Review
Cell Biology
Raymond C. Harris
Summary: Aberrant activation of EGFR has been implicated as a mediator in the progression of diabetic kidney disease, leading to injury of both glomerular and tubular cells.
Article
Endocrinology & Metabolism
Florian G. Scurt, Jan Menne, Sabine Brandt, Anja Bernhardt, Peter R. Mertens, Hermann Haller, Christos Chatzikyrkou
Summary: The study found that MCP-1 was associated with the development of microalbuminuria in patients with type 2 diabetes, suggesting it may be a marker and potentially a mediator of early diabetic nephropathy.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2022)
Review
Medicine, General & Internal
Zhuo Chen, Chenwei Li, Jian Yu
Summary: The study found that MCP-1 has diagnostic value for adult patients with sepsis, with high sensitivity and specificity, and can be used as a biomarker for clinical application.
FRONTIERS IN MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Hiroaki Okuda, Shuhei Hosomi, Shigehiro Itani, Noriyuki Kurimoto, Yumie Kobayashi, Rieko Nakata, Yu Nishida, Masaki Ominami, Yuji Nadatani, Shusei Fukunaga, Koji Otani, Noriko Kamata, Fumio Tanaka, Yasuaki Nagami, Koichi Taira, Satoko Ohfuji, Yasuhiro Fujiwara
Summary: This study evaluated the efficacy of ustekinumab and identified predictors of short-term and long-term efficacy in patients with Crohn's disease. The analysis found that pretreatment serum MCP-1 concentration and history of biologic use were predictive factors for the long-term efficacy of ustekinumab.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Medicine, Research & Experimental
Qiu Du, Ying-xue Fu, An-mei Shu, Xing Lv, Yu-ping Chen, Yu-yan Gao, Jing Chen, Wei Wang, Gao-hong Lv, Jin-fu Lu, Hui-qin Xu
Summary: Loganin protects the kidney from damage in diabetic nephropathy by inhibiting macrophage infiltration and activation. It regulates the RAGE/MCP-1/CCR2 signaling pathway, affecting macrophage phenotypic transformation and expression of inflammatory factors.
Article
Pharmacology & Pharmacy
Haider Jabbar Al Hassani, Wasan Sami Hameed, Ali M. Janabi, Najah R. Hadi
Summary: Diabetes mellitus is the most prevalent metabolic non-communicable disease globally, with diabetic microvascular and macro vascular complications causing significant morbidity and mortality. Chronic elevation of blood glucose levels can lead to thickening and weakening of the basement membrane in blood vessels, causing damage to arteries and small blood vessels, including the kidneys. Elevated levels of MCP-1, IL-1 beta and NGAL have been found in diabetic patients with varying degrees of nephropathy compared to healthy controls, indicating a potential association between these biomarkers and diabetic nephropathy incidence.
LATIN AMERICAN JOURNAL OF PHARMACY
(2021)
Article
Multidisciplinary Sciences
Jianqin Lei, Guolong Ding, Anming Xie, Yaguang Hu, Ning Gao, Xiaojuan Fan
Summary: The study found that MCP-1 was a predictor for the unfavorable visual outcome of PDR after IVB pretreatment and PPV.
Article
Medicine, General & Internal
Francesca Lanzaro, Annalisa Barlaba, Angelica De Nigris, Federica Di Domenico, Valentina Verde, Emanuele Miraglia del Giudice, Anna Di Sessa
Summary: Diabetic nephropathy (DN) is the most common microvascular complication in patients with diabetes. Novel potential biomarkers, such as microRNAs (miRNAs), have been proposed to improve early identification of DN. These regulatory biomolecules represent the most promising diagnostic and therapeutic options for DN in adult patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Xiang Tong, Dongdong Yu, Li Yu, Weiqian Chen, Yanling Wen, Pengcheng Gu
Summary: This study investigated the role of MCP-1 in RA, showing that MCP-1 promoted FLS proliferation and migration, and affected FLS apoptosis. Clinically, MCP-1 was closely related to RA activity and could serve as a measure of clinical RA activity.
Article
Cardiac & Cardiovascular Systems
Gyu S. Choi, Hye S. Min, Jin J. Cha, Ji E. Lee, Jung Y. Ghee, Ji A. Yoo, Ki T. Kim, Young S. Kang, Sang Y. Han, Yun S. Bae, Sae R. Lee, Jung Y. Yoo, Sung H. Moon, Soo J. Lee, Dae R. Cha
Summary: The study indicates that plasma level of SH3YL1 may serve as a promising new biomarker for diabetic nephropathy, showing significant correlations and independence from other factors.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Review
Biochemistry & Molecular Biology
Amit K. Maiti
Summary: Diabetic Nephropathy is a serious complication of diabetes affecting the kidneys, with current diagnosis and treatment options insufficient to halt disease progression. Advances in genetics and genomics have identified susceptibility genes associated with DN, many of which have inflammatory functions, providing new insights for precision medicine in treating the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Paula Dlugosz, Magdalena Teufl, Maximilian Schwab, Katharina Eva Kohl, Johannes Nimpf
Summary: Dab1 functions as an adapter protein for VLDLR and ApoER2 in the Reelin pathway, orchestrating neuronal layering in embryonic brain development. In addition, Dab1 can also act as an adaptor for EGFR and be phosphorylated by EGF, constituting a signaling pathway independent of Reelin and its receptors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Fangyang Shao, Lei Ci, Jiahao Shi, Fei Fang, Bowen Yan, Xijun Liu, Xiangyu Yao, Mengjie Zhang, Hua Yang, Zhugang Wang, Jian Fei
Summary: In this study, we established a transgenic mouse model to monitor MCP-1 expression by observing the luciferase levels in live mice. The results showed that the luciferase signal is correlated with endogenous MCP-1 expression in mice and the anti-inflammatory drug dexamethasone can inhibit MCP-1 and luciferase gene expression significantly.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2022)
Article
Endocrinology & Metabolism
Yuan-Yuan Yang, Zhong-Xiuzi Gao, Zi-Hui Mao, Dong-Wei Liu, Zhang-Suo Liu, Peng Wu
Summary: This study aims to identify potential key genes involved in mitophagy in diabetic nephropathy (DN). Several related genes were selected through analysis of gene expression datasets, and the ULK1 gene was determined as a potential biomarker for DN using multiple algorithms.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Urology & Nephrology
Maria Teresa Rocchetti, Francesco Pesce, Silvia Matino, Giovanni Piscopo, Ighli di Bari, Francesco Trepiccione, Giovanna Capolongo, Maria Antonietta Perniola, Xuewen Song, Saima Khowaja, Amirreza Haghighi, Dorien Peters, Simona Paolicelli, Paola Pontrelli, Giuseppe Stefano Netti, Elena Ranieri, Giovambattista Capasso, Marco Moschetta, York Pei, Loreto Gesualdo
Summary: The ratio of urinary epidermal growth factor and monocyte chemotactic peptide 1 is a non-invasive pathophysiological biomarker that can be used for clinical risk stratification in autosomal dominant polycystic kidney disease.
JOURNAL OF NEPHROLOGY
(2023)
Article
Urology & Nephrology
Krittika Saranburut, Prin Vathesatogkit, Anchalee Chittamma, Somlak Vanavanan, Nisakron Thongmung, Tuangrat Tangstheanphan, Piyamitr Sritara, Chagriya Kitiyakara
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2017)
Article
Urology & Nephrology
Krittika Saranburut, Prin Vathesatogkit, Nisakron Thongmung, Anchalee Chittamma, Somlak Vanavanan, Tuangrat Tangstheanphan, Piyamitr Sritara, Chagriya Kitiyakara
Article
Biochemistry & Molecular Biology
Eakkapat Chanrat, Supanat Worawichawong, Piyanuch Radinahamed, Nuankanya Sathirapongsasuti, Arkom Nongnuch, Montira Assanatham, Umapom Udomsubpayakul, Chagriya Kitiyakara
Article
Integrative & Complementary Medicine
Napatt Kanjanahattakij, Pakakrong Kwankhao, Prin Vathesatogkit, Nisakron Thongmung, Yingampa Gleebbua, Piyamitr Sritara, Chagriya Kitiyakara
BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2019)
Article
Cardiac & Cardiovascular Systems
Pimphen Charoen, Jakris Eu-ahsunthornwattana, Nisakron Thongmung, Pedro A. Jose, Piyamitr Sritara, Prin Vathesatogkit, Chagriya Kitiyakara
INTERNATIONAL JOURNAL OF HYPERTENSION
(2019)
Article
Public, Environmental & Occupational Health
Chagriya Kitiyakara, Krittika Saranburut, Nisakorn Thongmung, Anchalee Chittamma, Somlak Vanavanan, Kobkiat Donsakul, Piyamitr Sritara, Prin Vathesatogkit
JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH
(2020)
Article
Multidisciplinary Sciences
Suchin Worawichawong, Sirithep Plumworasawat, Wisit Liwlompaisan, Vasant Sumethkul, Bunyong Phakdeekitcharoen, Umaporn Udomsubpayakul, Panus Chalermsanyakorn, Chagriya Kitiyakara
Summary: Mesangial C4d deposits are associated with poor outcomes in Thai patients with IgA nephropathy, with less stringent criteria for C4d positivity showing similar outcomes between extensive and less extensive staining patterns. Further studies are needed to determine the optimal criteria for C4d positivity.
Article
Environmental Sciences
Kanawat Paoin, Kayo Ueda, Prin Vathesatogkit, Thammasin Ingviya, Suhaimee Buya, Racha Dejchanchaiwong, Arthit Phosri, Xerxes Tesoro Seposo, Chagriya Kitiyakara, Nisakron Thongmung, Akiko Honda, Hirohisa Takano, Piyamitr Sritara, Perapong Tekasakul
Summary: Using data from the EGAT cohort study in Thailand, this study found that long-term exposure to high concentrations of PM10 and SO2 is associated with the progression of kidney dysfunction. This further supports the hypothesis that air pollution can have a negative impact on kidney health.
Article
Multidisciplinary Sciences
Pintip Ngamjanyaporn, Suchin Worawichawong, Prapaporn Pisitkun, Khantong Khiewngam, Surasak Kantachuvesiri, Arkom Nongnuch, Montira Assanatham, Nuankanya Sathirapongsasuti, Chagriya Kitiyakara
Summary: This study evaluated the roles of MCP-1, EGF, or their ratio as biomarkers of histopathology and response to treatment in LN. MCP-1 increased with disease activity, whereas EGF decreased with low GFR and chronic damage. Urine EGF may be a promising biomarker to predict therapeutic response in LN, with EGF/MCP-1 not improving the prediction of response.
Article
Medical Laboratory Technology
Hyun Suk Yang, Mina Hur, Kyeong Ryong Lee, Hanah Kim, Hahn Young Kim, Jong Won Kim, Mui Teng Chua, Win Sen Kuan, Horng Ruey Chua, Chagriya Kitiyakara, Phatthranit Phattharapornjaroen, Anchalee Chittamma, Thiyapha Werayachankul, Urmila Anandh, Sanjeeva Herath, Zoltan Endre, Andrea Rita Horvath, Paola Antonini, Salvatore Di Somma
Summary: NephroCheck can predict the development of AKI and short-term mortality in the emergency department. NephroCheck is a useful biomarker for early ruling out or ruling in the diagnosis of AKI in the emergency department.
ANNALS OF LABORATORY MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Kassaporn Duangkumpha, Narumol Jariyasopit, Kwanjeera Wanichthanarak, Esha Dhakal, Pattipong Wisanpitayakorn, Sansanee Thotsiri, Yongyut Sirivatanauksorn, Chagriya Kitiyakara, Nuankanya Sathirapongsasuti, Sakda Khoomrung
Summary: This study evaluated and validated the performance of high resolution GCxGC-TOFMS for metabolomics analysis in different plasma matrices. The results showed that GCxGC-TOFMS outperformed traditional GC-TOFMS in terms of separation performance and metabolite coverage. The application of GCxGC-TOFMS identified key metabolites in complex plasma matrices, particularly in the sugar and sugar alcohol groups.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)