Article
Oncology
Lamis Yehia, Charis Eng
Summary: The study of characteristics of breast cancer in young women has important implications for personalized genomics-driven management.
CLINICAL CANCER RESEARCH
(2022)
Article
Psychiatry
Elias Langeland, Ingvild Faxvaag Johnsen, Kaja Kastrup Somme, Arne Magnus Morken, Eilin Kristine Erevik, Eirin Kolberg, Jakob Jonsson, Rune Aune Mentzoni, Stale Pallesen
Summary: This study examined whether gambling loss limits should be income-specific and found that income does moderate empirically derived gambling loss limits. The lowest income group had the lowest loss limits, while the highest income group had the highest loss limits. Income-based gambling loss limits may have higher applied value for preventing gambling related harm compared to general loss limits.
FRONTIERS IN PSYCHIATRY
(2022)
Review
Ophthalmology
Mohit Parekh, Davide Romano, Rintra Wongvisavavit, Giulia Coco, Giuseppe Giannaccare, Stefano Ferrari, Carlos Rocha-de-Lossada, Hannah J. Levis, Francesco Semeraro, Marina Rodriguez Calvo-de-Mora, Vincenzo Scorcia, Vito Romano
Summary: Descemet membrane endothelial keratoplasty (DMEK) is a popular surgical procedure for treating Fuchs endothelial corneal dystrophy (FECD) and pseudophakic bullous keratopathy (PBK). The size of the graft is crucial for the success of the procedure, with smaller grafts being preferred. However, larger diameter grafts pose challenges due to higher detachment rates.
ACTA OPHTHALMOLOGICA
(2023)
Article
Obstetrics & Gynecology
Lan N. Vuong
Summary: Freeze-all strategy has emerged as an alternative approach in in vitro fertilization (IVF) to reduce the negative effects of controlled ovarian stimulation. However, current studies have inconsistent results and a personalized approach should be taken based on individual patient characteristics and preference.
HUMAN REPRODUCTION
(2022)
Editorial Material
Biochemistry & Molecular Biology
Izhar Karbat, Eitan Reuveny
Summary: Ion channels can adjust their activity by incorporating auxiliary subunits, and this study reveals that a voltage-gated K+ channel auxiliary subunit can also modulate the gating of Ca2+-activated Cl- channels.
Review
Health Care Sciences & Services
Renske van der Meer, Erik B. Wilms, Harry G. M. Heijerman
Summary: CFTR modulators show strong treatment effects in specific mutation pwCF populations, but individual responses vary. Reconsidering dosing regimens can improve treatment responses and prevent side effects, but further research is needed to fully understand the pharmacokinetic properties and dosage responses.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Microbiology
Ayush Kumar, Georgia Stavrakis, Andrew H. Karaba
Summary: Herpesviruses are common DNA viruses that cause lifelong infections and are associated with various diseases. While they can evade the immune system, they are recognized by the innate immune system, leading to inflammation. Recent studies have found that inflammasome signaling plays a role in herpesvirus innate immune activation and impacts disease outcomes.
Review
Microbiology
Ayush Kumar, Georgia Stavrakis, Andrew H. Karaba
Summary: Herpesviruses are common DNA viruses that cause lifelong infections and are associated with various diseases. They activate the innate immune system by inflammasome signaling, leading to inflammation and potential disease outcomes.
Review
Urology & Nephrology
Tyrone G. Harrison, Marcello Tonelli
Summary: The measurement of proteinuria is crucial for diagnosing and monitoring kidney disease, but there is still controversy and uncertainty surrounding the optimal measurement method. International guidelines recommend the use of urinary albumin-to-creatinine ratio, but this method is not universally available and can be costly. Additionally, the accuracy of different measurement methods may vary depending on the magnitude of albuminuria, sex, and clinical contexts.
KIDNEY INTERNATIONAL
(2023)
Article
Endocrinology & Metabolism
Claudio Casella, Claudio Guarneri, Manuela Campanile, Xavier Adhoute, Pier Paolo Gelera, Riccardo Morandi
Summary: The study found that in patients treated with TPTX-AT or SPTX for 3HPT, the TPTX-AT group had lower plasma calcium concentrations compared to the SPTX group throughout the follow-up period, always remaining within the normal range. There was no significant difference between the two groups in terms of the persistence/recurrence of disease, incidence of transitory hypocalcemia, and temporary/permanent hypoparathyroidism.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Editorial Material
Oncology
Lynette M. Sholl, Balazs Halmos
Summary: Biomarker-guided treatment selection has revolutionized cancer management, with whole genome sequencing matching patients for precision oncology. Future expansion of genomic testing platforms will inform clinical cancer research and practice.
BRITISH JOURNAL OF CANCER
(2022)
Article
Business, Finance
Milena Petrova
Summary: We investigated the impact of internal corporate governance on market performance across multiple countries. Board characteristics, such as size, independence, gender diversity, CEO duality, and classified boards, were examined. Our findings suggest that CEO duality is generally negatively related to returns, while independent directors and board diversity are positively related to market performance. Additionally, the relationship between board structure and performance varies by country.
JOURNAL OF FINANCIAL RESEARCH
(2023)
Article
Urban Studies
Shaked Gilboa, Eugene Jaffe
Summary: Many city branding campaigns fail due to a lack of input from local residents at the planning stage and a failure to address the varying preferences and needs of different groups. The current study identifies different segments of residents based on their involvement and attachment to the city, revealing the heterogeneous nature of city residents and providing practical implications for city marketers and municipalities.
Review
Medicine, General & Internal
Vincenzo Villanacci, Rachele Del Sordo, Tommaso Lorenzo Parigi, Giuseppe Leoncini, Gabrio Bassotti
Summary: Mucosal healing (MH) is the main target for treating ulcerative colitis (UC) and Crohn's disease, with neutrophil infiltration being a key histological marker. Existing histological scoring systems for assessing disease severity are complex and subjective. Simplified mucosal healing schemes based on neutrophils and their distribution show advantages. Future developments include standardization with artificial intelligence models and new molecular markers for inflammation in diagnostic practice.
Editorial Material
Hematology
Lisa M. Shook, Russell E. Ware
Summary: Accurate laboratory screening for sickle cell disease and other haemoglobin disorders is expanding worldwide. Two recent reports from Mali and Denmark describe different screening methods and strategies, yielding encouraging results. The findings suggest that countries should tailor their screening programs to local needs, resources, and opportunities.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
