Review
Dermatology
Guoqi Wang, Haiyan Xu, Gaoxiang Xu, Hao Zhang, Zhirui Li, Daohong Liu
Summary: Comparing negative pressure wound therapy with instillation (NPWTi) and standard negative pressure wound therapy, this study found that NPWTi resulted in fewer surgeries and dressing changes, and smaller wound areas post-treatment compared to NPWT. However, no significant differences were observed in other clinical outcomes between NPWTi and NPWT. Further well-designed RCTs with larger sample sizes are needed to validate these conclusions due to heterogeneity.
INTERNATIONAL WOUND JOURNAL
(2023)
Review
Health Care Sciences & Services
Alvaro Astasio-Picado, Maria Dolores Murcia Montero, Miriam Lopez-Sanchez, Jesus Jurado-Palomo, Paula Cobos-Moreno, Beatriz Gomez-Martin
Summary: This review analyzed the effectiveness of negative pressure therapy in complex wounds, compared its effectiveness with other conventional treatments and their combination, and evaluated the quality of life and main characteristics of patients undergoing negative pressure therapy. The results showed that negative pressure therapy has the advantages of rapid rate of granulation, prevention and effective treatment of infections, variety and malleability of dressings, various applications, and the possibility of using it with other therapies to accelerate wound closure.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Dermatology
Maria Teresa Climent Marti, Sergi Fernandez-Gonzalez, Maria Dolores Marti, Maria Jesus Pla, Marc Barahona, Jordi Ponce
Summary: Closed-incisional negative pressure therapy (ciNPT) significantly reduces surgical complications such as infections, seromas, and wound dehiscence in gynaecologic cancer surgery. It also leads to a shorter hospital stay, making it particularly suitable for high-risk patients such as those with gynaecologic malignancies.
INTERNATIONAL WOUND JOURNAL
(2022)
Article
Health Care Sciences & Services
Kuo-Feng Hsu, Li-Ting Kao, Pei-Yi Chu, Chun-Yu Chen, Yu-Yu Chou, Dun-Wei Huang, Ting-Hsuan Liu, Sheng-Lin Tsai, Chien-Wei Wu, Chih-Chun Hou, Chih-Hsin Wang, Niann-Tzyy Dai, Shyi-Gen Chen, Yuan-Sheng Tzeng
Summary: This study aimed to analyze the clinical efficacy of closed-incision negative pressure wound therapy (CiNPWT) combined with primary closure (PC) in patients with pressure ulcers. The results showed that PC combined with CiNPWT can shorten operation time and hospitalization duration, reduce the frequency of debridement, and have similar wound healing and complication rates compared to traditional treatment.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Medicine, General & Internal
Niklas Biermann, Stefan Wallner, Teresa Martini, Steffen Spoerl, Lukas Prantl, Christian D. D. Taeger
Summary: This pilot study examined rinsing fluid samples from patients undergoing NPWTi treatment and found a correlation between various cytokines and the clinical course, especially in diabetic patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Surgery
Griffin Boll, Peter Callas, Daniel J. Bertges
Summary: This meta-analysis aimed to evaluate the efficacy of closed incision negative pressure wound therapy (ciNPWT) on vascular surgery groin wounds. The results showed that ciNPWT was associated with a significant reduction in surgical site infections (SSIs). However, no significant differences were found in other secondary outcomes.
JOURNAL OF VASCULAR SURGERY
(2022)
Article
Dermatology
Yixi Tao, Yusui Zhang, Yang Liu, Songjiang Tang
Summary: This study conducted a comprehensive analysis to evaluate the benefits of negative pressure wound therapy (NPWT) versus traditional dressings in preventing surgical site infections in patients undergoing cardiac surgery. The findings revealed that NPWT was more effective in reducing surgical site infections, deep wound infections, and hospital stays compared to conventional dressings. However, the rate of superficial wound infections was not significantly affected by the method of wound care.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Dermatology
Ronald P. Silverman, John Apostolides, Abhishek Chatterjee, Anthony N. Dardano, Regina M. Fearmonti, Allen Gabriel, Robert T. Grant, Owen N. Johnson, Suresh Koneru, Anna A. Kuang, Andrea A. Moreira, Steven R. Sigalove
Summary: With the increasing use of closed incision negative pressure therapy (ciNPT), new dressing designs have emerged to address implementation challenges. An expert panel has established consensus on the appropriate use of ciNPT with full-coverage dressings, and highlighted the need for further high-quality studies to better understand its benefits.
INTERNATIONAL WOUND JOURNAL
(2022)
Article
Cell Biology
Christian D. Taeger, Stefan Wallner, Teresa Martini, Daniel Schiltz, Andreas Kehrer, Lukas Prantl, Niklas Biermann
Summary: This study aimed to analyze rinsing fluid samples from the NPWTi device in patients with acute and chronic wounds. The results showed an increase in total cellular amount and polymorphonuclear cells, along with a decrease in red blood cells after surgery. The analysis of rinsing fluid was proposed as a novel and potentially promising tool to monitor wound status without removing the dressing, and establishing reference values may help improve NPWTi therapy.
Review
Biochemistry & Molecular Biology
Bharadhwaj Ravindhran, Nicole Schafer, Annabel Howitt, Daniel Carradice, George Smith, Ian Chetter
Summary: This systematic review summarizes the current evidence on the molecular mechanisms of action of NPWT. The review finds that NPWT can stimulate the modulation of cytokines and growth factors, promoting an anti-inflammatory response.
EXPERT REVIEWS IN MOLECULAR MEDICINE
(2023)
Article
Biotechnology & Applied Microbiology
Praveen Krishna Veerasubramanian, Victor C. Joe, Wendy F. Liu, Timothy L. Downing
Summary: This study investigates how negative-pressure wound therapy (NPWT) materials, such as Granufoam (TM) (GF) and Veraflo Cleanse (TM) (VC), affect the inflammatory response of macrophages. The findings suggest that both materials can reduce the expression of inflammatory genes in macrophages. VC discourages macrophage adhesion and spreading, potentially sequestering LPS/IFN gamma and cytokines. GF, on the other hand, is less suppressive of inflammation and supports macrophage adhesion and spreading better than VC.
BIOENGINEERING-BASEL
(2022)
Article
Emergency Medicine
Shizhao Ji, Xiaobin Liu, Jie Huang, Junmin Bao, Zhaohong Chen, Chunmao Han, Daifeng Hao, Jingsong Hong, Dahai Hu, Yufeng Jiang, Shang Ju, Hongye Li, Zongyu Li, Guangping Liang, Yan Liu, Gaoxing Luo, Guozhong Lv, Xingwu Ran, Zhongmin Shi, Juyu Tang, Aiping Wang, Guangyi Wang, Jiangning Wang, Xin Wang, Bing Wen, Jun Wu, Hailin Xu, Maojin Xu, Xiaofei Ye, Liangxi Yuan, Yi Zhang, Shichu Xiao, Zhaofan Xia
Summary: As China becomes an aging society, the incidence of diabetes and diabetic foot is increasing, making it a major health concern. Negative pressure wound therapy (NPWT) has shown great progress in the treatment of diabetic foot wounds, but irregular application can lead to complications. The consensus aims to provide clinicians with standardized treatment schemes for diabetic foot cases based on evidence-based practice.
Article
Nursing
Aiko Miyanaga, Toru Miyanaga, Keiko Sakai, Chizuko Konya, Kimi Asano, Kenichi Shimada
Summary: The aim of this study was to understand the treatment experience of patients undergoing negative pressure wound therapy (NPWT). Seventeen inpatients were interviewed and their answers were categorized into seven themes: pain and discomfort, physical limitations, mental burden, social limitations, advances in medical care and science, device personification, and mixed feelings towards medical staff. The patients were able to tolerate the limitations while feeling attachment and gratitude towards the device and medical staff. The future plan is to develop an NPWT care guide.
Article
Microbiology
David C. Nguyen, Angel M. Buettner, Khalid M. Dousa
Summary: This commentary discusses an emerging treatment strategy for refractory NTM skin and soft tissue infections, which involves adjunctive negative pressure wound therapy with instillation and dwell time combined with topical antibiotics. Clinical guidelines for NTM infections are often based on case series and observational studies due to the diversity in infections, host responses, and antimicrobials.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Article
Dermatology
Ping Li, Junhong Li
Summary: This meta-analysis found that Negative Pressure Wound Therapy (NPWT) was superior to conventional therapy in treating superficial wound infection and wound dehiscence, but showed no statistical difference in deep wound infection and wound exudate. Caution should be exercised when interpreting the results due to small sample sizes, and further high-quality research with larger sample sizes is needed to confirm these findings.
INTERNATIONAL WOUND JOURNAL
(2023)