Article
Endocrinology & Metabolism
Zhiyu Xi, Pamela S. Jones, Masaaki Mikamoto, Xiaobin Jiang, Alexander T. Faje, Chuansheng Nie, Kathryn E. Labelle, Yunli Zhou, Karen K. Miller, Roy J. Soberman, Xun Zhang
Summary: Aggressive pituitary adenomas have increased expression of PD-L2, CD80, and CD86 compared to normal pituitary glands, and significantly higher levels of CD80 and CD86 compared to non-aggressive tumors. These findings support further research on the potential role of immune checkpoint inhibition therapy in the treatment of pituitary adenomas.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Oncology
Jie Zhou, Yaomin Hu, Wende Zhu, Chuansheng Nie, Wenxiu Zhao, Alexander T. Faje, Kay E. Labelle, Brooke Swearingen, Hang Lee, E. Tessa Hedley-Whyte, Xun Zhang, Pamela S. Jones, Karen K. Miller, Anne Klibanski, Yunli Zhou, Roy J. Soberman
Summary: This study found that angiogenesis in pituitary tumors is more active compared to normal pituitary gland tissue and is regulated mainly by PGF and VEGFC. The expression of endothelial markers in tumor samples was highly correlated with the expression of VEGFC and PGF. Inhibition of angiogenesis using VEGFR inhibitors showed promising results in vitro and in mice. Therefore, angiogenesis inhibitors may have potential as therapies for aggressive pituitary tumors.
FRONTIERS IN ONCOLOGY
(2022)
Article
Endocrinology & Metabolism
Giuseppe Giuffrida, Valeria D'Argenio, Francesco Ferrau, Vito Alessandro Lasorsa, Francesca Polito, Federica Aliquo, Marta Ragonese, Oana Ruxandra Cotta, Ylenia Alessi, Rosaria Oteri, Federica Di Maggio, Alessio Asmundo, Petronilla Daniela Romeo, Federica Spagnolo, Lucio Pastore, Filippo Flavio Angileri, Mario Capasso, Salvatore Cannavo, M'Hammed Aguennouz
Summary: The study found that there are complex epigenetic modifications, mainly methylation and miRNA activity, in pituitary adenomas. Nonfunctioning tumors (NFPAs) showed higher methylation levels compared to GH-omas, with 178 differentially methylated regions (DMRs) mainly located in noncoding and intronic sequences. Additionally, the study identified three hypermethylated genes involved in tumorigenesis processes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Clinical Neurology
Dingkai Xu, Ling Wang
Summary: Pituitary adenomas (PAs) are among the most common primary intracranial tumors, causing severe endocrine disorders and malignant features. miRNAs play important roles in the invasion and metastasis of PAs and have been extensively studied as potential screening or prognostic biomarkers. This review summarizes recent studies on the emerging roles of miRNAs in PAs and their clinical significance.
EUROPEAN NEUROLOGY
(2022)
Article
Medicine, General & Internal
Kaori Takeshita, Ichiro Abe, Wataru Kameda, Kota Ishii, Yuya Fujita, Mai Nagata, Kentaro Ochi, Yuki Senda, Midori Koga, Tadachika Kudo, Yurika Hada, Kaoru Takase, Yusuke Morinaga, Miiko Ito, Makiko Abe, Kenichi Ishizawa, Kunihisa Kobayashi
Summary: Pituitary apoplexy is a rare syndrome that often leads to spontaneous bleeding or infarction in pituitary tumors or glands. This study found that pituitary apoplexy occurs most frequently in patients with nonfunctional pituitary adenomas and is not related to tumor size. However, it is associated with hormonal deficiencies, liver dysfunction, hyponatremia or hypochloremia, and dyslipidemia.
Review
Biochemistry & Molecular Biology
Simone Donati, Cinzia Aurilia, Gaia Palmini, Francesca Miglietta, Irene Falsetti, Teresa Iantomasi, Maria Luisa Brandi
Summary: Pituitary adenomas are common intracranial neoplasms, with some showing aggressive behavior. Research suggests that miRNA expression changes may be related to pituitary tumorigenesis, offering new possibilities for diagnosis and treatment of these tumors.
Article
Oncology
Giulia Cossu, Stefano La Rosa, Jean Philippe Brouland, Nelly Pitteloud, Ethan Harel, Federico Santoni, Maxime Brunner, Roy Thomas Daniel, Mahmoud Messerer
Summary: The expression of PD-L1 is associated with proliferative grades of Trouillas' classification and specific subtypes of PitNET expressing growth hormone.
Article
Oncology
Sherwin Tavakol, Michael P. Catalino, David J. Cote, Xian Boles, Edward R. Laws, Wenya Linda Bi
Summary: A novel classification scheme for cystic sellar lesions based on the heterogeneity of the cyst wall/contents and the presence of a solid component on imaging was proposed. The study found that different types of cysts were associated with the diagnoses of Rathke cleft cyst and cystic pituitary adenoma, with higher cyst types, fluid-fluid level presence, symptomatic hyperprolactinemia, and obesity being predictors of cystic pituitary adenoma.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Junyi Fu, Yanli Li, Lisha Wu, Xin Yang, Tingting Quan, Xi Li, Jiamin Zeng, Yinhui Deng, Jinxiu Yu
Summary: This study aimed to investigate the incidence, risk factors, and prognosis of pituitary hemorrhage in pituitary adenomas treated with gamma knife radiosurgery. It was found that nonfunctioning pituitary adenomas were an independent risk factor for new or worsened pituitary hemorrhage after gamma knife radiosurgery.
Review
Biochemistry & Molecular Biology
Samridhi Banskota, David C. Adamson
Summary: Pituitary adenomas are tumors that arise in the anterior pituitary gland, most commonly benign and exerting their effects through excess hormone secretion or mass effect. The clinical presentation varies based on the size and hormone secretion of the adenoma.
Review
Spectroscopy
Na Li, Dominic M. Desiderio, Xianquan Zhan
Summary: Pituitary adenoma is a common intracranial neoplasm, a complex, chronic whole-body disease with multiple causative factors, processes, and consequences. The advancement of multiomics and systems biology has shifted paradigms towards a systematic strategy for effective management of PAs, involving molecular alterations at multiple levels and a focus on phenomics for personalized, predictive, and preventive medicine.
MASS SPECTROMETRY REVIEWS
(2022)
Article
Endocrinology & Metabolism
Yu Zhang, Lei Li, Xin Ma, Chenan Liu, Gemingtian Liu, Zhixu Bie, Zhijun Yang, Pinan Liu
Summary: The study found that SLC2A1 is a potential diagnostic marker for invasive pituitary adenoma and is closely related to EMT. Evaluation: 8 points.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Oncology
Qizhi Zhang, Ying Wang, Yinting Zhou, Qiujuan Zhang, Chuan Xu
Summary: The abnormal expression of miRNAs has been closely linked to tumor development. This study found significantly lower levels of miRNA-26b, miRNA-138, miRNA-206, and miRNA-let-7e in the peripheral serum of NFPA patients compared to normal subjects. These miRNAs may play a role in the occurrence and progression of NFPAs, providing a basis for further exploration of tumor markers in pituitary adenomas.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Review
Oncology
Congxin Dai, Siyu Liang, Bowen Sun, Yong Li, Jun Kang
Summary: Refractory pituitary adenomas and pituitary carcinomas are difficult to treat, but anti-VEGF therapy is considered a promising alternative treatment. These tumors exhibit characteristics such as high Ki-67 index, rapid growth, frequent recurrence, and resistance to conventional treatments, and vascular endothelial growth factor plays a crucial role in these tumors.
FRONTIERS IN ONCOLOGY
(2021)
Article
Clinical Neurology
Salomon Cohen-Cohen, Desmond A. Brown, Benjamin T. Himes, Lydia P. Wheeler, Michael W. Ruff, Brittny T. Major, Naykky M. Singh Ospina, John L. D. Atkinson, Fredric B. Meyer, Irina Bancos, William F. Young Jr, Jamie J. Van Gompel
Summary: In patients with MEN1, the prevalence of pituitary adenomas is higher in females than in males. Functional adenomas, especially prolactin-secreting adenomas, are more common than nonfunctional ones. Most asymptomatic nonfunctional adenomas can be safely followed, with only a small percentage progressing to require surgery.
JOURNAL OF NEUROSURGERY
(2021)
Meeting Abstract
Oncology
Wenbin Ou, Weicai Chen, Jiaqing Zhu, Grant Eilers, Xuhui Li, Peipei Yang, Hailong Li, Fanguo Meng, Jonathan Fletcher
Article
Oncology
Shuang Lin, Senjun Zhou, Shaojie Jiang, Xiaolong Liu, Yifan Wang, Xueyong Zheng, Haimeng Zhou, Xuhui Li, Xiujun Cai
Article
Oncology
Peipei Yang, Weicai Chen, Xuhui Li, Grant Eilers, Quan He, Lili Liu, Yeqing Wu, Yuehong Wu, Wei Yu, Jonathan A. Fletcher, Wen-Bin Ou
Article
Medicine, Research & Experimental
Hou-Shi Ma, Elaine Lu Wang, Wen-Fei Xu, Shozo Yamada, Katsuhiko Yoshimoto, Zhi Rong Qian, Long Shi, Li-Li Liu, Xu-Hui Li
MEDICAL SCIENCE MONITOR
(2018)
Article
Integrative & Complementary Medicine
Yi-Tong Ma, Mi-Mi Li, Qing Wu, Wen-Fei Xu, Shuang Lin, Zi-Wei Chen, Li Liu, Long Shi, Qing Sheng, Ting-Ting Li, Qian Zhang, Xu-Hui Li
EUROPEAN JOURNAL OF INTEGRATIVE MEDICINE
(2019)
Article
Oncology
Yicong Ma, Cuiling Feng, Jingjing Wang, Ziwei Chen, Peng Wei, Angran Fan, Xu Wang, Xue Yu, Dongyu Ge, Hua Xie, Li Liu, Qian Zhang, Xu-Hui Li
Article
Cell Biology
Wen-Fei Xu, Yi-Cong Ma, Hou-Shi Ma, Long Shi, Hang Mu, Wen-Bin Ou, Jie Peng, Ting-Ting Li, Tianyi Qin, Hai-Meng Zhou, Xue-Qi Fu, Xu-Hui Li
Article
Medicine, Research & Experimental
Wen-Fei Xu, Feng Liu, Yi-Cong Ma, Zhi-Rong Qian, Long Shi, Hang Mu, Feng Ding, Xue-Qi Fu, Xu-Hui Li
MEDICAL SCIENCE MONITOR
(2019)
Article
Biochemistry & Molecular Biology
Feng Liu, Wen-Fei Xu, Hang Mu, Zhi-Rong Lv, Jie Peng, Chao Guo, Hai-Meng Zhou, Zhuo-Ming Ye, Xu-Hui Li
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
(2020)
Article
Chemistry, Analytical
Yingying Xue, Xinyi Luo, Wenfei Xu, Ke Wang, Mengqi Wu, Lei Chen, Gewei Yang, Kun Ma, Ming Yao, Qinghe Zhou, Qingshan Lv, Xuhui Li, Jianhua Zhou, Jiasi Wang
Summary: In this study, a polydisperse droplet digital CRISPR-Cas-based assay (PddCas) was developed for rapid and ultrasensitive detection of viral DNA/RNA. The method demonstrated high sensitivity, with a limit of detection of 100 aM for target DNA and 10 aM for target RNA. It also showed 100% sensitivity and specificity in detecting SARS-CoV-2 and HPV 18 in clinical samples.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Wenfei Xu, Jie Peng, Chao Guo, Yingjie Chai, Haimeng Zhou, Jiasi Wang, Xuhui Li
Summary: Cervical cancer is a common tumor in women, and early diagnosis is crucial. However, there is a lack of specific biomarkers and efficient methods. In this study, methylated SEPT9 (mSEPT9) was identified as a specific biomarker, and a novel method called MeCRISPR was developed for rapid and ultrasensitive detection of mSEPT9. The results showed high sensitivity and specificity in detecting mSEPT9 in clinical cervical cancer patients. This method has the potential for cancer screening in low-resource settings.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Applied
Xuhui Li, Chunxin Xia, Danni Kong, Ming Xu, Jin Zhu, Congfen He, Bingliang Wang, Junxiang Li
Summary: This study evaluated the therapeutic effects of Euglena gracilis-derived peptides on allergic inflammation and verified their efficacy through simulated experiments and clinical trials. The results showed that Euglena gracilis-derived peptides have antioxidant and anti-inflammatory activities, and can repair inflammation-induced damages. Therefore, Euglena gracilis-derived peptides can be considered as a novel cosmetic ingredient for preventing allergic responses.
JOURNAL OF COSMETIC SCIENCE
(2022)
Article
Immunology
Bin Tang, Xixi Wang, Yuqing Zhu, Xuhui Li, Shukun Yao
EUROPEAN JOURNAL OF INFLAMMATION
(2018)
Article
Biochemistry & Molecular Biology
Wu Qing, Zhou Hai-Meng, Li Xu-Hui
PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
(2015)
