Regulation of Neuroinflammation through Programed Death-1/Programed Death Ligand Signaling in Neurological Disorders

PD1 Negative and PD1 Positive CD4+ T Regulatory Cells in Mild Cognitive Impairment and Alzheimer's Disease

(2017) Marina Saresella et al.   JOURNAL OF ALZHEIMERS DISEASE

Cutting Edge: Programmed Death-1/Programmed Death Ligand 1 Interaction Regulates the Induction and Maintenance of Invariant NKT Cell Anergy

(2014) W.-S. Chang et al.   JOURNAL OF IMMUNOLOGY

Essential Role of Program Death 1-Ligand 1 in Regulatory T-Cell–Afforded Protection Against Blood–Brain Barrier Damage After Stroke

(2014) Peiying Li et al.   STROKE

Immunity and Alzheimer's disease: immunological perspectives on the development of novel therapies

(2013) Yu-Hui Liu et al.   DRUG DISCOVERY TODAY

PD-L1 enhances CNS inflammation and infarct volume following experimental stroke in mice in opposition to PD-1

(2013) Sheetal Bodhankar et al.   Journal of Neuroinflammation

IL-10-producing B-cells limit CNS inflammation and infarct volume in experimental stroke

(2013) Sheetal Bodhankar et al.   METABOLIC BRAIN DISEASE

A rheostat for immune responses: the unique properties of PD-1 and their advantages for clinical application

(2013) Taku Okazaki et al.   NATURE IMMUNOLOGY

Increased frequency of T cells expressing IL-10 in Alzheimer disease but not in late-onset depression patients

(2013) Karen Cecília Torres et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Adoptive regulatory T-cell therapy protects against cerebral ischemia

(2012) Peiying Li et al.   ANNALS OF NEUROLOGY

Immune checkpoints in central nervous system autoimmunity

(2012) Nicole Joller et al.   IMMUNOLOGICAL REVIEWS

Oestrogen treatment of experimental autoimmune encephalomyelitis requires 17β-oestradiol-receptor-positive B cells that up-regulate PD-1 on CD4+ Foxp3+regulatory T cells

(2012) Sheetal Bodhankar et al.   IMMUNOLOGY

Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2

(2012) Tadashi Yokosuka et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Review: Inflammatory Process in Alzheimer's Disease, Role of Cytokines

(2012) Jose Miguel Rubio-Perez et al.   TheScientificWorldJOURNAL

Inhibition of lymphocyte trafficking shields the brain against deleterious neuroinflammation after stroke

(2011) Arthur Liesz et al.   BRAIN

Estrogen-induced protection against experimental autoimmune encephalomyelitis is abrogated in the absence of B cells

(2011) Sheetal Bodhankar et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Human brain endothelial cells endeavor to immunoregulate CD8 T cells via PD-1 ligand expression in multiple sclerosis

(2011) Camille L Pittet et al.   Journal of Neuroinflammation

Regulatory B Cells Limit CNS Inflammation and Neurologic Deficits in Murine Experimental Stroke

(2011) X. Ren et al.   JOURNAL OF NEUROSCIENCE

The immunology of stroke: from mechanisms to translation

(2011) Costantino Iadecola et al.   NATURE MEDICINE

A potential role for the PD1/PD-L1 pathway in the neuroinflammation of Alzheimer's disease

(2011) Marina Saresella et al.   NEUROBIOLOGY OF AGING

Programmed Death-1 Pathway Limits Central Nervous System Inflammation and Neurologic Deficits in Murine Experimental Stroke

(2011) Xuefang Ren et al.   STROKE

PD-L1 and PD-L2 differ in their molecular mechanisms of interaction with PD-1

(2010) M. Ghiotto et al.   INTERNATIONAL IMMUNOLOGY

Programmed death-1–induced interleukin-10 production by monocytes impairs CD4+ T cell activation during HIV infection

(2010) Elias A Said et al.   NATURE MEDICINE

B7-H1-Deficiency Enhances the Potential of Tolerogenic Dendritic Cells by Activating CD1d-Restricted Type II NKT Cells

(2010) Carolin Brandl et al.   PLoS One

Costimulatory Pathways in Multiple Sclerosis: Distinctive Expression of PD-1 and PD-L1 in Patients with Different Patterns of Disease

(2009) D. Trabattoni et al.   JOURNAL OF IMMUNOLOGY

Intestinal Tolerance Is Converted to Autoimmune Enteritis upon PD-1 Ligand Blockade

(2009) E. D. Reynoso et al.   JOURNAL OF IMMUNOLOGY

Attenuation of AD-like neuropathology by harnessing peripheral immune cells: local elevation of IL-10 and MMP-9

(2009) Maya Koronyo-Hamaoui et al.   JOURNAL OF NEUROCHEMISTRY

Down-modulation of programmed death 1 alters regulatory T cells and promotes experimental autoimmune encephalomyelitis

(2009) Chunhe Wang et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR–induced stop signal

(2009) Brian T Fife et al.   NATURE IMMUNOLOGY

Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke

(2009) Arthur Liesz et al.   NATURE MEDICINE

Temporal and Spatial Dynamics of Cerebral Immune Cell Accumulation in Stroke

(2009) Mathias Gelderblom et al.   STROKE

The Blood-Central Nervous System Barriers Actively Control Immune Cell Entry into the Central Nervous System

(2008) Britta Engelhardt   CURRENT PHARMACEUTICAL DESIGN

PD-1 ligands expressed on myeloid-derived APC in the CNS regulate T-cell responses in EAE

(2008) Bettina Schreiner et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Multiple sclerosis

(2008) Alastair Compston et al.   LANCET

Interleukin-17 Production in Central Nervous System-Infiltrating T Cells and Glial Cells Is Associated with Active Disease in Multiple Sclerosis

(2007) John S. Tzartos et al.   AMERICAN JOURNAL OF PATHOLOGY