Review
Obstetrics & Gynecology
Richard A. Anderson, David Cameron, Florian Clatot, Isabelle Demeestere, Matteo Lambertini, Scott M. Nelson, Fedro Peccatori
Summary: Female patients undergoing anticancer treatment are at risk of adverse ovarian outcomes, and AMH can be used as a biomarker to assess ovarian reserve and POI. Chemotherapy or radiotherapy consistently led to reduced/undetectable AMH levels, but partial recovery was observed during follow-up. Oligo/amenorrhea was associated with post-treatment AMH decline, suggesting impending POI. Long-term follow-up of pediatric patients showed significantly lower AMH levels compared to control groups. AMH can identify the damaging effect of cancer treatments on ovarian function, but further studies are needed to determine its diagnostic and predictive value.
HUMAN REPRODUCTION UPDATE
(2022)
Review
Endocrinology & Metabolism
Akira Iwase, Yuko Hasegawa, Yumiko Tsukui, Mio Kobayashi, Hikaru Hiraishi, Tomoko Nakazato, Yoshikazu Kitahara
Summary: Anti-Mullerian hormone (AMH) is an indirect indicator of ovarian reserve and fertility. It is used to test the number of remaining follicles. A decline in AMH suggests a decrease in follicles, while polycystic ovary syndrome patients often have elevated AMH levels. AMH varies with folliculogenesis and changes in the follicle cohort, which play a crucial role in ovarian activity throughout a woman's lifetime.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Oncology
Marco Torella, Gaetano Riemma, Pasquale De Franciscis, Marco La Verde, Nicola Colacurci
Summary: Innovations in childhood cancer treatment have increased survival rates, but female childhood cancer survivors are at risk for late reproductive aftereffects. AMH is used for ovarian reserve screening in reproductive medicine, but is not the gold standard. This study found that female neuroblastoma survivors have higher risk for reduced AMH levels and POI.
Article
Oncology
Richard A. Anderson, Tom W. Kelsey, Anne Perdrix, Nathalie Olympios, Orianne Duhamel, Matteo Lambertini, Florian Clatot
Summary: This study investigated the value of anti-mullerian hormone (AMH) as a serum biomarker for predicting loss of ovarian function after chemotherapy in premenopausal women with early breast cancer (eBC). The results showed that AMH can accurately diagnose ovarian dysfunction after chemotherapy, and early analysis of AMH can accurately identify women who will not recover ovarian function.
BREAST CANCER RESEARCH AND TREATMENT
(2022)
Article
Oncology
Ya Xie, Haoran Duan, Dong Wang, Huiqing Li, Jia Jia, Jialin Zhang, Linlin Li
Summary: GnRH agonist co-therapy is effective in preserving ovarian function during platinum-based chemotherapy in patients with ovarian malignancy, reducing the risk of low AMH levels post-chemotherapy and improving menstrual resumption and quality of life. It provides a therapeutic reference for gynecologists, especially in economically and medically underdeveloped areas.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Hye Young Jin, Jun Ah Lee, Meerim Park, Hyeon Jin Park
Summary: The study aims to evaluate ovarian function and associated health outcomes in female adolescent and young adult survivors of childhood cancer. It found that premature ovarian insufficiency is common in childhood cancer survivors and is associated with certain treatment factors. Regular monitoring of ovarian function is necessary for better health outcomes.
CANCER RESEARCH AND TREATMENT
(2023)
Article
Oncology
Xiangyun Zong, Yang Yu, Wenhu Chen, Weiwei Zong, Hongjian Yang, Xuan Chen
Summary: This study analyzed the changes in anti-Mullerian hormone (AMH) levels and the factors influencing ovarian function in breast cancer patients before and after chemotherapy. The results showed that age, menarche age, baseline AMH level, and GnRHa application are the most important independent factors for the protection and recovery of ovarian reserve in premenopausal women with breast cancer.
Article
Obstetrics & Gynecology
Horace Roman, Isabella Chanavaz-Lacheray, Oana Mircea, Benoit Berby, Lise Dehan, Sophia Braund, Eric Verspyck, Lucian Puscasiu
Summary: The study examined the association between large ovarian endometriomas and high pre-operative AMH concentrations in 332 women with endometriosis. Results showed that women with cysts measuring over 6 cm had significantly increased AMH concentrations, regardless of age or presence of bilateral endometriomas. Surgeons and patients should take into consideration the impact of large endometriomas on AMH levels when planning surgery and post-operative conception.
REPRODUCTIVE BIOMEDICINE ONLINE
(2021)
Article
Obstetrics & Gynecology
Mahmut Oncul, Ipek Betul Ozcivit, Zafer Basibuyuk, Ceren Cebi, Sezai Sahmay
Summary: This study aimed to evaluate the usefulness of AMH and AFC as ovarian reserve markers in HH patients and to find cutoff values for gonadotropin levels in the diagnosis of HH. The results showed that serum AMH levels reflect the follicle cohort in HH cases, while AFC was significantly different between HH and control group. FSH and LH levels can be used with high sensitivity and specificity for the diagnosis of HH.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2022)
Review
Endocrinology & Metabolism
Xiaojun Kuang, Yongzhe Tang, Hong Xu, Min Ji, Dongmei Lai
Summary: This review assesses the effectiveness of various therapies in recovering ovarian function in patients with primary ovarian insufficiency (POI) and explores a comprehensive evaluation method. The results indicate a lack of scientific evidence supporting any therapy in effectively restoring ovarian function in patients with POI.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Obstetrics & Gynecology
Sofia Nilsson, Marianne Jarfelt, Stina Jarvholm, Linda Kluge, Ann Thurin-Kjellberg
Summary: Childhood cancer is rare in Sweden, but treatment can lead to reduced reproductive function and fertility. A prospective follow-up study on female childhood cancer survivors showed that one-third of participants had high risk of low ovarian reserve, and many displayed signs of anxiety.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2022)
Article
Oncology
Shari B. Goldfarb, Volkan Turan, Giuliano Bedoschi, Enes Taylan, Nadia Abdo, Tessa Cigler, Heejung Bang, Sujita Patil, Maura N. Dickler, Kutluk H. Oktay
Summary: This study found that both AC-based and CMF chemotherapy regimens significantly compromise ovarian reserve in women with breast cancer, with no significant recovery beyond 12 months post-chemotherapy. In contrast, tamoxifen-only treatment does not seem to alter ovarian reserve.
BREAST CANCER RESEARCH AND TREATMENT
(2021)
Review
Endocrinology & Metabolism
Nathalie di Clemente, Chrystele Racine, Alice Pierre, Joelle Taieb
Summary: Anti-Mullerian hormone (AMH) plays a significant role in regulating folliculogenesis and serves as a reliable marker for ovarian reserve. It is also involved in the pathogenesis of conditions like polycystic ovary syndrome (PCOS) and primary ovarian failure.
Article
Geriatrics & Gerontology
Renee M. G. Verdiesen, Carla H. van Gils, Rebecca K. Stellato, W. M. Monique Verschuren, Frank J. M. Broekmans, Annelien C. de Kat, Yvonne T. van der Schouw, N. Charlotte Onland-Moret
Summary: The study found that baseline age-specific AMH levels were not associated with overall cancer risk, but there may be an increased risk of breast cancer in women under 40. Analysis of age-related AMH trajectories suggested that women diagnosed with cancer had higher AMH levels at a younger age and declined faster compared to those who were not diagnosed with cancer, although there was no actual evidence for differences in trajectories.
Article
Agriculture, Dairy & Animal Science
S. J. Huang, L. Purevsuren, F. Jin, Y. P. Zhang, C. Y. Liang, M. Q. Zhu, F. Wang, C. L. Jia, Z. H. Wei
Summary: The study elucidated the role of AMH in regulating ovarian follicle development in laying hens by measuring expression of relevant genes and treating hens with AMH. Results showed changes in gene expressions post-follicular selection and significant effects on ovarian morphology and hormone levels after AMH injection.
Article
Medical Laboratory Technology
Beata Zelazowska-Rutkowska, Janusz Zak, Malgorzata Wojtkowska, Justyna Zaworonek, Bogdan Cylwik
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2019)
Article
Otorhinolaryngology
Beata Zelazowska-Rutkowska, Bozena Skotnicka, Elzbieta Hassmann-Poznanska, Bogdan Cylwik
INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY
(2020)
Article
Medicine, General & Internal
Beata Zelazowska-Rutkowska, Anna Jakubiuk-Tomaszuk, Bogdan Cylwik
ARCHIVES OF IRANIAN MEDICINE
(2020)
Article
Biochemistry & Molecular Biology
Beata Zelazowska-Rutkowska, Bozena Skotnicka, Bogdan Cylwik
Article
Biochemistry & Molecular Biology
Beata Zelazowska-Rutkowska, Gabriela Niewinska, Kacper Toczylowski, Bogdan Cylwik
Summary: The study found that serum concentration of interleukin 27 is significantly increased in children with mononucleosis, serving as an indicator of inflammation and a potential marker to differentiate between the acute and chronic phases of the disease.
Article
Chemistry, Analytical
Beata Szymanska, Zenon Lukaszewski, Beata Zelazowska-Rutkowska, Kinga Hermanowicz-Szamatowicz, Ewa Gorodkiewicz
Summary: An alternative biosensor for the determination of ovarian cancer marker HE4 in blood plasma has been developed, showing acceptable precision and recovery rates. The biosensor's results were in good agreement with commercial tests, validating its diagnostic application, such as studying the influence of ovarian tumor resection on the level of HE4 in blood serum.
Article
Oncology
Malgorzata Czogala, Walentyna Balwierz, Katarzyna Pawinska-Wasikowska, Teofila Ksiazek, Karolina Bukowska-Strakova, Wojciech Czogala, Barbara Sikorska-Fic, Michal Matysiak, Jolanta Skalska-Sadowska, Jacek Wachowiak, Malgorzata Moj-Hackemer, Krzysztof Kalwak, Katarzyna Muszynska-Roslan, Maryna Krawczuk-Rybak, Dominik Grabowski, Jerzy Kowalczyk, Lucyna Maciejka-Kemblowska, Ninela Irga-Jaworska, Katarzyna Bobeff, Wojciech Mlynarski, Renata Tomaszewska, Tomasz Szczepanski, Agnieszka Chodala-Grzywacz, Grazyna Karolczyk, Agnieszka Mizia-Malarz, Katarzyna Mycko, Wanda Badowska, Karolina Zielezinska, Tomasz Urasinski, Justyna Urbanska-Rakus, Malgorzata Ciebiera, Radoslaw Chaber, Natalia Bartoszewicz, Mariusz Wysocki, Szymon Skoczen
Summary: Poland has made significant progress in treating pediatric acute myeloid leukemia since 1983, with improved survival rates attributed to standardized treatment protocols and consideration of genetic prognostic factors.
Article
Oncology
Greta Sommerhaeuser, Anja Borgmann-Staudt, Ralph Schilling, Eva Frey, Jiri Hak, Veronika Janhubova, Katerina Kepakova, Tomas Kepak, Stephanie Klco-Brosius, Maryna Krawczuk-Rybak, Jarmila Kruseova, Herwig Lackner, Ales Luks, Gisela Michel, Anna Panasiuk, Melanie Tamesberger, Janine Vetsch, Magdalena Balcerek
Summary: The Multicenter Offspring Study investigated various aspects of health in offspring born to childhood cancer survivors and their siblings in five European countries. The study provided comprehensive information to address concerns about the overall health of survivor offspring, however, certain limitations were identified due to differences in approach among participating centers.
CANCER EPIDEMIOLOGY
(2021)
Article
Medicine, General & Internal
Eryk Latoch, Katarzyna Kononczuk, Katarzyna Taranta-Janusz, Katarzyna Muszynska-Roslan, Magdalena Sawicka, Anna Wasilewska, Maryna Krawczuk-Rybak
Summary: In this study, long-term childhood cancer survivors showed significantly increased urinary beta-2-microglobulin (beta 2M) levels compared to healthy peers, and the beta 2M level was positively correlated with body mass index. Additionally, individuals with longer follow-up times after treatment had higher levels of beta 2M in their urine. Decreased glomerular filtration rate was associated with elevated urinary beta 2M levels, suggesting a potential link between beta 2M and kidney injury in childhood cancer survivors.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Immunology
Ewa Bojkiewicz, Kacper Toczylowski, Sambor Grygorczuk, Beata Zelazowska-Rutkowska, Justyna Dunaj, Agnieszka Zebrowska, Piotr Czupryna, Anna Moniuszko-Malinowska, Artur Sulik
Summary: In Poland, the vaccination rate for tick-borne encephalitis is low, despite a high incidence of severe infections. A study found that many people have asymptomatic infections and have different attitudes towards the vaccine.
Article
Chemistry, Analytical
Beata Szymanska, Zenon Lukaszewski, Lukasz Oldak, Beata Zelazowska-Rutkowska, Kinga Hermanowicz-Szamatowicz, Ewa Gorodkiewicz
Summary: Interleukin-6 (IL-6) is a biomarker for inflammation, COVID-19, and various cancers including ovarian cancer. Two biosensors were developed for detecting IL-6 in blood plasma and validated for clinical application.
Article
Chemistry, Analytical
Anna Sankiewicz, Lukasz Oldak, Beata Zelazowska-Rutkowska, Adam Hermanowicz, Zenon Lukaszewski, Ewa Gorodkiewicz
Summary: Cortisol is an important hormone that plays a crucial role in multiple systems and serves as a significant biomarker for stress. A developed immunosensor for cortisol measurement demonstrates good specificity and accuracy. The results from the validation experiment show good agreement with the standard method.
Article
Chemistry, Analytical
Anna Sankiewicz, Beata Zelazowska-Rutkowska, Ewelina Gorska, Adam Hermanowicz, Ewa Gorodkiewicz
Summary: Neuropilin-1 is a transmembrane protein that plays a significant role in various physiological and pathological processes. A specific SPRI biosensor was developed to accurately determine neuropilin-1 levels using a mouse monoclonal antibody. The biosensor showed a linear analytical signal range, high precision, and good recovery rates. The biosensor was validated through parallel testing with ELISA, demonstrating consistent results.
Article
Nutrition & Dietetics
Eryk Latoch, Kacper Kozlowski, Katarzyna Kononczuk, Beata Zelazowska-Rutkowska, Monika Tomczuk-Ostapczuk, Maryna Krawczuk-Rybak, Katarzyna Muszynska-Roslan
Summary: This study investigated the prevalence of vitamin D deficiency among childhood cancer survivors and examined its association with carotid intima-media thickness. The results showed that nearly 70% of childhood cancer survivors have vitamin D deficiency, and those with deficiency had greater carotid intima-media thickness.
Article
Ophthalmology
Katarzyna Powierza, Jolanta Sawicka-Powierza, Beata Urban, Beata Zelazowska-Rutkowska, Bogdan Cylwik, Bozena Mikoluc, Olga Kowalewska, Alina Bakunowicz-Lazarczyk
Summary: This study aimed to determine endothelin-1 (ET-1) concentration in pediatric chronic idiopathic uveitis based on anatomical location and grade of inflammation. The results showed a significant difference in ET-1 concentration between patients with chronic idiopathic uveitis and healthy controls, with lower expression of ET-1 potentially leading to permanent visual impairment.
CLINICAL OPHTHALMOLOGY
(2021)
