Bacterial responses to antibiotics and their combinations

Large-Scale Identification and Analysis of Suppressive Drug Interactions

(2014) Murat Cokol et al.   CHEMISTRY & BIOLOGY

Microbiological effects of sublethal levels of antibiotics

(2014) Dan I. Andersson et al.   NATURE REVIEWS MICROBIOLOGY

Antibiotics induce redox-related physiological alterations as part of their lethality

(2014) D. J. Dwyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Uncovering Scaling Laws to Infer Multidrug Response of Resistant Microbes and Cancer Cells

(2014) Kevin B. Wood et al.   Cell Reports

When the Most Potent Combination of Antibiotics Selects for the Greatest Bacterial Load: The Smile-Frown Transition

(2014) Rafael Pena-Miller et al.   PLOS BIOLOGY

Fluidic and microfluidic tools for quantitative systems biology

(2013) Burak Okumus et al.   CURRENT OPINION IN BIOTECHNOLOGY

High-throughput approaches to understanding gene function and mapping network architecture in bacteria

(2013) Ana Rita Brochado et al.   CURRENT OPINION IN MICROBIOLOGY

Promoters maintain their relative activity levels under different growth conditions

(2013) L. Keren et al.   Molecular Systems Biology

Dissecting specific and global transcriptional regulation of bacterial gene expression

(2013) L. Gerosa et al.   Molecular Systems Biology

Bacterial evolution of antibiotic hypersensitivity

(2013) V. Lazar et al.   Molecular Systems Biology

Indirect and suboptimal control of gene expression is widespread in bacteria

(2013) M. N. Price et al.   Molecular Systems Biology

Shared control of gene expression in bacteria by transcription factors and global physiology of the cell

(2013) S. Berthoumieux et al.   Molecular Systems Biology

Dual role of transcription and transcript stability in the regulation of gene expression in Escherichia coli cells cultured on glucose at different growth rates

(2013) Thomas Esquerré et al.   NUCLEIC ACIDS RESEARCH

Salmonella typhimurium intercepts Escherichia coli signaling to enhance antibiotic tolerance

(2013) N. M. Vega et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Innate Growth Bistability and Fitness Landscapes of Antibiotic-Resistant Bacteria

(2013) J. B. Deris et al.   SCIENCE

Cell Death from Antibiotics Without the Involvement of Reactive Oxygen Species

(2013) Y. Liu et al.   SCIENCE

Killing by Bactericidal Antibiotics Does Not Depend on Reactive Oxygen Species

(2013) I. Keren et al.   SCIENCE

Combination approaches to combat multidrug-resistant bacteria

(2013) Roberta J. Worthington et al.   TRENDS IN BIOTECHNOLOGY

Bacterial Adaptation through Loss of Function

(2013) Alison K. Hottes et al.   PLoS Genetics

Trade-offs between drug toxicity and benefit in the multi-antibiotic resistance system underlie optimal growth of E. coli

(2012) Kevin B Wood et al.   BMC Systems Biology

The optimal deployment of synergistic antibiotics: a control-theoretic approach

(2012) R. Pena-Miller et al.   Journal of the Royal Society Interface

The inoculum effect and band-pass bacterial response to periodic antibiotic treatment

(2012) Cheemeng Tan et al.   Molecular Systems Biology

ppGpp: magic beyond RNA polymerase

(2012) Zachary D. Dalebroux et al.   NATURE REVIEWS MICROBIOLOGY

Mechanism-independent method for predicting response to multidrug combinations in bacteria

(2012) Kevin Wood et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Two-Drug Antimicrobial Chemotherapy: A Mathematical Model and Experiments with Mycobacterium marinum

(2012) Peter Ankomah et al.   PLoS Pathogens

Origin of diderm (Gram-negative) bacteria: antibiotic selection pressure rather than endosymbiosis likely led to the evolution of bacterial cells with two membranes

(2011) Radhey S. Gupta   ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY

The association of DNA damage response and nucleotide level modulation with the antibacterial mechanism of the anti-folate drug Trimethoprim

(2011) Dipen P Sangurdekar et al.   BMC GENOMICS

Tradeoffs and Optimality in the Evolution of Gene Regulation

(2011) Frank J. Poelwijk et al.   CELL

Antibiotics as Signal Molecules

(2011) Diego Romero et al.   CHEMICAL REVIEWS

Resolution of Gene Regulatory Conflicts Caused by Combinations of Antibiotics

(2011) Tobias Bollenbach et al.   MOLECULAR CELL

Quantification of mRNA and protein and integration with protein turnover in a bacterium

(2011) T. Maier et al.   Molecular Systems Biology

Systematic exploration of synergistic drug pairs

(2011) M. Cokol et al.   Molecular Systems Biology

Metabolite-enabled eradication of bacterial persisters by aminoglycosides

(2011) Kyle R. Allison et al.   NATURE

Combinations of antibiotics and nonantibiotic drugs enhance antimicrobial efficacy

(2011) Linda Ejim et al.   Nature Chemical Biology

Antibiotics as probes of biological complexity

(2011) Shannon B Falconer et al.   Nature Chemical Biology

Evolutionary paths to antibiotic resistance under dynamically sustained drug selection

(2011) Erdal Toprak et al.   NATURE GENETICS

Measuring single-cell gene expression dynamics in bacteria using fluorescence time-lapse microscopy

(2011) Jonathan W Young et al.   Nature Protocols

Depletion of antibiotic targets has widely varying effects on growth

(2011) J.-R. Wei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antifolate-Induced Depletion of Intracellular Glycine and Purines Inhibits Thymineless Death inE. coli

(2010) Yun Kyung Kwon et al.   ACS Chemical Biology

Protein Dynamics in Drug Combinations: a Linear Superposition of Individual-Drug Responses

(2010) Naama Geva-Zatorsky et al.   CELL

Phenotypic Landscape of a Bacterial Cell

(2010) Robert J. Nichols et al.   CELL

Best drug treatment for multidrug-resistant and extensively drug-resistant tuberculosis

(2010) José A Caminero et al.   LANCET INFECTIOUS DISEASES

Bacterial charity work leads to population-wide resistance

(2010) Henry H. Lee et al.   NATURE

How antibiotics kill bacteria: from targets to networks

(2010) Michael A. Kohanski et al.   NATURE REVIEWS MICROBIOLOGY

RegulonDB version 7.0: transcriptional regulation of Escherichia coli K-12 integrated within genetic sensory response units (Gensor Units)

(2010) S. Gama-Castro et al.   NUCLEIC ACIDS RESEARCH

EcoCyc: a comprehensive database of Escherichia coli biology

(2010) I. M. Keseler et al.   NUCLEIC ACIDS RESEARCH

Quantifying E. coli Proteome and Transcriptome with Single-Molecule Sensitivity in Single Cells

(2010) Y. Taniguchi et al.   SCIENCE

Interdependence of Cell Growth and Gene Expression: Origins and Consequences

(2010) M. Scott et al.   SCIENCE

Nonoptimal Microbial Response to Antibiotics Underlies Suppressive Drug Interactions

(2009) Tobias Bollenbach et al.   CELL

Growth Rate-Dependent Global Effects on Gene Expression in Bacteria

(2009) Stefan Klumpp et al.   CELL

On the Classification of Epistatic Interactions

(2009) H. Gao et al.   GENETICS

Meta-analysis: Four-Drug, Three-Antibiotic, Non-bismuth-Containing “Concomitant Therapy” Versus Triple Therapy forHelicobacter pyloriEradication

(2009) Abdallah Said Essa et al.   HELICOBACTER

Drug interactions and the evolution of antibiotic resistance

(2009) Pamela J. Yeh et al.   NATURE REVIEWS MICROBIOLOGY

(p)ppGpp: Still Magical?

(2008) Katarzyna Potrykus et al.   Annual Review of Microbiology

Bistability, Epigenetics, and Bet-Hedging in Bacteria

(2008) Jan-Willem Veening et al.   Annual Review of Microbiology

Effects of Antibiotics on Quorum Sensing in Pseudomonas aeruginosa

(2008) M. E. Skindersoe et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Accelerated evolution of resistance in multidrug environments

(2008) M. Hegreness et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drug interactions modulate the potential for evolution of resistance

(2008) J.-B. Michel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Growth-rate-dependent partitioning of RNA polymerases in bacteria

(2008) S. Klumpp et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bacteria Subsisting on Antibiotics

(2008) G. Dantas et al.   SCIENCE