Article
Neurosciences
Magdalena Kachlicka, Aeron Laffere, Fred Dick, Adam Tierney
Summary: To make sense of complex soundscapes, listeners must select and attend to task-relevant streams while ignoring uninformative sounds. One possible neural mechanism underlying this process is alignment of endogenous oscillations with the temporal structure of the target sound stream.
Article
Biochemical Research Methods
Zihao Xua, Yanru Bai, Ran Zhaoa, Hongmei Hu, Guangjian Ni, Dong Minga
Summary: In this study, a data-driven model for auditory attention detection (AAD) called AAD-transformer was proposed. The model utilized temporal self-attention and channel attention modules to dynamically assign weights and reconstruct speech envelope. The results showed that the AAD-transformer outperformed other models in decoding accuracy.
Article
Neurosciences
Ashley E. Symons, Fred Dick, Adam T. Tierney
Summary: The study found that attention can enhance the cortical tracking of specific acoustic dimensions rather than simply enhancing tracking of the auditory object as a whole. The results showed that cortical tracking was stronger in response to the attended dimension.
Article
Neurosciences
Siqi Cai, Peiwen Li, Enze Su, Longhan Xie
Summary: The study introduces a novel cross-modal attention-based auditory attention detection (CMAA) approach that dynamically adapts interactions and fuses cross-modal information to achieve excellent performance in a multi-speaker environment.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Neurosciences
Baiwei Liu, Anna C. Nobre, Freek van Ede
Summary: This article reports that spontaneous microsaccades can drive transient lateralisation of EEG alpha power. This finding reveals new links between microsaccades and human electrophysiological brain activity, highlighting their importance in studies on spatial cognition.
PROGRESS IN NEUROBIOLOGY
(2023)
Article
Neurosciences
Moran Aharoni, Assaf Breska, Matthias M. Mueller, Erich Schroeger
Summary: This study compared the explanations of neural oscillation and interval-based temporal prediction in temporal alignment of neural activity to rhythmic stimulation by analyzing behavioral and ERP data. The results showed that both neural oscillation and interval-based attentional gain mechanisms partially contributed to the behavioral and ERP P300 component, and a combination of both mechanisms best explained the data obtained.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Article
Neurosciences
Lars Hausfeld, Martha Shiell, Elia Formisano, Lars Riecke
Summary: Selective attention is crucial for processing auditory scenes with multiple speakers, as it involves separating relevant speech from irrelevant speech. This study found that increasing perceptual demand may reduce cortical processing of distractor speech and decrease their perceptual segregation.
Article
Computer Science, Artificial Intelligence
Faramarz Faghihi, Siqi Cai, Ahmed A. Moustafa
Summary: This study introduces a spiking neural network model for auditory spatial attention detection, showing improved accuracy with the use of limited training data. The model leverages the role of sparse coding in cognitive tasks and brain-inspired machine learning.
Article
Chemistry, Multidisciplinary
Hwan Shim, Leah Gibbs, Karsyn Rush, Jusung Ham, Subong Kim, Sungyoung Kim, Inyong Choi
Summary: Selective attention is an effective strategy for interpreting speech in noisy environments, as it strengthens cortical responses to attended inputs and suppresses others. This study reveals how neurofeedback training improves attentional modulation by activating a fronto-parietal brain network and increasing beta oscillation. The improvement in attentional modulation of beta oscillation in the temporal cortex suggests strengthened neural activity for predicting the target. These findings demonstrate the effectiveness of neurofeedback training in improving neural mechanisms underlying auditory selective attention.
APPLIED SCIENCES-BASEL
(2023)
Article
Engineering, Biomedical
Adele Simon, Gerard Loquet, Jan Ostergaard, Soren Bech
Summary: It has been demonstrated that cortical recordings can be used to detect which speaker a person is attending in a cocktail party scenario. The stimulus reconstruction approach, based on linear regression, can reconstruct an approximation of the envelopes of the attended and unattended sounds from EEG data. Previous studies mostly focused on speech listening, and this study applied auditory attention detection (AAD) techniques to both speech and music listening with differences in reconstruction accuracy. The results highlighted the importance of training data for model construction.
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
(2023)
Article
Engineering, Biomedical
Alain de Cheveigne, Malcolm Slaney, Soren A. Fuglsang, Jens Hjortkjaer
Summary: This study focuses on analyzing brain responses evoked by auditory stimuli through model fitting, providing insights into perceptual processes and serving as references for devices like BCIs. By using a match-mismatch task, models of varying complexity were compared to methods in literature, showcasing state-of-the-art performance. The MM task allows evaluation of stimulus-response models at high accuracy limits, offering an attractive alternative to commonly used auditory attention detection tasks.
JOURNAL OF NEURAL ENGINEERING
(2021)
Article
Audiology & Speech-Language Pathology
Jonghwa Jeonglok Park, Seung-Cheol Baek, Myung-Whan Suh, Jongsuk Choi, Sung June Kim, Yoonseob Lim
Summary: Selective auditory attention can modulate the cortical representation of speech, but the influence of topic familiarity and volatile listening environments on this process is not well understood. It was found that comprehension was affected when facing unfamiliar topics, but the ability to track the target speech was still intact. However, in volatile listening environments where auditory scenes constantly changed, the neural correlates of attended speech were degraded.
Article
Neurosciences
Tzvetan Popov, Bart Gips, Nathan Weisz, Ole Jensen
Summary: This study demonstrates the similarity in mechanisms between visual and auditory spatial attention in the brain, using alpha power modulation for top-down suppression of distractors and its close relationship with oculomotor action.
Article
Psychology, Biological
Hanna Ringer, Erich Schroeger, Sabine Grimm
Summary: It is remarkable how human listeners can perceive periodicity in noise, which lacks obvious physical cues. Previous research suggested that listeners rely on short temporally local and idiosyncratic features to perceptually segment periodic noise sequences. The present study aimed to examine the consistency of perceptual segmentation within and between listeners. Results showed that the consistency was stronger for interleaved periodic sequences, likely due to reduced temporal jitter. Additionally, the finding that certain noise sequences were segmented consistently across listeners challenges the assumption that the features are necessarily idiosyncratic.
Review
Clinical Neurology
Chiara Penengo, Chiara Colli, Carolina Bonivento, Andrea Boscutti, Matteo Balestrieri, Giuseppe Delvecchio, Paolo Brambilla
Summary: This review summarizes ERP studies on BPD, finding altered positive ERP amplitudes, latencies, and loudness dependence in BPD patients, possibly reflecting deficits in attention and executive functions.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Multidisciplinary Sciences
Alexandros Gelastopoulos, Miles A. Whittington, Nancy J. Kopell
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Biology
Roger D. Traub, Karen Hawkins, Natalie E. Adams, Stephen P. Hall, Anna Simon, Miles A. Whittington
COMMUNICATIONS BIOLOGY
(2020)
Review
Medicine, General & Internal
Zhe Kang Law, Carein Todd, Ramtin Mehraram, Julia Schumacher, Mark R. Baker, Fiona E. N. LeBeau, Alison Yarnall, Marco Onofrj, Laura Bonanni, Alan Thomas, John-Paul Taylor
Article
Biochemical Research Methods
Benjamin R. Pittman-Polletta, Yangyang Wang, David A. Stanley, Charles E. Schroeder, Miles A. Whittington, Nancy J. Kopell
Summary: The study highlights the role of inhibitory currents in flexible phase-locking of neuronal theta oscillators, crucial for initial syllabic segmentation in speech processing. Specific intrinsic inhibitory currents allow for exceptionally flexible phase-locking and precise segmentation of speech, suggesting their importance in the brain's auditory and speech processing architecture.
PLOS COMPUTATIONAL BIOLOGY
(2021)
Article
Clinical Neurology
Ana Belen Lopez-Rodriguez, Edel Hennessy, Carol L. Murray, Arshed Nazmi, Hugh J. Delaney, Daire Healy, Steven G. Fagan, Michael Rooney, Erika Stewart, Anouchka Lewis, Niamh de Barra, Philip Scarry, Louise Riggs-Miller, Delphine Boche, Mark O. Cunningham, Colm Cunningham
Summary: Neuroinflammation contributes to Alzheimer's disease progression, with secondary inflammatory insults potentially leading to delirium and accelerated cognitive decline. The presence of amyloid in the brain can make microglia, astrocytes, neurons, and cognition vulnerable to secondary inflammation, while infection can exacerbate neuroinflammatory cytokine synthesis. Investigating the exacerbation of neuroinflammation and its deleterious effects like delirium and disease progression in humans is warranted.
ALZHEIMERS & DEMENTIA
(2021)
Article
Clinical Neurology
Gareth Morris, Elena Langa, Conor Fearon, Karen Conboy, Kelvin Lau E-How, Amaya Sanz-Rodriguez, Donncha F. O'Brien, Kieron Sweeney, Austin Lacey, Norman Delanty, Alan Beausang, Francesca M. Brett, Jane B. Cryan, Mark O. Cunningham, David C. Henshall
Summary: This study developed a testing platform for antimiRs using human brain tissue sections and demonstrated the effects of ant-134 on miR-134 in live human brain tissues. The findings support the preclinical development of a therapy targeting miR-134 and provide a flexible platform for testing antimiRs and other antisense oligonucleotide therapeutics in human brain.
Article
Multidisciplinary Sciences
Roger D. Traub, Miles A. Whittington
Summary: Perception of odors is correlated with delayed brain magnetic field activities, which are absent in unperceived odors. The endopiriform nucleus and neurons with endopiriform properties play a role in generating delayed responses and determining the presence of conscious perception.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Editorial Material
Neurosciences
Giovanna O. O. Nogueira, Patricia P. P. Garcez, Cedric Bardy, Mark O. O. Cunningham, Adriano Sebollela
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Cell Biology
Michael Spedding, Claude Sebban, Therese M. Jay, Cyril Rocher, Brigitte Tesolin-Decros, Paul Chazot, Esther Schenker, Gabor Szenasi, Gyorgy Levay, Katalin Megyeri, Jozsef Barkoczy, Laszlo G. Harsing, Ian Thomson, Mark O. Cunningham, Miles A. Whittington, Lori-An Etherington, Jeremy J. Lambert, Ferenc A. Antoni, Istvan Gacsalyi
Summary: Dysfunction in the H-PFC circuit is a critical factor in schizophrenia, and a new drug called EGIS 11150 has been found to induce theta rhythm, enhance H-PFC coherence, and restore long-term potentiation in this circuit. This suggests that phenotypical screening on H-PFC connectivity can uncover novel antipsychotics.
Editorial Material
Neurosciences
Mark O. Cunningham
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Editorial Material
Neurosciences
Mark O. Cunningham
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Article
Neurosciences
Roger D. Traub, Miles A. Whittington, Mark O. Cunningham
Summary: This study predicts the oscillatory behavior of the medial entorhinal cortex (EC) using a neural circuit model and experimentally observed intracellular potentials. The findings have implications for understanding the neural oscillations in disorders such as Alzheimer's disease and schizophrenia.
REVIEWS IN THE NEUROSCIENCES
(2023)
Article
Clinical Neurology
Anderson Brito da Silva, Jane Pennifold, Ben Henley, Koustav Chatterjee, David Bateman, Roger W. Whittaker, Abhijit Joshi, Hrishikesh Kumar, Claire Nicholson, Mark R. Baker, Stuart D. Greenhill, Richard Walsh, Stefano Seri, Roland S. G. Jones, Gavin L. Woodhall, Mark O. Cunningham
Summary: For the first time, it has been shown that perampanel has potent antiepileptic action in human FCD brain slices, likely through reducing burst firing behavior. This finding may have implications for the treatment of refractory epilepsy associated with FCD in humans.
Review
Medicine, Research & Experimental
Gareth Morris, Rachel Rowell, Mark O. Cunningham
Summary: Advancement in understanding and treating epilepsy has relied heavily on the use of animal models, but an emerging trend is to study human epileptic tissue removed during surgery. This approach offers unique insights into refractory epilepsy mechanisms and the efficacy of novel treatments.
ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION
(2021)
Article
Multidisciplinary Sciences
Jacek Wrobel, Wladyslaw Sredniawa, Gabriela Jurkiewicz, Jaroslaw Zygierewicz, Daniel K. Wojcik, Miles Adrian Whittington, Mark Jeremy Hunt
SCIENTIFIC REPORTS
(2020)