Article
Medicine, General & Internal
Jose F. Figueroa, Dannie Dai, Yevgeniy Feyman, Melissa M. Garrido, Thomas C. Tsai, E. John Orav, Austin B. Frakt
Summary: Limiting the use of high-risk medications among older adults is a national priority for providing high-quality care. This study found that Medicare Advantage beneficiaries had consistently lower rates of high-risk medication fills compared to traditional Medicare beneficiaries. There was a concerning disparity in the higher rates of high-risk medication use among female, American Indian or Alaska Native, and White populations.
Article
Oncology
Anne-Laure Couderc, Pascale Tomasini, Laurent Greillier, Emilie Nouguerede, Dominique Rey, Coline Montegut, Pascal-Alexandre Thomas, Fabrice Barlesi, Patrick Villani
Summary: The evaluation of functional status using a combination of ADL and IADL scales serves as a prognostic marker for the 6-month mortality risk in older patients with lung cancer, and should be more widely utilized by oncologists in treatment decision making.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Public, Environmental & Occupational Health
Louise A. C. Millard, Alba Fernandez-Sanles, Alice R. Carter, Rachael A. Hughes, Kate Tilling, Tim P. Morris, Daniel Major-Smith, Gareth J. Griffith, Gemma L. Clayton, Emily Kawabata, George Davey Smith, Deborah A. Lawlor, Maria Carolina Borges
Summary: This study investigates potential selection bias in COVID-19 infection and prognosis studies due to non-random selection of analytic subsamples. The study finds that a broad range of characteristics is related to selection, with higher BMI being associated with increased odds of COVID-19 infection and death. The study also identifies significant bias in many simulated scenarios.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Health Care Sciences & Services
Lacey Loomer, Cyrus M. Kosar, David J. Meyers, Kali S. Thomas
Summary: Analysis of Medicare beneficiary data shows that MA enrollees are less likely to receive prescribed post-acute HH compared to TM enrollees. In MA plans, those with cost sharing, referrals, and pre-authorization are less likely to receive prescribed HH.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2021)
Article
Gerontology
Heng-Yu H. Lin, Amber Willink, Anna M. Jilla, Heather M. Weinreich, Esther S. Oh, Mariah Robertson, Hannah V. Ward, Nicholas S. Reed
Summary: The study found that Medicare beneficiaries with hearing trouble are more likely to avoid or delay seeking healthcare, without a significant association with concern for health status or sharing health status.
JOURNAL OF AGING AND HEALTH
(2021)
Article
Surgery
Andrew P. Loehrer, Louisa Chen, Qianfei Wang, Carrie H. Colla, Sandra L. Wong
Summary: The objective of this study was to examine the impact of rural residence on the access and outcomes of lung cancer surgery for Medicare beneficiaries. Lung cancer is the leading cause of cancer-related death in the United States, and rural patients have higher mortality rates. The study found that living in nonmetropolitan areas was associated with lower probability of cancer surgery, longer wait times for surgery, decreased use of minimally invasive surgery, and increased emergency department visits after surgery.
Article
Medical Informatics
Rahuldeb Sarkar, Christopher Martin, Heather Mattie, Judy Wawira Gichoya, David J. Stone, Leo Anthony Celi
Summary: Despite differences in discrimination among different ethnicities, severity scoring systems did not show systematic bias in predicting mortality. However, there were significant patterns of difference in calibration for Hispanic and Black individuals, with the scores consistently overpredicting mortality for these groups.
LANCET DIGITAL HEALTH
(2021)
Article
Biochemistry & Molecular Biology
Jordi Barrachina, Cesar Margarit, Javier Muriel, Vicente Lopez-Gil, Santiago Lopez-Gil, Pura Ballester, Laura Mira-Lorente, Laura Agullo, Ana M. Peiro
Summary: Despite a large amount of research on sex differences in pain, this study found that there is a lack of translation to real-world pain management. The study analyzed sex differences in the response to different opioids among patients with chronic non-cancer pain. The results showed that there were sex differences in drug tolerability and hospital resources, with females experiencing lower tolerability and higher hospital use, particularly in the group using oxycodone/naloxone. Other differences related to age and prescription of benzodiazepines were also found.
Article
Biochemistry & Molecular Biology
Braden T. Tierney, Elizabeth Anderson, Yingxuan Tan, Kajal Claypool, Sivateja Tangirala, Aleksandar D. Kostic, Arjun K. Manrai, Chirag J. Patel
Summary: In observational, biomedical data science, hypothesis generation often begins with computing the association between a dependent and an independent variable. The outcome of this process depends significantly on modeling strategy, with different strategies resulting in what is known as vibration of effects (VoE). VoE is characterized by variation in associations that can lead to contradictory results, highlighting the importance of modeling VoE in discerning robust associations and identifying adjusting variables that impact model output.
Article
Multidisciplinary Sciences
Anteo Di Napoli, Martina Ventura, Enrico Grande, Luisa Frova, Concetta Mirisola, Alessio Petrelli
Summary: This study found that immigrants in Italy have a lower mortality rate compared to native Italians for almost all causes of death and all areas of origin.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Joren Vanbraband, Nancy Van Damme, Gauthier Bouche, Geert Silversmit, Anke De Geyndt, Eric de Jonge, Gerd Jacomen, Frederic Goffin, Hannelore Denys, Frederic Amant
Summary: This study assesses the completeness and selection bias of the EFFECT database, finding bias in both the participating hospitals and the patients included. However, the EFFECT database provides detailed information on the real-world clinical care of corpus uteri cancer in Belgium, making it an important tool for measuring and improving patient care quality.
Article
Health Care Sciences & Services
Naleef Fareed, Pallavi Jonnalagadda, Sarah R. MacEwan, Gennaro Di Tosto, Seth Scarborough, Timothy R. Huerta, Ann Scheck McAlearney
Summary: This study aims to investigate how patients' use of an inpatient portal is influenced by their use of outpatient portals. The results suggest that new users of outpatient portals have higher usage rates of select inpatient portal functions, while nonusers have lower overall usage rates and less use of specific functions. Understanding the relationship between outpatient and inpatient portal use can help inform targeted implementation strategies to encourage individuals to better manage their health.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2021)
Article
Psychology, Multidisciplinary
Anna Mierzynska, Andrzej Kokoszka, Grazyna Jerzak-Wodzynska, Malgorzata Sobieszczanska-Malek, Tomasz Zielinski, Ryszard Piotrowicz
Summary: The majority of heart transplant patients are highly engaged in health behavior, with predictors including personality traits and health beliefs in the form of health locus of control. Patients often adhere less to a healthy diet post-transplant.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Oncology
Bruno Fattizzo, Carmelo Gurnari, Giulio Cassanello, Marta Bortolotti, Hussein Awada, Sabrina Giammarco, Dario Consonni, Simona Sica, Shreyans Gandhi, Roochi Trikha, Joanna Large, Sarah Salter, Jaroslaw P. Maciejewski, Wilma Barcellini, Austin G. Kulasekararaj
Summary: Non-severe aplastic anemia is a rare bone marrow failure disorder. A large multicentric study with 259 patients found that different treatment strategies had similar outcomes, with higher overall response rates observed for cyclosporine alone, cyclosporine plus anti-thymocyte globulin or eltrombopag, and eltrombopag alone. A trilineage response was achieved in a subset of patients, and progression to myeloid neoplasms was limited. Survival was affected by various factors, such as age and mutational status.
Article
Geriatrics & Gerontology
Aishwarya Shukla, Thomas K. M. Cudjoe, Frank R. Lin, Nicholas S. Reed
Summary: This study examined the association between functional hearing loss and social engagement in older adults, finding that trouble hearing was independently associated with a higher likelihood of limited social activity. This suggests that hearing loss may be an important risk factor for restricted social engagement and negative health consequences.
JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL SCIENCES
(2021)
Review
Oncology
Stuart M. Lichtman, Harvey J. Cohen, Hyman Muss, P. Tew William, Beatriz Korc-Grodzicki
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Oncology
Noam A. VanderWalde, Travis Dockter, Daniel Wakefield, Daniel Satele, Jeff Sloan, Reshma Jagsi, Stuart M. Lichtman, Rachel A. Freedman, Jacqueline M. Lafky, Hyman Muss, Harvey Jay Cohen, Jennifer Le-Rademacher, Aminah Jatoi
Summary: In cancer clinical trials sponsored by the Alliance for Clinical Trials in Oncology, older adults are under-represented with disparities varying across different types of trials. Non-genitourinary cancer types, trimodality+ trials, and phase 2 trials are associated with larger disparities in older adult enrollment. Future strategies to improve older adult inclusion should target these specific trial characteristics.
JOURNAL OF GERIATRIC ONCOLOGY
(2022)
Editorial Material
Oncology
Jessica R. Flynn, Edmund K. Bartlett, Stuart M. Lichtman, Katherine S. Panageas
JOURNAL OF GERIATRIC ONCOLOGY
(2022)
Article
Oncology
Beryl L. Manning-Geist, Sushmita B. Gordhandas, Dilip D. Giri, Alexia Iasonos, Qin Zhou, Jeffrey Girshman, Roisin E. O'Cearbhaill, Dmitriy Zamarin, Stuart M. Lichtman, Paul J. Sabbatini, William P. Tew, Karen Li, Autumn S. McDonnell, Emeline M. Aviki, Dennis S. Chi, Carol A. Aghajanian, Rachel N. Grisham
Summary: The study concluded that enzalutamide showed potential efficacy in PFS6 for patients with AR+ ovarian cancer, but had a low overall response rate. Enzalutamide was well tolerated and may serve as a potential treatment option for selected patients.
GYNECOLOGIC ONCOLOGY
(2022)
Article
Oncology
Arya Amini, Vivek Verma, Charles B. Simone, Indrin J. Chetty, Stephen G. Chun, Jessica Donington, Martin J. Edelman, Kristin A. Higgins, Larry L. Kestin, Benjamin Movsas, George B. Rodrigues, Kenneth E. Rosenzweig, Igor I. Rybkin, Benjamin J. Slotman, Andrea Wolf, Joe Y. Chang
Summary: Recent studies have shown that the addition of stereotactic body radiation therapy (SBRT) may improve outcomes for patients with oligometastatic non-small cell lung cancer. However, due to limited data, individualized management and multidisciplinary discussions are needed for treating oligometastatic disease.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Review
Oncology
Richard M. Goldberg, Richard Adams, Marc Buyse, Cathy Eng, Axel Grothey, Thierry Andre, Alberto F. Sobrero, Stuart M. Lichtman, Al B. Benson, Cornelis J. A. Punt, Tim Maughan, Tomasz Burzykowski, Dirkje Sommeijer, Everardo D. Saad, Qian Shi, Elisabeth Coart, Benoist Chibaudel, Miriam Koopman, Hans-Joachim Schmoll, Takayuki Yoshino, Julien Taieb, Niall C. Tebbutt, John Zalcberg, Josep Tabernero, Eric Van Cutsem, Alastair Matheson, Aimery de Gramont
Summary: Meta-analysis based on individual participant data is a powerful method for synthesizing evidence in clinical cancer research. The ARCAD database is a leader in using this methodology for methodological research, providing valuable insights into endpoint selection and clinical response assessment.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2022)
Article
Oncology
Daneng Li, Can-Lan Sun, Rebecca Allen, Christiana J. Crook, Abrahm Levi, Richard Ballena, Heidi D. Klepin, Rawad Elias, Supriya G. Mohile, William P. Tew, Cynthia Owusu, Hyman B. Muss, Stuart M. Lichtman, Cary P. Gross, Andrew E. Chapman, Ajeet Gajra, Harvey J. Cohen, Vani Katheria, Arti Hurria, William Dale
Summary: This study aimed to identify risk factors for hospitalization in older adults with GI cancers receiving chemotherapy. The findings suggest that cardiac comorbidity may be a risk factor for hospitalization in this population.
Article
Oncology
Noam VanderWalde, Jennifer Moughan, Stuart M. Lichtman, Reshma Jagsi, Matthew Ballo, Ari VanderWalde, Mohammed Mohiuddin, Neal J. Meropol, Lisa Kachnic, Adam Berger, Jaffer Ajani, Rani Anne, Judith L. Hopkins, Amit Arora, Joshua Meyer, Susannah G. Ellsworth, R. Jeffrey Lee, Nathan Green, Christopher H. Crane
Summary: This study compared the acute adverse events of older and younger adults with lower gastrointestinal malignancies undergoing combined modality therapy. The results showed that older patients were less likely to complete chemotherapy and had higher rates of grade 3+ gastrointestinal adverse events.
JOURNAL OF GERIATRIC ONCOLOGY
(2022)
Review
Oncology
Shreya M. Shah, Elena V. Demidova, Randy W. Lesh, Michael J. Hall, Mary B. Daly, Joshua E. Meyer, Martin J. Edelman, Sanjeevani Arora
Summary: DNA repair vulnerabilities are common in cancer, with germline alterations playing a role in both cancer risk and treatment response. Targeted therapies, such as PARP inhibitors and immune checkpoint blockade, have shown clinical success in exploiting these vulnerabilities. Advances in genetic profiling, particularly panel testing for germline assessment, have provided valuable data on DNA repair genes. Identifying patients with germline aberrations in DNA repair enables precision treatments, improving outcomes for cancer patients.
CANCER TREATMENT REVIEWS
(2022)
Article
Oncology
Enrique Soto-Perez-de-Celis, Anna Rachelle Mislang, Celia Gabriela Hernandez-Favela, Chiara Russo, Giuseppe Colloca, Grant R. Williams, Shane O'Hanlon, Lisa Cooper, Anita O'Donovan, Riccardo A. Audisio, Kwok-Leung Cheung, Regina Girones-Sarrio, Reinhard Stauder, Michael Jaklitsch, Clarito Cairo, Luiz Antonio Gil, Mahmood Alam, Schroder Sattar, Kumud Kantilal, Kah Poh Loh, Stuart M. Lichtman, Etienne Brain, Hans Wildiers, Ravindran Kanesvaran, Nicolo Matteo Luca Battisti
JOURNAL OF GERIATRIC ONCOLOGY
(2022)
Review
Urology & Nephrology
Ben Sprangers, Mark A. Perazella, Stuart M. Lichtman, Mitchell H. Rosner, Kenar D. Jhaveri
Summary: Chemotherapeutic agents used to treat cancer often have narrow therapeutic indices and potentially serious toxicities. Limited data on the safe and effective dosing of these drugs in patients with chronic kidney disease (CKD) contribute to the exclusion of CKD patients from cancer drug trials, preventing optimal clinical care for this population.
KIDNEY INTERNATIONAL REPORTS
(2022)
Review
Oncology
Nicolo Matteo Luca Battisti, Nienke De Glas, Enrique Soto-Perez-de-Celis, Gabor Liposits, Michael Bringuier, Christine Walko, Stuart M. Lichtman, Matti Aapro, Kwok-Leung Cheung, Laura Biganzoli, Alistair Ring, Johanneke Portielje, Hans Wildiers, Etienne Brain
Summary: This study summarizes the evidence on efficacy, safety, and quality-of-life impacts of chemotherapy and the use and impact of gene expression profiling (GEP) in older patients with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative early breast cancer (EBC). The results show that chemotherapy survival benefits in older patients are unclear and GEP is less used. The prognostic role of GEP is established, but its predictive role remains unknown.
EUROPEAN JOURNAL OF CANCER
(2022)
Editorial Material
Oncology
Grant R. Williams, Darryl Outlaw, R. Donald Harvey, Stuart M. Lichtman, William C. Zamboni, Smith Giri
JOURNAL OF GERIATRIC ONCOLOGY
(2023)
Article
Oncology
Maria M. Rubinstein, Eric Rios Doria, Jason Konner, Stuart Lichtman, Qin Zhou, Alexia Iasonos, Debra Sarasohn, Tiffany Troso-Sandoval, Claire Friedman, Roisin O'Cearbhaill, Karen Cadoo, Chrisann Kyi, Seth Cohen, Krysten Soldan, Eric Billinson, Imogen Caird, Dasom Jang, Khalil Eid, Pooja Shah, Joyce Guillen, Carol Aghajanian, Dmitriy Zamarin, Vicky Makker
Summary: This study examined the efficacy of single-agent immune checkpoint blockade and combination immune checkpoint blockade in patients with endometrial cancer. The results showed limited response to immune checkpoint blockade in these patients, indicating the need for further research into potential mechanisms of resistance to immunotherapy in endometrial cancer.
GYNECOLOGIC ONCOLOGY
(2023)
Editorial Material
Oncology
Stuart M. Lichtman
Summary: The field of geriatric oncology has made progress, but there are missed opportunities in research due to underrepresentation of older patients in clinical trials, lack of data collection from older patients, and inadequate analysis and reporting of trial data. To advance research, it is necessary to include older patients in trials, gather essential information, and thoroughly analyze and communicate results.
Article
Oncology
Vijaya R. Bhatt, Christopher Wichman, Thuy T. Koll, Alfred L. Fisher, Tanya M. Wildes, Ann Berger, James O. Armitage, Sarah A. Holstein, Lori J. Maness, Krishna Gundabolu
Summary: A study on older adults with AML receiving chemotherapy showed significant comorbidity burden and functional impairments at baseline, but cognitive and physical function improvements or stability, as well as improved depression scores, were observed in a high proportion of patients at three months post-treatment, indicating success of treatment.
JOURNAL OF GERIATRIC ONCOLOGY
(2024)
Correction
Oncology
Darren J. Walsh, Laura J. Sahm, Michelle O'Driscoll, Bronagh Bolger, Hitam Ameen, Michelle Hannan, Caitriona Goggin, Anne M. Horgan
JOURNAL OF GERIATRIC ONCOLOGY
(2024)
Article
Oncology
Eva Futtrup Maksten, Lasse Hjort Jakobsen, Boris Modrau, Hilde Jensvoll, Kristian Hay Kragholm, Judit Meszaros Jorgensen, Michael Roost Clausen, Robert Schou Pedersen, Andriette Dessau-Arp, Thomas Stauffer Larsen, Christian Bjorn Poulsen, Anne Ortved Gang, Peter Brown, Tarec C. El-Galaly, Marianne Tang Severinsen
Summary: The risk of developing dementia is not increased after lymphoma treatment among patients.
JOURNAL OF GERIATRIC ONCOLOGY
(2024)
Review
Oncology
P. A. L. Nelleke Seghers, Marije E. Hamaker, Shane O'Hanlon, Johanneke E. A. Portielje, Hans Wildiers, Pierre Soubeyran, Annemarie Coolbrandt, Siri Rostoft
Summary: This study identified a core set of symptoms to monitor in older patients with multimorbidity treated for cancer. These symptoms include those related to cancer, treatment side effects, functional decline, and destabilization of comorbidities. The results provide a basis for guiding symptom monitoring during cancer treatment.
JOURNAL OF GERIATRIC ONCOLOGY
(2024)