Article
Medicine, General & Internal
Rossella Cannarella, Rosita A. Condorelli, Carmelo Gusmano, Nunziata Barone, Nunziatina Burrello, Antonio Aversa, Aldo E. Calogero, Sandro La Vignera
Summary: The study observed a slight decrease in total sperm count and percentage of spermatozoa with normal morphology, while a significant increase in progressive sperm motility was found in men from Eastern Sicily between 2011 and 2020. The total sperm count was significantly lower and a trend of increasing progressive sperm motility was noticed in the quinquennium 2016-2020 compared to 2011-2015. The city of residence did not have a significant influence on sperm parameters.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Medicine, General & Internal
Giovanni M. Colpi, Ettore Caroppo
Summary: Microdissection testicular sperm extraction (mTESE) is considered the gold-standard surgical technique for retrieving testicular sperm in patients with non-obstructive azoospermia (NOA). A skilled surgeon is required for mTESE, and the learning curve may impact the sperm retrieval rate. This review provides a detailed description of the surgical procedure, accompanied by illustrations, and offers advice on pre-surgical and post-surgical patient management.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Anatomy & Morphology
Afsaneh-Jaberi Asl, Mohammadreza Sharifi, Abolfazl Dashti, Gholam reza Dashti
Summary: The study found that the expression of lncRNA MALAT1 and HOTAIR is related to sperm quality, DNA fragmentation, and MDA levels. The expression level is positively correlated with sperm motility and morphology, and negatively correlated with DNA damage and MDA levels.
Article
Energy & Fuels
Pingkuo Liu, Cunyu Lu, Ruiqi Zhao
Summary: This article constructs an evaluation model to assess the comprehensive development level and the orderliness-synergy degree of China's conventional and nonconventional energy industries. The results show that there is an upward trend in the overall orderliness-synergy degree of these two sub-industries, with some significant differences. Additionally, China's energy transition has made significant progress in structural upgrading, but there is still room for optimization.
FRONTIERS IN ENERGY RESEARCH
(2022)
Article
Obstetrics & Gynecology
Jiangman Gao, Renpei Yuan, Siwei Yang, Yuanyuan Wang, Ying Huang, Liying Yan, Hui Jiang, Jie Qiao
Summary: The study analyzed the correlations between male age, traditional semen parameters, sperm DNA fragmentation index (DFI), and high DNA stainability (HDS) in a large sample size. The results showed that age negatively impacted semen volume, total sperm count, motility, and HDS, while positively affecting sperm concentration and DFI. The study concluded that aging affects sperm quantity and quality, and there are significant correlations between routine sperm parameters and sperm DNA/chromatin integrity.
REPRODUCTIVE BIOMEDICINE ONLINE
(2021)
Article
Agriculture, Dairy & Animal Science
Krzysztof Gorski, Stanislaw Kondracki, Maria Iwanina, Wladyslaw Kordan, Leyland Fraser
Summary: This study aimed to investigate the differences in semen quality, sperm defects, dimensions, and shape between Large White and Landrace boars. Landrace boars showed higher ejaculate volume, sperm concentration, total numbers of spermatozoa, and lower frequency of morphological abnormalities compared to Large White boars. Furthermore, Landrace boar sperm had larger heads, longer flagellum, and different head-to-flagellum ratio, indicating distinct differences in sperm characteristics between the two breeds.
ANIMAL SCIENCE JOURNAL
(2021)
Article
Veterinary Sciences
Ali Salama, Elshymaa A. Abdelnaby, Ibrahim A. Emam, Mohamed Fathi
Summary: This study aimed to investigate the effects of melatonin administration on testicular vascular perfusion, steroid hormones, and semen characteristics in dogs. The results demonstrated that a single melatonin administration could improve semen volume, concentration, sperm motility, and total sperm count, as well as enhance testicular vascularization and intratesticular colored areas. Furthermore, melatonin administration increased testosterone, estradiol, and nitric oxide levels.
BMC VETERINARY RESEARCH
(2022)
Article
Agriculture, Dairy & Animal Science
Ana Martins-Bessa, Miguel Quaresma, Belen Leiva, Ana Calado, Francisco Javier Navas Gonzalez
Summary: The prediction of sperm output and quality in donkeys is crucial for reproductive management. Two Bayesian models were developed using testicular biometry to predict sperm traits. Results showed that combining biometry and testicular factors improved predictive power. These models may assist in reproductive decision-making and offer valuable information for assisted reproductive technologies.
Review
Obstetrics & Gynecology
Cennikon Pakpahan, Andri Rezano, Ria Margiana, Bella Amanda, Agustinus Agustinus, Darmadi Darmadi
Summary: Elevated lipid levels may have an impact on semen quality, although the findings of studies are not consistent. This review suggests that lipids significantly affect sperm quality and highlights the importance of maintaining lipid levels for preserving sperm quality and overall quality of life.
REPRODUCTIVE SCIENCES
(2023)
Article
Urology & Nephrology
Jason P. Van Batavia, Elizabeth Lawton, Jennifer R. Frazier, Stephen A. Zderic, Mark R. Zaontz, Aseem R. Shukla, Arun K. Srinivasan, Dana A. Weiss, Christopher J. Long, Douglas A. Canning, Thomas F. Kolon
Summary: In adolescents with varicocele, follicle-stimulating hormone levels are inversely associated with total motile sperm count, while inhibin B levels and total testicular volume are positively associated with total motile sperm count. Optimized cutoff values for follicle-stimulating hormone, inhibin B, and total testicular volume may serve as reasonable surrogates for total motile sperm count in boys who defer semen analysis for personal or religious/cultural reasons.
JOURNAL OF UROLOGY
(2021)
Article
Food Science & Technology
Samia Khnissi, Giovanni Bomboi, Ikram Khemiri, Imen Ben Salem, Maria Dattena, Salma Sai, Souha Ben Mustapha, Andrea Cabiddu, Narjess Lassoued
Summary: The supplementation of wormwood and rosemary in the diet of Barbarine rams positively affects reproductive traits such as body weight, scrotal circumference, sperm concentration, and sperm motility. It also leads to a decrease in blood glucose and insulin levels and an increase in plasma cortisol concentration. Therefore, the addition of wormwood and rosemary can enhance the reproductive function of rams.
FOOD SCIENCE & NUTRITION
(2023)
Article
Chemistry, Physical
Jenny Triptow, Gerard Meijer, Andre Fielicke, Otto Dopfer, Mallory Green
Summary: This study provides a better understanding of the interactions between gold and both conventional and nonconventional hydrogen bonding molecules, revealing similarities in their geometric and electronic properties. The results demonstrate that nonconventional hydrogen bonding molecules can also form hydrogen bonds, similar to conventional hydrogen bonding molecules.
JOURNAL OF PHYSICAL CHEMISTRY A
(2022)
Article
Engineering, Geological
Shengyuan Song, Qiang Xu, Jianping Chen, Fengyan Wang, Ying Liu, Yufeng Liu
Summary: This study utilizes the DFN model and 3D persistence to investigate the relationship between the REV size and discontinuity information. By analyzing the persistence values extracted from cubes of different sizes, the size effect is evaluated and the REV size is determined, revealing linear relationships between various discontinuity parameters and the REV size.
QUARTERLY JOURNAL OF ENGINEERING GEOLOGY AND HYDROGEOLOGY
(2021)
Article
Andrology
Seda Karabulut, Serol Korkmaz, Ertugrul Gunes, Erol Kabil, Ilknur Keskin, Melek Usta, Gulden Zehra Omurtag
Summary: This study aimed to evaluate the relationship between metals and trace elements in human seminal plasma and semen parameters. The results showed that selenium (Se) was significantly increased in normal semen, suggesting a positive effect on semen parameters.
Article
Biotechnology & Applied Microbiology
Vipul Batra, Vanya Bhushan, Syed Azmal Ali, Parul Sarwalia, Ankit Pal, Seema Karanwal, Subhash Solanki, Arumugam Kumaresan, Rakesh Kumar, Tirtha Kumar Datta
Summary: The study identified over 300 proteins on the ejaculated buffalo sperm surface, most of which were extracellular and involved in immune or reproductive processes. Flow cytometry with six FITC-labelled lectins confirmed glycosylation of these proteins, and various beta-defensins including BuBD-129 and 126 were identified on the sperm surface. The findings suggest that buffalo spermatozoa are heavily glycosylated and that BuBDs may play a role in sperm function and male fertility regulation.
Editorial Material
Medicine, General & Internal
Rossella Cannarella, Andrea Crafa, Aldo E. Calogero
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Sandro La Vignera, Rosita A. Condorelli, Aldo E. Calogero, Rossella Cannarella, Antonio Aversa
Summary: This study prospectively investigates the effects of liraglutide, a GLP1 analog, on reproductive and sexual function in men with metabolic hypogonadism. The results show that liraglutide significantly improves sperm parameters and erectile function, as well as increasing testosterone and sex hormone-binding globulin levels. This suggests that liraglutide is a useful pharmacological treatment for male patients with metabolic hypogonadism.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Claudio Manna, Federica Barbagallo, Francesca Sagnella, Ashraf Farrag, Aldo E. E. Calogero
Summary: The commonly used protocols in assisted reproductive technology (ART) involve long-term embryo culture up to the blastocyst stage, freezing of all embryos, and subsequent transfer one by one. These practices have the potential risks of obstetric and perinatal complications, adverse epigenetic consequences, and ethical-legal concerns regarding frozen embryo storage. To minimize risks, the study suggests selecting a limited number of oocytes for insemination and transferring embryos at the cleaving stage. The results showed a comparable live birth rate to the commonly used protocols in older women with reduced ovarian reserve.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Andrology
Andrea Crafa, Rosita Angela Condorelli, Sandro La Vignera, Aldo Eugenio Calogero, Rossella Cannarella
Summary: This article presents a clinical case of a globozoospermic patient with a new mutation of the DPY19L2 gene and provides recommendations based on a systematic literature review on gene mutations, assisted reproductive techniques, and the risk of genetic abnormalities transmission. The study highlights the importance of genetic evaluation and specific assisted reproductive techniques in managing globozoospermia patients.
WORLD JOURNAL OF MENS HEALTH
(2023)
Review
Biochemistry & Molecular Biology
Rossella Cannarella, Andrea Crafa, Federica Barbagallo, Scott D. D. Lundy, Sandro La Vignera, Rosita A. A. Condorelli, Aldo E. E. Calogero
Summary: This systematic review and meta-analysis examine the differences in H19 gene methylation between patients with abnormal versus normal sperm parameters. The study also explores the impact of age and sperm concentration on H19 methylation using meta-regression analysis. The results indicate that H19 methylation levels are lower in infertile patients, particularly those with oligozoospermia or recurrent pregnancy loss, and are independent of age and sperm concentration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Andrea Crafa, Aldo Eugenio Calogero, Rossella Cannarella, Rosita Angela Condorelli, Antonio Aversa, Sandro La Vignera
Summary: Male infertility and prostate cancer are the most researched andrological diseases, followed by benign prostatic hyperplasia and erectile dysfunction, which are expected to increase in prevalence due to population aging. However, research on inflammation of the accessory sexual glands is relatively scarce.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Livia Basile, Rosita A. Condorelli, Aldo E. Calogero, Rossella Cannarella, Federica Barbagallo, Andrea Crafa, Antonio Aversa, Sandro La Vignera
Summary: Red wine is rich in nutrients and has been the focus of numerous scientific studies. It has been reported that moderate consumption of red wine, with its phenolic and antioxidant properties, can have positive effects on various diseases. Additionally, the ethanol content in red wine has shown various biological properties. However, little is known about the correlation between red wine consumption and male sexual function. This review aimed to evaluate the effects of moderate red wine consumption on erectile function and found potential benefits in patients with erectile dysfunction as well as positive influences on reproductive function through vasorelaxant and antioxidant mechanisms.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Andrea Crafa, Rossella Cannarella, Federica Barbagallo, Claudia Leanza, Roberto Palazzolo, Hunter Ausley Flores, Sandro La Vignera, Rosita A. Condorelli, Aldo E. Calogero
Summary: Vitamin D deficiency and erectile dysfunction are common in males, especially in the elderly, suggesting a possible relationship between the two conditions. Studies indicate that vitamin D affects erectile function by regulating endothelial function and interfering with comorbidities associated with erectile dysfunction. Low levels of vitamin D may worsen erectile function through various mechanisms. However, the quality and heterogeneity of clinical trials evaluating the effects of vitamin D on erectile function and related comorbidities require further investigation.
Review
Biochemistry & Molecular Biology
Federica Barbagallo, Rossella Cannarella, Andrea Crafa, Sandro La Vignera, Rosita A. Condorelli, Claudio Manna, Aldo E. Calogero
Summary: This systematic review and meta-analysis found that a very short abstinence period (within 4 h) has a positive effect on assisted reproductive technique (ART) outcomes, significantly increasing the implantation rate, clinical pregnancy rate, and live birth rate. However, it does not have a significant impact on fertilization rate and miscarriage rate. It suggests that a second ejaculation shortly after the first one can be a simple strategy to improve ART outcomes, particularly in couples involving patients with abnormal sperm parameters.
Review
Health Care Sciences & Services
Rossella Cannarella, Raneen Sawaid Kaiyal, Marta Marino, Sandro La Vignera, Aldo E. Calogero
Summary: The risk of COVID-19 infection is not increased during pregnancy, but pregnant women with COVID-19 have worse clinical outcomes compared to non-pregnant women. Studies on the impact of COVID-19 on pregnancy are heterogeneous, but suggest an increased risk of fetal death and premature delivery.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Andrology
Ramy Abou Ghayda, Rossella Cannarella, Aldo E. Calogero, Rupin Shah, Amarnath Rambhatla, Wael Zohdy, Parviz Kavoussi, Tomer Avidor-Reiss, Florence Boitrelle, Taymour Mostafa, Ramadan Saleh, Tuncay Toprak, Ponco Birowo, Gianmaria Salvio, Gokhan Calik, Shinnosuke Kuroda, Raneen Sawaid Kaiyal, Imad Ziouziou, Andrea Crafa, Nguyen Ho Vinh Phuoc, Giorgio I. Russo, Damayanthi Durairajanayagam, Manaf Al-Hashimi, Taha Abo-Almagd Abdel-Meguid Hamoda, Germar-Michael Pinggera, Ricky Adriansjah, Israel Maldonado Rosas, Mohamed Arafa, Eric Chung, Widi Atmoko, Lucia Rocco, Haocheng Lin, Eric Huyghe, Priyank Kothari, Jesus Fernando Solorzano Vazquez, Fotios Dimitriadis, Nicolas Garrido, Sheryl Homa, Marco Falcone, Marjan Sabbaghian, Hussein Kandil, Edmund Ko, Marlon Martinez, Quang Nguyen, Ahmed M. Harraz, Ege Can Serefoglu, Vilvapathy Senguttuvan Karthikeyan, Dung Mai BaTien, Sunil Jindal, Sava Micic, Marina Bellavia, Hamed Alali, Nazim Gherabi, Sheena Lewis, Hyun Jun Park, Mara Simopoulou, Hassan Sallam, Liliana Ramirez, Giovanni Colpi, Ashok Agarwal
Summary: Artificial intelligence (AI) has made significant progress in the field of medicine and has been applied to various areas. Advances in computer science, medical informatics, robotics, and personalized medicine have facilitated AI's role in modern healthcare. In andrology and reproductive medicine, AI applications such as machine learning, artificial neural networks, and deep learning have shown great potential in diagnosing and treating male infertility, as well as improving patient care.
WORLD JOURNAL OF MENS HEALTH
(2023)
Review
Andrology
Rossella Cannarella, Marta Marino, Rosita A. Condorelli, Sandro La Vignera, Aldo E. Calogero
Summary: Epidemiologists emphasize that male factors account for about half of couple infertility cases, yet the importance of andrologists or endocrinologists in ART centers is undervalued. A lack of comprehensive clinical evaluation for male partners, often limited to semen analysis, performed by laboratory technicians, leads to missed opportunities for identifying treatable causes, recognizing diseases requiring immediate treatment, and detecting genetic diseases in offspring. Integrating medical personnel with expertise in andrology and endocrinology in ART centers is the first step towards precision medicine. It can enhance the success rate of ART, reducing psychological and financial burdens on public health resources and infertile couples. Guideline of scientific societies should acknowledge this possibility.
WORLD JOURNAL OF MENS HEALTH
(2023)
Review
Nutrition & Dietetics
Vincenzo Garofalo, Rosita A. Condorelli, Rossella Cannarella, Antonio Aversa, Aldo E. Calogero, Sandro La Vignera
Summary: This systematic review and meta-analysis examines the relationship between iron deficiency and thyroid function. The analysis reveals that patients with iron deficiency have lower thyroid hormone levels, especially in pregnant women. It also shows that iron deficiency increases the prevalence of thyroid autoantibodies.
Article
Biochemistry & Molecular Biology
Sabrina Bossio, Anna Perri, Raffaella Gallo, Anna De Bartolo, Vittoria Rago, Daniele La Russa, Michele Di Dio, Sandro La Vignera, Aldo E. Calogero, Giovanni Vitale, Antonio Aversa
Summary: Alpha-lipoic acid (ALA) has been shown to inhibit cell growth and reduce viability in prostate cancer cells by inhibiting autophagy and affecting the redox balance system. ALA also reduces cell migration and invasion by regulating signaling pathways. These findings contribute to a better understanding of the potential therapeutic effects of ALA in prostate cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Andrology
Rossella Cannarella, Claudia Leanza, Andrea Crafa, Federica Barbagallo, Sandro La Vignera, Rosita Angela Condorelli, Aldo Eugenio Calogero
Summary: This study examined the impact of MEST gene methylation pattern on sperm parameters in infertile patients and found that MEST gene methylation was higher in infertile patients compared to normal men.
WORLD JOURNAL OF MENS HEALTH
(2023)
