Article
Rheumatology
Linda Hartman, Maurizio Cutolo, Reinhard Bos, Daniela Opris-Belinski, Marc R. Kok, Hanneke J. R. M. Griep-Wentink, Ruth Klaasen, Cornelia F. Allaart, George A. W. Bruyn, Hennie G. Raterman, Marieke J. H. Voshaar, Nuno Gomes, Rui M. A. Pinto, L. Thomas Klausch, Willem F. Lems, M. Boers
Summary: The majority of older patients with RA in the trial appeared to be adherent to medication according to pill count, while results from caps monitoring conflicted with those of pill counts.
Article
Multidisciplinary Sciences
Alice P. McCloskey, Andrew Lunn, Michael J. Traynor, Emma J. Lim, Yincent Tse, Philippa G. McCabe, Ravi D. Mistry, Nicola Vasey, Ailsa Pickering, Adam P. Rathbone
Summary: This study aimed to explore UK student pharmacists' views on e-learning to support swallowing solid oral dosage forms. The results showed that most students believed that e-learning could help them teach patients to swallow pills correctly. However, further research is needed to determine whether these skills can be effectively applied in clinical settings.
Article
Medicine, General & Internal
Michel Azizi, Kintur Sanghvi, Manish Saxena, Philippe Gosse, John P. Reilly, Terry Levy, Lars C. Rump, Alexandre Persu, Jan Basile, Michael J. Bloch, Joost Daemen, Melvin D. Lobo, Felix Mahfoud, Roland E. Schmieder, Andrew S. P. Sharp, Michael A. Weber, Marc Sapoval, Pete Fong, Atul Pathak, Pierre Lantelme, David Hsi, Sripal Bangalore, Adam Witkowski, Joachim Weil, Benjamin Kably, Neil C. Barman, Helen Reeve-Stoffer, Leslie Coleman, Candace K. McClure, Ajay J. Kirtane
Summary: Renal denervation through ultrasound treatment shows promising results in reducing blood pressure for patients with resistant hypertension, with greater effectiveness compared to a sham procedure within 2 months and similar safety outcomes. This may provide an alternative approach for patients with resistant hypertension to avoid adding more antihypertensive medications.
Article
Public, Environmental & Occupational Health
Peter R. Chai, Georgia R. Goodman, Olivia Bronzi, Gerard Gonzales, Alejandro Baez, Maria J. Bustamante, Jesse Najarro, Yassir Mohamed, Matthew C. Sullivan, Kenneth H. Mayer, Edward W. Boyer, Conall O'Cleirigh, Rochelle K. Rosen
Summary: Qualitative interviews were conducted with 15 MSM to investigate their experiences using a digital pill system (DPS) to measure PrEP adherence, finding that most participants found the system easy to integrate into their daily routines and suggested some improvements for long-term use.
Article
Peripheral Vascular Disease
Federico Rea, Gabriella Morabito, Laura Savare, Atul Pathak, Giovanni Corrao, Giuseppe Mancia
Summary: The objective of this study was to compare adherence to antihypertensive treatment between patients prescribed a three-drug single-pill combination and a combination of two drugs plus a separate third drug. The results showed that patients using the three-drug single-pill combination had higher adherence to treatment.
JOURNAL OF HYPERTENSION
(2023)
Article
Pharmacology & Pharmacy
Marlous Langendoen-Gort, Femke Rutters, Danielle Huijts, Petra J. M. Elders, Caroline B. Terwee, Jacqueline G. Hugtenburg
Summary: This study aimed to assess the validity of an announced telephone pill count in people with type 2 diabetes or cardiovascular disease by comparing it to a home-visit pill count. The results showed that the telephone pill count was highly consistent with the home-visit pill count, and a single pill count was sufficient.
CLINICAL PHARMACOLOGY IN DRUG DEVELOPMENT
(2023)
Article
Endocrinology & Metabolism
Megumi Shiomi, Momoka Kurobuchi, Yoichi Tanaka, Tesshu Takada, Katsuya Otori
Summary: This study found that poor medication adherence in patients with type 2 diabetes mellitus was independently associated with having a lower number of chronic diseases and taking a higher number of oral hypoglycemic agents.
Review
Health Care Sciences & Services
Peter R. Chai, Clint Vaz, Georgia R. Goodman, Hannah Albrechta, Henwei Huang, Rochelle K. Rosen, Edward W. Boyer, Kenneth H. Mayer, Conall O'Cleirigh
Summary: Digital pill systems are a novel and direct method of measuring adherence, providing instantaneous adherence support. Research based on clinical trials and qualitative investigations has shown the potential of digital pill systems in measuring medication adherence and improving adherence.
Article
Integrative & Complementary Medicine
Catherine S. Nagawa, Jessica A. Palakshappa, Rajani S. Sadasivam, Thomas K. Houston
Summary: This study utilized data from the National Health and Nutrition Examination Survey to investigate the relationship between herbal or dietary supplement (HDS) use, prescribed antihypertensive medication use, and blood pressure control in hypertensive adults. The results showed that overall HDS use prevalence was 62%, and using hypertension HDS was associated with improved blood pressure control. Further research is needed to understand why HDS use is linked to better blood pressure control.
JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE
(2021)
Article
Medicine, Research & Experimental
Jidong Sung, Kye Taek Ahn, Byung-Ryul Cho, Sung Yun Lee, Byung Jin Kim, Dae Kyeong Kim, Joong-il Park, Wang-Soo Lee
Summary: The study confirmed that a single-pill combination for hypertension treatment leads to better adherence compared to an equivalent two-pill regimen, which suggests that reducing pill burden can improve patient compliance to medication.
CTS-CLINICAL AND TRANSLATIONAL SCIENCE
(2021)
Article
Orthopedics
Cedric Bender, Lucy Dove, Annina B. Schmid
Summary: Neurological testing is crucial for screening and diagnosing suspected peripheral neuropathies, and detecting changes in nerve function can directly impact treatment decisions. However, there is significant inconsistency in the content and methods of bedside neurological examinations. These examinations are often used as screening tools but not fully utilized for monitoring progress or deterioration. This viewpoint advocates for better integration of neurological examinations within a clinical reasoning framework, highlighting challenges faced by clinicians and proposing ways to overcome them in practice.
JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY
(2023)
Article
Medicine, Research & Experimental
Federico Rea, Laura Savare, Giovanni Corrao, Giuseppe Mancia
Summary: Patients who were prescribed a single-pill combination of statin/ezetimibe were more likely to exhibit good adherence and less likely to have poor adherence to treatment compared to those prescribed a two-pill combination. This was associated with a decreased risk of cardiovascular events in patients with high adherence.
ADVANCES IN THERAPY
(2021)
Article
Medicine, General & Internal
Matthew P. Genelin, Laura J. Helmkamp, John F. Steiner, Julie A. Maertens, Rebecca Hanratty, Suma Vupputuri, Edward P. Havranek, L. Miriam Dickinson, Irene Blair, Stacie L. Daugherty
Summary: This study examined the association between medication organization strategies at home and medication adherence. It found that combining same prescriptions was associated with lower adherence as measured by pill counts. Understanding patients' medication organization strategies is important for clinicians and researchers in assessing patient adherence.
PATIENT PREFERENCE AND ADHERENCE
(2023)
Article
Gastroenterology & Hepatology
Adam M. Awe, Victoria R. Rendell, Meghan G. Lubner, Sharon Weber, Emily R. Winslow
Summary: The study showed a strong correlation between unidimensional size and volume/surface area, but weaker correlations for cysts in the 1-2cm and 2-3cm range. Volume and surface areas varied widely within unidimensional size groups, and estimated volume changes poorly predicted actual changes in volume.
Article
Business
Jose M. Labeaga, Ester Martinez-Ros, Amparo Sanchis, Juan A. Sanchis
Summary: This study investigates whether the persistence of tax credits is positively related to product innovation outcomes. The results indicate that the number of product innovations positively depends on tax credit persistence only for SMEs, which provides important insights for firms.
TECHNOLOGICAL FORECASTING AND SOCIAL CHANGE
(2021)
Article
Otorhinolaryngology
Flora Yan, Dylan A. Levy, Chun-Che Wen, Cathy L. Melvin, Marvella E. Ford, Paul J. Nietert, Phayvanh P. Pecha
Summary: Rural-dwelling children experience longer wait times and driving distance to tonsillectomy with or without adenoidectomy. This study suggests that rurality may be a potential barrier to surgical intervention, highlighting the need for further investigation into geographic access as an important determinant of care in pediatric SDB.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2022)
Article
Public, Environmental & Occupational Health
Melanie L. Davis, Brian Neelon, Paul J. Nietert, Lane F. Burgette, Kelly J. Hunt, Andrew B. Lawson, Leonard E. Egede
Summary: This study highlights the importance of accounting for spatial heterogeneity in propensity score analysis, and suggests the need for clinical care and management strategies that are culturally sensitive and racially inclusive. Incorporating spatial random effects improves inferences and reduces bias, especially when dealing with unmeasured geographic confounders. The results demonstrate the impact of geographic clustering on racial disparities in diabetes specialty care among military veterans.
INTERNATIONAL JOURNAL OF HEALTH GEOGRAPHICS
(2021)
Article
Psychiatry
Zachary D. Zuschlag, Ebele Compean, Paul Nietert, Steven Lauzon, Mark Hamner, Zhewu Wang
Summary: The study found that the absence of the 10R/10R genotype of the DAT1 gene is associated with an increased risk of developing PTSD and higher CAPS total scores. This suggests that certain genotypes of the DAT1 gene may play a role in the development of PTSD in combat veterans.
PSYCHIATRY RESEARCH
(2021)
Article
Genetics & Heredity
Janardan P. Pandey, Paul J. Nietert, Ronald T. Kothera, Lisa L. Barnes, David A. Bennett
Summary: In European American individuals, neither GM nor HLA alleles were associated with the development of Alzheimer's disease (AD) individually or epistatically. However, in African American individuals, there was a significant interaction between the presence of GM 3 and the HLA-C allele, leading to a greater likelihood of developing AD. This suggests that specific GM and HLA alleles may interact to contribute to the risk of AD.
NEUROLOGY-GENETICS
(2021)
Article
Hematology
Nadirah El-Amin, Steven D. Lauzon, Paul J. Nietert, Julie Kanter
Summary: Individuals with sickle cell disease are at higher risk of venous thrombo-embolism, including pulmonary embolisms, with high mortality rates. Current lack of validated models for predicting PEs leads to frequent CT scans. This study aimed to evaluate clinical biomarkers, including the Wells score, to create a more accurate diagnostic algorithm for predicting PEs in SCD patients.
BRITISH JOURNAL OF HAEMATOLOGY
(2021)
Article
Respiratory System
Janardan P. Pandey, Aryan M. Namboodiri, Paul J. Nietert, Michael R. Knowles, Rhonda G. Pace, Gerald B. Pier
Summary: The study found that immunoglobulin GM and KM genotypes influence the humoral immune response to LPS O, alginate, and PNAG antigens in CF patients, potentially offering novel immunotherapeutic approaches against P. aeruginosa.
JOURNAL OF CYSTIC FIBROSIS
(2021)
Article
Pediatrics
Mileka Gilbert, Beatrice Goilav, Joyce J. Hsu, Paul J. Nietert, Esra Meidan, Annabelle Chua, Stacy P. Ardoin, Scott E. Wenderfer, Emily von Scheven, Natasha M. Ruth
Summary: The study found that there were significant differences in treatment choices between pediatric rheumatologists and nephrologists in treating refractory proliferative LN or LN flare, with rheumatologists more often choosing rituximab. More research is needed to understand the reasons behind this disparity. Collaborative efforts in developing consensus treatment plans for pediatric LN are crucial.
PEDIATRIC RHEUMATOLOGY
(2021)
Article
Immunology
Samar M. M. Hammad, Olivia C. Harden, Dulaney A. Wilson, Waleed O. Twal, Paul J. Nietert, Jim C. Oates
Summary: SLE is a chronic autoimmune disease with African American SLE patients showing higher levels of certain sphingolipids, which are correlated with the severity of atherosclerosis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Neurosciences
Janardan P. Pandey, Aryan M. Namboodiri, Paul J. Nietert, Lisa L. Barnes, David A. Bennett
Summary: The study revealed that FCGRIIB and PILRA genotypes may contribute to the development of Alzheimer's disease, particularly the significant impact of the FCGRIIB C allele in African Americans.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Health Care Sciences & Services
Steven D. Lauzon, Wenle Zhao, Paul J. Nietert, Jody D. Ciolino, Michael D. Hill, Viswanathan Ramakrishnan
Summary: Minimization is a common method for controlling baseline covariate imbalance at the randomization phase of clinical trials, but it may not preserve allocation randomness as well as other methods, making it vulnerable to predictability and bias. In comparison, minimal sufficient balance method has been found to have the least impact on power and bias in covariate-adjusted analyses, making it a recommended alternative to minimization in clinical trials.
STATISTICAL METHODS IN MEDICAL RESEARCH
(2022)
Article
Substance Abuse
Xingbao Li, Benjamin A. Toll, Matthew J. Carpenter, Paul J. Nietert, Morgan Dancy, Mark S. George
Summary: This study investigated the safety and efficacy of using rTMS for smoking cessation in cancer patients. The results showed that 5 sessions of daily rTMS over the left DLPFC may help reduce smoking and cue craving in cancer patients who smoke cigarettes. However, further research is needed to determine its therapeutic effect and adverse effects.
JOURNAL OF SMOKING CESSATION
(2022)
Article
Dermatology
Fatema Khamdan, McKenzie A. Dirr, Pelin Sagut, Caroline J. Brailsford, Jacob A. Williams, Paul J. Nietert, Dirk M. Elston
Summary: This study aimed to quantify cytologic features in benign and premalignant/malignant squamous cell lesions in order to improve the characterization of malignancy criteria. The presence and quantity of specific cytological features were evaluated in histopathology slides, and certain nuclear features were found to have a higher association with premalignancy/malignancy, providing guidance for histologic evaluation.
JOURNAL OF CUTANEOUS PATHOLOGY
(2023)
Review
Medicine, Research & Experimental
Jody D. Ciolino, Cathie Spino, Walter T. Ambrosius, Shokoufeh Khalatbari, Shari Messinger Cayetano, Jodi A. Lapidus, Paul J. Nietert, Robert A. Oster, Susan M. Perkins, Brad H. Pollock, Gina-Maria Pomann, Lori Lyn Price, Todd W. Rice, Tor D. Tosteson, Christopher J. Lindsell, Heidi Spratt
Summary: Rigorous scientific review of research protocols is crucial for funding decisions and participant protection. Biostatisticians play a vital role in evaluating method rigor and reproducibility. This work aims to provide guidance for biostatisticians on key elements to consider during protocol review.
JOURNAL OF CLINICAL AND TRANSLATIONAL SCIENCE
(2021)
Article
Health Care Sciences & Services
Mary Dooley, Annie N. Simpson, Paul J. Nietert, Dunc Williams, Kit N. Simpson
Summary: As healthcare costs rise, there is a lack of consensus among researchers on what constitutes small or large cost savings. Other fields of research have developed methods to define minimal important differences for planning studies. Three approaches (anchor-based, distribution-based, consensus-based) are used to identify magnitudes for resource measures, with a recommendation to explore both Delphi and distribution-based method when acceptable anchors are not available.
HEALTH SERVICES AND OUTCOMES RESEARCH METHODOLOGY
(2021)
Article
Medicine, Research & Experimental
Robert A. Oster, Katrina L. Devick, Sally W. Thurston, Joseph J. Larson, Leah J. Welty, Paul J. Nietert, Brad H. Pollock, Gina-Maria Pomann, Heidi Spratt, Christopher J. Lindsell, Felicity T. Enders
Summary: While graduate courses in CTS tend to cover many statistical fundamentals, learning gaps exist, particularly for more specialized competencies. Educational material to fill these gaps is necessary for learners pursuing these activities.
JOURNAL OF CLINICAL AND TRANSLATIONAL SCIENCE
(2021)