Journal
JOURNAL OF CHEMICAL RESEARCH
Volume -, Issue 5, Pages 298-301Publisher
SAGE PUBLICATIONS LTD
DOI: 10.3184/174751911X13053065216840
Keywords
iodine; amide; water; Lieben iodoform reaction
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Funding
- National Natural Science Foundation of China [20872042, 21032001]
- PCSIRT [IRT0953]
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Secondary or tertiary amides have been prepared directly from aryl, heteroaryl methyl ketones using an iodine-amine-NaOH system which afforded the expected products in good yields in an aqueous medium. The present method has the advantages of using inexpensive reagents, mild reaction condition and ease of manipulation.
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