Article
Oncology
Xiaoliu Qi, Yuxin Liu, Ming Yang
Summary: The study revealed that circ_0057452 competitively binds to miR-145-5p to induce the expression of TGF-beta 2, promoting fibroblast proliferation and VEGF secretion in hypertrophic scars. This finding is expected to have therapeutic implications for hypertrophic scars.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Hui Song Cui, So Young Joo, Seung Yeol Lee, Yoon Soo Cho, Dong Hyun Kim, Cheong Hoon Seo
Summary: It is unclear how scar fibroblasts (SFs) affect keratinocytes in hypertrophic scars (HTS) through cell-cell interaction. This study investigated the effects of HTS-derived exosomes on the proliferation and differentiation of normal human keratinocytes (NHKs) and compared them with normal fibroblasts (NFs).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Dermatology
Binyu Song, Yuhan Zhu, Ying Zhao, Kai Wang, Yixuan Peng, Lin Chen, Zhou Yu, Baoqiang Song
Summary: Our study identifies distinct fibroblast subpopulations in hypertrophic scars (HS) and establishes a diagnostic and predictive model using machine learning algorithms and deep learning. We have identified key genes associated with HS and demonstrated the role of THBS2 in its formation and development.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Ya Gao, Yangdan Liu, Danning Zheng, Chiakang Ho, Dongsheng Wen, Jiaming Sun, Lu Huang, Yuxin Liu, Qingfeng Li, Yifan Zhang
Summary: This study reveals the overexpression of HDAC5 in hypertrophic scars and its depletion can inhibit scar formation. Knockdown of HDAC5 downregulates Smad2/3 phosphorylation in the TGF-8 signaling pathway and increases Smad7 expression. Moreover, HDAC5 interacts with MEF2A to suppress its binding to the Smad7 promoter region, resulting in repression of Smad7 promoter activity. Luciferase reporter assays and ChIP-qPCR assays confirmed this mechanism.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Sebastian P. Nischwitz, Julia Fink, Marlies Schellnegger, Hanna Luze, Vladimir Bubalo, Carolin Tetyczka, Eva Roblegg, Christian Holecek, Martin Zacharias, Lars-Peter Kamolz, Petra Kotzbeck
Summary: Persistent inflammation during wound healing is identified as a precipitating factor in the development of hypertrophic scars. However, lack of standardized models and limited evidence for therapeutic approaches hinder research progress. This study aimed to investigate scar formation mechanisms and develop a method for generating standardized hypertrophic scars through prolonged inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Maja Schlittler, Peter P. Pramstaller, Alessandra Rossini, Marzia De Bortoli
Summary: Hypertrophic cardiomyopathy is the most common inherited heart disease and a leading cause of sudden cardiac death in young people. Mutations in genes that encode structural proteins of the heart can cause hypertrophic cardiomyopathy, leading to myocardial fibrosis and impaired cardiac function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Emergency Medicine
Xinxian Meng, Zhixi Yu, Wanyu Xu, Jun Chai, Shuo Fang, Peiru Min, Yunsheng Chen, Yixin Zhang, Zheng Zhang
Summary: This study confirms the link between augmented glycolysis and fibrotic activity in hypertrophic scars and proposes a method of controlling scar formation through regulation of glycolysis. The introduction of IR780 effectively down-regulated glycolysis and suppressed fibrotic activity, both in vitro and in vivo, by targeting activated fibroblasts.
Article
Emergency Medicine
Jie Li, Yan Li, Yunchuan Wang, Xiang He, Jing Wang, Weixia Cai, Yanhui Jia, Dan Xiao, Jian Zhang, Ming Zhao, Kuo Shen, Zichao Li, Wenbin Jia, Kejia Wang, Yue Zhang, Linlin Su, Huayu Zhu, Dahai Hu
Summary: MicroRNA-101 (miR-101) is a tumor suppressor microRNA associated with various diseases, but its role in hypertrophic scars (HS) remained unclear. Research showed that low miR-101 expression in HS and HSF, overexpressing miR-101 reduced collagen expression in HSF, while high EZH2 expression was detected in HS and HSF. MiR-101 targeted EZH2 to suppress collagen deposition in HS.
Review
Pharmacology & Pharmacy
David Dolivo, Pamela Weathers, Tanja Dominko
Summary: Fibrosis is a pathological reparative process in most organs, and artemisinin compounds demonstrate anti-fibrotic effects which can be used for treating fibrotic diseases.
ACTA PHARMACEUTICA SINICA B
(2021)
Article
Biochemistry & Molecular Biology
Hui Song Cui, Dong Hyun Kim, So Young Joo, Yoon Soo Cho, June-Bum Kim, Cheong Hoon Seo
Summary: In this study, it was found that exosomes derived from hypertrophic scar fibroblasts can change fibrosis-related signaling pathways in normal fibroblasts, leading to increased cell proliferation, migration, and epithelial-mesenchymal transition, as well as increased expression of fibronectin, type I collagen, and type III collagen.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2022)
Article
Biochemistry & Molecular Biology
Kai Wu, Fang Ma, Jiangyong Shen, Hui Zhang, Yu Wan, Xi He, Anning Yang, Jiantuan Xiong, Yun Jiao, Zhigang Bai, Shengchao Ma, Yideng Jiang, Huiping Zhang, Yinju Hao
Summary: The downregulation of lncRNA FPASL in hypertrophic scar promotes fibroblast proliferation, and this is mediated by DNMT3b-induced hypermethylation of the FPASL promoter.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2022)
Article
Biochemistry & Molecular Biology
Ane Nishitha Vijayan, Anbuthiruselvan Solaimuthu, Padmaja Murali, Janani Gopi, Teja Y. Madhan, Priya R. Akshaya, Purna Sai Korrapati
Summary: Scars occur as a result of tissue damage or surgery, and excessive TGF-beta activity can lead to progressive fibrosis. This study developed PCL-Gelatin biomimetic scaffolds for sustained delivery of Decorin to reduce TGF-beta levels and subsequent scar formation. In vitro experiments and a fibrotic model demonstrated that the Decorin-loaded nanofiber could effectively decrease the expression of ECM-related proteins, potentially obstructing scar formation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Endocrinology & Metabolism
Hao Zhang, Yongqian Bian, Congying Zhao, Yan Wang, Rong Huang, Bin Lin, Danying Qin, Wei Xiong, Jing Li, Xueyong Li
Summary: This study found bacterial colonization in keloids and hypertrophic scars, and the differences in the species and number of colonizing bacteria may cause the heterogeneity of clinical manifestations. The pathogenicity and athletic ability of colonizing bacteria were positively correlated with the degree of hyperplasia and invasions of scars.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Dermatology
Ariel Knowles, Donald A. Glass II
Summary: Keloids remain a painful condition, especially for patients with skin of color. Recent research has revealed associations with other medical conditions and an inflammatory component to the disease, shedding light on its complexity. Future studies aim to identify causal genes and systemic diseases linked to keloids, and explore therapeutic options targeting the upregulated inflammatory and fibroproliferative genes. The ultimate goal is to prevent or reverse the irreversible scarring process in keloids.
DERMATOLOGIC CLINICS
(2023)
Article
Oncology
Song Tian, Yongjun Zheng, Shichu Xiao, Pengfei Luo, Rongju Sun, Jun Liu, Zhaofan Xia
Summary: The study identified ivermectin as a potential therapeutic agent for hypertrophic scars, as it was found to inhibit the proliferation of HPS fibroblasts and decrease the production of key proteins associated with HPS. These results suggest that ivermectin may offer a new approach for the treatment of hypertrophic scars.
MOLECULAR MEDICINE REPORTS
(2021)
