Article
Food Science & Technology
Iva Potocnjak, Lidija Simic, Lara Baticic, Hrvoje Krizan, Robert Domitrovic
Summary: Sinomenine has been found to alleviate kidney injury caused by cisplatin by targeting multiple signaling pathways to reduce oxidative stress, inflammation and apoptosis.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ye Zhao, Qin Jiang, Xuefei Zhang, Xiaoxiao Zhu, Xia Dong, Linyuan Shen, Shunhua Zhang, Lili Niu, Lei Chen, Ming Zhang, Jun Jiang, Daiwen Chen, Li Zhu
Summary: l-Arginine has been shown to reduce muscle injury by regulating the SIRT1-Akt-Nrf2 and SIRT1-FOXO3a-mitochondria apoptosis signaling pathways as a potential nutraceutical.
Review
Biochemistry & Molecular Biology
Suma Elumalai, Udayakumar Karunakaran, Jun-Sung Moon, Kyu-Chang Won
Summary: Metabolic stress impairs pancreatic beta-cell survival and function, which is associated with the imbalance in redox equilibrium and ferroptotic-like malfunction in beta-cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Junmin Zhang, Xinming Li, Zhengjia Zhao, Wenqing Cai, Jianguo Fang
Summary: This article reviews the importance of thioredoxin (Trx) in regulating cancer-related signaling pathways and its potential therapeutic opportunities. Research has shown that Trx participates in multiple signaling pathways that influence cancer development and treatment by modulating the dynamic changes in protein structure and function. Future research directions include further exploring Trx-related signaling pathways and their upstream and downstream regulatory proteins, as well as developing novel anticancer drugs targeting the Trx signaling pathways.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Article
Environmental Sciences
Claudia Daniele Bianco, Fabiana Ourique, Daniela Coelho dos Santos, Rozangela Curi Pedrosa, Maicon Roberto Kviecisnki, Ariane Zamoner
Summary: This study investigated the effects of glyphosate herbicide on the survival and proliferation of glioblastoma cells and found that it may lead to oxidative damage and inflammation, giving the cells an advantage in terms of growth. The study also explored the molecular mechanisms underlying these effects, including the activation of signaling pathways, oxidative imbalance, and inflammation.
ENVIRONMENTAL POLLUTION
(2023)
Article
Nutrition & Dietetics
Qianwen Han, Haiyan Li, Fen Zhao, Ji'an Gao, Xinqi Liu, Biao Ma
Summary: This study investigated the anti-aging effects and mechanism of Auricularia auricula peptides (AAPs) on HepG2 cells. The results showed that AAPs could reduce intracellular reactive oxygen species (ROS) and malondialdehyde (MDA) levels, increase antioxidant enzyme activities, and inhibit senescence. Furthermore, AAPs could also inhibit inflammation through the MAPK/NF-κB signaling pathway, delaying cell senescence.
Article
Medicine, Research & Experimental
Danni Xie, Ting Deng, Zhenwei Zhai, Tao Qin, Caiyou Song, Ying Xu, Tao Sun
Summary: The characteristics of Alzheimer's disease include irreversible memory loss and progressive cognitive decline. Oxidative stress is considered to be a significant factor contributing to brain diseases such as Alzheimer's. Chinese herbal medicine, specifically Moschus, has antioxidant and antiapoptotic effects and has been used for treating various brain-related conditions. This study aims to evaluate the potential neuroprotective effects of Moschus on hydrogen peroxide-induced cellular injury.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Veterinary Sciences
Minglong Bao, Mei Liang, Xinyi Sun, Sahar Ghulam Mohyuddin, Shengwei Chen, Jiaying Wen, Yanhong Yong, Xingbin Ma, Zhichao Yu, Xianghong Ju, Xiaoxi Liu
Summary: Baicalin exerts anti-inflammatory effects by inhibiting the NF-κB signaling pathway and exerts antioxidant effects by activating the Nrf2-HO1 signaling pathway, thereby inhibiting LPS-induced oxidative stress and protecting the normal physiological function of IPEC-J2 cells.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Immunology
Xianbo Liu, He Yang, Zhenning Liu
Summary: Paraquat poisoning is a severe global health issue, particularly in developing countries, with a mortality rate higher than other pesticide poisoning. The potential mechanisms of toxicity are extremely complicated, causing damage in various organs such as lung, liver, and kidney.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Cell Biology
Saixian Shi, Ye Chen, Zhijian Luo, Guojun Nie, Yan Dai
Summary: Doxorubicin is a powerful chemotherapeutic drug used in cancer treatment, but it can cause serious cardiac side effects. Researchers are exploring the molecular mechanisms of doxorubicin-induced cardiomyopathy, focusing on oxidative stress and inflammation.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Environmental Sciences
Yanli Liu, Xia Gong, Juan Wang, Yongxiang Wang, Yong Zhang, Tao Li, Juan Yan, Min Zhou, Benzhong Zhang
Summary: Nickel and its compounds can inhibit cell growth, induce oxidative stress, inflammation, and apoptosis responses, possibly mediated through the P38 and JNK MAPK stress response pathways.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Pharmacology & Pharmacy
Ting-Li Tang, Yan Yang, Lin Guo, Shuang Xia, Bikui Zhang, Miao Yan
Summary: Experimental findings indicate that Sunitinib induces hepatocellular death primarily by inducing apoptosis and autophagy, with the ROS/MAPKs signaling pathway playing a crucial role. Glycyrrhetinic acid can mitigate Sunitinib-induced cell damage by inhibiting apoptosis and autophagy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sajin Zhou, Hongyan Zhu, Piaopiao Xiong, Lei Shi, Weibin Bai, Xiaoling Li
Summary: Oxidative stress damage of pancreatic beta-cells is a crucial factor in the development of type 2 diabetes mellitus. Ganoderma lucidum spore oil functionalized selenium nanoparticles (GLSO@SeNPs) with high stability and uniform particle size were synthesized. The GLSO@SeNPs demonstrated good stability and biocompatibility, and effectively inhibited palmitic-acid-induced apoptosis in INS-1E pancreatic cells. The protective effects of GLSO@SeNPs were mediated through regulation of antioxidant enzymes and MAPK pathway protein expression levels.
Article
Biology
Mengjue Tu, Xingshuo Fan, Jianan Shi, Shengnan Jing, Xiaole Xu, Yuqin Wang
Summary: This study demonstrates that 2-fluorofucose (2FF) can improve cell viability and reduce hydrogen peroxide (H2O2)-induced oxidative damage by inhibiting fucosylation. Furthermore, 2FF enhances antioxidant capacity and suppresses inflammation-associated protein expression through Nrf2/keap1 and NF-kappa B signaling pathways.
Article
Plant Sciences
Xiudong Yang, Zi-Fan Bai, Yan Zhang, Hao Cui, Hong-Li Zhou
Summary: The study demonstrated that flavonoids-rich extract from Bidens bipinnata exhibited protective effects on H2O2-induced pancreatic beta cell damage by influencing the expression of apoptosis-related proteins and regulating cell signaling pathways.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Habeebat Adekilekun Oyewusi, Yuan-Seng Wu, Sher Zaman Safi, Roswanira Abdul Wahab, Mohd Hayrie Mohd Hatta, Kalaivani Batumalaie
Summary: The study found that Withanolide A has the potential to inhibit the activity of alpha-amylase and alpha-glucosidase, and it has good pharmacokinetic properties and bioavailability. Compared to the synthetic drug Acarbose, Withanolide A has better binding to the active sites of the enzymes and exhibits lower binding free energy.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Biochemistry & Molecular Biology
Sher Zaman Safi, Laiba Saeed, Humaira Shah, Zahina Latif, Abid Ali, Muhammad Imran, Nawshad Muhammad, Talha Bin Emran, Vetriselvan Subramaniyan, Ikram Shah Bin Ismail
Summary: This study investigated the stimulatory effect of beta-adrenergic receptors (beta-ARs) on brain-derived neurotropic factor (BDNF) and cAMP response element binding protein (CREB) in Muller cells. The results showed that beta-AR agonists reduced apoptosis, increased BDNF expression, and decreased reactive oxygen species (ROS) production. These findings suggest that beta-ARs play a protective role in Muller cells under high glucose conditions.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Biotechnology & Applied Microbiology
Chandrashekar Thalluri, Ruhul Amin, Jithendar Reddy Mandhadi, Amel Gacem, Talha Bin Emran, Biplab Kumar Dey, Arpita Roy, Mohammed S. Alqahtani, Moamen S. Refat, Sher Zaman Safi, Amnah Mohammed Alsuhaibani
Summary: This study optimized the formulation of Ondansetron tablets by using a central composite design and evaluated various parameters pre- and postcompression. The results showed a strong correlation between the predicted and experimental data, indicating the successful selection of the optimal formulation.
BIOMED RESEARCH INTERNATIONAL
(2022)
Article
Pharmacology & Pharmacy
Srikanth Jeyabalan, Logeshwari Bala, Kavimani Subramanian, Sugin Lal Jabaris, Mahendran Sekar, Ling Shing Wong, Vetriselvan Subramaniyan, Kumarappan Chidambaram, Siew Hua Gan, Nur Najihah Izzati Mat Rani, M. Yasmin Begum, Sher Zaman Safi, Siddharthan Selvaraj, Adel Al Fatease, Ali Alamri, Kamini Vijeepallam, Shivkanya Fuloria, Neeraj Kumar Fuloria, Sinouvassane Djearamane
Summary: This study evaluated the potential therapeutic effect of Morinda citrifolia fruit extract on obsessive-compulsive disorder in mice models. The extract significantly improved behavior tasks and increased serotonin levels without affecting locomotor functions or causing toxicity or abnormalities. These findings suggest that Morinda citrifolia fruit extract could be a potential drug candidate for OCD treatment.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Genetics & Heredity
Muhammad Sadiq Aziz, Aziz-ul-Hasan Aamir, Ajab Khan, Zahid Khan, Syed Qaiser Shah, Sher Zaman Safi, Kalaivani Batumalaie, Hussah M. Alobaid, Abid Ali, Muhammad Imran
Summary: This study found that the G395A polymorphism of the Klotho gene is associated with the risk of type 2 diabetes in the Pashtun population of Pakistan. Additionally, the C1818T and G395A polymorphisms are also associated with high fasting glucose and HbA1c levels in T2DM patients.
Review
Cell Biology
Anandakrishnan Karthic, Arpita Roy, Jaya Lakkakula, Saad Alghamdi, Afnan Shakoori, Ahmad O. Babalghith, Talha Bin Emran, Rohit Sharma, Clara Mariana Goncalves Lima, Bonglee Kim, Moon Nyeo Park, Sher Zaman Safi, Ray Silva de Almeida, Henrique Douglas Melo Coutinho
Summary: Cancer remains one of the deadliest health concerns worldwide, and traditional chemotherapy has limited effectiveness. Novel nano-drug delivery systems, such as cyclodextrin nanocomposites, have the potential to improve drug solubility and biocompatibility. These nanocomposites possess unique physicochemical characteristics that allow better drug accumulation, improved solubility, and stability, offering a targeted approach for cancer cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Microbiology
Shumaila Alam, Mehran Khan, Abdulaziz Alouffi, Mashal M. Almutairi, Shafi Ullah, Muhammad Numan, Nabila Islam, Zaibullah Khan, Ome Aiman, Sher Zaman Safi, Tetsuya Tanaka, Abid Ali
Summary: This study investigated the tick prevalence, host range, genetic diversity, and molecular survey of Anaplasma spp. in different tick species in the southern regions of Khyber Pakhtunkhwa (KP), Pakistan. The results revealed variations in infection rates and genetic characteristics among different tick species, and provided the first molecular level information on Haemaphysalis cornupunctata.
Article
Nanoscience & Nanotechnology
Zuleikha Malik, Nawshad Muhammad, Muhammad Kaleem, Maleeha Nayyar, Asma Saleem Qazi, Danial Qasim Butt, Sher Zaman Safi, Abdul Samad Khan
Summary: This study synthesized and characterized lignin-decorated zinc oxide nanoparticles and incorporated them into resin-modified glass ionomer cement (RMGIC) to enhance their anticariogenic potential and mechanical properties. The experimental groups demonstrated significantly greater anticariogenic potential compared to the control group. The shear bond strength test showed the highest value for the experimental group with the highest nanoparticle concentration, and the microhardness test yielded the highest value for the same group. Evaluation over 28 days indicated sustained anticariogenic potential without detrimental effects on shear bond strength and microhardness.
ACS APPLIED BIO MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Zaib Us Sama, Asif Jamal Khan, Fozia Rehman, Saima Gul, Sher Zaman Safi, Muhammad Imran, Zia Ud Din
Summary: In this study, hydrazone derivatives were synthesized for evaluating their anti-chikungunya activity using computational methods. The electronic density of these molecules was found to concentrate on the central aromatic rings. The docking studies revealed significant interactions between the synthesized compounds and the active site of protein 2vbc. Based on the computational approach, these compounds showed strong potential as anti-chikungunya drugs and should be further investigated.
Review
Chemistry, Medicinal
Namy George, Md. Jawaid Akhtar, Khalid Al Balushi, Sher Zaman Safi, Syed Najmul Hejaz Azmi, Shah Alam Khan
Summary: Proteolysis-targeting technology is a new technique that targets mutated, denatured, and misfolded proteins. Accumulation of these harmful proteins in the brain is a cause of neurodegenerative diseases such as Alzheimer's disease. Developing small molecule inhibitors to target these proteins is challenging due to their undruggable nature. However, the body's protein quality control systems can remove these aggregates. Medicinal chemistry advancements have led to the development of chemical mediated targeted protein degradation techniques, such as PROTACs, which degrade misfolded proteins through the ubiquitin-proteasome system. This article provides an update on the design and advantages/disadvantages of PROTACs as therapeutic modalities for Alzheimer's disease.
MEDICINAL CHEMISTRY RESEARCH
(2023)
Review
Chemistry, Medicinal
Naurah Nabihah Nasir, Mahendran Sekar, Subban Ravi, Ling Shing Wong, Sreenivas Patro Sisinthy, Siew Hua Gan, Vetriselvan Subramaniyan, Kumarappan Chidambaram, Nur Najihah Izzati Mat Rani, M. Yasmin Begum, Mohankumar Ramar, Sher Zaman Safi, Siddharthan Selvaraj, Senthil Kumar Chinna Maruthu, Shivkanya Fuloria, Neeraj Kumar Fuloria, Pei Teng Lum, Sinouvassane Djearamane
Summary: Streptonigrin, an aminoquinone alkaloid derived from Streptomyces flocculus, has potential antitumor and antibiotic effects. Despite its previous use as an anticancer drug being discontinued due to toxicity, recent studies have shown reduced toxicity of streptonigrin and its derivatives while maintaining pharmacological action at lower concentrations. This comprehensive review aims to discuss the prospects of streptonigrin and its derived compounds as interesting target molecules for new drug design, development, and therapy, providing a reference for their development and utilization as pharmaceuticals.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Article
Genetics & Heredity
Dalal Nasser Binjawhar, Alaa T. Alhazmi, Wejdan Nasser Bin Jawhar, Walaa MohammedSaeed, Sher Zaman Safi
Summary: This study aims to investigate the effects of hyperglycemia on oxidative stress and the expression and methylation of the endothelin 1 (ET-1) gene in human umbilical vein endothelial cells (HUVEC). The results showed that hyperglycemia significantly increased reactive oxygen species synthesis and the relative expression of the ET-1 gene, while reducing cell viability. However, there was no significant change in methylation when cells were treated with high and low glucose concentrations.
FRONTIERS IN GENETICS
(2023)
Review
Chemistry, Multidisciplinary
Mohd Hayrie Mohd Hatta, Juan Matmin, Nik Ahmad Nizam Nik Malek, Farah Hidayah Kamisan, Aishah Badruzzaman, Kalaivani Batumalaie, Siew Ling Lee, Roswanira Abdul Wahab
Summary: The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was responsible for the outbreak of coronavirus disease (COVID-19), which has rapidly spread worldwide and claimed millions of lives. Since clinical trials of antiviral drugs for COVID-19 may last even a year before approval, developing alternative approaches using carbon nanotubes (CNTs) becomes mandatory. This article reviews recent applications of CNTs in the prevention, detection, and treatment of COVID-19, highlighting their potential in producing PPE, vaccines, biosensors, and therapeutic strategies.
Article
Pathology
Gaythri Thergarajan, Shamala Devi Sekaran
Summary: Every year, the incidence of dengue fever increases significantly and accounts for 10% of fever cases in children and adolescents in endemic countries. The diagnosis of dengue has been challenging due to its similarity to symptoms of other viruses, and the lack of sensitive diagnostic tools may contribute to the rise in dengue incidence.
EXPERT REVIEW OF MOLECULAR DIAGNOSTICS
(2023)
Article
Polymer Science
Uzma Shahzadi, Rabia Zeeshan, Sobia Tabassum, Hina Khadim, Muhammad Arshad, Arsalan Ahmad Ansari, Sher Zaman Safi, Rana Intisar ul Haq, Anila Asif
Summary: This research presents the synthesis of a novel antibacterial thermo-sensitive hydrogel with potential applications in drug delivery and tissue regeneration. The hydrogel exhibited good biocompatibility and promoted cell migration.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2023)