Article
Biochemistry & Molecular Biology
Wolfram Heitzmann, Mitja Mossing, Paul Christian Fuchs, Jan Akkan, Harun Seyhan, Gerrit Grieb, Christian Oplander, Jennifer Lynn Schiefer
Summary: Both Suprathel (R) and Jelonet (R) dressings are effective in promoting safe and rapid wound healing after enzymatic debridement of deep dermal burns of the hands and feet. However, Suprathel (R) shows superior results in terms of patient comfort and pain reduction compared to Jelonet (R).
Article
Dermatology
Yizhao Ma, Zhifang Liu, LinLin Miao, Xinyu Jiang, Hongyu Ruan, Rongrong Xuan, Suling Xu
Summary: Pathological scarring is caused by excessive proliferation and transdifferentiation of fibroblasts, as well as excessive deposition of extracellular matrix during wound healing. Factors that promote pathological scar formation affect the proliferation and function of fibroblasts. This study explores the microenvironment, signaling pathways, epigenetics, and autophagy related to the abnormal formation of fibroblasts in pathological scarring. Understanding the causes of abnormal fibroblast formation may lead to improved prevention and treatment strategies for pathological scarring and enhance patients' quality of life.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Chemistry, Physical
Kirti Singh, Virendra Bahadur Yadav, Umakant Yadav, Gopal Nath, Anchal Srivastava, Paolo Zamboni, Pranali Kerkar, Preeti Suman Saxena, Ajay Vikram Singh
Summary: This study synthesized silver nanoparticles using green synthesis and developed a silver nanoparticle acticoat by incorporating them into carrageenan for wound healing. The acticoat showed excellent antibacterial properties and promoted wound healing and collagen deposition. The in vivo studies demonstrated its potential application in burn, accidental, and diabetic wound infections.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2023)
Review
Pharmacology & Pharmacy
Gaofeng Wang, Zhen Lin, Yue Li, Lu Chen, Sashank K. Reddy, Zhiqi Hu, Luis Garza
Summary: With the development of society and the improvement of life quality, over 500 million people are affected by diabetes. More than 10% of diabetes patients suffer from diabetic wounds, and 80% of these wounds reoccur, highlighting the importance of developing new diabetic wound treatments. Skin microbe research has shed light on the complex relationship between microbes and diabetic wounds. Understanding the skin microbe composition in diabetic wounds can provide valuable guidance for clinical treatment and even lead to potential therapies.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Review
Pharmacology & Pharmacy
Haisheng Li, Buying Li, Dalun Lv, Wenhong Li, Yifei Lu, Gaoxing Luo
Summary: This article discusses recent advances in stimuli-responsive biomaterials for regulating local microenvironments during wound healing. It emphasizes on the design and application of different biomaterials that respond to wound biological/biochemical microenvironments (ROS, pH, enzymes, glucose, and glutathione), physical microenvironments (mechanical force, temperature, light, ultrasound, magnetic, and electric field), and combination modes. Moreover, several novel promising drug carriers (microbiota, metal-organic frameworks, and microneedles) are also discussed.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Article
Materials Science, Multidisciplinary
Ling Li, Qian Zhao, Fan Feng, Chenglin Li, Tiantian Wang, Weichao Chen, Xiaochuan Ren, Yuesheng Huang, Jiwei Li
Summary: This study developed a Janus dressing (TPU/Cotton) by directly electrospinning thermoplastic polyurethane (TPU) nanofiber on cotton microfibers, which can drain excess exudate unidirectionally. Ag/Zn dot electrodes were deposited on the TPU layer to produce an electric field that penetrates the wound when activated by wound exudate. Hydro-activated Ag/Zn's electrical stimulation (ES) promotes fibroblast cell migration and exhibits strong antibacterial activity. In vivo experiments showed that exudate management coupled with ES accelerates wound healing by promoting re-epithelization, collagen deposition, and vascularization. Additionally, the Ag/Zn@TPU/Cotton dressing demonstrates excellent biocompatibility in vitro cytotoxicity experiments. This research provides insights for developing next-generation wound dressings with self-activated electrical stimulation and exudate management.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Article
Dermatology
Yi-Kai Hong, Yi-Han Chang, Yu-Chen Lin, Brandon Chen, Bryan Edgar K. Guevara, Chao-Kai Hsu
Summary: This review provides a summary of the current knowledge on the immunopathogenesis and treatment options for pathological scars. Pathological scars, such as hypertrophic scars and keloids, result from abnormal inflammation during wound healing and have negative impacts on patients' quality of life due to their disfiguring appearance and symptoms of itch and pain.
ADVANCES IN WOUND CARE
(2023)
Article
Engineering, Biomedical
Wei Zhang, Sizhan Xia, Tingting Weng, Min Yang, Jiaming Shao, Manjia Zhang, Jialiang Wang, Pengqing Xu, Jintao Wei, Ronghua Jin, Meirong Yu, Zhongtao Zhang, Chunmao Han, Xingang Wang
Summary: This study developed bioactive fibrous membranes with anti-inflammatory and antibacterial functions for diabetic wound repair. The membranes could alter macrophage activation and improve the crosstalk between macrophages and fibroblasts.
MATERIALS TODAY BIO
(2022)
Review
Chemistry, Multidisciplinary
Yuheng Liao, Zhenhe Zhang, Lizhi Ouyang, Bobin Mi, Guohui Liu
Summary: Extracellular vesicles (EVs) have emerged as a promising cell-free therapy strategy for wound repair due to their excellent biocompatibility and stability. However, there is a growing focus on engineering EVs to overcome their inherent limitations.
Article
Dermatology
Francois Sterpione, Karine Mas, Mark Rippon, Alan Rogers, Georges Mayeux, Florian Rigaudier, Pierre Chauvelot, Ludovic Robilliart, Christine Juhel, Yann Lecomte
Summary: This study demonstrates the clinical effectiveness of a coordinated wound dressing treatment regimen in managing hard-to-heal wounds. By using a hydro-responsive wound dressing (HydroClean) for initial wound cleansing and debridement, followed by treatment with HydroTac or RespoSorb, the study shows significant improvement in wound healing progression.
JOURNAL OF WOUND CARE
(2022)
Article
Surgery
Dorthe Seidel, Rolf Lefering
Summary: This study compared the resource utilization of NPWT and CWT in patients with SAWHI after surgery. The results showed that although the treatment length was shorter in the NPWT group, the hospitalization time was shorter in the CWT group. In addition, there were fewer outpatient participants in the NPWT group, but the dressing changes and wound-related procedures took less time per participant.
Article
Dermatology
Fahimeh Abdollahimajd, Mohammad Reza Pourani, Hamid Mahdavi, Hamid Mirzadeh, Shima Younespour, Hamideh Moravvej
Summary: This study aimed to compare the clinical efficacy and safety of chitosan and nanosilver dressings in the treatment of refractory diabetic wounds. The results showed that both dressings had similar effectiveness and safety profiles. However, the relatively small sample size was a limitation of the study, and further research with larger sample sizes and longer follow-up periods is recommended.
DERMATOLOGIC THERAPY
(2022)
Review
Chemistry, Multidisciplinary
Ruonan Dong, Baolin Guo
Summary: Wound management is a major challenge globally, and smart wound dressings offer potential solutions for promoting wound healing. By employing built-in sensors and smart materials, smart wound dressings can interact with wounds, sense and respond to changes in wound conditions or environment.
Article
Chemistry, Physical
Nhien Nguyen, Zong-Hong Lin, Snigdha Roy Barman, Chiranjeevi Korupalli, Ji-Yen Cheng, Ni-Xuan Song, Yen Chang, Fwu-Long Mi, Hsiang-Lin Song, Hsing-Wen Sung, Yu-Jung Lin
Summary: This study developed an engineered electroactive dressing that promotes wound healing and monitors the progress in real-time. The dressing transmits bioelectrical signals to stimulate cells and accelerate tissue restoration, while an electrode detects electrical resistance or output current to monitor the overall healing process. The system can be connected to a smartphone for wireless data transmission to medical staff and provide early warnings of potential infections.
Review
Biochemistry & Molecular Biology
Roxana Delia Zaharie, Calin Popa, Diana Schlanger, Dan Valean, Florin Zaharie
Summary: Wound healing process is influenced by various cytokines, chemokines, and growth factors, and interleukin-22 (IL-22) is a crucial cytokine for tissue regeneration. This systematic review examined the implications of IL-22 in wound healing caused by external factors. The findings suggest that IL-22 plays a central role in stimulating cell proliferation, migration, and differentiation during tissue repair. However, excessive IL-22 expression can have negative effects. Further research is needed to validate the roles of IL-22 in clinical practice and its potential implications in surgical healing.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Zafer Sayin, Ali Uslu, Osman Erganis, Abdullah Basoglu, Ozgur Ozdemir, Asli Sakmanoglu, Uckun Sait Ucan, Zeki Aras
Summary: Vaccination is the most effective way to prevent infectious diseases, and adjuvants are necessary to enhance the immune response. This study revealed the potential adjuvant effect of boric acid in vaccines, showing reduced inflammatory reactions and increased antibody levels. Further target animal studies are needed to confirm these findings.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
Article
Neurosciences
Filiz Kazak, Pinar Peker Akalin, Gul Fatma Yarim, Nuri Baspinar, Ozgur Ozdemir, Mehmet Burak Ates, Muhammed Enes Altug, Mehmet Zeki Yilmaz Deveci
Summary: The study found that nobiletin increased BDNF concentration and G6PD activity in the brain, reduced neuronal degeneration and edema, and decreased the damage caused by cisplatin to the rat's nervous system.
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2022)
Article
Agriculture, Dairy & Animal Science
M. B. Ates, M. Ortatatli, H. Oguz, O. Ozdemir, F. Terzi, M. K. Ciftci, F. Hatipoglu
Summary: The study found that supplementation with Nigella sativa seeds and thymoquinone enhanced the detoxification of aflatoxins and reduced hepatocyte apoptosis when exposed to aflatoxins.
BRITISH POULTRY SCIENCE
(2022)
Article
Agriculture, Dairy & Animal Science
Mahmut Ok, Amir Naseri, Mehmet Burak Ates, Merve Ider, Kamil Uney, Mutlu Sevinc, Fatih Hatipoglu, Ramazan Yildiz, Alper Erturk, Nuri Baspinar, Suleyman Serhat Iyigun
Summary: The aim of this study was to determine hypoxic brain damage in calves with perinatal asphyxia using brain-specific damage biomarkers. The results showed that asphyxia and hypoxemia caused hypoxic-ischemic encephalopathy in perinatal calves, and UCHL1 and S100B concentrations were found to be useful markers for the determination of hypoxic-ischemic encephalopathy in calves with perinatal asphyxia. Neurological status scores and some blood gas parameters were helpful in mortality prediction.
Article
Veterinary Sciences
Fatih Hatipoglu, Funda Terzi, Ozgur Ozdemir, Mustafa Ortatatli, Mustafa Kemal Ciftci, Mehmet Burak Ates
Summary: This study compared the effectiveness of immunohistochemical (IHC) and Real-Time PCR methods in detecting Listeria monocytogenes. It found that the IHC method was more effective in revealing the presence of antigen from paraffin blocks stored for many years.
KAFKAS UNIVERSITESI VETERINER FAKULTESI DERGISI
(2022)
Article
Veterinary Sciences
Ozgur Ozdemir, Mehmet Burak Ates, Gokhan Akcakavak
Summary: In this study, the effects of single or combined use of IL-1 and TNF-a antagonists anakinra and etanercept on streptozotocin-induced type 2 diabetes in rats were evaluated. The treatments showed significant improvements in pathological changes related to diabetes in internal organs, with etanercept being more effective on pancreatic lesion scores and anakinra being more effective on testicular changes. There were no toxic-pathological effects observed, indicating the potential of these antagonists in treating type 2 diabetes.
ACTA VETERINARIA BRNO
(2021)
Article
Veterinary Sciences
Mahmut Ok, Ramazan Yildiz, Fatih Hatipoglu, Nuri Baspinar, Merve Ider, Kamil Uney, Alper Erturk, Murat K. Durgut, Funda Terzi
AMERICAN JOURNAL OF VETERINARY RESEARCH
(2020)
Article
Veterinary Sciences
Ozgur Ozdemir, Mehmet Burak Ates, Mustafa Ortatatli, Funda Terzi, Tulay Avci, Fatih Hatipoglu, Mustafa Kemal Ciftci
KAFKAS UNIVERSITESI VETERINER FAKULTESI DERGISI
(2019)
Article
Veterinary Sciences
Ozgur Ozdemir, Orhan Yavuz, Hudaverdi Erer, Zafer Sayin
ACTA SCIENTIAE VETERINARIAE
(2019)
Article
Veterinary Sciences
A. Er, O. Ozdemir, D. Coskun, B. Dik, E. Bahcivan, H. Eser Faki, E. Yazar
REVUE DE MEDECINE VETERINAIRE
(2019)
Article
Veterinary Sciences
Fatih Hatipoglu, Funda Terzi, Ozgur Ozdemir, Mustafa Ortatatli, Mustafa Kemal Ciftci, Mehmet Burak Ates
Summary: Encephalitic listeriosis is a significant problem in ruminants, and this study compared the presence of Listeria monocytogenes using immunohistochemistry and Real-Time PCR. The results showed that sheep and goats had more severe staining for L. monocytogenesis antigen in immunohistochemistry, and microabscesses were more severe in these animals as well. Additionally, some patients with Coenurus cerebralis cysts tested positive for Listeria in immunohistochemistry.
KAFKAS UNIVERSITESI VETERINER FAKULTESI DERGISI
(2022)
Article
Veterinary Sciences
Ozgur Ozdemir, Mustafa Ortatatli, Funda Terzi, Fatih Hatipoglu, Mustafa Kemal Ciftci, Mehmet Burak Ates
Summary: The study showed that cytological examination of the pons and medulla oblongata can provide a rapid pre-diagnosis of listeriosis based on the presence of intense neutrophils. Immunocytochemical staining of cytological preparations showed a 92.3% accuracy in diagnosing listeriosis. There was a strong positive correlation among cytology, ICC, histopathology, and IHC methods in diagnosing encephalitic listeriosis.
KAFKAS UNIVERSITESI VETERINER FAKULTESI DERGISI
(2021)