Article
Biochemistry & Molecular Biology
Sofia Persson, Kumari A. Ubhayasekera, Jonas Bergquist, Sahruh Turkmen, Inger Sundstroem Poromaa, Evangelia Elenis
Summary: Polycystic ovary syndrome (PCOS) is a common endocrine disorder among women, and hyperandrogenism can cause psychological morbidity and impaired quality of life. This study aimed to investigate whether hyperandrogenism persists into midlife and its impact on quality of life.
Article
Medicine, General & Internal
Valentin Borzan, Elisabeth Lerchbaum, Cornelia Missbrenner, Annemieke C. Heijboer, Michaela Goschnik, Christian Trummer, Verena Theiler-Schwetz, Christoph Haudum, Roswitha Gumpold, Natascha Schweighofer, Barbara Obermayer-Pietsch
Summary: The study found that women with hyperandrogenism have a higher risk of developing insulin resistance, even without other PCOS symptoms. It is recommended to adopt different diagnostic and therapeutic approaches for PCOS phenotypes to consider varying risks of developing metabolic diseases.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Ali Aflatounian, Valentina Rodriguez Paris, Dulama Richani, Melissa C. Edwards, Blake J. Cochran, William L. Ledger, Robert B. Gilchrist, Michael J. Bertoldo, Lindsay E. Wu, Kirsty A. Walters
Summary: PCOS is characterized by reproductive and endocrine abnormalities, with metabolic dysregulation. Recent study found that treating obese, pre-diabetic women with NMN could improve skeletal muscle insulin sensitivity. The research on DHT-induced PCOS mouse model showed that NMN treatment could normalize NAD levels in muscle, leading to the improvement of metabolic dysfunction and insulin sensitivity.
MOLECULAR METABOLISM
(2022)
Article
Multidisciplinary Sciences
Leili Rahmatnezhad, Lida Moghaddam-Banaem, Tahereh Lak, Afshin Shiva, Javad Rasuli
Summary: This study aimed to determine the levels of free androgen index (FAI) and its association with oxidative stress and insulin resistance (IR) in polycystic ovary syndrome (PCOS) patients. The prevalence of the four PCOS phenotypes in 160 participants was determined, and it was found that phenotype C had the highest FAI levels. In linear regression analysis, PCOS phenotype, follicle-stimulating hormone (FSH) levels, and malondialdehyde (MDA) levels were significantly related to FAI, while homeostatic model assessment for insulin resistance (HOMA-IR) was not associated with FAI.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Vittorio Unfer, Michele Russo, Cesare Aragona, Gabriele Bilotta, Mario Montanino Oliva, Mariano Bizzarri
Summary: This study aimed to investigate the effects of myo-Inositol treatment on different phenotypes of polycystic ovary syndrome (PCOS). Through a retrospective study, it was found that myo-Inositol significantly improved metabolic and endocrine parameters in patients with hyperandrogenic PCOS, but had negligible effects on patients with non-hyperandrogenic PCOS.
Article
Cell Biology
Enrico Carmina, Rosa Alba Longo
Summary: It is well known that some women with PCOS have excessive adrenal androgen production, which is generally associated with ovarian hyperandrogenism. This study found that adrenal hyperandrogenism is more common in non-classic PCOS phenotypes and is generally part of a generalized higher production of androgens in a subgroup of PCOS patients. However, other factors may increase adrenal androgen production and influence the clinical expression of the syndrome.
Article
Multidisciplinary Sciences
Francis de Zegher, Marta Diaz, Joan Villarroya, Montserrat Cairo, Abel Lopez-Bermejo, Francesc Villarroya, Lourdes Ibanez
Summary: The study found that young patients with early PCOS may have a relative deficit of GDF15, explaining their difficulties in controlling body adiposity. SPIOMET treatment can increase GDF15 concentrations and reduce inflammation levels.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Irene E. Sucquart, Ruchi Nagarkar, Melissa C. Edwards, Valentina Rodriguez Paris, Ali Aflatounian, Michael J. Bertoldo, Rebecca E. Campbell, Robert B. Gilchrist, Denovan P. Begg, David J. Handelsman, Vasantha Padmanabhan, Richard A. Anderson, Kirsty A. Walters
Summary: PCOS is a prevalent endocrine condition with a range of endocrine, reproductive, and metabolic abnormalities; Androgen actions play a key role in PCOS pathogenesis; NK3R antagonism may be beneficial in treating adverse metabolic features associated with PCOS and support the development of novel therapeutic strategies.
Article
Endocrinology & Metabolism
F. Fruzzetti, T. Fidecicchi, E. Benelli, F. Baldari, M. Tonacchera
Summary: This study aims to determine which parameters, including hyperandrogenism, SHBG, and BMI, can better predict metabolic changes in women with PCOS. The results suggest that BMI is a good predictor of metabolic alterations in these women.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Article
Psychiatry
Han Lin, Mingxing Liu, Dongmei Zhong, Ernest Hung Yu Ng, Jianping Liu, Juan Li, Yu Shi, Chunren Zhang, Xiaohui Wen, Zhefen Mai, Miaoxian Ou, Hongxia Ma
Summary: The study found that the prevalence of anxiety-like and depression-like behaviors among PCOS patients was 26.1% and 52.0%, respectively. These behaviors were associated with factors such as age, body image-related factors, hyperandrogenism-related factors, and metabolic factors. Body image-related factors and hyperandrogenism-related factors were related to both anxiety-like and depression-like behaviors in both infertile and fertile PCOS patients.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Obstetrics & Gynecology
Orquidia A. Torres, Elizabeth Miller, Selma F. Witchel
Summary: There were inconsistencies in diagnosing polycystic ovary syndrome (PCOS) among adolescent medicine providers, but an educational intervention based on international consensus recommendations improved awareness of diagnostic criteria. However, there is still room for improvement in medical record documentation and the use of "at risk for PCOS" terminology.
JOURNAL OF PEDIATRIC AND ADOLESCENT GYNECOLOGY
(2021)
Article
Medicine, General & Internal
Kim van der Ham, Maria P. H. Koster, Birgitta K. Velthuis, Ricardo P. J. Budde, Bart C. J. M. Fauser, Joop S. E. Laven, Yvonne V. Louwers
Summary: Understanding the cardiovascular disease (CVD) risk for women with polycystic ovary syndrome (PCOS) is crucial, and a study comparing cardiometabolic profiles in different PCOS groups found that women with hyperandrogenism during their reproductive years exhibited an unfavorable cardiometabolic profile during their post-reproductive years, even if they transitioned to a normoandrogenic status. The study also found that the HA-HA and HA-NA groups had higher body mass indexes, blood pressure, prevalence of hypertension, serum triglycerides, and insulin levels, as well as lower levels of HDL cholesterol compared to the NA-NA group.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Katherine VanHise, Jessica L. Chan, Sahar Wertheimer, Roy G. Handelsman, Ekaterina Clark, Rae Buttle, Erica T. Wang, Ricardo Azziz, Margareta D. Pisarska
Summary: This study compares women with PCOS in Alabama and California and finds geographical differences in hormonal and metabolic parameters. Women with PCOS in Alabama are more likely to have hirsutism and metabolic dysfunction, while women with PCOS in California are more likely to have hyperandrogenemia.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Obstetrics & Gynecology
Neena Malhotra, Reeta Mahey, Rohitha Cheluvaraju, Keerthana Rajasekaran, Deeksha Patkar, Priyanka Prabhakar, Monika Rajput, Ashish Upadhyay
Summary: This study evaluated the serum AMH levels among different PCOS phenotypes and found that high AMH levels are associated with worse clinical, endocrinological, and metabolic parameters. The ROC analysis identified a cutoff value of >= 6.06 ng/mL for the diagnosis of PCOS. These findings can be used to guide treatment response, individualized management, and prediction of reproductive and long-term metabolic outcomes.
REPRODUCTIVE SCIENCES
(2023)
Article
Genetics & Heredity
Xinyue Ma, Zhao Wang, Changming Zhang, Yuehong Bian, Xin Zhang, Xin Liu, Yongzhi Cao, Yueran Zhao
Summary: The study revealed associations between certain single-nucleotide polymorphisms in the FKBP5 gene and PCOS with hyperandrogenism, suggesting a potential genetic influence on the development of these conditions.
BMC MEDICAL GENOMICS
(2022)
Article
Endocrinology & Metabolism
Nichole R. Kelly, Lauren B. Shomaker, Courtney K. Pickworth, Sheila M. Brady, Amber B. Courville, Shanna Bernstein, Natasha A. Schvey, Andrew P. Demidowich, Ovidiu Galescu, Susan Z. Yanovski, Marian Tanofsky-Kraff, Jack A. Yanovski
Article
Psychology, Developmental
Natasha A. Schvey, Lauren B. Shomaker, Nichole R. Kelly, Courtney K. Pickworth, Omni Cassidy, Ovidiu Galescu, Andrew P. Demidowich, Sheila M. Brady, Marian Tanofsky-Kraff, Jack A. Yanovski
JOURNAL OF ADOLESCENT HEALTH
(2016)
Article
Endocrinology & Metabolism
Ovidiu Galescu, Amrit Bhangoo, Svetlana Ten
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2013)
Article
Pediatrics
R. M. Radin, L. B. Shomaker, N. R. Kelly, C. K. Pickworth, K. A. Thompson, S. M. Brady, A. Demidowich, O. Galescu, A. M. Altschul, L. M. Shank, S. Z. Yanovski, M. Tanofsky-Kraff, J. A. Yanovski
Article
Psychology, Clinical
Camden E. Matherne, Marian Tanofsky-Kraff, Anne M. Altschul, Lisa M. Shank, Natasha A. Schvey, Sheila M. Brady, Ovidiu Galescu, Andrew P. Demidowich, Susan Z. Yanovski, Jack A. Yanovski
Article
Pediatrics
Ovidiu Galescu, Minu George, Sudhakar Basetty, Iuliana Predescu, Anil Mongia, Svetlana Ten, Amrit Bhangoo
INTERNATIONAL JOURNAL OF PEDIATRICS
(2012)