Editorial Material
Medicine, General & Internal
Linda N. Geng, Abraham Verghese, Jon C. Tilburt
Summary: Consultative medicine is a new specialty that combines Oslerian diagnostic tradition with multidisciplinary collaboration and modern technologies to address uncertain, difficult, or complex diagnoses.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Review
Food Science & Technology
Yimeng Fang, Jiahui Ma, Pengyu Lei, Lei Wang, Junying Qu, Jing Zhao, Fan Liu, Xiaoqing Yan, Wei Wu, Libo Jin, Hao Ji, Da Sun
Summary: T2DM is difficult to prevent and cure, leading to the development of a treatment strategy combining diet therapy and traditional medication. Konjac flour and its derivatives, especially Konjac glucomannan (KGM), have gained popularity as a natural and healthy product. KGM plays an important role in T2DM by extending gastric emptying time, increasing satiety, promoting liver glycogen synthesis, improving intestinal flora and the metabolic system through various molecular pathways, and protecting the liver and kidneys. This article outlines the physicochemical features of KGM and emphasizes its advantages as a meal for special medical purposes in T2DM.
Article
Biochemistry & Molecular Biology
Patricia Carloni, Alfonso Albacete, Purificacion A. Martinez-Melgarejo, Federico Girolametti, Cristina Truzzi, Elisabetta Damiani
Summary: Through a series of antioxidant assays and analytical methods, this study found that teas grown in Europe have similar antioxidant capacity and rich content of health-promoting polyphenols as teas grown in other parts of the world. This research provides important information for the characterization of European teas, and can guide European tea growers and consumers in selecting teas with the best health benefits.
Review
Biochemistry & Molecular Biology
Xiaofeng Dai, Erik W. Thompson, Kostya (Ken) Ostrikov
Summary: Cancer cells are more susceptible to abnormal redox fluctuations due to their imbalanced antioxidant system and cell surface receptors can sense stress and trigger intracellular signals. Targeting cell receptors can sensitize cancer cells to specific drugs, but cell receptor mutations are often associated with drug resistance. Therefore, exploring effective therapeutics targeting diverse cell receptors is significant for combating aggressive cancers. Cold atmospheric plasma (CAP) is considered a promising redox modulation medium and highly selective anti-cancer treatment, offering dynamically changing receptor targets and reduced drug resistance against aggressive cancers.
Review
Clinical Neurology
Gargi Banerjee, Kiran Samra, Matthew E. Adams, Zane Jaunmuktane, Adrian Robert Parry-Jones, Joan Grieve, Ahmed K. Toma, Simon F. Farmer, Richard Sylvester, Henry Houlden, Peter Rudge, Simon Mead, Sebastian Brandner, Jonathan M. Schott, John Collinge, David J. Werring
Summary: This review summarizes the clinical spectrum of iatrogenic CAA, provides a diagnostic framework, and discusses the clinical features and diagnostic methods.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Pharmacology & Pharmacy
Kirti Gupta, Sneha Pandey, Newly Bagang, Kamalpreet Mehra, Gaaminepreet Singh
Summary: Trimetazidine (TMZ) not only shows protective effects on kidney injuries in addition to treating angina pectoris, by attenuating oxidative stress, suppressing inflammation, and maintaining oxygen and energy balance. However, further investigations are needed to explore its mechanisms in other types of renal diseases.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Review
Oncology
Kikkie Poels, Suzanne I. M. Neppelenbroek, Marie Jose Kersten, M. Louisa Antoni, Esther Lutgens, Tom T. P. Seijkens
Summary: ICI treatment may exacerbate atherosclerosis and increase the incidence of cardiovascular diseases such as myocardial infarction, ischemic stroke, and coronary artery disease. Improved monitoring and cardiovascular risk assessment of patients receiving ICI therapy are necessary to mitigate the detrimental effects on atherosclerotic CVD.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Dermatology
Tenzin Sung-rab Brookes, Richard Barlow, Padma Mohandas, Anthony Bewley
Summary: Topical steroid withdrawal (TSW) is a newly described disease characterized by erythema and burning following discontinuation of prolonged use of mid- to high-potency topical corticosteroids. Patients with TSW are very distressed and some consider suicide; dermatologists need to be aware of TSW and offer support with shared decision-making when considering treatments.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2023)
Review
Medicine, General & Internal
Messoud Ashina, Dawn C. Buse, Hakan Ashina, Patricia Pozo-Rosich, Mario F. P. Peres, Mi Ji Lee, Gisela M. Terwindt, Rashmi Halker Singh, Cristina Tassorelli, Thien Phu Do, Dimos D. Mitsikostas, David W. Dodick
Summary: Migraine is a highly disabling neurological disorder affecting over 1 billion people worldwide. Treatment options include pharmacological and non-pharmacological therapies. Building a personalized treatment plan and exploring emerging mechanism-based treatments are crucial for effective management.
Review
Chemistry, Multidisciplinary
Yan Fang, Yuxin Liu, Lu Qi, Yurui Xue, Yuliang Li
Summary: Graphdiyne (GDY), as a new member of carbon allotropes, possesses unique chemical and electronic structures and has found applications in energy, catalysis, environmental science, and electronic devices. It has been recognized for its scientific value and development potential.
CHEMICAL SOCIETY REVIEWS
(2022)
Article
Oncology
Daniel R. Schmidt, Rutulkumar Patel, David G. Kirsch, Caroline A. Lewis, Matthew G. Vander Heiden, Jason W. Locasale
Summary: Cancer has complex effects on cellular and systemic metabolism, with metabolomics playing a crucial role in providing insights for cancer diagnosis, monitoring, and therapy. Advances in technology have expanded the applications of metabolomics in clinical research, with the potential to further enhance cancer patient management in the future.
CA-A CANCER JOURNAL FOR CLINICIANS
(2021)
Review
Chemistry, Multidisciplinary
Lin Zhang, Wenya Du, Jin-Hoon Kim, Chia-Chen Yu, Canan Dagdeviren
Summary: Piezoelectric-based conformable ultrasound electronics (cUSE) are intensively studied due to their unique capabilities for various applications. This review provides a comprehensive understanding of cUSE for use in biomedical and healthcare monitoring systems, as well as a synopsis of its recent advancements.
ADVANCED MATERIALS
(2023)
Article
Cardiac & Cardiovascular Systems
Trisha Singh, Hilal Khan, David T. Gamble, Caroline Scally, David E. Newby, Dana Dawson
Summary: “Takotsubo syndrome is an acute condition with transient dysfunction of the left ventricle, which is challenging to differentiate from acute myocardial infarction. Recent studies have shown that patients with this syndrome have persistent cardiac dysfunction and limiting symptoms. They also have a substantial burden of morbidity and mortality, similar to patients with acute coronary syndrome. The underlying pathophysiology of this condition remains unclear, and further research is needed to inform evidence-based management strategies.”
Article
Biochemistry & Molecular Biology
Francesca Di Lorenzo, Enrica Marchionni, Valentina Ferradini, Andrea Latini, Laura Pezzoli, Annamaria Martino, Fabiana Romeo, Annamaria Iorio, Stefano Bianchi, Maria Iascone, Leonardo Calo, Giuseppe Novelli, Ruggiero Mango, Federica Sangiuolo
Summary: Variants in desmoplakin gene (DSP) are usually associated with arrhythmogenic cardiomyopathy (ACM) or dilated cardiomyopathy (DCM) inherited in an autosomal dominant manner. This study analyzed a cohort of 18 probands with heterozygous DSP variants and identified 16 pathogenic or likely pathogenic variants. Patients generally presented as asymptomatic or mildly symptomatic, and cardiac magnetic resonance imaging revealed left ventricular myocardial fibrosis. These findings confirm that DSP-related cardiomyopathy is a distinct clinical entity characterized by a high arrhythmic burden, variable degrees of left ventricular enlargement, and myocarditis-like episodes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Chemistry, Physical
Duraisami Dhamodharan, Veeman Dhinakaran, Hun-Soo Byun
Summary: The paper discusses the synthesis, properties, and potential applications of layered two-dimensional (2D) nitrides and carbides (2D-MXenes) in different fields. These materials possess valuable and adjustable mechanical, optical, electrochemical, and electronic properties, making them suitable for electromagnetic interference shielding, medicine, sensing, optoelectronics, energy storage, and catalysis. Additionally, the challenges and prospects of MXenes as materials are highlighted.
Article
Dermatology
Rhiannon L. Harries, Abdullah Alqallaf, Jared Torkington, Keith G. Harding
INTERNATIONAL WOUND JOURNAL
(2019)
Article
Surgery
D. C. Bosanquet, A. J. Sanders, F. Ruge, J. Lane, C. A. Morris, W. G. Jiang, K. G. Harding
BRITISH JOURNAL OF SURGERY
(2019)
Review
Health Care Sciences & Services
Amy Ferris, Annie Price, Keith Harding
PALLIATIVE MEDICINE
(2019)
Article
Dermatology
Gurudutt Naik, Nicola M. Ivins, Keith G. Harding
INTERNATIONAL WOUND JOURNAL
(2019)
Editorial Material
Dermatology
Douglas Queen, Keith Harding
INTERNATIONAL WOUND JOURNAL
(2019)
Letter
Dermatology
Rosana E. Pacella, Ruth Tulleners, Laura McCosker, Qinglu Cheng, Keith Harding, Helen Edwards, Stephen Yelland, Anthony Dyer, William McGuiness, Nicholas Graves
INTERNATIONAL WOUND JOURNAL
(2019)
Article
Medicine, Research & Experimental
Tilbrook Helen, Cook Liz, Clark Laura, Sbizzera Illary, Bland Martin, Buckley Hannah, Chetter Ian, Dumville Jo, Fenner Chris, Forsythe Rachael, Gabe Rhian, Harding Keith, Layton Alison, Lindsay Ellie, Mc Daid Catriona, Moffatt Christine, Rolfe Debbie, Stansby Gerard, Torgerson David, Vowden Peter, Williams Laurie, Hinchliffe Robert
Editorial Material
Dermatology
Douglas Queen, Keith Harding
INTERNATIONAL WOUND JOURNAL
(2019)
Letter
Dermatology
Keith Harding, Paul Chadwick, S. L. A. Jeffery, David Gray, Ellie Lindsay, Ibby Younis, Andew Sharpe, Keith Cutting, Martyn Butcher
JOURNAL OF WOUND CARE
(2019)
Review
Dermatology
N. Graves, C. J. Phillips, K. Harding
Summary: Chronic wounds have a significant impact on quality of life and health system budgets, warranting greater attention. This review aims to summarize the nature, extent, economic costs, and management efficiency of chronic wound problems facing health systems globally.
BRITISH JOURNAL OF DERMATOLOGY
(2022)
Review
Dermatology
D. C. Bosanquet, K. G. Harding
Summary: This review highlights the range of therapeutic options for difficult-to-heal wounds, emphasizing the lack of robust data for most interventions. The purpose is to provide a broad overview of interventions and summarize the evidence base for each.
BRITISH JOURNAL OF DERMATOLOGY
(2022)
Editorial Material
Dermatology
Keith G. Harding
BRITISH JOURNAL OF DERMATOLOGY
(2022)
Article
Medicine, General & Internal
Vincent Falanga, Roslyn Rivkah Isseroff, Athena M. Soulika, Marco Romanelli, David Margolis, Suzanne Kapp, Mark Granick, Keith Harding
Summary: Chronic wounds are wounds that do not heal within an expected time frame due to prolonged dysregulated inflammation. Advances in understanding the cellular and molecular aspects of basic science and innovative treatment modalities have improved the management of chronic wounds. However, gaps still exist in scientific knowledge, highlighting the need for further research to enhance understanding of chronic wounds.
NATURE REVIEWS DISEASE PRIMERS
(2022)
Article
Dermatology
Richard Hillson Bull, Donna Clements, Agnes Juguilon Collarte, Keith Gordon Harding
Summary: This study investigates the healing effect of intermittent NMES on venous leg ulcers and finds that it significantly accelerates the healing process. PAR is used as a metric to compare the performance of different wound healing interventions. The self-controlled trial design allows for sensitive discrimination of healing rates in a relatively short trial period.
ADVANCES IN WOUND CARE
(2023)
Review
Health Care Sciences & Services
Gurudutt Naik, Keith G. Harding
CHRONIC WOUND CARE MANAGEMENT AND RESEARCH
(2019)
