GABAergic neurotransmission and new strategies of neuromodulation to compensate synaptic dysfunction in early stages of Alzheimer’s disease

Fyn, a Potential Target for Alzheimer's Disease

(2018) Kai Yang et al.   JOURNAL OF ALZHEIMERS DISEASE

Astrocytic Adenosine A2A Receptors Control the Amyloid-β Peptide-Induced Decrease of Glutamate Uptake

(2018) Marco Matos et al.   JOURNAL OF ALZHEIMERS DISEASE

Picomolar Amyloid-β Peptides Enhance Spontaneous Astrocyte Calcium Transients

(2018) Linda Lee et al.   JOURNAL OF ALZHEIMERS DISEASE

RNA Interference-Mediated Knockdown of Long-Form Phosphodiesterase-4D (PDE4D) Enzyme Reverses Amyloid-β42-Induced Memory Deficits in Mice

(2018) Cong Zhang et al.   JOURNAL OF ALZHEIMERS DISEASE

Astrocytes in Alzheimer's Disease: Emerging Roles in Calcium Dysregulation and Synaptic Plasticity

(2017) Adele J. Vincent et al.   JOURNAL OF ALZHEIMERS DISEASE

Calretinin Interneurons are Early Targets of Extracellular Amyloid-β Pathology in PS1/AβPP Alzheimer Mice Hippocampus

(2017) David Baglietto-Vargas et al.   JOURNAL OF ALZHEIMERS DISEASE

Therapeutic implications of the prostaglandin pathway in Alzheimer's disease

(2014) Eiron Cudaback et al.   BIOCHEMICAL PHARMACOLOGY

From the Multifactorial Nature of Alzheimer`s Disease to Multitarget Therapy: The Contribution of the Translational Approach

(2014) Laura Calzà et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Neuronal and Astrocytic Metabolism in a Transgenic Rat Model of Alzheimer's Disease

(2014) Linn Hege Nilsen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

ML297 (VU0456810), the First Potent and Selective Activator of the GIRK Potassium Channel, Displays Antiepileptic Properties in Mice

(2013) Kristian Kaufmann et al.   ACS Chemical Neuroscience

Discriminative analysis of early-stage Alzheimer’s disease and normal aging with automatic segmentation technique in subcortical gray matter structures: a multicenter in vivo MRI volumetric and DTI study

(2013) Ya-di Li et al.   ACTA RADIOLOGICA

Neuroimaging predictors of brain amyloidosis in mild cognitive impairment

(2013) Duygu Tosun et al.   ANNALS OF NEUROLOGY

Prefrontal cognitive deficits in mice with altered cerebral cortical GABAergic interneurons

(2013) Gregory B. Bissonette et al.   BEHAVIOURAL BRAIN RESEARCH

Discovery and SAR of a novel series of GIRK1/2 and GIRK1/4 activators

(2013) Susan J. Ramos-Hunter et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of ‘molecular switches’ within a GIRK activator scaffold that afford selective GIRK inhibitors

(2013) Wandong Wen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Novel analogues of chlormethiazole are neuroprotective in four cellular models of neurodegeneration by a mechanism with variable dependence on GABAAreceptor potentiation

(2013) Lawren VandeVrede et al.   BRITISH JOURNAL OF PHARMACOLOGY

Antiepileptics Topiramate and Levetiracetam Alleviate Behavioral Deficits and Reduce Neuropathology in APPswe/PS1dE9 Transgenic Mice

(2013) Jian-Quan Shi et al.   CNS Neuroscience & Therapeutics

Differential effects of acute and repeated stress on hippocampus and amygdala inputs to the nucleus accumbens shell

(2013) Kathryn M. Gill et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Feedforward Inhibition Underlies the Propagation of Cholinergically Induced Gamma Oscillations from Hippocampal CA3 to CA1

(2013) R. Zemankovics et al.   JOURNAL OF NEUROSCIENCE

Septo-hippocampal GABAergic signaling across multiple modalities in awake mice

(2013) Patrick Kaifosh et al.   NATURE NEUROSCIENCE

Amyloid β peptides modify the expression of antioxidant repair enzymes and a potassium channel in the septohippocampal system

(2013) Jorge Durán-González et al.   NEUROBIOLOGY OF AGING

Altered synapses and gliotransmission in Alzheimer's disease and AD model mice

(2013) Stanislaw Mitew et al.   NEUROBIOLOGY OF AGING

Metabotropic Glutamate Receptor 5 Is a Coreceptor for Alzheimer Aβ Oligomer Bound to Cellular Prion Protein

(2013) Ji Won Um et al.   NEURON

Dysfunctional synapse in Alzheimer's disease – A focus on NMDA receptors

(2013) Sandra I. Mota et al.   NEUROPHARMACOLOGY

Predominant loss of glutamatergic terminal markers in a β-amyloid peptide model of Alzheimer's disease

(2013) Paula M. Canas et al.   NEUROPHARMACOLOGY

Glial Biology in Learning and Cognition

(2013) R. Douglas Fields et al.   NEUROSCIENTIST

Impairment of Cognitive Function and Synaptic Plasticity Associated with Alteration of Information Flow in Theta and Gamma Oscillations in Melamine-Treated Rats

(2013) Xiaxia Xu et al.   PLoS One

A  induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss

(2013) M. Talantova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Melatonin protects against amyloid-β-induced impairments of hippocampal LTP and spatial learning in rats

(2013) Xiao-Jie Liu et al.   SYNAPSE

New insights into the therapeutic potential of Girk channels

(2013) Rafael Luján et al.   TRENDS IN NEUROSCIENCES

Amyloid-β induces synaptic dysfunction through G protein-gated inwardly rectifying potassium channels in the fimbria-CA3 hippocampal synapse

(2013) Mauricio O. Nava-Mesa et al.   Frontiers in Cellular Neuroscience

Neurotoxicity of Amyloid  -Protein: Synaptic and Network Dysfunction

(2013) L. Mucke et al.   Cold Spring Harbor Perspectives in Medicine

Seizures and Epileptiform Activity in the Early Stages of Alzheimer Disease

(2013) Keith A. Vossel et al.   JAMA Neurology

The Glutamate–Glutamine (GABA) Cycle: Importance of Late Postnatal Development and Potential Reciprocal Interactions between Biosynthesis and Degradation

(2013) Leif Hertz   Frontiers in Endocrinology

Functional role of astrocyte glutamate receptors and carbon monoxide in cerebral vasodilation response to glutamate

(2012) Helena Parfenova et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Deficits in emotional learning and memory in an animal model of schizophrenia

(2012) Monica M. Bolton et al.   BEHAVIOURAL BRAIN RESEARCH

Alzheimer Mechanisms and Therapeutic Strategies

(2012) Yadong Huang et al.   CELL

Inhibitory Interneuron Deficit Links Altered Network Activity and Cognitive Dysfunction in Alzheimer Model

(2012) Laure Verret et al.   CELL

Accelerated aging of the GABAergic septohippocampal pathway and decreased hippocampal rhythms in a mouse model of Alzheimer's disease

(2012) Sara E. Rubio et al.   FASEB JOURNAL

GABAergic contributions to gating, timing, and phase precession of hippocampal neuronal activity during theta oscillations

(2012) Vassilis Cutsuridis et al.   HIPPOCAMPUS

Amyloid β (Aβ) Peptide Directly Activates Amylin-3 Receptor Subtype by Triggering Multiple Intracellular Signaling Pathways

(2012) Wen Fu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective degeneration of septal and hippocampal GABAergic neurons in a mouse model of amyloidosis and tauopathy

(2012) Desirée Loreth et al.   NEUROBIOLOGY OF DISEASE

CSF biomarkers for Alzheimer disease correlate with cortical brain biopsy findings

(2012) T. T. Seppala et al.   NEUROLOGY

Cell-Type-Specific Recruitment of Amygdala Interneurons to Hippocampal Theta Rhythm and Noxious Stimuli In Vivo

(2012) Thomas C.M. Bienvenu et al.   NEURON

Uncoupling of M1 muscarinic receptor/G-protein interaction by amyloid β1–42

(2012) Helena Janíčková et al.   NEUROPHARMACOLOGY

Trisomy of the G protein-coupled K+ channel gene, Kcnj6, affects reward mechanisms, cognitive functions, and synaptic plasticity in mice

(2012) A. Cooper et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer's disease model

(2012) P. E. Sanchez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of functional GABAA receptors in the Alzheimer diseased brain

(2012) A. Limon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chronic Divalproex Sodium to Attenuate Agitation and Clinical Progression of Alzheimer Disease

(2011) Pierre N. Tariot   ARCHIVES OF GENERAL PSYCHIATRY

Tramiprosate in mild-to-moderate Alzheimer’s disease – a randomized, double-blind, placebo-controlled, multi-centre study (the Alphase Study)

(2011) Paul S. Aisen et al.   Archives of Medical Science

Naringin directly activates inwardly rectifying potassium channels at an overlapping binding site to tertiapin-Q

(2011) Tin T Yow et al.   BRITISH JOURNAL OF PHARMACOLOGY

Distinct pharmacological and functional properties of NMDA receptors in mouse cortical astrocytes

(2011) Oleg Palygin et al.   BRITISH JOURNAL OF PHARMACOLOGY

Crystal Structure of the Mammalian GIRK2 K+ Channel and Gating Regulation by G Proteins, PIP2, and Sodium

(2011) Matthew R. Whorton et al.   CELL

Combination Treatment in Alzheimers Disease: Results of a Randomized, Controlled Trial with Cerebrolysin and Donepezil

(2011) X. A. Alvarez et al.   Current Alzheimer Research

Pharmacologic Treatment with GABAB Receptor Agonist of Methamphetamine-Induced Cognitive Impairment in Mice

(2011) Hiroyuki Mizoguchi et al.   Current Neuropharmacology

GABAergic drugs and Alzheimer’s disease

(2011) Agenor Limon et al.   Future Medicinal Chemistry

Benzodiazepine use and risk of dementia: evidence from the Caerphilly Prospective Study (CaPS)

(2011) John Gallacher et al.   JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH

The role of G protein-coupled receptors in the pathology of Alzheimer's disease

(2011) Amantha Thathiah et al.   NATURE REVIEWS NEUROSCIENCE

A new neuronal target for beta-amyloid peptide in the rat hippocampus

(2011) Vincent Villette et al.   NEUROBIOLOGY OF AGING

Medial septal dysfunction by Aβ-induced KCNQ channel-block in glutamatergic neurons

(2011) Richardson N. Leão et al.   NEUROBIOLOGY OF AGING

Spines, Plasticity, and Cognition in Alzheimer's Model Mice

(2011) Tara Spires-Jones et al.   NEURAL PLASTICITY

Hippocampal interneuron loss in an APP/PS1 double mutant mouse and in Alzheimer’s disease

(2010) Hisaaki Takahashi et al.   Brain Structure & Function

Ionotropic NMDA and P2X1/5 receptors mediate synaptically induced Ca2+ signalling in cortical astrocytes

(2010) Oleg Palygin et al.   CELL CALCIUM

Evidence for oligomerization between GABAB receptors and GIRK channels containing the GIRK1 and GIRK3 subunits

(2010) Francisco Ciruela et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Decreased Rhythmic GABAergic Septal Activity and Memory-Associated   Oscillations after Hippocampal Amyloid-  Pathology in the Rat

(2010) V. Villette et al.   JOURNAL OF NEUROSCIENCE

Glutamatergic Neurons of the Mouse Medial Septum and Diagonal Band of Broca Synaptically Drive Hippocampal Pyramidal Cells: Relevance for Hippocampal Theta Rhythm

(2010) C. Y. L. Huh et al.   JOURNAL OF NEUROSCIENCE

Amyloid-β–induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks

(2010) Jorge J Palop et al.   NATURE NEUROSCIENCE

Emerging roles for G protein-gated inwardly rectifying potassium (GIRK) channels in health and disease

(2010) Christian Lüscher et al.   NATURE REVIEWS NEUROSCIENCE

The memory function of sleep

(2010) Susanne Diekelmann et al.   NATURE REVIEWS NEUROSCIENCE

17A, a novel non-coding RNA, regulates GABA B alternative splicing and signaling in response to inflammatory stimuli and in Alzheimer disease

(2010) Sara Massone et al.   NEUROBIOLOGY OF DISEASE

Activation of nicotinic α7 acetylcholine receptor enhances long term potentation in wild type mice but not in APPswe/PS1ΔE9 mice

(2010) Andreas Söderman et al.   NEUROSCIENCE LETTERS

Alzheimer's Disease Amyloid-β Links Lens and Brain Pathology in Down Syndrome

(2010) Juliet A. Moncaster et al.   PLoS One

Characterisation of the Expression of NMDA Receptors in Human Astrocytes

(2010) Ming-Chak Lee et al.   PLoS One

Selective cell death in neurodegeneration: Why are some neurons spared in vulnerable regions?

(2010) K.L. Double et al.   PROGRESS IN NEUROBIOLOGY

Senile myoclonic epilepsy: Delineation of a common condition associated with Alzheimer's disease in Down syndrome

(2010) Roberto De Simone et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

GLT-1 promoter activity in astrocytes and neurons of mouse hippocampus and somatic sensory cortex

(2010) Luisa de Vivo   Frontiers in Neuroanatomy

Drug development for Alzheimer's disease: Where are we now and where are we headed?

(2009) Marwan N. Sabbagh   American Journal Geriatric Pharmacotherapy

Epilepsy and Cognitive Impairments in Alzheimer Disease

(2009) Jorge J. Palop   ARCHIVES OF NEUROLOGY

Baclofen enhances extinction of opiate conditioned place preference

(2009) S.C. Heinrichs et al.   BEHAVIOURAL BRAIN RESEARCH

Intraneuronal β-Amyloid Accumulation in the Amygdala Enhances Fear and Anxiety in Alzheimer's Disease Transgenic Mice

(2009) Judit España et al.   BIOLOGICAL PSYCHIATRY

Imbalance between GABAergic and Glutamatergic Transmission Impairs Adult Neurogenesis in an Animal Model of Alzheimer's Disease

(2009) Binggui Sun et al.   Cell Stem Cell

GABAergic Interneuron Dysfunction Impairs Hippocampal Neurogenesis in Adult Apolipoprotein E4 Knockin Mice

(2009) Gang Li et al.   Cell Stem Cell

Memantine

(2009) Kate McKeage   CNS DRUGS

M1 Agonists as a Potential Disease-Modifying Therapy for Alzheimers Disease

(2009) Antonella Caccamo et al.   Current Alzheimer Research

Treatment of Mild Cognitive Impairment (MCI)

(2009) M. Farlow   Current Alzheimer Research

Genetic reductions of β-site amyloid precursor protein-cleaving enzyme 1 and amyloid-β ameliorate impairment of conditioned taste aversion memory in 5XFAD Alzheimer’s disease model mice

(2009) Latha Devi et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Encoding and retrieval in a model of the hippocampal CA1 microcircuit

(2009) Vassilis Cutsuridis et al.   HIPPOCAMPUS

Hippocampal synapsin isoform levels are linked to spatial memory enhancement by SGS742

(2009) Julius Paul Pradeep John et al.   HIPPOCAMPUS

Double-Blind Crossover Study of the Cognitive Effects of Lorazepam in Healthy Apolipoprotein E (APOE)-ε4 Carriers

(2009) Cynthia M. Stonnington et al.   JOURNAL OF CLINICAL PSYCHIATRY

GABA Transporter-1 Activity Modulates Hippocampal Theta Oscillation and Theta Burst Stimulation-Induced Long-Term Potentiation

(2009) N. Gong et al.   JOURNAL OF NEUROSCIENCE

Deletion of the  7 Nicotinic Acetylcholine Receptor Gene Improves Cognitive Deficits and Synaptic Pathology in a Mouse Model of Alzheimer's Disease

(2009) G. Dziewczapolski et al.   JOURNAL OF NEUROSCIENCE

GABAergic Neurons of the Medial Septum Lead the Hippocampal Network during Theta Activity

(2009) B. Hangya et al.   JOURNAL OF NEUROSCIENCE

New sites of action for GIRK and SK channels

(2009) Rafael Luján et al.   NATURE REVIEWS NEUROSCIENCE

Synaptic Depression and Aberrant Excitatory Network Activity in Alzheimer’s Disease: Two Faces of the Same Coin?

(2009) Jorge J. Palop et al.   NEUROMOLECULAR MEDICINE

Alzheimer’s Disease Amyloid β-Protein and Synaptic Function

(2009) Tomas Ondrejcak et al.   NEUROMOLECULAR MEDICINE

Blockade of GABA(B) receptors completely reverses age-related learning impairment

(2009) C.L. Lasarge et al.   NEUROSCIENCE

Preclinical and clinical pharmacology of the GABAA receptor α5 subtype-selective inverse agonist α5IA

(2009) John R. Atack   PHARMACOLOGY & THERAPEUTICS

Opposite Effects of Low and High Doses of Aβ42 on Electrical Network and Neuronal Excitability in the Rat Prefrontal Cortex

(2009) Yun Wang et al.   PLoS One

G Protein-Coupled Receptors, Cholinergic Dysfunction, and A  Toxicity in Alzheimer's Disease

(2009) A. Thathiah et al.   Science Signaling

Tripartite synapses: astrocytes process and control synaptic information

(2009) Gertrudis Perea et al.   TRENDS IN NEUROSCIENCES

The nicotinic α 7 acetylcholine receptor agonist ssr180711 is unable to activate limbic neurons in mice overexpressing human amyloid-β 1–42

(2008) Andreas Søderman et al.   BRAIN RESEARCH

Etazolate, a neuroprotective drug linking GABAAreceptor pharmacology to amyloid precursor protein processing

(2008) Maryline Marcade et al.   JOURNAL OF NEUROCHEMISTRY

Microglial Dysfunction and Defective  -Amyloid Clearance Pathways in Aging Alzheimer's Disease Mice

(2008) S. E. Hickman et al.   JOURNAL OF NEUROSCIENCE

Cognitive Enhancement by SGS742 in OF1 Mice Is Linked to Specific Hippocampal Protein Expression

(2008) Berta Sunyer et al.   JOURNAL OF PROTEOME RESEARCH

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE

Medial septal β-amyloid 1-40 injections alter septo-hippocampal anatomy and function

(2008) Luis V. Colom et al.   NEUROBIOLOGY OF AGING

An immunohistochemical study of GABAAreceptor gamma subunits in Alzheimer's disease hippocampus: Relationship to neurofibrillary tangle progression

(2008) Masahiko Iwakiri et al.   NEUROPATHOLOGY

GABAA Receptor-Mediated Acceleration of Aging-Associated Memory Decline in APP/PS1 Mice and Its Pharmacological Treatment by Picrotoxin

(2008) Yuji Yoshiike et al.   PLoS One

Clusters of Hyperactive Neurons Near Amyloid Plaques in a Mouse Model of Alzheimer's Disease

(2008) M. A. Busche et al.   SCIENCE

Amyloid beta peptides and glutamatergic synaptic dysregulation

(2007) Kodeeswaran Parameshwaran et al.   EXPERIMENTAL NEUROLOGY

Muscarinic acetylcholine receptors as CNS drug targets

(2007) Christopher J. Langmead et al.   PHARMACOLOGY & THERAPEUTICS