvulsant treatment were also examined for their potential influence on tonic inhibitory currents in human neurons.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Grzegorz Wiera, Patrycja Brzdak, Anna Maria Lech, Katarzyna Lebida, Jadwiga Jablonska, Przemyslaw Gmerek, Jerzy W. Mozrzymas
Summary: This study provides the first evidence that integrins play a key role in regulating the endogenous modulatory mechanisms of GABAergic inhibition and plasticity in the hippocampus.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Maithe Loisy, Guillaume Bouisset, Sebastien Lopez, Maud Muller, Alena Spitsyn, Jeanne Duval, Rebecca Ann Piskorowski, Laure Verret, Vivien Chevaleyre
Summary: This study reveals a novel inhibitory plasticity mediated by cannabinoid type 1 receptor activation (CB1R-iLTD) in the CA2 region of the hippocampus, which plays a crucial role in social memory formation. The study also demonstrates that the previous induction of Delta-opioid receptor-mediated long-term depression (DOR-iLTDs) is necessary for the CB1R-iLTD to occur. The findings provide insights into the interplay between inhibitory plasticities and a new mechanism for social memory formation.
Article
Biochemistry & Molecular Biology
Faouzi Zarrouki, Sebastien Goutal, Ophelie Vacca, Luis Garcia, Nicolas Tournier, Aurelie Goyenvalle, Cyrille Vaillend
Summary: This study found that the loss of dystrophin in a mouse model of Duchenne muscular dystrophy (DMD) affects not only the stability of synaptic GABA(A) receptors, but also the composition and expression of subunits at both synaptic and extrasynaptic sites. These findings provide new measures to evaluate compensation for nervous system alterations in DMD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Mason S. Kleinjan, William C. Buchta, Roberto Ogelman, In-Wook Hwang, Masaaki Kuwajima, Dusten D. Hubbard, Dean J. Kareemo, Olga Prikhodko, Samantha L. Olah, Luis E. Gomez Wulschner, Wickliffe C. Abraham, Santos J. Franco, Kristen M. Harris, Won Chan Oh, Matthew J. Kennedy
Summary: Dendritic spines in the hippocampus can be directly connected to inhibitory and excitatory presynaptic terminals, resulting in close proximity of opposing synaptic functions at the nanometer scale. By using a combination of electron microscopy, live imaging, and synaptic activity manipulations, researchers have found that dual innervation occurs early in development, even when the excitatory input is silenced. The NMDA receptor currents are selectively reduced at dually innervated spines through GABAB receptor signaling, blocking the spine enlargement associated with long-term potentiation. Silencing somatostatin interneurons or blocking GABAB receptors restores NMDA receptor function and structural plasticity at dually innervated spines. Therefore, GABAergic signaling at the nanometer scale strongly regulates the function and plasticity of hippocampal dual innervated spines.
Article
Biochemistry & Molecular Biology
Giuseppe Di Giovanni, Laura Clara Grandi, Ernesto Fedele, Gergely Orban, Agnese Salvade, Wei Song, Eleonora Cuboni, Alessandro Stefani, Alain Kaelin-Lang, Salvatore Galati
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Ilaria Rosa, Davide Di Censo, Brigida Ranieri, Giuseppe Di Giovanni, Eugenio Scarnati, Marcello Alecci, Angelo Galante, Tiziana Marilena Florio
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Editorial Material
Biochemistry & Molecular Biology
Philippe De Deurwaerdere, Giuseppe Di Giovanni
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Cristiano Bombardi, Francis Delicata, Claudio Tagliavia, Massimo Pierucci, Gabriele Deidda, Maurizio Casarrubea, Philippe De Deurwaerdere, Giuseppe Di Giovanni
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Cristiano Bombardi, Francis Delicata, Claudio Tagliavia, Annamaria Grandis, Massimo Pierucci, Antonella Marino Gammazza, Maurizio Casarrubea, Philippe De Deurwaerdere, Giuseppe Di Giovanni
Summary: Serotonin is crucial in nicotine actions in the CNS, with the 5-HT2CR receptor identified as a potential drug target for smoking cessation. Acute and chronic nicotine exposure have differential effects on the central 5-HT2CR function, primarily in the LHb, which may have implications for nicotine addiction and its treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Mary Gazea, Szabina Furdan, Peter Sere, Lukas Oesch, Benedek Molnar, Giuseppe Di Giovanni, Lief E. Fenno, Charu Ramakrishnan, Joanna Mattis, Karl Deisseroth, Susan M. Dymecki, Antoine R. Adamantidis, Magor L. Lorincz
Summary: The lateral hypothalamus selectively inhibits GABAergic neurons in the dorsal raphe nucleus, leading to increased firing of a substantial fraction of its neurons that ultimately promotes arousal. These wake active DRGABA neurons project to multiple brain areas involved in the control of arousal, including the LH, where their specific activation influences local network activity leading to arousal from sleep. Mutual inhibitory projections between the LH and the DR promote wakefulness and suggest a complex arousal control by intimate interactions between long-range connections and local circuit dynamics.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Cell Biology
Bhavana Gupta, Adam C. Errington, Ana Jimenez-Pascual, Vasileios Eftychidis, Simone Brabletz, Marc P. Stemmler, Thomas Brabletz, David Petrik, Florian A. Siebzehnrubl
Summary: The study reveals that the transcription factor ZEB1 plays a crucial role in the self-renewal of active RGL cells in the adult mammalian hippocampus, with its deletion leading to a shift towards symmetric cell division and an increase in newborn neurons while decreasing newly generated astrocytes. ZEB1 is identified as a positive regulator of the ets-domain transcription factor ETV5, which is essential for asymmetric division.
Article
Neurosciences
Maurizio Casarrubea, Giuseppe Di Giovanni, Giuseppe Crescimanno
Summary: The study using Hole-Board to test emotional behavior in rats found that Edge-Sniff and Head-Dip are among the most important behaviors for evaluating anxiety level, playing a significant role in T-pattern analysis.
Article
Neurosciences
Massimo Pierucci, Francis Delicata, Roberto Colangeli, Antonella Marino Gammazza, Alessandro Pitruzzella, Maurizio Casarrubea, Philippe De Deurwaerdere, Giuseppe Di Giovanni
Summary: This study found that nicotine-induced neuronal activity in the VTA is regulated by the LHb region, with acute and chronic nicotine having different effects on VTA DA neurons.
Article
Multidisciplinary Sciences
Bret Sanders, Daniel D'Andrea, Mark O. Collins, Elliott Rees, Tom G. J. Steward, Ying Zhu, Gareth Chapman, Sophie E. Legge, Antonio F. Pardinas, Adrian J. Harwood, William P. Gray, Michael C. O'Donovan, Michael J. Owen, Adam C. Errington, Derek J. Blake, Daniel J. Whitcomb, Andrew J. Pocklington, Eunju Shin
Summary: The coordinated programs of gene expression driving brain development have been studied in relation to neuropsychiatric disorders and cognition. This research combines human genetics with transcriptomic data and analyzes genetic variants and GWAS statistics to reveal the convergence on transcriptional programs regulating excitatory cortical neurogenesis.
NATURE COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Abdeslam Chagraoui, Giuseppe Di Giovanni, Philippe De Deurwaerdere
Summary: The discovery of the D3 receptor has sparked interest in the field of neurological diseases, particularly Parkinson's disease. This article discusses the role of D3 receptors in Parkinson's disease and their relationship with current treatments, highlighting the potential interactions between D1 and D3 receptors that may contribute to motor side effects.
Letter
Neurosciences
Daniel Cassar, Manuela Radic, Maurizio Casarrubea, Vincenzo Crunelli, Giuseppe Di Giovanni
Summary: In this study, GAERS and NEC rats were treated with the CB1/2 receptor agonist WIN 55,212-2 (2 mg/kg) and tested on the Elevated Plus-Maze.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Editorial Material
Biochemistry & Molecular Biology
Philippe De Deurwaerdere, Giuseppe Di Giovanni
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Eluned Broom, Vivian Imbriotis, Frank Sengpiel, William M. Connelly, Adam Ranson
Summary: This study uses in vivo two-photon functional imaging to investigate the role of A24b/M2-V1(axons) in visual selective attention in mice. The results suggest that the activity of these axons is associated with licking behavior, modulated by reward, and biased toward the sensory cortical hemisphere representing the currently discriminated stimulus.
Article
Neurosciences
Maurizio Casarrubea, Manuela Radic, Tatiana Pinto Morais, Erika Mifsud, Eleonora Cuboni, Stefania Aiello, Giuseppe Crescimanno, Vincenzo Crunelli, Giuseppe Di Giovanni
Summary: The study compared Genetic Absence Epilepsy Rats from Strasbourg (GAERS), non-epileptic control (NEC), and Wistar rats bred under the same conditions, along with commercially available Wistar rats (Cm Wistar) as a control. The results showed that male GAERS rats lacked comorbid anxiety, and the study emphasized the importance of using Wistar rats from the same breeding conditions.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
