Article
Biochemistry & Molecular Biology
Mingfa Ling, Lulu Quan, Xumin Lai, Limin Lang, Fan Li, Xiaohua Yang, Yiming Fu, Shengchun Feng, Xin Yi, Canjun Zhu, Ping Gao, Xiaotong Zhu, Lina Wang, Gang Shu, Qingyan Jiang, Songbo Wang
Summary: VEGFB promotes C2C12 myoblast proliferation and differentiation via the VEGFR1-PI3K/Akt signaling pathway, providing new insights into the regulation of skeletal muscle development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Chunlei Guo, Shuang Li, Ang Liang, Mengchao Cui, Yunwei Lou, Hui Wang
Summary: PPA1 is highly expressed in breast cancer and correlated with poor survival in patients. Silencing PPA1 can inhibit breast cancer proliferation and metastasis. PPA1 serves as an activator of the PI3K/AKT/GSK3 beta/Slug-mediated breast cancer progression and is a potential therapeutic target for inhibiting tumor progression.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Qianxu Jin, Jiahui Zhao, Zijun Zhao, Shiyang Zhang, Zhimin Sun, Yunpeng Shi, Hongshan Yan, Yizheng Wang, Liping Liu, Zongmao Zhao
Summary: CAMK1D is expressed at lower levels in glioma tissues and is positively correlated with the WHO classification of gliomas. Knockdown of CAMK1D promotes the proliferation, migration, and invasion of glioma cells, while overexpression has the opposite effect. Mechanistically, CAMK1D regulates glioma cell function through the PI3K/AKT/mTOR pathway. These findings suggest that CAMK1D may serve as a prognostic predictor and a potential therapeutic target for glioma.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Dimitrios Agas, Reem Hanna, Stefano Benedicenti, Nicola De Angelis, Maria Giovanna Sabbieti, Andrea Amaroli
Summary: The study investigates how photobiomodulation by 900-nm wavelengths can induce molecular changes in vitro in pre-osteoblasts, showing that the 980-nm wavelength can regulate the metabolic schedule of the cells by signaling through the PI3K/Akt/Bcl-2 pathway. Differentiation markers were not affected under these conditions, and other parameters did not seem to stimulate the cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Yue Wang, Ying Li, Liang Wang, Buze Chen, Miaolin Zhu, Chunyi Ma, Chunyan Mu, Aibin Tao, Shibao Li, Lan Luo, Ping Ma, Shuai Ji, Ting Lan
Summary: In this study, it was found that cinnamaldehyde (CA) inhibits the proliferation and invasion ability of ovarian cancer cells and plays a role in promoting apoptosis and inhibiting the PI3K/AKT signaling pathway. Additionally, CA also inhibits the EGF-induced EMT process. In vivo experiments showed significant repression of ovarian cancer progression and metastasis by CA.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Yalan Deng, Liqing Lu, Xujun Liang, Jingzhi Li, Dandan Zhu, Huichao Huang, Ye Zhang, Xiangqian Zhang, Yongheng Chen, Xiaojin Liu, Ying Fu
Summary: This study reveals that NNAT is significantly downregulated in hepatocellular carcinoma (HCC), and its downregulation is associated with tumor growth and patient prognosis. The decreased expression of NNAT in HCC is induced by hypermethylation of CpG islands in the promoter region, and hypermethylation is correlated with overall survival of HCC. Moreover, NNAT overexpression inhibits HCC cell proliferation by dysregulating the PI3K-Akt signaling pathway.
Article
Biochemistry & Molecular Biology
Xiang Gao, Wenqu Jiang, Zunliang Ke, Qiwei Huang, Liang Chen, Guobin Zhang, Chao Li, Xiaojun Yu
Summary: Molecular biomarker TRAM2 is overexpressed in glioma and associated with malignancy properties and poorer survival. Silencing of TRAM2 inhibits glioma cell proliferation, invasion, migration, and EMT. TRAM2 is positively associated with the activation of the PI3K/AKT/mTOR signaling pathway.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Cell Biology
Rui Zhao, Yuzhen Ge, Yongjun Gong, Bo Li, Benli Xiao, Shi Zuo
Summary: Hepatocellular carcinoma (HCC) is a major cause of cancer death worldwide. This study found that low expression of NAP1L5 in HCC was associated with shorter survival and disease-free survival. NAP1L5 inhibited the proliferation, migration, and invasion of hepatoma cells, and induced apoptosis. It also inhibited the growth and metastasis of HCC cells in vivo. Mechanistically, NAP1L5 regulated the PI3K/AKT/mTOR signaling pathway by controlling MYH9 to affect the occurrence and development of HCC. NAP1L5 may be a potential target for liver cancer treatment.
Article
Agriculture, Dairy & Animal Science
Jian Wang, Yongzhen Huang, Jiawei Xu, Binglin Yue, Yifan Wen, Xiao Wang, Chuzhao Lei, Hong Chen
Summary: This study reveals the role of PLAG1 in promoting proliferation and inhibiting apoptosis of bovine primary myoblasts through the PI3K-Akt signaling pathway. Additionally, a potential positive feedback regulation between PLAG1 and MI3K-Akt, with miR-1 as a key mediator, is identified.
JOURNAL OF ANIMAL SCIENCE
(2022)
Article
Chemistry, Medicinal
Zheng Wei, Tingting Li, Yanping Sun, Huilin Su, Yuanning Zeng, Qiuhong Wang, Haixue Kuang
Summary: DTA induces autophagy in HaCaT cells, leading to cell senescence and cell cycle arrest, while negatively regulating inflammation by activating autophagy. This may be one of the mechanisms underlying the action of Datura metel L. preparation used for the treatment of psoriasis.
PHYTOTHERAPY RESEARCH
(2021)
Article
Cell Biology
Xudong Xie, Liangcong Hu, Bobin Mi, Adriana C. Panayi, Hang Xue, Yiqiang Hu, Guodong Liu, Lang Chen, Chenchen Yan, Kangkang Zha, Ze Lin, Wu Zhou, Fei Gao, Guohui Liu
Summary: With the increasing global aging population, the prevalence of osteoporosis, especially among postmenopausal women, is on the rise. Developing new treatment options is, therefore, crucial. This study investigated the potential use of AQX-1125, an activator of inositol phosphatase-1 (SHIP1), and found that it demonstrated a protective effect against bone loss in ovariectomized (OVX) mice. This effect was attributed to the promotion of osteogenesis and mineralization and inhibition of osteoclastogenesis in a time- and dose-dependent manner. The protective effect was identified to be SHIP1-dependent, as the inhibition of SHIP1 using RNA interference diminished the osteoprotective effects. Furthermore, in vivo administration of SHIP1 RNA interference resulted in significant bone loss and decreased bone mass. Mechanistically, AQX-1125 upregulated the expression and activity of SHIP1, consequently upregulating the phosphorylation levels of PI3K and Akt, leading to the promotion of osteoblast-related gene expressions and the inhibition of NF-kappa B signaling and osteoclastogenesis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Environmental Sciences
Lulu Niu, Wenwen Li, Xin Chen, Xiaosan Su, Jingjing Dong, Quanyang Liao, Xuhong Zhou, Shaoqing Shi, Ruifen Sun
Summary: The active constituent 1-Monopalmitin (1-Mono) in Mougeotia nummuloides and Spirulina major inhibits the proliferation of lung cancer cells and induces apoptosis through the PI3K/Akt pathway. It also suppresses autophagy, and combining with autophagy inhibitor Chloroquine enhances its cytotoxicity.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Donghee Kim, Hyo-Jin Kim, Jin-Ok Baek, Joo-Young Roh, Hee-Sook Jun
Summary: The study revealed that LPAR1/3 antagonist alleviates IMQ-induced psoriasis-like symptoms in mice, with LPAR1 signaling playing a crucial role in cell cycle progression in keratinocytes via the ROCK2/PI3K/AKT pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Yanqing Ye, Maosheng Liu, Fengfei Wu, Shiyu Ou, Weidong Wang, Jieying Fei, Fang Xie, Lan Bai
Summary: TRMT6 is overexpressed in HCC tissues and associated with TNM stage, T classification, and N classification. Overexpression of TRMT6 promotes HCC cell proliferation through the PI3K/AKT/mTOR axis in vivo and in vitro. Inhibition of TRMT6 reduces tumor growth and is related to the PI3K/AKT pathway.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Lan Ma, Ruixue Zhang, Demin Li, Tingting Qiao, Xiaoying Guo
Summary: Fluoride inhibits chondrocyte proliferation and promotes autophagy through the PI3K/AKT/mTOR signaling pathway in chondrogenesis. The study also showed that fluoride downregulates the mTOR signaling pathway-related genes and is associated with changes in autophagy-related gene expressions. MHY1485, a small-molecular mTOR activator, can reverse the fluoride-induced promotion of autophagy and recover the downregulation of proliferative chondrocyte markers induced by fluoride in chondrogenic cells.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Cell Biology
Xiao Lin, Ting Zhu, Feng Xu, Jia-Yu Zhong, Fuxingzi Li, Su-Kang Shan, Feng Wu, Bei Guo, Ming-Hui Zheng, Yi Wang, Qiu-Shuang Xu, Xiao-Bo Liao, Hong-Yu Lu, Xu-Biao Xie, Ling-Qing Yuan
Summary: This study found that plasma exosomes from ESRD patients significantly promoted vascular smooth muscle cells calcification, while renal transplantation partially attenuated this procalcification effect. Fetuin-A and MGP were decreased, but Annexin-A2 was increased in ESRD-Ex, and renal transplantation could increase the level of Fetuin-A rather than MGP. The levels of Fetuin-A and MGP in plasma exosomes were negatively while the levels of Annexin-A2 in plasma exosomes were positively correlated to coronary artery calcification scores (CACS).
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Li-Min Lei, Xiao Lin, Feng Xu, Su-Kang Shan, Bei Guo, Fu-Xing-Zi Li, Ming-Hui Zheng, Yi Wang, Qiu-Shuang Xu, Ling-Qing Yuan
Summary: Exosomes are extracellular vesicles that play a crucial role in delivering signal molecules from donor cells to recipient cells, with a cargo that includes proteins, DNA, and RNA targeting recipient tissues and organs, influencing disease development. Research indicates that exosomes are significant in the development of insulin resistance caused by obesity, showing promise for diagnosis and therapy of insulin resistance.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Orthopedics
Hong-Li Li, Yi Shen, Li-Hua Tan, Song-Bo Fu, Ru-Chun Dai, Ling-Qing Yuan, Zhi-Feng Sheng, Zhong-Jian Xie, Xian-Ping Wu, Er-Yuan Liao, Xu-Lei Tang, Xi-Yu Wu
Summary: This study investigated the relationship between BMD and risk of fragility fracture in native Chinese population. The findings showed that decreasing BMD measurement parameters and anthropometric indicators increased the risk of clinical fragility fracture, with variations in fracture HR based on gender and site.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Cell Biology
Feng Xu, Jia-Yu Zhong, Bei Guo, Xiao Lin, Feng Wu, Fu-Xing-Zi Li, Su-Kang Shan, Ming-Hui Zheng, Yi Wang, Qiu-Shuang Xu, Li-Min Lei, Chang-Ming Tan, Xiao-Bo Liao, Ling-Qing Yuan
Summary: The study found that H19 plays a promoting role in arterial medial calcification, functioning as a competing endogenous RNA for miR-140-5p and activating the ERK1/2 and p38MAPK signaling pathways induced by Satb2.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Xiao Lin, Muhammad Hasnain Ehsan Ullah, Xiong Wu, Feng Xu, Su-Kang Shan, Li-Min Lei, Ling-Qing Yuan, Jun Liu
Summary: This review summarizes the cerebro-cardiovascular risk in primary aldosteronism (PA) and emphasizes the harmful effects of excess aldosterone on target organs. Both surgical and medical treatments show long-term benefits in improving cerebro-cardiovascular outcomes and reducing mortality. Understanding these risks is essential for early diagnosis and treatment.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Multidisciplinary Sciences
Zhen-Xing Wang, Zhong-Wei Luo, Fu-Xing-Zi Li, Jia Cao, Shan-Shan Rao, Yi-Wei Liu, Yi-Yi Wang, Guo-Qiang Zhu, Jiang-Shan Gong, Jing-Tao Zou, Qiang Wang, Yi-Juan Tan, Yan Zhang, Yin Hu, You-You Li, Hao Yin, Xiao-Kai Wang, Ze-Hui He, Lu Ren, Zheng-Zhao Liu, Xiong-Ke Hu, Ling-Qing Yuan, Ran Xu, Chun-Yuan Chen, Hui Xie
Summary: This study uncovers the role of extracellular vesicles from bone matrix as a messenger in the development of osteoporosis and vascular calcification (calcification paradox) during skeletal aging and menopause by transferring miR-483-5p and miR-2861.
NATURE COMMUNICATIONS
(2022)
Editorial Material
Endocrinology & Metabolism
Bei Guo, Ling-Qing Yuan
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Yun-Yun Wu, Su-Kang Shan, Xiao Lin, Feng Xu, Jia-Yu Zhong, Feng Wu, Jia-Yue Duan, Bei Guo, Fu-Xing-Zi Li, Yi Wang, Ming-Hui Zheng, Qiu-Shuang Xu, Li-Min Lei, Wen-Lu Ou-Yang, Ke-Xin Tang, Chang-Chun Li, Muhammad Hasnain Ehsan Ullah, Ling-Qing Yuan
Summary: This review introduces the prevalence of vascular calcification in various diseases and the impact of the bidirectional interactions between vascular cells and their microenvironment on the calcification process. Additionally, the review highlights the significant role of exosomes in cardiovascular disease.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cell Biology
Xiao Lin, Su-Kang Shan, Feng Xu, Jia-Yu Zhong, Feng Wu, Jia-Yue Duan, Bei Guo, Fu-Xing-Zi Li, Yi Wang, Ming-Hui Zheng, Qiu-Shuang Xu, Li-Min Lei, Wen-Lu Ou-Yang, Yun-Yun Wu, Ke-Xin Tang, Muhammad Hasnain Ehsan Ullah, Xiao-Bo Liao, Ling-Qing Yuan
Summary: Exosomal miR-670-3p derived from ECs can promote arterial calcification by targeting IGF-1, which may serve as a potential therapeutic target for arterial calcification in ESRD patients.
CELL DEATH & DISEASE
(2022)
Article
Biotechnology & Applied Microbiology
Bei Guo, Su-Kang Shan, Feng Xu, Xiao Lin, Fu-Xing-zi Li, Yi Wang, Qiu-Shuang Xu, Ming-Hui Zheng, Li-Min Lei, Chang-Chun Li, Zhi-Ang Zhou, Muhammad Hasnain Ehsan Ullah, Feng Wu, Xiao-Bo Liao, Ling-Qing Yuan
Summary: The pathogenesis of vascular calcification in diabetic patients is still not clear. In this study, it was found that small extracellular vesicles (sEVs) secreted by human umbilical vein endothelial cells (HUVECs) stimulated with advanced glycation end-products (AGEs) can target and regulate the calcification-related signaling pathway through miR-126-5p, inhibiting the osteogenic differentiation of vascular smooth muscle cells (VSMCs). Knockdown of miR-126-5p in HUVECs attenuated the anti-calcification effect of sEVs in a mouse model of type 2 diabetes.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Endocrinology & Metabolism
Xi-Yu Wu, Hong-Li Li, Yi Shen, Li-Hua Tan, Ling-Qing Yuan, Ru-Chun Dai, Hong Zhang, Yi-Qun Peng, Zhong-Jian Xie, Zhi-Feng Sheng
Summary: The study found a significant positive correlation between body surface area (BSA) and bone mineral density (BMD) in both male and female fracture patients. Decreased BSA may be a potential new risk factor for osteoporotic fractures in Chinese men.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Ye-Chi Cao, Su-Kang Shan, Bei Guo, Chang-Chun Li, Fu-Xing-Zi Li, Ming-Hui Zheng, Qiu-Shuang Xu, Yi Wang, Li-Min Lei, Ke-Xin Tang, Wen-Lu Ou-Yang, Jia-Yue Duan, Yun-Yun Wu, Muhammad Hasnain Ehsan Ullah, Zhi-Ang Zhou, Feng Xu, Xiao Lin, Feng Wu, Xiao-Bo Liao, Ling-Qing Yuan
Summary: Histone methylation modification may play a key role in the development of vascular calcification, which involves various complex pathophysiological processes. Comprehensive research on the role and mechanism of lysine methylation modification in VC is crucial for identifying new therapeutic targets and developing new drugs.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Chang-Chun Li, Muhammad Hasnain Ehsan Ullah, Xiao Lin, Su-Kang Shan, Bei Guo, Ming-Hui Zheng, Yi Wang, Fuxingzi Li, Ling-Qing Yuan
Summary: The incidence of thyroid cancer has increased, particularly in women with papillary thyroid cancer. Although the mortality rate of thyroid cancer has remained stable or declined, the clinical prognosis of papillary thyroid cancer still poses challenges.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Editorial Material
Endocrinology & Metabolism
Su-Kang Shan, Tong Yan, Ling-Qing Yuan
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Yan-Lin Wu, Zheng-Jun Lin, Chang-Chun Li, Xiao Lin, Su-Kang Shan, Bei Guo, Ming-Hui Zheng, Fuxingzi Li, Ling-Qing Yuan, Zhi-hong Li
Summary: Epigenetics, which regulates gene expression, plays a critical role in metabolic diseases. The term 'epigenetics' was proposed in 1942 and has since made significant progress with the development of technologies. There are four main epigenetic mechanisms, including DNA methylation, histone modification, chromatin remodelling, and noncoding RNA (ncRNA), which have different effects on metabolic diseases. Understanding epigenetics can be applied to diagnosing and treating metabolic diseases, including the use of epigenetic biomarkers, drugs, and editing.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
