Article
Medicine, General & Internal
Timothy J. Whelan, Sally Smith, Sameer Parpia, Anthony W. Fyles, Anita Bane, Fei-Fei Liu, Eileen Rakovitch, Lynn Chang, Christiaan Stevens, Julie Bowen, Sawyna Provencher, Valerie Theberge, Anna Marie Mulligan, Zuzana Kos, Mohamed A. Akra, K. David Voduc, Tarek Hijal, Ian S. Dayes, Gregory Pond, James R. Wright, Torsten O. Nielsen, Mark N. Levine
Summary: Among women with T1N0 grade 1 or 2 luminal A breast cancer who had undergone breast-conserving surgery and received endocrine therapy, the incidence of local recurrence at 5 years was low without radiotherapy.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Review
Surgery
A. Fancellu, N. Houssami, V Sanna, A. Porcu, C. Ninniri, M. L. Marinovich
Summary: This meta-analysis compared the outcomes of breast-conserving surgery (BCS) versus mastectomy in patients with triple-negative breast cancer (TNBC). The results showed that BCS was associated with lower rates of locoregional recurrence, distant metastasis, and all-cause mortality compared to mastectomy. However, caution should be taken due to potential differences in patient selection for the two surgical options.
BRITISH JOURNAL OF SURGERY
(2021)
Article
Medicine, General & Internal
Ian H. H. Kunkler, Linda J. J. Williams, Wilma J. L. Jack, David A. A. Cameron, J. Michael Dixon
Summary: This study suggests that omission of radiotherapy in older women with low-risk, hormone receptor-positive early breast cancer may increase the risk of local recurrence, but has no detrimental effect on distant recurrence and overall survival.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Oncology
Conny Vrieling, Samson Y. Assele, Lotte Moser, Nicolas Sauve, Saskia Litiere, Alain Fourquet, Philip Poortmans, Henk Struikmans, Geertjan van Tienhoven, Harry Bartelink, Laurence Collette
Summary: The study analyzed the prognostic impact of isolated local recurrence (ILR) in early-breast cancer patients treated with breast-conserving therapy, and found that the cumulative breast cancer mortality rates after ILR varied depending on the timing of ILR. A multistate model was able to predict long-term outcomes based on individual patient characteristics.
EUROPEAN JOURNAL OF CANCER
(2021)
Article
Oncology
Kathryn R. Tringale, Elizabeth R. Berger, Varadan Sevilimedu, Hannah Y. Wen, Erin F. Gillespie, Boris A. Mueller, Beryl McCormick, Amy J. Xu, John J. Cuaron, Oren Cahlon, Atif J. Khan, Simon N. Powell, Monica Morrow, Alexandra S. Heerdt, Lior Z. Braunstein
Summary: In this study, it was found that for older women with early-stage ER+/HER2- breast cancer, adjuvant RT and HT monotherapy both reduce the risk of locoregional recurrence, with a slightly better outcome for the combination therapy. Distant recurrence and breast cancer-specific survival rates did not significantly differ between the treatment groups. Further research is needed to determine the optimal treatment approach for these patients.
Article
Oncology
Dang Van Nguyen, Sang-Won Kim, Young-Taek Oh, O. Kyu Noh, Yongsik Jung, Mison Chun, Dae Sung Yoon
Summary: Young women undergoing breast conserving therapy have a higher risk of local recurrence compared to mastectomy alone. Despite aggressive salvage treatments, those with local recurrence after breast conserving therapy have poor prognosis. Novel systemic treatments are needed to improve outcomes for young women with breast cancer undergoing breast conserving therapy.
Article
Medicine, General & Internal
Evan D. Bander, Tarek Y. El Ahmadieh, Justin Chen, Anne S. Reiner, Samantha Brown, Alexandra M. Giantini-Larsen, Robert J. Young, Kathryn Beal, Brandon S. Imber, Luke R. G. Pike, Cameron W. Brennan, Viviane Tabar, Katherine S. Panageas, Nelson S. Moss
Summary: This study aimed to evaluate the optimal timing for adjuvant SRS following surgical resection of brain metastases. The findings suggest that performing adjuvant SRS within 22 to 30 days postoperatively can achieve a balanced approach that minimizes the risks associated with local failure and adverse radiation effects.
Article
Oncology
Jin Wang, Hailin Tang, Kanhua Yin, Xing Li, Xiaoming Xie, Kevin S. Hughes
Summary: After breast-conserving therapy, patients may experience ipsilateral breast tumor recurrence, new primary tumor, or contralateral breast cancer. Patients with true recurrence have poorer survival outcomes compared to those with new primary tumors, while the survival outcomes of contralateral breast cancer are better.
Article
Oncology
Changjun Wang, Yan Lin, Hanjiang Zhu, Yidong Zhou, Feng Mao, Xin Huang, Xingtong Zhou, Xi Cao, Qiang Sun
Summary: This meta-analysis found that breast-conserving therapy (BCT) carries an increased risk of local recurrence but does not significantly impact patient survival in terms of disease-free survival, metastasis-free survival, breast cancer-specific survival, and overall survival.
Article
Health Care Sciences & Services
Jiaqiang Zhang, Shao-Yin Sum, Jeng-Guan Hsu, Ming-Feng Chiang, Tian-Shyug Lee, Szu-Yuan Wu
Summary: The study found that adjuvant whole breast radiotherapy was significantly associated with decreased all-cause death, locoregional recurrence, and distant metastasis in women with left-sided breast invasive ductal carcinoma and heart failure with reduced ejection fraction compared to non-adjuvant WBRT.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Oncology
Hyunjung Kim, Tae Gyu Kim, Byungdo Park, Jeong Ho Kim, Si-Youl Jun, Jun Ho Lee, Hee Jun Choi, Chang Shin Jung, Yoon Ju Bang, Hyoun Wook Lee, Jae Seok Lee, Hyun Yeol Nam, Seunghyeon Shin, Sung Min Kim, Haeyoung Kim
Summary: This study aimed to evaluate the effectiveness of high-dose radiation therapy for positive margins in breast cancer surgery and compare the local recurrence between patients with positive and negative margins. The results showed that positive margins were not associated with poor local control in older patients after a high-dose boost, but had higher risk of local recurrence in younger patients.
Review
Oncology
Francesca Magnoni, Virgilio Sacchini, Paolo Veronesi, Beatrice Bianchi, Elisa Bottazzoli, Valentina Tagliaferri, Erica Mazzotta, Giulia Castelnovo, Giulia Deguidi, Elisabetta Maria Cristina Rossi, Giovanni Corso
Summary: The optimal surgical approach to hereditary breast cancer and the management of patients carrying mutations in high-penetrance genes are significant current clinical and scientific issues. Studies have shown that breast-conserving surgery is oncologically safe in BRCA carriers in terms of overall survival, despite an increased risk of ipsilateral recurrence.
Article
Oncology
Nayan Lamba, Daniel N. Cagney, Paul J. Catalano, Dewey Kim, Hesham Elhalawani, Daphne A. Haas-Kogan, Patrick Y. Wen, Nikhil Wagle, Ayal A. Aizer
Summary: A DNA-based signature has been developed to predict the risk of local recurrence in patients with brain metastases after radiotherapy, providing a better understanding of recurrence risk. Genetic alterations in 84 genes were found to be associated with local recurrence. A Brain-Radiation Prediction Score (Brain-RPS) was established to predict the risk of local failure.
Article
Oncology
Fei-Lin Qu, Rui Mao, Zhe-Bin Liu, Cai-Jin Lin, A-Yong Cao, Jiong Wu, Guang-Yu Liu, Ke-Da Yu, Gen-Hong Di, Jun-Jie Li, Zhi-Ming Shao
Summary: Background Loco-regional recurrences following breast-conserving surgery remain a heterogeneous class of disease with significant variation in biological behavior and prognosis. Different recurrence patterns after BCS are related to distinct clinical outcomes. Management of LRR should be individualized and tailored based on disease extent, molecular profile, and baseline clinical variables.
FRONTIERS IN ONCOLOGY
(2021)
Article
Surgery
Jessica R. Schumacher, Alyssa A. Wiener, Caprice C. Greenberg, Bret Hanlon, Stephen B. Edge, Kathryn J. Ruddy, Ann H. Partridge, Jennifer G. Le-Rademacher, Menggang Yu, David J. Vanness, Dou-Yan Yang, Jeffrey Havlena, Carrie Strand, Heather B. Neuman
Summary: This study evaluated local/regional recurrence rates after breast-conserving surgery in patients enrolled in legacy trials of the Alliance for Clinical Trials in Oncology, and assessed variation in recurrence rates by receptor subtype. The results showed that the rates of local/regional recurrence after breast conservation were significantly lower in patients with ER+ or PR+ tumors.
Article
Oncology
Vijaya R. Bhatt, Christopher Wichman, Thuy T. Koll, Alfred L. Fisher, Tanya M. Wildes, Ann Berger, James O. Armitage, Sarah A. Holstein, Lori J. Maness, Krishna Gundabolu
Summary: A study on older adults with AML receiving chemotherapy showed significant comorbidity burden and functional impairments at baseline, but cognitive and physical function improvements or stability, as well as improved depression scores, were observed in a high proportion of patients at three months post-treatment, indicating success of treatment.
JOURNAL OF GERIATRIC ONCOLOGY
(2024)
Correction
Oncology
Darren J. Walsh, Laura J. Sahm, Michelle O'Driscoll, Bronagh Bolger, Hitam Ameen, Michelle Hannan, Caitriona Goggin, Anne M. Horgan
JOURNAL OF GERIATRIC ONCOLOGY
(2024)
Article
Oncology
Eva Futtrup Maksten, Lasse Hjort Jakobsen, Boris Modrau, Hilde Jensvoll, Kristian Hay Kragholm, Judit Meszaros Jorgensen, Michael Roost Clausen, Robert Schou Pedersen, Andriette Dessau-Arp, Thomas Stauffer Larsen, Christian Bjorn Poulsen, Anne Ortved Gang, Peter Brown, Tarec C. El-Galaly, Marianne Tang Severinsen
Summary: The risk of developing dementia is not increased after lymphoma treatment among patients.
JOURNAL OF GERIATRIC ONCOLOGY
(2024)
Review
Oncology
P. A. L. Nelleke Seghers, Marije E. Hamaker, Shane O'Hanlon, Johanneke E. A. Portielje, Hans Wildiers, Pierre Soubeyran, Annemarie Coolbrandt, Siri Rostoft
Summary: This study identified a core set of symptoms to monitor in older patients with multimorbidity treated for cancer. These symptoms include those related to cancer, treatment side effects, functional decline, and destabilization of comorbidities. The results provide a basis for guiding symptom monitoring during cancer treatment.
JOURNAL OF GERIATRIC ONCOLOGY
(2024)