Article
Environmental Sciences
Rose Hefferon, Dana E. Goin, Jeremy A. Sarnat, Anne E. Nigra
Summary: Although fluoridation of community water systems is considered a major public health achievement, recent evidence suggests that chronic exposure to fluoride may have adverse effects on child neurodevelopment. We investigated regional and sociodemographic disparities in fluoride concentrations in US community water systems and found that Hispanic/Latino communities had higher levels of fluoride. Our findings highlight the need for further research on the potential association between chronic fluoride exposure and adverse outcomes.
JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY
(2023)
Article
Chemistry, Applied
Tanmay Das, Mrittika Mohar
Summary: This study investigated the mechanism of protonation of a Meisenheimer complex derived from picric acid and N,N '-dicyclohexylcarbodiimide to determine the correct protonated structure and proposed a general colorimetric volatile acid sensor that can detect volatile acids in both solid and solution states. Additionally, the sensor was able to automatically detect hydrogen chloride vapor with a detection limit of 43.5 ppm.
COLORATION TECHNOLOGY
(2021)
Article
Chemistry, Analytical
Qiaobin Chen, Lihua Xu, Qingqing Feng, Jiang Zhao
Summary: In this study, two anion sensors ICZ-o-1S and ICZ-o-2S were synthesized for the sensitive detection of F- ion. The results demonstrated that these sensors showed selective and sensitive sensing of F- ion, and their detection performance was confirmed by theoretical calculation and experimental validation. By increasing the number of sensing units, the detection limit of ICZ-o-2S was reduced by 3 times, validating the rationality of the design strategy to improve detection capability by increasing sensing unit numbers.
Article
Chemistry, Physical
Jukkrit Nootem, Rathawat Daengngern, Chanchai Sattayanon, Worawat Wattanathana, Suttipong Wannapaiboon, Paitoon Rashatasakhon, Kantapat Chansaenpak
Summary: New push-pull schiff base ligands based on benzothiazole units were developed for the selective detection of Cu2+ through a fluorescence 'turn-on' mechanism. These ligands demonstrate significant fluorescence enhancement upon binding with copper ions, potentially due to a synergistic effect between chelation-enhanced fluorescence and intramolecular charge transfer processes. The complexes exhibit non-centrosymmetric structures and strong intramolecular charge transfer effects after Cu2+ binding, which are key processes for promoting the fluorescence 'turn-on' mechanism.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2021)
Article
Chemistry, Applied
Duygu Aydin, Sinan Dinckan, Sukriye Nihan Karuk Elmas, Tahir Savran, Fatma Nur Arslan, Ibrahim Yilmaz
Summary: In this study, a turn-on fluorogenic chemosensor HMBP was designed to detect Al3+. The chemosensor showed high sensitivity and binding capacity towards Al3+, with a stoichiometric ratio of 1:2 and a binding constant of 1.21 x 10(8) M-1. The response of the chemosensor to Al3+ was attributed to blocking the PET and C=N isomerisation mechanisms. The sensor was successfully employed for the determination of Al3+ in real food samples, drinking waters, and herbal teas.
Article
Environmental Sciences
Jesus Ibarluzea, Mikel Subiza-Perez, Ane Arregi, Amaia Molinuevo, Enrique Arranz-Freijo, Manuel Sanchez-de Miguel, Ana Jimenez, Ainara Andiarena, Loreto Santa-Marina, Aitana Lertxundi
Summary: This study investigated the association between prenatal maternal urinary fluoride levels and symptoms of attention-deficit/hyperactivity disorder (ADHD) in children aged 8 and 11 years. The results showed no association between maternal urinary fluoride levels during pregnancy and cognitive problems-inattention symptoms at 8 or 11 years old. However, at age 11, there was a significant inverse association between maternal urinary fluoride levels and being categorized as a cognitive problems-inattention case. These findings contradict previous studies and highlight the need for further population-based research to confirm or challenge these results.
ENVIRONMENTAL RESEARCH
(2023)
Article
Medicine, Legal
Mohamed Amine Kerdoun, Sabah Mekhloufi, Oum El Kheir Adjaine, Zineb Bechki, Mohamed Gana, Hakim Belkhalfa
Summary: The average fluoride level in drinking water in southern Algeria is below the WHO recommended limit, but higher in rural areas than in urban areas. Children and infants may face health risks from fluoride intake through water consumption. Surveillance and control measures for fluorosis are crucial to prevent potential health risks.
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2022)
Article
Environmental Sciences
Feiqing Wang, Yanju Li, Dongxin Tang, Jianing Zhao, Xu Yang, Yanqing Liu, Fengtao Peng, Liping Shu, Jishi Wang, Zhixu He, Yang Liu
Summary: This meta-analysis systematically evaluated the effects of water improvement and defluoridation in fluorosis-endemic areas in North and South China. The results showed significant reductions in dental fluorosis and skeletal fluorosis prevalence, as well as urinary fluoride levels after water improvement. Additionally, the effects were greater in South China compared to North China.
ENVIRONMENTAL POLLUTION
(2021)
Article
Materials Science, Multidisciplinary
Ting Wang, Haiyin Gang, Yiyun Cao, Lvji Yan, Dun Wei, Haiying Wang, Jiao Zhang
Summary: A highly efficient hydrous CeO2 polypyrrole nanocomposite (HCeO2@PPy) was prepared and studied for the removal of fluoride in acidic wastewater. The adsorption capacity of HCeO2@PPy for F- was 43.6 mg/g, three times higher than that of ordinary polypyrrrole. The material achieved a fluoride removal efficiency of 71.7% in acidic wastewater. This study provides new insights for the development of efficient and stable fluoride removal materials in acidic fluoride wastewater with complex compositions.
JOURNAL OF MATERIALS SCIENCE
(2023)
Article
Biotechnology & Applied Microbiology
Eugenio Hernan Otal, Manuela Leticia Kim, Yoshiyuki Hattori, Yu Kitazawa, Juan Paulo Hinestroza, Mutsumi Kimura
Summary: This study reports a post-synthetic functionalization method of metal organic frameworks for detecting fluoride in water, with high yield, reduced reagent costs, and minimal by-products. Among them, a Rhodamine B functionalized Al-BDC-NH2 metal organic framework was identified as particularly suitable for fluoride detection in water.
BIOENGINEERING-BASEL
(2021)
Article
Spectroscopy
Yongshan Ma, Yanzhao Xia, Xiaodi Wang, Guangxiang Ma, Fengxia Zhang, Tianyi Jiang, Yanyan Zhu, Xuemei Li
Summary: Two novel fluorescent probes (P1 and P2) containing a perylene tetra-(alkoxycarbonyl) derivative (PTAC) and its copper chelate were designed and synthesized. The probes showed high selectivity and sensitivity towards fluoride ions, with their sensing mechanism involving the formation of H-bond between the O-H moiety and fluoride ions. The coordination of copper ion enhanced the H-bond donor capacity of the receptor unit (O-H).
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Environmental Sciences
Haitao Dong, Xin Yang, Shixuan Zhang, Xueting Wang, Chunlan Guo, Xinyuan Zhang, Junxiang Ma, Piye Niu, Tian Chen
Summary: Our study found that even low levels of water or plasma fluoride exposure were associated with an increased risk of dental fluorosis. Further research on the safety of public health approaches to drinking water fluoridation for global dental caries reduction is urgently needed.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Spectroscopy
Furkan Burak Sen, Nilay Begic, Mustafa Bener, Resat Apak
Summary: In this study, a fluorescent polyethylenimine capped carbon quantum dots (PEI-C-dots) probe was synthesized and used to detect TNT residues. The synthesized PEI-C-dots exhibited high fluorescence quantum yield and low detection limit for TNT. The detection of TNT was not interfered by similar structured explosives, common soil ions, and camouflage agents.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Chemistry, Analytical
Qiaoyin Li, Haiyan Chen, Shumin You, Zhenyu Lin, Zhitao Chen, Fengping Huang, Bin Qiu
Summary: Proper amount of fluorion is important for human health, but excessive fluorion is harmful. A colorimetric and fluorescence enhanced sensor, using MOF material UiO-66 combined with fluorescent dye FITC, is proposed to detect fluorion with high selectivity. It has a good linear relationship in the range of 2-150 mu M (0.038-2.85 ppm), and has been applied to the detection of actual water samples. Field visual detection of fluoride ion is realized, expanding the application of MOF in fluorescence sensing.
MICROCHEMICAL JOURNAL
(2023)
Article
Environmental Sciences
Jasmyn E. A. Cunningham, Hugh McCague, Ashley J. Malin, David Flora, Christine Till
Summary: Exposure to fluoride may contribute to sleeping less than the recommended duration among older adolescents and adults in Canada, but is not significantly associated with the frequency of sleep problems or daytime sleepiness.
ENVIRONMENTAL HEALTH
(2021)
Article
Chemistry, Multidisciplinary
Elishua D. Litle, Francois P. Gabbai
Summary: This study reports on the formation process of M -> C-carbenium bonds in a series of Group 10 complexes and confirms their dative nature through combined experimental and computational studies.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Inorganic & Nuclear
Mohammadjavad Karimi, Francois P. Gabbai
Summary: This study reports the synthesis and photoreduction of a complex featuring a tetravalent platinum center connected to a germyl ligand. In the presence of a chlorine trap, the complex undergoes a clean photolysis to produce two different products, which were confirmed and quantified using NMR spectroscopy and GC-MS analysis.
Article
Chemistry, Inorganic & Nuclear
M. Karimi, F. P. Gabbai
Summary: To enhance the fluoride binding ability of Lewis acidic stiboranes, a Sb-V derivative has been synthesized and characterized. The derivative features diarylamine groups positioned near the antimony center, allowing for hydrogen bonding interactions with Sb-bound fluoride anions. Experimental and computational results demonstrate that the fluoride ion affinity of this derivative is superior to other compounds.
ZEITSCHRIFT FUR ANORGANISCHE UND ALLGEMEINE CHEMIE
(2022)
Article
Chemistry, Multidisciplinary
Wei-Chun Liu, Francois P. Gabbai
Summary: In this study, we synthesized a tetrafluoroborate salt and found that it can function as a fluorescent fluoride anion sensor. Through spectroscopic and computational analysis, we revealed the mechanism behind the color change, and further investigated the properties of the system through electrochemical studies.
CANADIAN JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Mohammadjavad Karimi, Elishua Litle, Francois P. Gabbai
Summary: In this study, gold complexes with halogermanes as ligands were synthesized and investigated. Experimental and computational analyses revealed the presence of an Au -> Ge interaction in these complexes. Chloride abstraction reactions were also studied, and a putative dication was formed by double chloride abstraction with AgSbF6. This dication showed higher catalytic activity than its monocationic analog in alkyne hydroamination reactions.
ISRAEL JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Elishua D. Litle, Francois P. Gabbai
Summary: In this study, two compounds were synthesized to investigate the interaction of gold with fluorenyl cation. Computational results showed that one of the compounds possesses a strong Au -> C+ bond and can effectively activate enyne compounds.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Inorganic & Nuclear
Francois P. Gabbai, Jesse E. Smith
Summary: As part of our investigations into the Lewis acidic behavior of antimony derivatives, we studied the properties of 5-phenyl-5,5-dichloro-lambda 5-dibenzostibole (1), a dichlorostiborane with an antimony atom confined to a five-membered heterocycle. Our work confirmed that the geometric constraints of this compound enhance the Lewis acidity of the antimony atom, as evidenced by crystal structure analysis and solution studies. The compound's enhanced Lewis acidic properties were also observed in pnictogen bonding catalysis experiments involving imine reductions.
Article
Chemistry, Multidisciplinary
Wei-Chun Liu, Francois P. Gabbai
Summary: We have described a new gold chloride complex with an ambiphilic phosphine/xanthylium ligand, in which the AuCl interacts with the pi(+) surface of the xanthylium unit. Energy decomposition analyses on a model system revealed the dominance of non-covalent interactions, particularly electrostatic and dispersion terms. The presence of these AuCl-pi(+) interactions correlates with the high catalytic activity of the complex in various cyclisation reactions.
Article
Chemistry, Multidisciplinary
Benyu Zhou, Francois P. Gabbai
Summary: This study investigates the reaction of O-2 with two distibines in the presence of an ortho-quinone, resulting in the formation of tetraolate complexes. The formation process involves oxidation of the antimony atoms to the +V state and the formation of an alpha,alpha,beta,beta-tetraolate ligand that bridges the two antimony(V) centers. Under aerobic conditions, the tetraolate complexes react with O-2 to form semiquinone/peroxoantimony intermediates and then evolve into bis(antimony(V)) alpha,alpha,beta,beta-tetraolate complexes. The controlled protonolysis and reduction of the bis(antimony(V)) alpha,alpha,beta,beta-tetraolate complexes regenerate the starting distibine and ortho-quinone, producing two equivalents of water as the product of O-2 reduction.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Inorganic & Nuclear
Logan T. Maltz, Francois P. Gabbai
Summary: We present the findings of a computational study on the binding of fluoride by various pentavalent pnictogen Lewis acids. Through activation strain and energy decomposition analyses, we identified the electrostatic and orbital contributions to these acid-base interactions, as well as the significance of Pauli repulsion and molecular flexibility in determining relative Lewis acidity among the pnictogens. Our results highlight antimony-based species as the strongest fluoride binders, and emphasize the importance of Pauli repulsion and molecular flexibility in determining this relative Lewis acidity.
INORGANIC CHEMISTRY
(2023)
Review
Chemistry, Multidisciplinary
Brendan L. Murphy, Francois P. Gabbai
Summary: This article introduces the research on the use of antimony compounds as new platforms for anion capture, sensing, and transport, emphasizing the excellent Lewis acidic properties of antimony and its potential in supramolecular chemistry and catalysis. It also mentions the recent advances in anion sensing in aqueous media and anion binding catalysis and anion transport across phospholipid membranes.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Inorganic & Nuclear
Asima Munawar, Logan T. Maltz, Wei-Chun Liu, Francois P. Gabbai
Summary: This study presents the design of a novel ligand structure, allowing facile introduction of cationic charge through methylation, to investigate the effect of positive charge insertion on the catalytic activity of gold catalysts. Experimental results demonstrate significant differences in catalytic activity between neutral and cationic gold species.
Article
Chemistry, Multidisciplinary
Alessio Cataldo, Matus Chvojka, Gyeongjin Park, Vladimir Sindelar, Francois P. Gabbai, Stephen J. Butler, Hennie Valkenier
Summary: Here we introduce a novel approach using a europium(iii) complex to monitor the transmembrane transport of fluoride into liposomes. By utilizing the long emission lifetime of this probe, we are able to accurately measure the transport activity of fluorescent transporters. The high sensitivity, selectivity, and versatility of this assay enable us to investigate various types of fluoride transporters and unravel their mechanisms of action.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Benyu Zhou, Shantabh Bedajna, Francois P. Gabbai
Summary: The design of a gold catalyst activation system through the formation of a pnictogen bond with a neighboring antimony unit is described. The resulting complex shows efficient catalytic reactivity, possibly through an intramolecular Au-Cl -> Sb(v) interaction for carbophilic catalysis.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Logan T. Maltz, Lewis C. Wilkins, Francois P. Gabbai
Summary: We synthesized and characterized two phosphine gold carbinol species designed to enhance intramolecular Au-M hydrogen bonding. By substituting the chloride ligand with a phenyl group, we observed a significant increase in the strength of this hydrogen bond, which was analyzed both experimentally and computationally.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Alexander M. Prophet, Kritanjan Polley, Gary J. Van Berkel, David T. Limmer, Kevin R. Wilson
Summary: The oxidation kinetics of iodide by ozone at the air-water interface is studied in single microdroplets. Molecular simulations and kinetic modeling are used to understand the underlying multiphase mechanism.
Article
Chemistry, Multidisciplinary
Rong Zhang, Jiajing Lan, Fei Wang, Shumei Chen, Jian Zhang
Summary: By utilizing 1,1'-ferrocene dicarboxylic acid as a chelating and surface protection ligand, we have synthesized multi-nuclear indium oxide clusters with varying nuclear sizes, including heptanuclear and thirteen-nuclear clusters. These clusters possess labile coordination sites, allowing for structural modification and self-assembly, resulting in the formation of various cluster structures.
Article
Chemistry, Multidisciplinary
Hui Wang, Hui Liu, Mingsen Wang, Jiaheng Hou, Yongjun Li, Yuancheng Wang, Yingjie Zhao
Summary: Two supramolecular complexes were prepared using CBs and M1, and their single-crystal structures were analyzed by SCXRD. The unexpected 1:2 self-assembly structure between M1 and CB[8] was discovered for the first time. These complexes exhibit unique photophysical properties and provide valuable information about the structure and photophysical properties of supramolecular complexes.
Article
Chemistry, Multidisciplinary
Chang-Hee Lee, Sookil Park, Sanggil Kim, Ji Young Hyun, Hyun Soo Lee, Injae Shin
Summary: The epidermal growth factor receptor (EGFR) is a cell-surface glycoprotein involved in cell proliferation and tumor development. This study used a fluorescently labeled EGFR to investigate its time-dependent endocytosis in live cells and found that appended glycans affect EGFR internalization. Additionally, the study detected sialic acid residues attached to EGFR on the live cell surface using FRET-based imaging. This research provides valuable insights into the cellular functions of EGFR.
Article
Chemistry, Multidisciplinary
Subhankar Sahu, Lokesh Kumar, Sumita Das, Dipti Gupta, Ruchi Anand
Summary: This study proposes a strategy that combines organic electronics with biosensor scaffolds to create a compact device for monitoring environmental aromatic pollution. By coupling biosensing protein MopR with an organic electrochemical transistor (OECT), a sensor module capable of efficient detection of phenol was designed. Exclusive phenol detection with minimal loss of sensitivity could be achieved in complex pollutant mixtures and real environmental samples.
Review
Chemistry, Multidisciplinary
Changseok Lee, Hyung-Joon Kang, Sungwoo Hong
Summary: The formation of C-N bonds through hydroamination reactions catalyzed by nickel hydrides has been a topic of recent interest. This approach offers a way to efficiently transform a variety of alkene and alkyne substrates into compounds enriched with C-N bonds. The review provides a concise overview of the underlying reaction mechanisms and aims to stimulate further progress in NiH-catalytic techniques and catalyst design.
Article
Chemistry, Multidisciplinary
Yueci Wu, Lu-Lu Sun, Hai-Hao Han, Xiao-Peng He, Weiguo Cao, Tony D. James
Summary: Drug-induced liver injury (DILI) is a common cause of acute liver failure in the USA and Europe, but most cases can be recovered or prevented by discontinuing the offending drug. Recent research has found that peroxynitrite (ONOO-) can be used as a potential indicator for early diagnosis of DILI, and there is an urgent need to establish a method to detect and track peroxynitrite in DILI cases. In this study, a FRET-based nano fluorescent probe CD-N-I was developed, which showed high selectivity and sensitivity in detecting peroxynitrite. The probe successfully detected exogenous peroxynitrite in live cells and endogenous peroxynitrite in APAP-induced liver injury of HepG2 cells.
Article
Chemistry, Multidisciplinary
Dmitry L. Lipilin, Mikhail O. Zubkov, Mikhail D. Kosobokov, Alexander D. Dilman
Summary: This article describes a direct photocatalytic method for the thiolation of unprotected acids, which was previously challenging. By using a thionocarbonate reagent with an N-O bond, the efficient conversion of carboxylic acids to thiols is achieved.
Article
Chemistry, Multidisciplinary
Jason Malenfant, Lucille Kuster, Yohann Gagne, Kouassi Signo, Maxime Denis, Sylvain Canesi, Mathieu Frenette
Summary: Raman microscopy can reveal compound-specific vibrational fingerprints without sample preparation. The combination of efficient theoretical calculations and a user-friendly software can accurately predict peak positions and provide match scores to assist with structure determination.
Article
Chemistry, Multidisciplinary
Jayoh A. Hernandez, Paul S. Micus, Sean Alec Lois Sunga, Luca Mazzei, Stefano Ciurli, Gabriele Meloni
Summary: Essential trace metals play crucial roles in the survival and virulence of bacterial pathogens. Helicobacter pylori requires nickel for colonization and persistence in the stomach, and NixA is an essential nickel transporter in this process. This study characterizes the selectivity and electrogenic nature of NixA-mediated nickel transport.
Article
Chemistry, Multidisciplinary
Tarali Devi, Kuheli Dutta, Jennifer Deutscher, Stefan Mebs, Uwe Kuhlmann, Michael Haumann, Beatrice Cula, Holger Dau, Peter Hildebrandt, Kallol Ray
Summary: This study emphasizes the importance of subtle electronic changes and secondary interactions in the stability of biologically relevant metal-dioxygen intermediates. It also shows that the role of the chloride ligand in stabilizing the Fe-III-(OOBu)-Bu-t moiety can extend to other anions, including the thiolate ligand.
Article
Chemistry, Multidisciplinary
Jacqueline R. Santhouse, Jeremy M. G. Leung, Lillian T. Chong, W. Seth Horne
Summary: By studying the folding kinetics and mechanism of the BdpA sequence, researchers found that altering the backbone connectivity can affect protein folding. This suggests that protein mimetic chains have a significant degree of plasticity in transitioning between unfolded and folded states.
Article
Chemistry, Multidisciplinary
Divanshu Gupta, Ralf Einholz, Holger F. Bettinger
Summary: This study presents the first direct spectroscopic evidence of a cyclic seven-membered iminoborane. Compared to linear amino-iminoboranes, this cyclic iminoborane exhibits weakened bond strength and lower Lewis acidity value. The study suggests that the reduced ring strain of cyclic iminoborane prevents nitrogen fixation but allows facile (2 + 2) cycloaddition reaction with C2H4.
Article
Chemistry, Multidisciplinary
Renny Mathew, Aniruddha Mazumder, Praveen Kumar, Julie Matula, Sharmarke Mohamed, Petr Brazda, Mahesh Hariharan, Brijith Thomas
Summary: This study reveals the packing arrangement of partially disordered nitro-perylenediimide (NO2-PDI) using a synergistic approach that combines 3D ED, ssNMR, and DFT techniques. By overcoming these challenges, this methodology opens up new avenues for material characterization, driving exciting advancements in the field.