Article
Multidisciplinary Sciences
Katsunori Kobayashi, Kisako Shikano, Mahomi Kuroiwa, Mio Horikawa, Wakana Ito, Akinori Nishi, Eri Segi-Nishida, Hidenori Suzuki
Summary: The activation of D(1)Rs by noradrenaline is crucial for the antidepressant effects, suggesting a potential therapeutic target for depressive disorders. Increased voluntary exercise enhances the synaptic potentiation mediated by D(1)Rs, indicating a distinct role of noradrenaline-D(1)R signaling. This pathway may play a critical role in determining the responsiveness to antidepressant drugs.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Neurosciences
Wahab Imam Abdulmajeed, Kai-Yi Wang, Jei-Wei Wu, Musa Iyiola Ajibola, Irene Han-Juo Cheng, Cheng-Chang Lien
Summary: This study reveals the differential regulation of local and distant granule cell activity by mossy cells in the hippocampus, highlighting the distinct synaptic mechanisms involved. These findings provide new insights into the functional organization of hippocampal circuits.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Review
Biochemistry & Molecular Biology
Gabriel Berdugo-Vega, Shonali Dhingra, Federico Calegari
Summary: This article reviews a wealth of research in cellular, anatomical, behavioral, and computational studies on the mammalian hippocampus, aiming to understand the fundamental mechanisms underlying cognition. Despite accumulating knowledge on how the hippocampus processes and stores information for learning and memory, our understanding of hippocampal cognitive function remains incomplete. The article discusses the structural separability of the two blades of the dentate gyrus in the hippocampus and proposes a model that suggests differences in connectivity and adult neurogenesis in the two blades may contribute to subtly different cognitive functions.
Article
Neurosciences
George Andrew Reid, Sultan Darvesh
Summary: The study on the Atlantic white-sided dolphin's hippocampal formation revealed similarities and differences compared to terrestrial mammals, particularly in terms of acetylcholinesterase distribution, indicating possible alterations in connectivity. Overall, the cholinergic innervation and function of the hippocampal formation in the dolphin appears to be conserved like in other mammals.
JOURNAL OF COMPARATIVE NEUROLOGY
(2021)
Review
Neurosciences
Jesse D. Cushman, Michael R. Drew, Franklin B. Krasne
Summary: The primary function of juvenile and adult hippocampal neurogenesis appears to be allowing behavioral experience to shape connectivity in the dentate gyrus and optimize hippocampal circuits for future learning. This environmental sculpting reduces overlap among memory representations, provides more information, and allows for more memories to be stored accurately. The decline of neurogenesis prior to adulthood may be explained by this prospective function of sculpting hippocampal circuits.
PROGRESS IN NEUROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Paul J. Lamothe-Molina, Andreas Franzelin, Lennart Beck, Dong Li, Lea Auksutat, Tim Fieblinger, Laura Laprell, Joachim Alhbeck, Christine E. Gee, Matthias Kneussel, Andreas K. Engel, Claus C. Hilgetag, Fabio Morellini, Thomas G. Oertner
Summary: Research shows that cFos expression patterns in the mouse dentate gyrus change dramatically from day to day, suggesting that this clock-like selection mechanism may aid in encoding episodic memories.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Ain Chung, Claudia Jou, Alejandro Grau-Perales, Eliott R. J. Levy, Dino Dvorak, Nida Hussain, Andre A. Fenton
Summary: Research suggests that cognitive control training can persistently alter hippocampal neural circuit function, facilitating learning of new tasks in novel environments and enhancing signal-to-noise ratio.
Article
Neurosciences
Carolina Tecuatl, Diek W. Wheeler, Nate Sutton, Giorgio A. Ascoli
Summary: A systematic pipeline is presented to estimate local connection parameters between different neuron types in the hippocampal formation, greatly increasing the available quantitative assessments. The study also provides approximate measurements of synaptic distances, filling substantial gaps in the knowledge and offering useful model specifications for neural network simulations.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Cristian Morales, Juan Facundo Morici, Nelson Espinosa, Agostina Sacson, Ariel Lara-Vasquez, M. A. Garcia-Perez, Pedro Bekinschtein, Noelia Weisstaub, Pablo Fuentealba
Summary: Memory systems store and discriminate representations of similar experiences through pattern separation to guide future decisions efficiently. Somatostatin cells in the dentate gyrus play a crucial role in the acquisition of contextual and spatial overlapping memories.
Article
Neurosciences
Carla C. Schmidt, Fang Zheng, Christian Alzheimer
Summary: Activin, a member of the TGF-beta family, has been found to have a neuromodulatory effect on mossy cells (MCs), affecting their excitatory and inhibitory inputs. Increased activin can enhance MC activity, while disruption of activin receptor signaling can reduce MC firing.
Review
Biochemistry & Molecular Biology
Angela Kecskes, Boldizsar Czeh, Miklos Kecskes
Summary: This review summarizes the role of mossy cells in healthy and overexcited hippocampus, discussing the controversy surrounding their involvement in temporal lobe epilepsy.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2022)
Article
Multidisciplinary Sciences
Jinhu Kim, Dongseok Park, Na-Young Seo, Taek-Han Yoon, Gyu Hyun Kim, Sang-Hoon Lee, Jinsoo Seo, Ji Won Um, Kea Joo Lee, Jaewon Ko
Summary: Synaptic cell-adhesion molecules (CAMs) play a crucial role in organizing the structure and properties of neural circuits. This study found that Leucine-rich repeat transmembrane protein 3 (LRRTM3) is important for the development of excitatory synapses in hippocampal dentate gyrus (DG) granule neurons. The deletion of LRRTM3 leads to reduced synapse density and synaptic strength in specific projections involving the medial entorhinal cortex (MEC) and DG granule neurons. Additionally, LRRTM3 loss affects neurotransmitter release, excitability of granule neurons, and long-term potentiation of mossy fiber synapses in DG neurons. Silencing the MEC-DG circuits protects against the negative effects of LRRTM3 deficiency on excitatory synapse inputs, granule neuron excitability, and mossy fiber long-term potentiation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Clinical Neurology
Mahsa Mohammadi, Kiarash Eskandari, Ronak Azizbeigi, Abbas Haghparast
Summary: Cannabidiol (CBD) has the potential to decrease the rewarding effects of psychostimulants, but the exact mechanism and neuroanatomical areas responsible for its effects are unclear. This study investigated the involvement of D1-like dopamine receptors (D1R) in the hippocampal dentate gyrus (DG) in CBD's inhibitory effects on the acquisition and expression of METH-induced conditioned place preference (CPP).
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2023)
Article
Neurosciences
Minghua Li, Jessica L. Kinney, Yu-Qiu Jiang, Daniel K. Lee, Qiwen Wu, Daehoon Lee, Wen-Cheng Xiong, Qian Sun
Summary: A key mode of neuronal communication between distant brain regions is through excitatory synaptic transmission mediated by long-range glutamatergic projections. However, we found that the glutamatergic projection from the hypothalamic supramammillary nucleus (SuM) largely avoids pyramidal neurons in hippocampal CA3 region and instead targets interneurons to provide feedforward inhibition. This novel long-range glutamatergic pathway suppresses the activity of principal neurons and reveals a new means by which SuM regulates hippocampal activity.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Geriatrics & Gerontology
Shayan Aliakbari, Mohammad Sayyah, Hadi Mirzapourdelavar, Niloufar Amini, Naser Naghdi, Hamid Gholami Pourbadie
Summary: EC amyloidopathy leads to impaired synaptic transmission and memory deficits, while overexpression of PKM zeta in DG enhances synaptic responses and improves memory performance, suggesting PKM zeta may serve as a potential therapeutic target for early stage AD.
NEUROBIOLOGY OF AGING
(2021)