Article
Chemistry, Inorganic & Nuclear
Chuan-Kuei Chiang, Yu-Chiao Liu, Kai-Ti Chu, Jing-Ting Chen, Cheng-Yeh Tsai, Gene-Hsiang Lee, Ming-Hsi Chiang, Chien-Ming Lee
Summary: In this study, a dimeric and mononuclear Fe-NO model complex were synthesized and characterized, showing the formation of a thiolate-bridged bimetallic complex during the reduction of the mononuclear complex. The electronic structure of the bimetallic complex was described as a FeII/{Fe(NO)2}9 state, providing insights into the NO scrambling behavior in the activity of flavodiiron nitric oxide reductases (FNORs).
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Luca Bondi, Santiago Rodriguez-Jimenez, Humphrey L. C. Feltham, Anna L. Garden, Sally Brooker
Summary: Four new bidentate ligands and their corresponding iron complexes were prepared and studied, showing different SCO activities at various temperatures. NMR studies in solution further confirmed the properties of the ligands and complexes. The correlation between NMR chemical shifts and SCO behavior was explored to understand the electronic effects of different substituents.
INORGANIC CHEMISTRY FRONTIERS
(2021)
Article
Chemistry, Multidisciplinary
Daan den Boer, Dennis G. H. Hetterscheid
Summary: This study systematically investigates the influence of electron-donating groups (EDGs) or electron-withdrawing groups (EWGs) on elementary steps in electrochemical water oxidation catalysis. The authors find that electron transfer and proton transfer steps are more sensitive to the presence of EDGs or EWGs, while proton-coupled electron transfer steps are relatively unaffected. Additionally, the influence of substituents decreases with an increasing oxidation state.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Biochemistry & Molecular Biology
Olga V. Kosmachevskaya, Elvira I. Nasybullina, Konstantin B. Shumaev, Natalia N. Novikova, Alexey F. Topunov
Summary: DNICs, a physiological form of nitric oxide in organisms, act as antioxidants and antiradical agents to protect hemoglobin from oxidative modification caused by peroxynitrite through intercepting peroxynitrite and free radicals.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Anatoly F. Vanin
Summary: This article discusses the oxidative mechanism of M-DNICs formation and the effect of thiol-containing ligands on the stability of these complexes. The results demonstrate that thiol-containing ligands help M-DNICs maintain stability at neutral pH values.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Inorganic & Nuclear
Miguel A. Baeza Cinco, Guang Wu, Trevor W. Hayton
Summary: The reaction of [K(18-crown-6)][O2N2CPh3] with [(LCo)-L-Me(& mu;-Br)(2)Li(OEt2)] generates the trityl diazeniumdiolate complex, [(LCo)-L-Me(O2N2CPh3)] (1). Similar metathesis reactions result in the formation of the Fe and Cu analogues, [(LM)-L-Me(O2N2CPh3)] (Fe, 2; Cu, 3). Complexes 1-3 were characterized by spectroscopy and their structures were determined by X-ray crystallography. Photolysis of the C-diazeniumdiolate complexes, [(LM)-L-Me(O2N2CPh3)] (L-Me = {(2,6-(Pr2C6H3)-Pr- i )NC(Me)}(2)CH; M = Fe, Co), results in the disassembly of their C-diazeniumdiolate ligands to yield [(LM)-L-Me(NO)(2)] via a proposed hyponitrite intermediate.
INORGANIC CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Wen-Han Chuang, Yu-Ting Chou, Yi-Hong Chen, Ting-Han Kuo, Wen-Feng Liaw, Tsai-Te Lu, Chih-Fei Kao, Yun-Ming Wang
Summary: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by cognitive impairment, memory loss, and behavioral deficits. The aggregation of β-amyloid(1-42) (Aβ(1-42)) is a significant cause of AD pathogenesis. Despite extensive research, current treatment efficacy for AD remains insufficient. Nitric oxide (NO) has a neuroprotective role in the central nervous system by inhibiting Aβ aggregation and rescuing memory and learning deficits through the NO signaling pathway. Targeting the NO pathway may be a therapeutic option, but the limited half-life of NO in the biological system poses a challenge. This study explored a biomimetic dinitrosyl iron complex (DNIC-COOH) that can stably deliver NO to address this issue. Adding DNIC-COOH to neuron-like cells and primary cortical neurons along with Aβ(1-42) demonstrated its ability to protect neuronal cells, enhance neuronal functions, and facilitate Aβ(1-42) degradation through the NO-sGC-cGMP-AKT-GSK3β-CREB/MMP-9 pathway.
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Jill B. Harland, Subhra Samanta, Nicolai Lehnert
Summary: In this study, three new synthetic model systems for NorBC were designed and characterized using spectroscopy. It was found that replacing the carboxylate ligand with a phenolate or pyridine group restored the reactivity towards NO, resulting in the formation of diiron dinitrosyl complexes. However, no N2O production was detected.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Chi-Yen Tung, Wei-Chih Shih, Tzung-Wen Chiou, I-Jui Hsu, Wen-Feng Liaw
Summary: The study reveals that DNIC 1 can facilitate versatile chemical reactions associated with two-electron hydrogen evolution reaction processes, and a three-component photocatalytic system has been developed to achieve efficient hydrogen generation.
JOURNAL OF THE CHINESE CHEMICAL SOCIETY
(2022)
Article
Nanoscience & Nanotechnology
Chang Tu, Chiheng Dong, Caida Fu, Meng Han, MingHui Tang, He Huang, Chao Yao, Dongliang Wang, Xianping Zhang, Yanwei Ma
Summary: Iron impurities in BaxK1-xFe2As2 wires and tapes not only suppress superconductivity locally but also hinder current transport. These impurities are not introduced externally or caused by incomplete reactions, but are a result of the chemical environments determined by nominal compositions. Adjusting the nominal composition by slightly excessive addition of As effectively eliminates iron impurities and enhances the critical current density of the tape.
SCRIPTA MATERIALIA
(2023)
Article
Biochemistry & Molecular Biology
Taiming Liu, Hobe Schroeder, Gordon G. Power, Arlin B. Blood
Summary: This review proposes a classification of compounds called "nitrodilators" that dilate vessels by activating a preformed nitrodilator-activated NO store (NANOS) within the cell, despite not releasing free NO.
Article
Chemistry, Inorganic & Nuclear
Wen-Chieh Chang, Wan-Tin Du, Yi-Xuan Lin, Ruei-Lin Jhang, Chung-Hung Hsieh
Summary: This article describes the synthesis and characterization of cationic, neutral, and anionic DNCCs, demonstrating the interconversions and NO releasing ability akin to what is observed in DNICs.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Inorganic & Nuclear
Wen-Chieh Chang, Wan-Tin Du, Yi-Xuan Lin, Ruei-Lin Jhang, Chung-Hung Hsieh
Summary: This article describes the synthesis and characterization of cationic, neutral, and anionic DNCCs, demonstrating the interconversions and NO releasing ability akin to what is observed in DNICs.
DALTON TRANSACTIONS
(2023)
Article
Biochemistry & Molecular Biology
Alexandra Igrunkova, Alexey Fayzullin, Natalia Serejnikova, Tatiana Lipina, Alexandr Pekshev, Anatoly Vanin, Victoria Zaborova, Elena Budanova, Dmitry Shestakov, Igor Kastyro, Anatoly Shekhter
Summary: This study compared the wound healing effects of B-DNIC-GSH and NO-CGF. The results showed that B-DNIC-GSH had a more pronounced effect in reducing inflammation and promoting wound healing compared to NO-CGF.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Inorganic & Nuclear
Ibrahim Habib, Tsai-Te Lu, Amr Sabbah, Kuei-Hsien Chen, Fu-Te Tsai, Wen-Feng Liaw
Summary: This study presents a novel strategy for the efficient preparation of nanoscale zerovalent iron (NZVI) composites using a one-pot photosynthetic process. The obtained NZVI composites showed potential applications in biomedicine, catalysis, and environmental remediation.
INORGANIC CHEMISTRY
(2022)
Article
Polymer Science
Gulzar A. Bhat, Marcetta Y. Darensbourg, Donald J. Darensbourg
Summary: The synthesis of poly(propylene carbonate) with 100% C-13-labeled carbonate carbons has been reported, where the nu(CO3) vibration is lowered by 45 cm(-1), allowing for the observation of nu(NO) stretching motions in incorporated dinitrosyl iron complexes.
Article
Chemistry, Inorganic & Nuclear
Xuemei Yang, Christopher R. DeLaney, Kyle T. Burns, Lindy C. Elrod, Wenting Mo, Haley Naumann, Nattamai Bhuvanesh, Michael B. Hall, Marcetta Y. Darensbourg
Summary: A self-assembled tetrameric nickel cage with carboxylate linkages was obtained through various synthetic routes. The tetramer can dissociate into monomeric units in solution, and removal of four iodides by silver ion precipitation results in an analogous species with an additional vacant coordination site. Electrochemical experiments demonstrated that trifluoroacetic acid as a proton source led to hydrogen production from both electroprecatalysts, with electrocatalysis primarily developing from uncharacterized deposits on the electrode.
INORGANIC CHEMISTRY
(2021)
Review
Chemistry, Inorganic & Nuclear
Paulina Guerrero-Almaraz, Manuel Quiroz, Joseph H. Reibenspies, Marcetta Y. Darensbourg
Summary: Two synthetic approaches were used to install metallodithiolate ligands on molybdenum centers, resulting in a trimetallic dication, CoMoCo', with unique structure and characteristics, including bisnitrosylation and the generation of unpaired electrons.
INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Mani Sengoden, Gulzar A. Bhat, Donald J. Darensbourg
Summary: Polymers obtained from renewable monomers have attracted attention for their ability to address environmental issues and depletion of fossil fuels. In this study, a renewable eugenol-based epoxide was synthesized and its reactions with CO2, COS, and CS2 were examined. It was found that eugenol epoxide preferentially formed cyclic products with CO2 and CS2, while reacting with COS resulted in the regioselective formation of polymonothiocarbonate polymers at room temperature. The molecular structures of the renewable monomers and their cyclic products were determined using single crystal X-ray diffraction studies. Thermal gravimetric analysis and differential scanning calorimetry revealed that the polymonothiocarbonate polymers were stable up to 200 degrees C and had high glass transition temperatures.
Article
Chemistry, Inorganic & Nuclear
Zachary M. Martinez, Tucker M. Folsom, Yicheng Tong, Ashley K. Archambeau, Donald J. Darensbourg, Michael B. Hall, Cynthia B. Powell, Gregory L. Powell
Summary: The mechanism of CO substitution reaction involving diosmium carbonyl sawhorse complex was studied experimentally and theoretically, revealing a dissociative interchange mechanism. Kinetic measurements and stability studies were in agreement with each other, explaining the unexpected combination of kinetics and stability characteristics observed in the reaction.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Fang-Yu Ren, Kaihong Chen, Li-Qi Qiu, Jin-Mei Chen, Donald J. Darensbourg, Liang-Nian He
Summary: A triblock amphiphilic polymer derived from the copolymerization of CO2 and epoxides is able to efficiently catalyze the visible-light-driven reduction of CO2 to CO. The polymer forms spherical micelles in water, where the metal catalyst is sequestered. The amphiphilic polycarbonate micelle rhenium catalyst shows enhanced catalytic activity and selectivity compared to the corresponding molecular rhenium catalyst in organic solvent, while also suppressing the generation of H-2.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Peiran Wei, Gulzar A. Bhat, Ciera E. Cipriani, Hamza Mohammad, Krista Schoonover, Emily B. Pentzer, Donald J. Darensbourg
Summary: This study reports on the facile synthesis and 3D printing of triblock copolymers that can be covalently modified. Thixotropic inks suitable for direct ink write printing were formulated by dissolving the block copolymers in organic solvent and dispersing NaCl particles. Printed structures with surfaces that could be modified and objects with high solvent resistance and selective degradability were achieved.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Multidisciplinary Sciences
Manuel Quiroz, Molly M. Lockart, Mohamed R. Saber, Shaik Waseem Vali, Lindy C. Elrod, Brad S. Pierce, Michael B. Hall, Marcetta Y. Darensbourg
Summary: Inspired by strategies found in nature, sulfur-bridged Fe-Ni heterobimetallics have been synthesized and exhibit intricate physical properties. Experimental and theoretical investigations have revealed the structures, redox reactions, and magnetic properties of these compounds.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Chemistry, Inorganic & Nuclear
Trung H. Le, Hao Nguyen, Heather A. Arnold, Donald J. Darensbourg, Marcetta Y. Darensbourg
Summary: The discovery of ligand transfer from M(N2S2) to MnI in Mn(CO)5Br led to the synthesis of a ligand-tethered dimanganese complex, (mu 4-N,N'-ethylenebis(mercaptoacetamide))-[Mn2(CO)6], which has numerous analogues of the type (mu-S-E)2[Mn2(CO)6]. These complexes constitute an understudied class with Mn2S2 rhomb structures. Comparison of the infrared spectra and frequency calculation of the tethered and nontethered complexes suggested the existence of both syn- and anti-isomers and their interconversion in solution. The analysis of the dimanganese components revealed that the anti-form is centrosymmetric RS isomer, while the syn-form is limited by C2 symmetry to be either RR or SS.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Paulina Guerrero-Almaraz, Manuel Quiroz, Marcetta Y. Darensbourg
Summary: This article describes the reaction between [Cr(NO)(MeCN)5]2+ and Ni(N2S2) metallodithiolate ligand, and the co-crystallized products that could be obtained from the reaction. The two products, [Cr(NO)Ni2]2+ and [CrNi3]3+, have symmetrical butterfly and pinwheel-type structures, respectively.
Article
Polymer Science
Mani Sengoden, Gulzar A. Bhat, Donald J. Darensbourg
Summary: In recent years, chemists worldwide have made significant progress in synthesizing sustainable polymers from natural product-based building blocks. This shift is driven by the environmental impact of non-biodegradable oil-based polymers and the need to utilize renewable feedstocks. This study presents the synthesis of novel terpolymer using a well-defined catalyst system and investigates the mechanistic details of the polymerization reactions. The resulting terpolymers show increased thermal stability with higher proportions of the renewable building block.
Review
Chemistry, Multidisciplinary
Peiran Wei, Gulzar A. Bhat, Donald J. Darensbourg
Summary: This paper presents a concise review of recent progress in processing techniques for aliphatic polycarbonates, including controlled self-assembly, electrospinning, additive manufacturing, and others. The aim is to provide researchers with an enriched toolbox for selecting the most suitable technique for their materials.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Mani Sengoden, Gulzar A. Bhat, Donald J. Darensbourg
Summary: Recent years have seen significant research efforts in the development of metal-free organocatalysts for coupling reactions of CO2 and epoxides. In this study, a series of boron-phosphonium organocatalysts were synthesized and characterized for catalyzing these reactions. The catalysts exhibited high selectivity and were found to be less hygroscopic compared to metal-based catalysts. They successfully facilitated the copolymerization of CO2 and epoxides to form polycarbonates.
Review
Chemistry, Multidisciplinary
Gulzar A. Bhat, Donald J. Darensbourg
Summary: Sustainability requires the reuse of carbon sources from CO2 emissions, making carbon capture and utilization essential. Coupling of oxiranes (epoxides) with CO2 can generate cyclic carbonates and polymeric materials, providing a potential solution. It is important to use epoxides derived from renewable resources for a sustainable process.
Article
Chemistry, Inorganic & Nuclear
Christopher DeLaney, Yan Sheng, D. Chase Pectol, Erol Vantansever, Hanyuan Zhang, Nattamai Bhuvanesh, Isaiah Salas, Wenshe R. Liu, Carol F. Fierke, Marcetta Y. Darensbourg
Summary: This study explores the mechanism of zinc ions binding to the SC2M(pro) enzyme in combination with lipophilic tropolone and thiotropolone ligands, blocking substrate docking and inhibiting function. The Zn-L combinations show improved inhibition of the enzyme, providing potential for developing anti-viral therapies against SARS-CoV-2.
DALTON TRANSACTIONS
(2021)
Article
Chemistry, Multidisciplinary
Alexander M. Prophet, Kritanjan Polley, Gary J. Van Berkel, David T. Limmer, Kevin R. Wilson
Summary: The oxidation kinetics of iodide by ozone at the air-water interface is studied in single microdroplets. Molecular simulations and kinetic modeling are used to understand the underlying multiphase mechanism.
Article
Chemistry, Multidisciplinary
Rong Zhang, Jiajing Lan, Fei Wang, Shumei Chen, Jian Zhang
Summary: By utilizing 1,1'-ferrocene dicarboxylic acid as a chelating and surface protection ligand, we have synthesized multi-nuclear indium oxide clusters with varying nuclear sizes, including heptanuclear and thirteen-nuclear clusters. These clusters possess labile coordination sites, allowing for structural modification and self-assembly, resulting in the formation of various cluster structures.
Article
Chemistry, Multidisciplinary
Hui Wang, Hui Liu, Mingsen Wang, Jiaheng Hou, Yongjun Li, Yuancheng Wang, Yingjie Zhao
Summary: Two supramolecular complexes were prepared using CBs and M1, and their single-crystal structures were analyzed by SCXRD. The unexpected 1:2 self-assembly structure between M1 and CB[8] was discovered for the first time. These complexes exhibit unique photophysical properties and provide valuable information about the structure and photophysical properties of supramolecular complexes.
Article
Chemistry, Multidisciplinary
Chang-Hee Lee, Sookil Park, Sanggil Kim, Ji Young Hyun, Hyun Soo Lee, Injae Shin
Summary: The epidermal growth factor receptor (EGFR) is a cell-surface glycoprotein involved in cell proliferation and tumor development. This study used a fluorescently labeled EGFR to investigate its time-dependent endocytosis in live cells and found that appended glycans affect EGFR internalization. Additionally, the study detected sialic acid residues attached to EGFR on the live cell surface using FRET-based imaging. This research provides valuable insights into the cellular functions of EGFR.
Article
Chemistry, Multidisciplinary
Subhankar Sahu, Lokesh Kumar, Sumita Das, Dipti Gupta, Ruchi Anand
Summary: This study proposes a strategy that combines organic electronics with biosensor scaffolds to create a compact device for monitoring environmental aromatic pollution. By coupling biosensing protein MopR with an organic electrochemical transistor (OECT), a sensor module capable of efficient detection of phenol was designed. Exclusive phenol detection with minimal loss of sensitivity could be achieved in complex pollutant mixtures and real environmental samples.
Review
Chemistry, Multidisciplinary
Changseok Lee, Hyung-Joon Kang, Sungwoo Hong
Summary: The formation of C-N bonds through hydroamination reactions catalyzed by nickel hydrides has been a topic of recent interest. This approach offers a way to efficiently transform a variety of alkene and alkyne substrates into compounds enriched with C-N bonds. The review provides a concise overview of the underlying reaction mechanisms and aims to stimulate further progress in NiH-catalytic techniques and catalyst design.
Article
Chemistry, Multidisciplinary
Yueci Wu, Lu-Lu Sun, Hai-Hao Han, Xiao-Peng He, Weiguo Cao, Tony D. James
Summary: Drug-induced liver injury (DILI) is a common cause of acute liver failure in the USA and Europe, but most cases can be recovered or prevented by discontinuing the offending drug. Recent research has found that peroxynitrite (ONOO-) can be used as a potential indicator for early diagnosis of DILI, and there is an urgent need to establish a method to detect and track peroxynitrite in DILI cases. In this study, a FRET-based nano fluorescent probe CD-N-I was developed, which showed high selectivity and sensitivity in detecting peroxynitrite. The probe successfully detected exogenous peroxynitrite in live cells and endogenous peroxynitrite in APAP-induced liver injury of HepG2 cells.
Article
Chemistry, Multidisciplinary
Dmitry L. Lipilin, Mikhail O. Zubkov, Mikhail D. Kosobokov, Alexander D. Dilman
Summary: This article describes a direct photocatalytic method for the thiolation of unprotected acids, which was previously challenging. By using a thionocarbonate reagent with an N-O bond, the efficient conversion of carboxylic acids to thiols is achieved.
Article
Chemistry, Multidisciplinary
Jason Malenfant, Lucille Kuster, Yohann Gagne, Kouassi Signo, Maxime Denis, Sylvain Canesi, Mathieu Frenette
Summary: Raman microscopy can reveal compound-specific vibrational fingerprints without sample preparation. The combination of efficient theoretical calculations and a user-friendly software can accurately predict peak positions and provide match scores to assist with structure determination.
Article
Chemistry, Multidisciplinary
Jayoh A. Hernandez, Paul S. Micus, Sean Alec Lois Sunga, Luca Mazzei, Stefano Ciurli, Gabriele Meloni
Summary: Essential trace metals play crucial roles in the survival and virulence of bacterial pathogens. Helicobacter pylori requires nickel for colonization and persistence in the stomach, and NixA is an essential nickel transporter in this process. This study characterizes the selectivity and electrogenic nature of NixA-mediated nickel transport.
Article
Chemistry, Multidisciplinary
Tarali Devi, Kuheli Dutta, Jennifer Deutscher, Stefan Mebs, Uwe Kuhlmann, Michael Haumann, Beatrice Cula, Holger Dau, Peter Hildebrandt, Kallol Ray
Summary: This study emphasizes the importance of subtle electronic changes and secondary interactions in the stability of biologically relevant metal-dioxygen intermediates. It also shows that the role of the chloride ligand in stabilizing the Fe-III-(OOBu)-Bu-t moiety can extend to other anions, including the thiolate ligand.
Article
Chemistry, Multidisciplinary
Jacqueline R. Santhouse, Jeremy M. G. Leung, Lillian T. Chong, W. Seth Horne
Summary: By studying the folding kinetics and mechanism of the BdpA sequence, researchers found that altering the backbone connectivity can affect protein folding. This suggests that protein mimetic chains have a significant degree of plasticity in transitioning between unfolded and folded states.
Article
Chemistry, Multidisciplinary
Divanshu Gupta, Ralf Einholz, Holger F. Bettinger
Summary: This study presents the first direct spectroscopic evidence of a cyclic seven-membered iminoborane. Compared to linear amino-iminoboranes, this cyclic iminoborane exhibits weakened bond strength and lower Lewis acidity value. The study suggests that the reduced ring strain of cyclic iminoborane prevents nitrogen fixation but allows facile (2 + 2) cycloaddition reaction with C2H4.
Article
Chemistry, Multidisciplinary
Renny Mathew, Aniruddha Mazumder, Praveen Kumar, Julie Matula, Sharmarke Mohamed, Petr Brazda, Mahesh Hariharan, Brijith Thomas
Summary: This study reveals the packing arrangement of partially disordered nitro-perylenediimide (NO2-PDI) using a synergistic approach that combines 3D ED, ssNMR, and DFT techniques. By overcoming these challenges, this methodology opens up new avenues for material characterization, driving exciting advancements in the field.
