Article
Biochemistry & Molecular Biology
Zachary J. Ward, Rifat Atun, Gary King, Brenda Sequeira Dmello, Sue J. Goldie
Summary: Analyses from the Global Maternal Health microsimulation model showed that a comprehensive strategy involving family planning and community-based interventions would have the highest impact in reducing maternal mortality, with the priority of interventions varying by setting. However, the current trends indicate that the Sustainable Development Goals for maternal mortality reduction are unlikely to be met. The study used a globally calibrated microsimulation model to evaluate the impact of different interventions and strategies, showing that integrated strategies had a greater effectiveness than individual interventions in reducing maternal mortality.
Article
Biochemistry & Molecular Biology
Ziad M. El-Zaatari, Luan D. Truong
Summary: Renal cell carcinoma (RCC) occurring in the setting of end-stage renal disease (ESRD) shows unique clinicopathological characteristics, with acquired cystic kidney disease-associated renal cell carcinoma (ACKD-RCC) and clear-cell papillary renal cell carcinoma (ccpRCC) being the most frequent types. Other types of RCC also occur in ESRD, albeit with different frequencies from the non-ESRD general population. While the histological features of RCC do not vary in the setting of ESRD vs. non-ESRD, other findings, such as multifocality and multiple tumor types, are more frequent in ESRD. Studies have generated novel and important knowledge of the etiology, epidemiology, diagnosis, treatment, immunophenotype, and molecular characteristics of ESRD-associated RCC.
Article
Pharmacology & Pharmacy
Saad Hanif Abbasi, Raja Ahsan Aftab, Pauline Siew Mei Lai, Soo Kun Lim, Ruwaida Nur Zainol Abidin
Summary: This study highlights the significant impact of HCAIs on ESRD patients undergoing RRT, affecting both their survival and treatment outcomes. Factors such as advancing age, low hemoglobin concentration were associated with death, while recurrent HCAIs, use of central venous catheters were risk factors for treatment failure.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Takuya Ogami, Paul Kurlansky, Hiroo Takayama, Yuming Ning, Ziad A. Ali, Tamim M. Nazif, Torsten P. Vahl, Omar Khalique, Amisha Patel, Nadira Hamid, Vivian G. Ng, Rebecca T. Hahn, Dimitrios V. Avgerinos, Martin B. Leon, Susheel K. Kodali, Isaac George
Summary: Aortic stenosis is common in end-stage renal disease patients. TAVR is an alternative for surgical aortic valve replacement. Short-term outcomes of TAVR in these patients have improved significantly, but long-term mortality remains high for dialysis patients.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Samuel Ji Quan Koh, Jonathan Yap, Yilin Jiang, Gerald Gui Ren Sng, Yi Hua Low, Yee How Lau, Yoong Kong Kenny Sin, Khung Keong Yeo
Summary: This study aimed to determine the optimal management of patients with end-stage renal disease (ESRD) on dialysis with severe coronary artery disease (CAD). The treatment modality did not impact on 1-year mortality, however, the CABG group had significantly lower 1-year MACE rates. Independent predictors of overall mortality included STEMI presentation, prior heart failure, LM disease, NSTE-ACS presentation, and increased age.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Cell Biology
Zaipul I. Md Dom, Eiichiro Satake, Jan Skupien, Bozena Krolewski, Kristina O'Neil, Jill A. Willency, Simon T. Dillon, Jonathan M. Wilson, Hiroki Kobayashi, Katsuhito Ihara, Towia A. Libermann, Marlon Pragnell, Kevin L. Duffin, Andrzej S. Krolewski
Summary: This study identified three elevated plasma proteins associated with protection against progressive renal decline and progression to endstage renal disease in individuals with diabetes. These protective proteins may serve as biomarkers for stratifying diabetic individuals by their risk of developing ESRD, and could be explored as potential therapeutics to delay or prevent ESRD onset.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Yinghui Wang, Lu Gao
Summary: Chronic kidney disease and cardiac insufficiency often co-exist, especially in uremic patients on hemodialysis. Impaired renal function is often indicative of poor prognosis in patients with cardiac insufficiency. Inflammation plays a significant role in the development of cardiovascular complications in patients with chronic kidney disease and is indicative of prognosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Hui-Teng Cheng, Xiaoqi Xu, Paik Seong Lim, Kuan-Yu Hung
Summary: The study compared the incidence of diabetes-related end-stage renal disease globally from 2000 to 2015, finding significant geographic variation in the risk of diabetic patients reaching ESRD in different regions during the study period.
Article
Clinical Neurology
Chang Min Heo, Won Ho Lee, Bong Soo Park, Yoo Jin Lee, Sihyung Park, Yang Wook Kim, Dong Ah Lee, Byeong Cheol Yoo, Kang Min Park
Summary: This study compares glymphatic dysfunction between patients with end-stage renal disease (ESRD) and healthy controls, and reveals the presence of glymphatic dysfunction in patients with ESRD as demonstrated by the DTI-ALPS index. Additionally, a significant positive correlation is found between the DTI-ALPS index and serum parathyroid hormone levels in ESRD patients.
FRONTIERS IN NEUROLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Nirat Beohar, Gorav Ailawadi, Lak N. Kotinkaduwa, Bjorn Redfors, Matheus Simonato, Zixuan Zhang, Loren Garrison Morgan, Esteban Escolar, Saibal Kar, David Scott Lim, Jacob M. Mishell, Brian K. Whisenant, William T. Abraham, JoAnn Lindenfeld, Michael J. Mack, Gregg W. Stone
Summary: This study aimed to assess the impact of renal dysfunction on patients with heart failure and severe secondary mitral regurgitation, as well as the effect of transcatheter mitral valve repair on the development of end-stage renal disease and the need for renal replacement therapy. The results showed that baseline renal dysfunction predicted the risk of death and heart failure hospitalization within 2 years, and transcatheter mitral valve repair reduced the incidence of new-onset end-stage renal disease and the need for renal replacement therapy.
EUROPEAN HEART JOURNAL
(2022)
Review
Cardiac & Cardiovascular Systems
Takahide Ito, Kanako Akamatsu
Summary: End-stage renal disease (ESRD) is a clinical condition associated with high morbidity and mortality. It is characterized by myocardial hypertrophy, heart failure, valvular calcification, and pericardial effusion. Multiple factors contribute to these abnormalities, including pressure/volume overload, oxidative stress, and neurohormonal imbalances.
HEART FAILURE REVIEWS
(2023)
Article
Multidisciplinary Sciences
Ryoichi Maenosono, Tatsuo Fukushima, Daisuke Kobayashi, Tomohisa Matsunaga, Yusuke Yano, Shunri Taniguchi, Yuya Fujiwara, Kazumasa Komura, Hirofumi Uehara, Maki Kagitani, Hajime Hirano, Teruo Inamoto, Hayahito Nomi, Haruhito Azuma
Summary: Patients with ESRD are at risk of malnutrition and high mortality. The study found an association between unplanned hemodialysis and low GNRI scores with mortality risk.
SCIENTIFIC REPORTS
(2022)
Review
Health Care Sciences & Services
Tae Young Park, Chang Seok Bang, Jae Hyuk Do, Hyoung Chul Oh
Summary: This study conducted a systematic review and pooled analysis to evaluate the morbidity and mortality associated with endoscopic retrograde cholangiopancreatography (ERCP) in end-stage renal disease (ESRD) patients undergoing hemodialysis (HD). The analysis indicated that the adverse events and mortality rates are higher in HD patients compared to non-dialysis patients.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Nutrition & Dietetics
Hugo de Luca Correa, Victor Manuel Alfaro-Magallanes, Sting Ray Gouveia Moura, Rodrigo Vanerson Passos Neves, Lysleine Alves Deus, Fernando Sousa Honorato, Victor Lopes Silva, Artur Temizio Oppelt Raab, Beatriz Carneiro Habbema Maia, Isabela Akaishi Padula, Lucas Santos de Gusmao Alves, Rafaela Araujo Machado, Andrea Lucena Reis, Jonato Prestes, Carlos Ernesto Santos Ferreira, Luiz Sinesio da Silva Neto, Fernanda Silveira Tavares, Rosangela Vieira Andrade, Thiago dos Santos Rosa
Summary: The study found that the RT group, regardless of iron treatment, improved iron metabolism in older individuals with ESRD, suggesting that RT may be an important factor in addressing iron deficiency in this population.
Article
Medicine, General & Internal
Elzbieta Dembowska, Aleksandra Jaron, Ewa Gabrysz-Trybek, Joanna Bladowska, Szymon Gacek, Grzegorz Trybek
Summary: Patients with end-stage renal disease undergoing hemodialysis experience lower quality of life, especially in the physical sphere, compared to healthy subjects. Comprehensive psychological care is indicated for hemodialysis patients due to their poor psychosocial status.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Transplantation
David Collister, Gwen Herrington, Lucy Delgado, Reid Whitlock, Karthik Tennankore, Navdeep Tangri, Remi Goupil, Annie-Claire Nadeau Fredette, Sara N. Davison, Ron Wald, Michael Walsh
Summary: This study examined the use of cannabis among Canadian adults with kidney disease. The findings suggest that many patients with kidney disease have used cannabis and are interested in using it for symptom control.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Surgery
Christine Park, Tyler Schappe, Sarah Peskoe, Dinushika Mohottige, Norine W. Chan, Nrupen A. Bhavsar, Jane Pendergast, Allan D. Kirk, Lisa M. McElroy
Summary: The choice of deprivation index has an impact on conclusions about deprivation extent and identifying the most deprived communities. This study aimed to determine correlations among commonly used deprivation indices for transplant populations. Different deprivation indices were compared using a retrospective cohort of liver or kidney transplant patients. The choice of deprivation index affects the applicability of research findings on social risk and clinical outcomes. Careful selection of indices based on intended use and variable relevance is necessary for transplant populations.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Article
Urology & Nephrology
Morgan E. Grams, Nigel J. Brunskill, Shoshana H. Ballew, Yingying Sang, Josef Coresh, Kunihiro Matsushita, Aditya Surapaneni, Samira Bell, Juan J. Carrero, Gabriel Chodick, Marie Evans, Hiddo J. L. Heerspink, Lesley A. Inker, Kunitoshi Iseki, Philip A. Kalra, H. Lester Kirchner, Brian J. Lee, Adeera Levin, Rupert W. Major, James Medcalf, Girish N. Nadkarni, David M. J. Naimark, Ana C. Ricardo, Simon Sawhney, Manish M. Sood, Natalie Staplin, Nikita Stempniewicz, Benedicte Stengel, Keiichi Sumida, Jamie P. Traynor, Jan van den Brand, Chi-Pang Wen, Mark Woodward, Jae Won Yang, Angela Yee-Moon Wang, Navdeep Tangri
Summary: The kidney failure risk equation (KFRE) accurately predicts kidney failure risk in people with GFR < 60 ml/min per 1.73 m(2) when using the CKD-EPI 2021 creatinine equation. Other modifications to the KFRE did not improve its performance.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Urology & Nephrology
Navdeep Tangri, Thomas W. Ferguson, Nancy L. Reaven, Julie Lai, Susan E. Funk, Vandana Mathur
Summary: Low serum bicarbonate at a single point in time is associated with accelerated kidney decline in patients with chronic kidney disease (CKD). This study modeled how changes in serum bicarbonate over time affect the incidence of adverse kidney outcomes, and the results showed that an increase in serum bicarbonate in CKD patients with metabolic acidosis is associated with a decreased risk of kidney disease progression.
KIDNEY INTERNATIONAL REPORTS
(2023)
Editorial Material
Emergency Medicine
Albert W. Wu, Julius Cuong Pham
EMERGENCY MEDICINE JOURNAL
(2023)
Article
Medicine, General & Internal
Anirudh Saraswathula, Samantha J. Merck, Ge Bai, Christine M. Weston, Elizabeth Ann Skinner, April Taylor, Allen Kachalia, Renee Demski, Albert W. Wu, Stephen A. Berry
Summary: US hospitals report data on many health care quality metrics, but the cost of data collection and reporting, independent of quality-improvement efforts, is not well known. This study evaluated inpatient quality metrics for adult patients and estimated the cost of data collection and reporting. The results showed that significant resources are expended exclusively for quality reporting, and some methods of quality assessment are far more expensive than others.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Orthopedics
Chao Long Azad, Laura K. Beres, Albert W. Wu, Aviram M. Giladi
Summary: The understanding of patients regarding PROMIS-UE is still unknown. Through cognitive interviews with 12 patients with hand/upper extremity conditions, six themes were identified: difficulty answering questions due to insufficient information; uncertainty about how to respond with respect to ability and injury status; lack of experience with certain tasks; uncertainty about responding based on adaptive techniques; answering questions based on limitations unrelated to upper extremity function; and uncertainty regarding whether to answer based on ability or pain. This study demonstrates the challenges in questionnaire completion and the potential limitations of the PROMIS-UE.
JOURNAL OF HAND SURGERY-EUROPEAN VOLUME
(2023)
Article
Urology & Nephrology
Krista Rossum, Evelyn Hancock, Stephanie Thompson, Ranveer Brar, Victoria Riehl-Tonn, Eric Garcia, Silvia J. Leon, Monica Sharma, Emilie Ford, Paul Komenda, Claudio Rigatto, Navdeep Tangri, Jennifer M. MacRae, Clara Bohm
Summary: The timing of intradialytic cycling does not affect the rate of intradialytic hypotension. Delaying exercise during hemodialysis can optimize the use of exercise programs and may be a potential treatment for symptoms common in late hemodialysis.
KIDNEY INTERNATIONAL REPORTS
(2023)
Article
Urology & Nephrology
Nancy L. Reaven, Susan E. Funk, Vandana Mathur, Thomas W. Ferguson, Julie Lai, Navdeep Tangri
Summary: This study found that the Kidney Failure Risk Equations (KFRE) can predict healthcare costs for patients with chronic kidney disease (CKD). For the 8-variable KFRE, each 1% increase in risk was associated with a 13.5% and 4.1% increase in monthly costs for CKD stage G3 and G4 patients, respectively. For the 4-variable KFRE, a 1% increase in risk was associated with a 6.7% and 2.9% increase in monthly costs for CKD stage G3 and G4 patients, respectively.
KIDNEY INTERNATIONAL REPORTS
(2023)
Review
Health Care Sciences & Services
Marja Haerkaenen, Adriana Lopez Pineda, Susanna Tella, Sanu Mahat, Massimiliano Panella, Matteo Ratti, Kris Vanhaecht, Reinhard Strametz, Irene Carrillo, Anne Marie Rafferty, Albert W. Wu, Veli-Jukka Anttila, Jose Joaquin Mira
Summary: This systematic review aims to synthesize the characteristics of emotional support programs and interventions targeted to healthcare workers and students since the onset of COVID-19 and other SARS-CoV pandemics and to describe the effectiveness and experiences of these programs. Through the review of 19 articles, it was found that interventions mostly showed good effectiveness and acceptance, but there were some conflicting results.
BMC HEALTH SERVICES RESEARCH
(2023)
Article
Education & Educational Research
Hosam H. Alkhatib, Mary Catherine Beach, Kelly A. Gebo, Eric B. Bass, Jenny R. Park, Meredith A. Atkinson, Sapna R. Kudchadkar, Stephen M. Sozio
Summary: This study examined the association between medical school Scholarly Concentrations (SC) programs and students' specialty choices. The results showed that students' interest in a specialty at baseline and their research productivity with SC mentors were associated with increased odds of entering a related specialty. However, completing an SC project did not increase the odds of matching into that specialty or a higher ranked program.
MEDICAL EDUCATION ONLINE
(2023)
Review
Medicine, General & Internal
Matt Norvell, Cheryl A. Connors, Albert W. Wu
Summary: Reflecting on the efforts to provide emotional support to health care workers before and after the COVID-19 pandemic, three guiding principles are proposed for health care organizations: 1) normalize the use of support resources for health care workers; 2) assess actual needs instead of making assumptions; 3) reduce barriers for health care workers to access necessary support. These principles are described in terms of their usefulness and potential for further development to enhance emotional support for health care workers in the future.
POLISH ARCHIVES OF INTERNAL MEDICINE-POLSKIE ARCHIWUM MEDYCYNY WEWNETRZNEJ
(2023)
Article
Urology & Nephrology
Reid H. Whitlock, Mohammad Nour-Mohammadi, Sarah Curtis, Paul Komenda, Clara Bohm, David Collister, Navdeep Tangri, Claudio Rigatto
Summary: This study used administrative health databases to identify patients at high risk of Fabry disease and found that 1364 high-risk patients had not been tested. Administrative health databases can assist in identifying high-risk populations and further design screening programs for Fabry disease.
CANADIAN JOURNAL OF KIDNEY HEALTH AND DISEASE
(2023)
Review
Urology & Nephrology
Donald E. E. Wesson, Vandana Mathur, Navdeep Tangri
Summary: Research suggests that metabolic derangements of skeletal muscle dysfunction in both chronic kidney disease and aging-related frailty offer potential avenues for identifying new preventive and treatment strategies. Targeting these derangements unique to CKD may help improve quality and quantity of life for patients with CKD.
AMERICAN JOURNAL OF NEPHROLOGY
(2023)
Article
Urology & Nephrology
Vandana S. Mathur, Donald E. Wesson, Elizabeth Li, Navdeep Tangri
Summary: Nearly half of US nephrologists base their decision to initiate dialysis on eGFR alone. However, their understanding of uremia and how they weigh various factors in the decision-making process is unclear.
AMERICAN JOURNAL OF NEPHROLOGY
(2023)
